The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
The Inflammation–Fibrosis Link? A Jekyll and Hyde Role for Blood Cells during Wound Repair
Open accessAbstract
The healing of a skin wound is a complex process involving many cell lineages. In adult tissues, repair is always accompanied by a robust inflammatory response, which is necessary to counter the potential for infection at any site where the skin barrier is breached. Unlike embryonic tissues that can repair perfectly without a remnant scar at the wound site, adult tissue repair always leads to formation of a fibrotic scar where the wound has healed. In recent years, it has become clear that the wound inflammatory response may be, at least in part, responsible for fibrosis at sites of tissue repair. In this review, we consider the beneficial vs the detrimental functions of inflammatory cells during the repair response and compare data from other tissues, the lung, and liver, where fibrosis and its resolution may be related to a damage-triggered inflammatory response. We also consider how it may be possible to molecularly disentangle the potentially good from the bad influences of inflammatory cells during tissue repair and how fundamental studies in inflammatory cell biology may prove the way forward for development of drug targets in this respect.
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“However, if ECM synthesis in myofibroblasts is not kept in check, then excessive matrix deposition can lead to fibrosis, scarring, and loss of tissue function [120–122].”
From CCN1/CYR61: the very model of a modern matricellular protein (2011) · cites this paper as [121]
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Inflammatory responses and inflammation-associated diseases in organs
Chen, L., Deng, H., Cui, H., Fang, J. S., Zuo, Z., Deng, J., Li, Y., Wang, X., & Zhao, L. (2017) · Oncotarget · doi:10.18632/oncotarget.23208 · Cited by 5,541
The extracellular matrix modulates the hallmarks of cancer
Pickup, M. W., Mouw, J. K., & Weaver, V. M. (2014) · EMBO Reports · doi:10.15252/embr.201439246 · Cited by 2,098
“Intriguingly, a chronically inflamed tissue is frequently fibrotic and shows increased collagen and fibronectin deposition [113,114].”
Franz, S., Rammelt, S., Scharnweber, D., & Simon, J. C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.05.078 · Cited by 1,391
Jun, J.-I., & Lau, L. F. (2010) · Nature Cell Biology · doi:10.1038/ncb2070 · Cited by 998
Reparative inflammation takes charge of tissue regeneration
Karin, M., & Clevers, H. (2016) · Nature · doi:10.1038/nature17039 · Cited by 767
Metadata
- Authors
- Stramer, B. M., Mori, R., & Martin, P.
- Affiliations
- University of Bristol (GB)
- Corresponding author
- Stramer, Brian M.
- Venue
- Journal of Investigative Dermatology
- Publisher
- Elsevier BV
- Published
- 2007-05
- Volume
- 127
- Issue
- 5
- Pages
- 1009-1017
- ISSN
- 0022-202X (ISSN-L)
- OpenAlex
- W1996789266
- Cited by
- 251
- References
- 88
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 15 · 2023: 11 · 2022: 7 · 2021: 5 · 2020: 8 · 2019: 8 · 2018: 22 · 2017: 12 · 2016: 19 · 2015: 11 · 2014: 16 · 2013: 16 · 2012: 13
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Journal of Investigative Dermatology (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- wound healing, skin fibrosis, inflammation, inflammatory cells, scar formation, tissue repair, pulmonary fibrosis, liver fibrosis, fibrosis resolution, therapeutic target
- MeSH terms
- Animals, Blood Cells, Cicatrix, Fibrosis, Humans, Inflammation, Liver Cirrhosis, Pulmonary Fibrosis, Skin, Wound Healing
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