The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
TRBP, a regulator of cellular PKR and HIV‐1 virus expression, interacts with Dicer and functions in RNA silencing
Abstract
Dicer is a key enzyme involved in RNA interference (RNAi) and microRNA (miRNA) pathways. It is required for biogenesis of miRNAs and small interfering RNAs (siRNAs), and also has a role in the effector steps of RNA silencing. Apart from Argonautes, no proteins are known to associate with Dicer in mammalian cells. In this work, we describe the ide.jpgication of TRBP (human immunodeficiency virus (HIV‐1) transactivating response (TAR) RNA‐binding protein) as a protein partner of human Dicer. We show that TRBP is required for optimal RNA silencing mediated by siRNAs and endogenous miRNAs, and that it facilitates cleavage of pre‐miRNA in vitro . TRBP had previously been assigned several functions, including inhibition of the interferon‐induced double‐stranded RNA‐regulated protein kinase PKR and modulation of HIV‐1 gene expression by association with TAR. The TRBP–Dicer interaction shown raises interesting questions about the potential interplay between RNAi and interferon–PKR pathways.
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Cites
MicroRNA biogenesis: coordinated cropping and dicing
Kim, V. N. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1644 · Cited by 2,546
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencing
Chendrimada, T. P., Gregory, R. I., Kumaraswamy, E., Norman, J., Cooch, N., Nishikura, K., & Shiekhattar, R. (2005) · Nature · doi:10.1038/nature03868 · Cited by 2,100
Dicer is essential for mouse development
Bernstein, E., Kim, S. Y., Carmell, M. A., Murchison, E. P., Alcorn, H., Li, M. Z., Mills, A. A., Elledge, S. J., Anderson, K. V., & Hannon, G. J. (2003) · Nature Genetics · doi:10.1038/ng1253 · Cited by 1,627
Perspective: machines for RNAi
Tomari, Y., & Zamore, P. D. (2005) · Genes & Development · doi:10.1101/gad.1284105 · Cited by 948
RNAi-mediated pathways in the nucleus
Matzke, M. A., & Birchler, J. A. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1500 · Cited by 844
R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway
Liu, Q., Rand, T. A., Kalidas, S., Du, F., Kim, H.-E., Smith, D. P., & Wang, X. (2003) · Science · doi:10.1126/science.1088710 · Cited by 704
A Protein Sensor for siRNA Asymmetry
Tomari, Y., Matranga, C., Haley, B., Martinez, N., & Zamore, P. D. (2004) · Science · doi:10.1126/science.1102755 · Cited by 599
Förstemann, K., Tomari, Y., Du, T., Vagin, V. V., Denli, A. M., Bratu, D. P., Klattenhoff, C., Theurkauf, W. E., & Zamore, P. D. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030236 · Cited by 545
Processing of Pre-microRNAs by the Dicer-1–Loquacious Complex in Drosophila Cells
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Evidence that HIV-1 Encodes an siRNA and a Suppressor of RNA Silencing
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Cited by
Regulation of microRNA biogenesis
Ha, M., & Kim, V. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3838 · Cited by 5,462
Biogenesis of small RNAs in animals
Kim, V. N., Han, J., & Siomi, M. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2632 · Cited by 2,814
Many roads to maturity: microRNA biogenesis pathways and their regulation
Winter, J., Jung, S., Keller, S., Gregory, R. I., & Diederichs, S. (2009) · Nature Cell Biology · doi:10.1038/ncb0309-228 · Cited by 2,656
MicroRNA: Biogenesis, Function and Role in Cancer
MacFarlane, L.-A., & R. Murphy, P. (2010) · Current Genomics · doi:10.2174/138920210793175895 · Cited by 1,584
Cancer Exosomes Perform Cell-Independent MicroRNA Biogenesis and Promote Tumorigenesis
Melo, S. A., Sugimoto, H., O’Connell, J. T., Kato, N., Villanueva, A., Vidal, A., Qiu, L., Vitkin, E., Perelman, L. T., Melo, C. A., et al. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.09.005 · Cited by 1,531
Metadata
- Authors
- Haase, A. D., Jaskiewicz, L., Zhang, H., Lainé, S., Sack, R., Gatignol, A., & Filipowicz, W.
- Venue
- EMBO reports
- Published
- 2005-10
- Volume
- 6
- Issue
- 10
- Pages
- 961-967
- ISSN
- 1469-221X (ISSN-L)
- 1469-3178
- OpenAlex
- W2070647652
- Cited by
- 657
- References
- 22
- FWCI
- 16.59
- Type
- journal article
- Language
- en
- Open access
- closed
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- Haase, A. D., Jaskiewicz, L., Zhang, H., Lainé, S., Sack, R., Gatignol, A., & Filipowicz, W. (2005). TRBP, a regulator of cellular PKR and HIV‐1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO reports. https://doi.org/10.1038/sj.embor.7400509
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