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Human TopBP1 Participates in Cyclin E/CDK2 Activation and Preinitiation Complex Assembly during G1/S Transition

Jeon, Y., Lee, K. Y., Ko, M. J., Lee, Y. S., Kang, S., & Hwang, D. S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609116200 · Cited by 33 · see citing works

Growth inhibitory effect and Chk1-dependent signaling involved in G2/M arrest on human gastric cancer cells induced by diallyl disulfide

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Ciclopirox inhibits cancer cell proliferation by suppression of Cdc25A

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Chk1 phosphorylates the tumour suppressor Mig‐6, regulating the activation of EGF signalling

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Fumonisin B1 Epigenetically Regulates PTEN Expression and Modulates DNA Damage Checkpoint Regulation in HepG2 Liver Cells

Arumugam, T., Ghazi, T., & Chuturgoon, A. A. (2020) · Toxins · doi:10.3390/toxins12100625 · Cited by 27 · see citing works

Midblastula transition (MBT) of the cell cycles in the yolk and pigment granule‐free translucent blastomeres obtained from centrifuged Xenopus embryos

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Cell Cycle Remodeling and Zygotic Gene Activation at the Midblastula Transition

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Impact of DNA repair and stability defects on cortical development

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The ascidian natural product eusynstyelamide B is a novel topoisomerase II poison that induces DNA damage and growth arrest in prostate and breast cancer cells

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PTEN is required for the normal progression of gastrulation by repressing cell proliferation after MBT in Xenopus embryos

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STK295900, a Dual Inhibitor of Topoisomerase 1 and 2, Induces G2 Arrest in the Absence of DNA Damage

Kim, S.-O., Sakchaisri, K., Thimmegowda, N. R., Soung, N., Jang, J., Kim, Y. S., Lee, K. S., Kwon, Y. T., Asami, Y., Ahn, J. S., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053908 · Cited by 19 · see citing works

Small Molecule Inhibitors Targeting Key Proteins in the DNA Damage Response for Cancer Therapy

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Cryo-EM structure of the CDK2-cyclin A-CDC25A complex

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The effect of ATM kinase inhibition on the initial response of human dental pulp and periodontal ligament mesenchymal stem cells to ionizing radiation

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Radiation-induced G2/M arrest rarely occurred in glioblastoma stem-like cells

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Mechanism-Based Screen Establishes Signalling Framework for DNA Damage-Associated G1 Checkpoint Response

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Inappropriate Activation of Cyclin-dependent Kinases by the Phosphatase Cdc25b Results in Premature Mitotic Entry and Triggers a p53-dependent Checkpoint

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Amino Acids C-Terminal to the 14-3-3 Binding Motif in CDC25B Affect the Efficiency of 14-3-3 Binding

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ELK3 destabilization by speckle-type POZ protein suppresses prostate cancer progression and docetaxel resistance

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Aberrant activation of cyclin A-CDK induces G2/M-phase checkpoint in human cells

Akaike, Y., & Chibazakura, T. (2019) · Cell Cycle · doi:10.1080/15384101.2019.1693119 · Cited by 13 · see citing works

NanoLC-MS/MS Analysis Provides New Insights into the Phosphorylation Pattern of Cdc25B in Vivo: Full Overlap with Sites of Phosphorylation by Chk1 and Cdk1/cycB Kinases in Vitro

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FBXW7 -loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe

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WEE1 Inhibition Augments CDC7 (DDK) Inhibitor–induced Cell Death in Ewing Sarcoma by Forcing Premature Mitotic Entry and Mitotic Catastrophe

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Activation of both Mos and Cdc25 is required for G2‐M transition in perch oocyte

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Carboxy-terminal phosphorylation sites in Cdc25 contribute to enforcement of the DNA damage and replication checkpoints in fission yeast

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Identification of a novel catalytic inhibitor of topoisomerase II alpha that engages distinct mechanisms in p53wt or p53−/− cells to trigger G2/M arrest and senescence

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Targeting ATR-CHK1 and ATM-CHK2 Axes in Pancreatic Cancer—A Comprehensive Review of Literature

Kciuk, M., Wanke, K., Marciniak, B., Kołat, D., Aleksandrowicz, M., Mujwar, S., Ainane, T., & Kontek, R. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031152 · Cited by 6 · see citing works

Maintaining Genome Stability in Defiance of Mitotic DNA Damage

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Regulation of Myt1 kinase activity via its N-terminal region in Xenopus meiosis and mitosis

Aiba, Y., Kim, J., Imamura, A., Okumoto, K., & Nakajo, N. (2021) · Cells and Development · doi:10.1016/j.cdev.2021.203754 · Cited by 5 · see citing works

Hornerin mediates phosphorylation of the polo-box domain in Plk1 by Chk1 to induce death in mitosis

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Phosphorylation Mediated Regulation of Cdc25 Activity, Localization and Stability

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Cyanopyridyl containing 1,4-dihydroindeno[1,2-c]pyrazoles as potent checkpoint kinase 1 inhibitors: Improving oral biovailability

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Role of Non-coding RNAs on the Radiotherapy Sensitivity and Resistance in Cancer Cells

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Inhibition of Melanoma Cell Growth by Salvianolic Acid A through CHK2-CDC25A Pathway Modulation

Pu, X.-Y., Mei, Y., Zheng, Q., & Ko, C. (2024) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2906213 · Cited by 4 · see citing works

Phosphoproteomics Analysis Reveals a Potential Role of CHK1 in Regulation of Innate Immunity through IRF3

Chen, Z., Wang, C., Lei, C., Feng, X., Li, C., Jung, S. Y., Qin, J., & Chen, J. (2020) · Journal of Proteome Research · doi:10.1021/acs.jproteome.9b00829 · Cited by 4 · see citing works

Damsel in distress calling on her knights: Illuminating the pioneering role of E3 ubiquitin ligases in guarding the genome integrity

Sahay, O., Barik, G. K., Sharma, T., Pillai, A. D., Rapole, S., & Santra, M. K. (2021) · DNA repair · doi:10.1016/j.dnarep.2021.103261 · Cited by 4 · see citing works

Mechanism and regulation of secondary immunoglobulin diversification

Bello, A., Hirth, G., Voigt, S., Tepper, S., & Jungnickel, B. (2023) · Cell Cycle · doi:10.1080/15384101.2023.2275397 · Cited by 3 · see citing works

Chk1 Activation Protects Rad9A from Degradation as Part of a Positive Feedback Loop during Checkpoint Signalling

Osorio-Zambrano, W. F., & Davey, S. K. (2015) · PLoS ONE · doi:10.1371/journal.pone.0144434 · Cited by 3 · see citing works

Characterization of NimA-related Kinase 10 (NEK10): A Role in Checkpoint Control

Moniz, L. S. (2010) · TSpace (University of Toronto) · Cited by 3 · see citing works

Correction: STK295900, a Dual Inhibitor of Topoisomerase 1 and 2, Induces G 2 Arrest in the Absence of DNA Damage

Kim, S.-O., Sakchaisri, K., Thimmegowda, N. R., Soung, N., Jang, J., Kim, Y. S., Lee, K. S., Kwon, Y. T., Asami, Y., Ahn, J. S., et al. (2013) · PLoS ONE · doi:10.1371/annotation/c5f432f6-1e92-42c0-8727-7ae972215d6f · Cited by 3 · see citing works

In Fanconi anemia, impaired accumulation of bone marrow neutrophils during emergency granulopoiesis induces hematopoietic stem cell stress

Hu, L., Huang, W., Liu, B., & Eklund, E. A. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107548 · Cited by 2 · see citing works

Environmental radiobiology of amphibians – knowledge gaps to be filled using cell lines

Vo, N. T. K. (2021) · International Journal of Radiation Biology · doi:10.1080/09553002.2021.1872815 · Cited by 2 · see citing works

Cdc25 Family Phosphatases in Cancer

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A functional variant in CHK1 contributes to increased risk of nasopharyngeal carcinoma in a Han Chinese population

Guo, Z., Wang, Y., Zhao, Y., Jin, Y., An, L., Xu, H. Y., Liu, Z., Chen, X., Zhou, H., Wang, H., et al. (2020) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29592 · Cited by 2 · see citing works

Cytofluorometric assessment of cell cycle progression in irradiated cells

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Intratumoral Heterogeneity of Vimentin Modulates Nuclear Mechanotransduction, DNA Damage Response and Cancer Cell SurvivalPreprint

Infante, E., Terriac, E., Gélin, M., Siegfried, H., Pereira, D., Roca, V., Varet, H., Khalilian, S., Reinier, R., Asnacios, A., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.27.661506 · Cited by 2 · see citing works

Dihydroxyacetone decreases the dATP pool, inducing replication stress and genomic instability in BEAS-2B cells

Hussain, S., Mukherjee, N., & Gassman, N. R. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.110876 · Cited by 1 · see citing works

Unsaturated fatty acids are required for germline proliferation and membrane structural integrity in Caenorhabditis elegans

Battista, B., Láscarez-Lagunas, L. I., de Mendoza, D., & Colaiácovo, M. P. (2025) · Genetics · doi:10.1093/genetics/iyaf269 · Cited by 1 · see citing works

Vimentin Loss Inhibits DNA Damage Responses and Promotes Cancer Cell Survival.

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The role of Cdc25 phosphatases in cell cycle checkpoints

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Chk1 Kinase Negatively Regulates Mitotic Function of Cdc25A Phosphatase through 14-3-3 Binding

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Conservation of the Chk1 Checkpoint Pathway in Mammals: Linkage of DNA Damage to Cdk Regulation Through Cdc25

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Chk1 versus Cdc25: Chking One’s Levels of Cellular Proliferation

Lam, M. H., & Rosen, J. M. (2004) · Cell Cycle · doi:10.4161/cc.3.11.1225 · Cited by 33 · see citing works

CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage

Schmitt, E., Boutros, R., Froment, C., Monsarrat, B., Ducommun, B., & Dozier, C. (2006) · Journal of Cell Science · doi:10.1242/jcs.03200 · Cited by 100 · see citing works