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Cited by 121Bariatric Surgery and OutcomesBone health and osteoporosis researchParathyroid Disorders and Treatments

Bone metabolism and risk of secondary hyperparathyroidism 12 months after gastric banding in obese pre-menopausal women

Pugnale, N, Giusti, V, Suter, M, Zysset, E, Héraïef, E, Gaillard, R C, Burckhardt, P·2003·International Journal of Obesity
DOI 10.1038/sj.ijo.0802177
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Abstract

Objective To evaluate, during the first postoperative year in obese pre-menopausal women, the effects of laparoscopic gastric banding on calcium and vitamin D metabolism, the potential modifications of bone mineral content and bone mineral density, and the risk of development of secondary hyperparathyroidism.Subjects Thirty-one obese pre-menopausal women aged between 25 and 52 y with a mean body mass index (BMI) of 43.6 kg/m(2), scheduled for gastric banding were included. Patients with renal, hepatic, metabolic and bone disease were excluded.Methods Body composition and bone mineral density (BMD) were measured at baseline, 6 and 12 months after gastric banding using dual-energy X-ray absorptiometry. Serum calcium, phosphate, alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, gamma-glutamyltransferase, bilirubin, urea, creatinine, uric acid, proteins, parathormone, vitamin D(3), IGF-1, IGF-BP3 and telopeptide, as well as urinary telopeptide, were measured at baseline and 1, 3, 6, 9 and 12 months after surgery.Results After 1 y vitamin D3 remained stable and PTH decreased by 12%, but the difference was not significant. Serum telopeptide C increased significantly by 100% (P<0.001). There was an initial drop of the IGF-BP3 during the first 6 months (P<0.05), but the reduction was no longer significant after 1 y. The BMD of cortical bone (femoral neck) decreased significantly and showed a trend of a positive correlation with the increase of telopeptides (P<0.06). The BMD of trabecular bone, at the lumbar spine, increased proportionally to the reduction of hip circumference and of body fat.Conclusion There is no evidence of secondary hyperparathyroidism 1 y after gastric banding. Nevertheless biochemical bone markers show a negative remodelling balance, characterized by an increase of bone resorption. The serum telopeptide seems to be a reliable parameter, not affected by weight loss, to follow up bone turnover after gastroplasty.

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  • After gastric banding, lumbar spine BMD does not change or increases slightly.

    “Studies have reported that LS BMD does not change, or increases slightly 40, 41, 43, 44.”

    From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [44]

  • RYGB subjects typically lose more weight and more bone at the hip and femoral neck at one year than those who undergo gastric banding or vertical banded gastroplasty.

    “Typically, RYGB subjects lose more weight and more bone at the hip and FN at one year than those who undergo GB44, 52 or VBG.72.”

    From Bone loss after bariatric surgery: causes, consequences, and management (2014) · cites this paper as [44]

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Authors
Pugnale, N., Giusti, V, Suter, M., Zysset, E., Héraïef, E., Gaillard, R. C., & Burckhardt, P.
Affiliations
Centre Hospitalier Universitaire Vaudois (CH)
Corresponding author
Giusti, V
ORCID
Venue
International Journal of Obesity
Publisher
Springer Science and Business Media LLC
Published
2003-01
Volume
27
Issue
1
Pages
110-116
ISSN
  • 0307-0565 (ISSN-L)
  • 1476-5497
DOI
10.1038/sj.ijo.0802177
OpenAlex
W2070301360
Cited by
121
References
54
Citations by year
2024: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 6 · 2015: 10 · 2014: 11 · 2013: 4 · 2012: 9
FWCI
3.52
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • International Journal of Obesity (publishedVersion)
  • PubMed (publishedVersion)
  • IRIS (submittedVersion)
  • SERVAL (Université de Lausanne) (submittedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Bariatric Surgery and Outcomes
  • Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
  • Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
Keywords
gastric banding, bariatric surgery, secondary hyperparathyroidism, bone metabolism, bone mineral density, bone turnover markers, telopeptides, vitamin D, parathyroid hormone, IGFBP-3, obesity, premenopausal women, bone resorption, weight loss
MeSH terms
Adult, Calcium, Female, Follow-Up Studies, Gastroscopy, Humans, Hyperparathyroidism, Secondary, Middle Aged, Obesity, Morbid, Risk Factors, Vitamin D, Gastric Bypass, Bone Density, Body Mass Index, Bone Remodeling, Premenopause

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