Cited by 251Wound Healing and TreatmentsLiver physiology and pathologyCardiac Fibrosis and Remodeling

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The Inflammation–Fibrosis Link? A Jekyll and Hyde Role for Blood Cells during Wound Repair

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Stramer, Brian M., Mori, Ryoichi, Martin, Paul·2007·Journal of Investigative Dermatology

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Abstract

The healing of a skin wound is a complex process involving many cell lineages. In adult tissues, repair is always accompanied by a robust inflammatory response, which is necessary to counter the potential for infection at any site where the skin barrier is breached. Unlike embryonic tissues that can repair perfectly without a remnant scar at the wound site, adult tissue repair always leads to formation of a fibrotic scar where the wound has healed. In recent years, it has become clear that the wound inflammatory response may be, at least in part, responsible for fibrosis at sites of tissue repair. In this review, we consider the beneficial vs the detrimental functions of inflammatory cells during the repair response and compare data from other tissues, the lung, and liver, where fibrosis and its resolution may be related to a damage-triggered inflammatory response. We also consider how it may be possible to molecularly disentangle the potentially good from the bad influences of inflammatory cells during tissue repair and how fundamental studies in inflammatory cell biology may prove the way forward for development of drug targets in this respect.

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See all 251

Authors: Stramer, B. M., Mori, R., & Martin, P.
Affiliations: University of Bristol (GB)
Corresponding author: Stramer, Brian M.
ORCID: Stramer, Brian M.
Mori, Ryoichi
Martin, Paul
Venue: Journal of Investigative Dermatology
Publisher: Elsevier BV
Published: 2007-05
Volume: 127
Issue: 5
Pages: 1009-1017
ISSN: 0022-202X (ISSN-L)
DOI: 10.1038/sj.jid.5700811
OpenAlex: W1996789266
Cited by: 251
References: 88
Citations by year: 2026: 7 · 2025: 7 · 2024: 15 · 2023: 11 · 2022: 7 · 2021: 5 · 2020: 8 · 2019: 8 · 2018: 22 · 2017: 12 · 2016: 19 · 2015: 11 · 2014: 16 · 2013: 16 · 2012: 13
FWCI: 2.24
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3137 d)
Locations: Journal of Investigative Dermatology (publishedVersion)
PubMed (publishedVersion)
Bristol Research (University of Bristol) (publishedVersion)
Topics: Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords: wound healing, skin fibrosis, inflammation, inflammatory cells, scar formation, tissue repair, pulmonary fibrosis, liver fibrosis, fibrosis resolution, therapeutic target
MeSH terms: Animals, Blood Cells, Cicatrix, Fibrosis, Humans, Inflammation, Liver Cirrhosis, Pulmonary Fibrosis, Skin, Wound Healing

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The Inflammation–Fibrosis Link? A Jekyll and Hyde Role for Blood Cells during Wound Repair

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