Adaptation to environmental pH: integrating the Rim101 and calcineurin signal transduction pathways

Kullas, Amy L.; Martin, Samuel J.; Davis, Dana

doi:10.1111/j.1365-2958.2007.05929.x

Cited by 75Fungal and yeast genetics researchAntifungal resistance and susceptibilitySignaling Pathways in Disease

Adaptation to environmental pH: integrating the Rim101 and calcineurin signal transduction pathways

Kullas, Amy L., Martin, Samuel J., Davis, Dana·2007·Molecular Microbiology

DOI 10.1111/j.1365-2958.2007.05929.x

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Abstract

The ability to appropriately respond to environmental conditions is critical for the survival of simple microbes and for development of complex multicellular organisms. Sensing and responding to a given environmental condition requires the integration of numerous signals through one or more signal transduction pathways. This leads to changes in gene expression, and potentially post-translational modifications, that favour growth in the given environment. In the fungus Candida albicans, an important opportunistic pathogen, environmental pH has profound effects on morphology and proper adaptation to extracellular pH is critical for pathogenesis. Here, we demonstrate that the Rim101/PacC pH-sensing pathway acts in parallel to Crz1, via calcineurin, to adapt to alkaline pH. We also show that the Rim101 pathway acts in parallel to Crz2, independent of calcineurin, to adapt to high lithium concentrations and to repress filamentation at acidic pH. Our studies also revealed a novel requirement for Crz1, Crz2 and calcineurin for growth at acidic pH. From these studies, we propose that the Crz1 homologue Crz2 is calcineurin-independent, but like Crz1, acts in parallel to promote specific Rim101-dependent processes. These results establish and begin to dissect the complex interactions between important signal transduction pathways in C. albicans, which are critical for virulence.

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In C. albicans, calcineurin is required for growth at both alkaline and acidic pH.
“In C. albicans, previous studies also revealed a novel requirement for calcineurin for growth at both alkaline and acidic pH (Bader et al., 2006; Kullas et al., 2007).”
From Calcineurin as a multifunctional regulator: Unraveling novel functions in fungal stress responses, hyphal growth, drug resistance, and pathogenesis (2014) · cites this paper as Kullas et al., 2007

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Authors: Kullas, A. L., Martin, S. J., & Davis, D.
Affiliations: University of Minnesota (US)
Corresponding author: Davis, Dana
ORCID: Kullas, Amy L.
Venue: Molecular Microbiology
Publisher: Wiley
Published: 2007-08-28
Volume: 66
Issue: 4
Pages: 858-871
ISSN: 0950-382X (ISSN-L)
1365-2958
DOI: 10.1111/j.1365-2958.2007.05929.x
OpenAlex: W1971123127
Cited by: 75
References: 65
Citations by year: 2026: 2 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 4 · 2018: 1 · 2017: 4 · 2016: 5 · 2015: 5 · 2014: 4 · 2013: 7 · 2012: 7
FWCI: 2.78
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Molecular Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: Burroughs Wellcome Fund
National Institutes of Health
National Institute of Allergy and Infectious Diseases (R01AI064054)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords: Candida albicans, calcineurin, Crz1, pH sensing, filamentation, virulence, transcription factors
MeSH terms: Adaptation, Physiological, Candida albicans, Fungal Proteins, Humans, Hydrogen-Ion Concentration, Mutation, Signal Transduction, Gene Expression Regulation, Fungal, Calcineurin

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Adaptation to environmental pH: integrating the Rim101 and calcineurin signal transduction pathways

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