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Cited by 245Obesity, Physical Activity, DietDiabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Health and Disease Prevention

The relation of obesity throughout life to carotid intima-media thickness in adulthood: the Bogalusa Heart Study

Freedman, D S, Dietz, W H, Tang, R, Mensah, G A, Bond, M G, Urbina, E M, Srinivasan, S, Berenson, G S·2004·International Journal of Obesity
DOI 10.1038/sj.ijo.0802515
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Abstract

Objective Although obese children are at increased risk for coronary heart disease in later life, it is not clear if this association results from the persistence of childhood obesity into adulthood. We examined the relation of adiposity at various ages to the carotid intima-media thickness (IMT) at age 35 y.Design Prior to the determination of IMT by B-mode ultrasound, subjects (203 men, 310 women) had, on average, six measurements of body mass index (BMI) and triceps skinfold thickness (TSF) between the ages of 4 and 35 y. Mixed regression models for longitudinal data were used to assess the relation of these characteristics to adult IMT.Results Overall, adult IMT was associated with levels of both BMI and TSF (P<0.001), with the magnitudes of the associations with childhood adiposity comparable to those with adult levels of BMI and TSF. Furthermore, adult obesity modified the association between childhood adiposity and IMT: high IMT levels were seen only among overweight (BMI > or =95th percentile) children who became obese (BMI > or =30 kg/m2) adults (P<0.01 for linear trend). In contrast, IMT levels were not elevated among (1) overweight children who were not obese in adulthood, or among (2) thinner children who became obese adults.Conclusions These results emphasize the adverse, cumulative effects of childhood-onset obesity that persists into adulthood. Since many overweight children become obese adults, the prevention of childhood obesity should be emphasized.

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  • Central obesity is a risk marker, and probably a risk factor, for the development and progression of coronary artery disease.

    “Indeed, central obesity is undeniably a risk marker, and probably a risk factor for the development and progression of coronary artery disease (43, 105, 185–188, 229, 241, 328).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [105]

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Authors
Freedman, D. S., Dietz, W. H., Tang, R., Mensah, G. A., Bond, M. G., Urbina, E. M., Srinivasan, S., & Berenson, G. S.
Affiliations
  • Centers for Disease Control and Prevention (US)
  • Atrium Health Wake Forest Baptist (US)
  • Tulane University (US)
Corresponding author
Freedman, D S
ORCID
Venue
International Journal of Obesity
Publisher
Springer Science and Business Media LLC
Published
2003-10-28
Volume
28
Issue
1
Pages
159-166
ISSN
  • 0307-0565 (ISSN-L)
  • 1476-5497
DOI
10.1038/sj.ijo.0802515
OpenAlex
W2088313372
Cited by
244
References
50
Citations by year
2026: 4 · 2025: 7 · 2024: 2 · 2023: 15 · 2022: 12 · 2021: 9 · 2020: 14 · 2019: 7 · 2018: 12 · 2017: 7 · 2016: 6 · 2015: 12 · 2014: 9 · 2013: 15 · 2012: 12
FWCI
8.66
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • International Journal of Obesity (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Heart Association
  • National Institutes of Health
  • National Institute on Aging (AG16592, R01AG016592)
  • National Heart, Lung, and Blood Institute (HL 38 844)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Keywords
childhood obesity, carotid intima-media thickness, adult obesity, adiposity, body mass index, triceps skinfold thickness, overweight children, coronary heart disease risk, Bogalusa Heart Study, linear growth
MeSH terms
Adipose Tissue, Adolescent, Adult, Body Constitution, Carotid Arteries, Child, Child, Preschool, Cross-Sectional Studies, Female, Humans, Male, Obesity, Ultrasonography, Body Mass Index, Tunica Intima

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