Extrapyramidal symptoms and antidepressant drugs: neuropharmacological aspects of a frequent interaction in the elderly

Govoni, S; Racchi, M; Masoero, E; Zamboni, M; Ferini-Strambi, L

doi:10.1038/sj.mp.4000801

Cited by 35Treatment of Major DepressionParkinson's Disease Mechanisms and TreatmentsNeurotransmitter Receptor Influence on Behavior

Extrapyramidal symptoms and antidepressant drugs: neuropharmacological aspects of a frequent interaction in the elderly

Govoni, S, Racchi, M, Masoero, E, Zamboni, M, Ferini-Strambi, L·2001·Molecular Psychiatry

DOI 10.1038/sj.mp.4000801

Open this paper in CoChat — free account

Abstract

Depression is the most prevalent functional psychiatric disorder in late life. The problem of motor disorders associated with antidepressant use is relevant in the elderly. Elderly people are physically more frail and more likely to be suffering from physical illness, and any drug given may exacerbate pre-existing diseases, or interact with other drug treatments being administered for physical conditions. Antidepressants have been reported to induce extrapyramidal symptoms, including parkinsonism. These observations prompted us to review the neurobiological mechanism that may be involved in this complex interplay including neurotransmitters and neuronal circuits involved in movement and emotion control and their changes related to aging and disease. The study of the correlations between motor and mood disorders and their putative biochemical bases, as presented in this review, provide a rationale either to understand or to foresee motor side effects for psychotropic drugs, in particular antidepressants.

Integrity signals

Registry

Crossref · 10.1038/sj.mp.4000801

Cites

72 of 72 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

For those who do receive treatment for psychiatric symptoms in dystonia, treatment is often pharmacological, with many currently available treatments adversely affecting the underlying movement disorder.
“for those who do receive treatment, this is often pharmacological, with many of the currently available treatments adversely affecting the underlying movement disorder [9].”
From Internet-based cognitive behavioural therapy programme as an intervention for people diagnosed with adult-onset, focal, isolated, idiopathic cervical dystonia: A feasibility study protocol (2020) · cites this paper as [9]

THE CATECHOLAMINE HYPOTHESIS OF AFFECTIVE DISORDERS: A REVIEW OF SUPPORTING EVIDENCE
Schildkraut, J. J. (1965) · American Journal of Psychiatry · doi:10.1176/ajp.122.5.509 · Cited by 3,499 · see citing works
Psychopharmacology: The third generation of progress
O’Connell, R. A. (1988) · Comprehensive Psychiatry · doi:10.1016/0010-440x(88)90057-0 · Cited by 3,014 · see citing works
Psychopharmacology: The Fourth Generation of Progress
Brophy, J. J. (1995) · JAMA · doi:10.1001/jama.1995.03530220079046 · Cited by 1,582 · see citing works
Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus
Nibuya, M., Nestler, E., & Duman, R. (1996) · The Journal of Neuroscience · doi:10.1523/jneurosci.16-07-02365.1996 · Cited by 1,206 · see citing works
Parkinson's disease. Second of two parts.
Lang, A., & Lozano, A. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810153391607 · Cited by 1,193 · see citing works
Dopamine transporter occupancies in the human brain induced by therapeutic doses of oral methylphenidate
Volkow, N. D., Wang, G.-J., Fowler, J. S., Gatley, S. J., Logan, J., Ding, Y.-S., Hitzemann, R., & Pappas, N. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.10.1325 · Cited by 885 · see citing works
Association between decline in brain dopamine activity with age and cognitive and motor impairment in healthy individuals.
(1998) · PubMed · doi:10.1176/ajp.155.3.344 · Cited by 784 · see citing works
Acute stress facilitates long-lasting changes in cholinergic gene expression
Kaufer, D., Friedman, A., Seidman, S., & Soreq, H. (1998) · Nature · doi:10.1038/30741 · Cited by 588 · see citing works
Chronic central nervous system effects of acute organophosphate pesticide intoxication
ROSENSTOCK, L. (1991) · The Lancet · doi:10.1016/0140-6736(91)90356-t · Cited by 516 · see citing works
Treatment resistant depression: methodological overview and operational criteria
Souery, D., Amsterdam, J. D., de Montigny, C., Lecrubier, Y., Montgomery, S., Lipp, O., Racagni, G., Zohar, J., & Mendlewicz, J. (1999) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(98)00004-2 · Cited by 443 · see citing works
Neurochemical Characteristics of Amisulpride, an Atypical Dopamine D2/D3 Receptor Antagonist with Both Presynaptic and Limbic Selectivity
Schoemaker, H., Claustre, Y., Fage, D., Rouquier, L., Chergui, K., Curet, O., Oblin, A., Gonon, F., Carter, C. J., Bénavidès, J., et al. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36395-5 · Cited by 371 · see citing works
Dopamine and depression
Brown, A. S., & Gershon, S. (1993) · Journal of Neural Transmission · doi:10.1007/bf01245227 · Cited by 359 · see citing works
Post mortem studies in Parkinson’s disease — is it possible to detect brain areas for specific symptoms?
Jellinger, K. A. (1999) · Journal of neural transmission. Supplementum · doi:10.1007/978-3-7091-6360-3_1 · Cited by 349 · see citing works
Adaptation of N-Methyl-D-Aspartate (NMDA) Receptors following Antidepressant Treatment: Implications for the Pharmacotherapy of Depression
Skolnick, P., Layer, R. T., Popik, P., Nowak, G., Paul, I. A., & Trullás, R. (1996) · Pharmacopsychiatry · doi:10.1055/s-2007-979537 · Cited by 344 · see citing works
Mechanism of action of antidepressant medications.
Feighner, J. P. (1999) · PubMed · Cited by 319 · see citing works
AGITATED DEPRESSION AS A MIXED STATE AND THE PROBLEM OF MELANCHOLIA
Koukopoulos, A., & Koukopoulos, A. (1999) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70095-2 · Cited by 310 · see citing works
Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients
John Mann, J., & Malone, K. M. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00217-x · Cited by 278 · see citing works
Ritanserin, a 5-HT2 receptor antagonist, activates midbrain dopamine neurons by blocking serotonergic inhibition
Ugedo, L., Grenhoff, J., & Svensson, T. H. (1989) · Psychopharmacology · doi:10.1007/bf00442004 · Cited by 267 · see citing works
Psychopharmacological Profile of Amisulpride: An Antipsychotic Drug with Presynaptic D2/D3 Dopamine Receptor Antagonist Activity and Limbic Selectivity
Perrault, G., Depoortère, R., Morel, E., Sanger, D. J., & Scatton, B. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36394-3 · Cited by 230 · see citing works
Platelet serotonin-2 receptor binding sites in depression and suicide
Pandey, G. N., Pandey, S. C., Janicak, P. G., Marks, R., & Davis, J. M. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90576-n · Cited by 212 · see citing works
The mesolimbic dopamine system as a target for rapid antidepressant action
Willner, P. (1997) · International Clinical Psychopharmacology · doi:10.1097/00004850-199707003-00002 · Cited by 209 · see citing works
Neuromodulatory actions of dopamine on synaptically-evoked neostriatal responses in slices
Levine, M. S., Li, Z., Cepeda, C., Cromwell, H. C., & Altemus, K. L. (1996) · Synapse · doi:10.1002/(sici)1098-2396(199609)24:1 · Cited by 200 · see citing works
Risk Factors for Depression in Parkinson Disease
Tandberg, E., Larsen, J. O., Aarsland, D., Laake, K., & Cummings, J. L. (1997) · Archives of Neurology · doi:10.1001/archneur.1997.00550170097020 · Cited by 200 · see citing works
Metabolism of the Newer Antidepressants
Caccia, S. (1998) · Clinical Pharmacokinetics · doi:10.2165/00003088-199834040-00002 · Cited by 175 · see citing works
Multicenter, Placebo-Controlled, Fixed-Dose Study of Citalopram in Moderate-to-Severe Depression
Feighner, J. P., & Overø, K. F. (1999) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v60n1204 · Cited by 169 · see citing works
Neurochemical alterations of serotonergic neuronal systems in depression.
Risch, S. C., & Nemeroff, C. B. (1992) · PubMed · Cited by 139 · see citing works
Sertraline for the treatment of depression in parkinson's disease
Hauser, R. A., & Zesiewicz, T. A. (1997) · Movement Disorders · doi:10.1002/mds.870120522 · Cited by 136 · see citing works
Depression and parkinson's disease: possible role of serotonergic mechanisms
Kostić, V., Djuričič, B., Čovičković-Šternić, N., Bumbaširević, L., Nikolić, M., & Mršulja, B. B. (1987) · Journal of Neurology · doi:10.1007/bf00314109 · Cited by 132 · see citing works
Depression in Parkinson's disease: brainstem midline alteration on transcranial sonography and magnetic resonance imaging
Berg, D., Supprian, T., Hofmann, E. P., Zeiler, B., Jäger, A. H., Lange, K. W., Reiners, K., Becker, T., & Becker, G. (1999) · Journal of Neurology · doi:10.1007/s004150050541 · Cited by 129 · see citing works
Amisulpride versus imipramine and placebo in dysthymia and major depression
Lecrubier, Y., Boyer, P., Turjanski, S., & Rein, W. (1997) · Journal of Affective Disorders · doi:10.1016/s0165-0327(96)00103-6 · Cited by 118 · see citing works
Parkinson's disease and depression: evidence for an alteration of the basal limbic system detected by transcranial sonography
Becker, T., Becker, G., Seufert, J., Hofmann, E. P., Lange, K. W., Naumann, M., Lindner, A., Reichmann, H., Riederer, P. F., Beckmann, H., et al. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.63.5.590 · Cited by 113 · see citing works
CSF amine metabolites in depression
Reddy, P. L., Khanna, S., Subhash, M. N., Channabasavanna, S. M., & Rao, B. S. S. R. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90198-9 · Cited by 108 · see citing works
Amisulpride: A Review of its Pharmacodynamic and Pharmacokinetic Properties and Therapeutic Efficacy in the Management of Schizophrenia
Coukell, A. J., Spencer, C. M., & Benfield, P. (1996) · CNS Drugs · doi:10.2165/00023210-199606030-00006 · Cited by 108 · see citing works
Extrapyramidal Symptoms Associated With Cyclic Antidepressant Treatment
Gill, H. S., DeVane, C. L., & Risch, S. C. (1997) · Journal of Clinical Psychopharmacology · doi:10.1097/00004714-199710000-00007 · Cited by 107 · see citing works
Amisulpride versus fluoxetine in patients with dysthymia or major depression in partial remission A double-blind, comparative study
Smeraldi, E. (1998) · Journal of Affective Disorders · doi:10.1016/s0165-0327(97)00139-0 · Cited by 104 · see citing works
Amisulpride versus Amineptine and Placebo for the Treatment of Dysthymia
Boyer, P., Lecrubier, Y., Stalla‐Bourdillon, A., & Fleurot, O. (1999) · Neuropsychobiology · doi:10.1159/000026556 · Cited by 103 · see citing works
The role of noradrenaline in depression: a review.
Leonard, B. E. (1997) · PubMed · Cited by 101 · see citing works
Novel Pharmacological Approaches to the Treatment of Depression
Elias, E., Zhang, A. Y., & Manners, M. T. (2022) · Life · doi:10.3390/life12020196 · Cited by 74 · see citing works
Tricyclic antidepressant-induced extrapyramidal side effects.
Vandel, P., Bonin, B., Lévêque, E., Sechter, D., & Bízouard, P. (1997) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(97)00405-7 · Cited by 73 · see citing works
Platelet serotonin markers and depressive symptomatology
Sheline, Y. I., Bardgett, M. E., Jackson, J. L., Newcomer, J. W., & Csernansky, J. G. (1995) · Biological Psychiatry · doi:10.1016/0006-3223(94)00160-5 · Cited by 68 · see citing works
Sensitivity to ageing of the limbic dopaminergic system: a review
Barili, P., Carolis, G. D., Zaccheo, D., & Amenta, F. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(98)00104-3 · Cited by 64 · see citing works
Platelet 3H-paroxetine binding in depressed patients
D’Haenen, H., Waele, M. D., & Leysen, J. E. (1988) · Psychiatry Research · doi:10.1016/0165-1781(88)90082-0 · Cited by 61 · see citing works
Central dopaminergic transmission is selectively increased in the limbic system of rats chronically exposed to antidepressants
Montis, M. G. D., Devoto, P., Gessa, G. L., Meloni, D., Porcella, A., Saba, P., Serra, G., & Tagliamonte, A. (1990) · European Journal of Pharmacology · doi:10.1016/0014-2999(90)90589-x · Cited by 60 · see citing works
Slowness of movement in melancholic depression
Sachdev, P. S., & Aniss, A. M. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)91256-4 · Cited by 60 · see citing works
A role for 5-HT in the action of antidepressant drugs
Cowen, P. J. (1990) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(90)90033-x · Cited by 56 · see citing works
Mechanisms of Action of Antidepressants
Leonard, B. E. (1995) · CNS Drugs · doi:10.2165/00023210-199500041-00003 · Cited by 55 · see citing works
Complex movement disorders induced by fluoxetine
Bharucha, K. J., & Sethi, K. D. (1996) · Movement Disorders · doi:10.1002/mds.870110318 · Cited by 47 · see citing works
Depression and antidepressant therapy: Receptor dynamics
Zemlan, F. P., & Garver, D. L. (1990) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(90)90004-z · Cited by 45 · see citing works
Effects of Acute and Repeated Administration of Amisulpride, a Dopamine D2/D3 Receptor Antagonist, on the Electrical Activity of Midbrain Dopaminergic Neurons
Giovanni, G. D., Mascio, M. D., Matteo, V. D., & Esposito, E. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37762-6 · Cited by 44 · see citing works
Binding of [3H]paroxetine to platelets of depressed patients: seasonal differences and effects of diagnostic classification
D'Hondt, P., Maes, M. H. J., Leysen, J. E., Gommeren, W., Scharpé, S., & Cosyns, P. R. (1994) · Journal of Affective Disorders · doi:10.1016/0165-0327(94)90058-2 · Cited by 41 · see citing works
Biochemical hypotheses on antidepressant drugs: a guide for clinicians or a toy for pharmacologists?
Garattini, S. K., & SAMANIN, R. (1988) · Psychological Medicine · doi:10.1017/s0033291700007844 · Cited by 40 · see citing works
Death of PC12 cells and hippocampal neurons induced by adenoviral-mediated FAD human amyloid precursor protein gene expression
Luo, J. J., Wallace, W., Riccioni, T., Ingram, D. K., Roth, G. S., & Kusiak, J. W. (1999) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19990301)55:5 · Cited by 39 · see citing works
Fluoxetine Induced Dyskinesia
Mander, A. G., McCausland, M., Workman, B., Flamer, H. E., & Christophidis, N. (1994) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/00048679409075647 · Cited by 37 · see citing works
Studies on the serotonin transporter in platelets
Langer, S. Z., & Galzin, A. (1988) · Cellular and Molecular Life Sciences · doi:10.1007/bf01952194 · Cited by 36 · see citing works
Parkinsonism Associated with Fluoxetine and Cimetidine: A Case Report
Leo, R. J., Lichter, D. G., & Hershey, L. A. (1995) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198879500800406 · Cited by 34 · see citing works
Long Term Blockade of Serotonin Reuptake Affects Synaptotagmin Phosphorylation in the Hippocampus
Popoli, M., Venegoni, A., Vocaturo, C., Buffa, L., Pérez, J., Smeraldi, E., & Racagni, G. (1997) · Molecular Pharmacology · doi:10.1124/mol.51.1.19 · Cited by 34 · see citing works
cAMP-dependent phosphorylation system after short and long-term administration of moclobemide
Mori, S., Zanardi, R., Popoli, M., Garbini, S., Brunello, N., Smeraldi, E., Racagni, G., & Pérez, J. (1998) · Journal of Psychiatric Research · doi:10.1016/s0022-3956(98)00003-x · Cited by 32 · see citing works
Management of Psychiatric Symptoms of Parkinson’s Disease
Miyoshi, K., Ueki, A., & Nagano, O. (2008) · European Neurology · doi:10.1159/000118884 · Cited by 28 · see citing works
The effects of L-tryptophan on haloperidol-induced movement disorder in the rat
Kozell, L. B., Sandyk, R., Wagner, G. C., & Fisher, H. (1987) · Life Sciences · doi:10.1016/0024-3205(87)90602-3 · Cited by 28 · see citing works
Aminergic Studies and Cerebrospinal Fluid Cations in Suicide
Bánki, C. M., Arató, M., & Kilts, C. D. (1986) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1986.tb27901.x · Cited by 28 · see citing works
Dopamine and Depression
Rampello, L., Nicoletti, F., & Nicoletti, F. (2000) · CNS Drugs · doi:10.2165/00023210-200013010-00004 · Cited by 25 · see citing works
Effects of fluvoxamine on the protein phosphorylation system associated with rat neuronal microtubules
Pérez, J., Mori, S., Caivano, M., Popoli, M., Zanardi, R., Smeraldi, E., & Racagnib, G. (1995) · European Neuropsychopharmacology · doi:10.1016/0924-977x(95)00024-j · Cited by 25 · see citing works
AGING AND THE BASAL GANGLIA
Hubble, J. P. (1998) · Neurologic Clinics · doi:10.1016/s0733-8619(05)70086-4 · Cited by 22 · see citing works
The Many Effects of Lactulose
Bircher, J. (1972) · Drugs · doi:10.2165/00003495-197204010-00001 · Cited by 22 · see citing works
Noradrenaline (Norepinephrine) and Depression
Moffaert, M. V., & Dierick, M. (1999) · CNS Drugs · doi:10.2165/00023210-199912040-00004 · Cited by 20 · see citing works
Antidepressant-induced tardive dyskinesia: review and case report.
Clayton, A. H. (1995) · PubMed · Cited by 19 · see citing works
Dysthymia and depressive disorders: dopamine hypothesis
Gessa, G. L. (1996) · European Psychiatry · doi:10.1016/0924-9338(96)85186-8 · Cited by 15 · see citing works
Treatment of Depression in Late Life
Hay, D. P., Rodriguez, M. M., & Franson, K. L. (1998) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(18)30129-0 · Cited by 15 · see citing works
[Depression in the aged: diagnosis and treatment].
Waintraub, L. (1998) · PubMed · Cited by 8 · see citing works
Antidepressants. Current concepts of mode of action.
Leonard, B. E. (1991) · PubMed · Cited by 7 · see citing works
Neurotransmitter Changes in Human Brain During Ageing
Hornykiewicz, O. (1987) · Springer eBooks · doi:10.1007/978-3-642-72729-0_13 · Cited by 6 · see citing works
Diagnosis and Treatment of the Irritable Bowel Syndrome
Goulston, K. (1973) · Drugs · doi:10.2165/00003495-197306030-00008 · Cited by 4 · see citing works

Flagged first, then by citations

3 of the 75 references couldn’t be matched to a known paper.

Sorted by citations

Drug-induced parkinsonism
Mena, M. A., & de Yébenes, J. G. (2006) · Expert Opinion on Drug Safety · doi:10.1517/14740338.5.6.759 · Cited by 136 · see citing works
Drug-induced parkinsonism
López-Sendón, J. L., Mena, M. A., & de Yébenes, J. G. (2013) · Expert Opinion on Drug Safety · doi:10.1517/14740338.2013.787065 · Cited by 110 · see citing works
Drug and ECT treatment of depression in the elderly, 1996–2001: a literature review
Salzman, C., Wong, E., & Wright, B. C. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01337-9 · Cited by 80 · see citing works
Antipsychotic Treatment of Behavioral and Psychological Symptoms of Dementia (BPSD): Management of Extrapyramidal Side Effects
Ohno, Y., Kunisawa, N., & Shimizu, S. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01045 · Cited by 77 · see citing works
Extrapyramidal Reactions Associated With Serotonergic Antidepressants
Hawthorne, J. M., & Caley, C. F. (2015) · Annals of Pharmacotherapy · doi:10.1177/1060028015594812 · Cited by 73 · see citing works
Modulation of antipsychotic-induced extrapyramidal side effects by medications for mood disorders
Tatara, A., Shimizu, S., Shin, N., Sato, M., Sugiuchi, T., Imaki, J., & Ohno, Y. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.04.008 · Cited by 43 · see citing works
Randomized Controlled Trials of Add-On Antidepressants in Schizophrenia
Terevnikov, V., Joffe, G., & Stenberg, J. (2015) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyv049 · Cited by 37 · see citing works
Data-mining for detecting signals of adverse drug reactions of fluoxetine using the Korea Adverse Event Reporting System (KAERS) database
Kim, S., Park, K., Kim, M.-S., Yang, B. R., Choi, H. J., & Park, B. (2017) · Psychiatry Research · doi:10.1016/j.psychres.2017.06.038 · Cited by 27 · see citing works
Fluoxetine Administration Exacerbates Oral Tremor and Striatal Dopamine Depletion in a Rodent Pharmacological Model of Parkinsonism
Podurgiel, S. J., Milligan, M. N., Yohn, S. E., Purcell, L. J., Contreras-Mora, H. M., Correa, M., & Salamone, J. D. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.69 · Cited by 24 · see citing works
Non‐motor phenotypic subgroups in adult‐onset idiopathic, isolated, focal cervical dystonia
Wadon, M. E., Bailey, G. A., Yılmaz, Z., Hubbard, E., Alsaeed, M., Robinson, A., McLauchlan, D. J., Barbano, R. L., Marsh, L., Factor, S. A., et al. (2021) · Brain and Behavior · doi:10.1002/brb3.2292 · Cited by 20 · see citing works
Trazodone and Parkinsonism: The Link Strengthens
Sarwar, A. (2018) · Clinical Neuropharmacology · doi:10.1097/wnf.0000000000000278 · Cited by 19 · see citing works
Manipulating facial musculature with functional electrical stimulation as an intervention for major depressive disorder: a focused search of literature for a proposal
Demchenko, I., Kapadia, N. M., Iwasa, S. N., Nezhad, F. G., Zariffa, J., Kennedy, S. H., Rule, N. O., Cohn, J. F., Popović, M. R., Mulsant, B. H., et al. (2023) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-023-01187-8 · Cited by 14 · see citing works
Internet-based cognitive behavioural therapy programme as an intervention for people diagnosed with adult-onset, focal, isolated, idiopathic cervical dystonia: A feasibility study protocol
Wadon, M. E., Winter, M., & Peall, K. J. (2020) · Pilot and Feasibility Studies · doi:10.1186/s40814-020-00641-x · Cited by 9 · see citing works
“toms, and for those who do receive treatment, this is often pharmacological, with many of the currently available treatments adversely affecting the underlying movement disorder [9].”
Background
Internet-based cognitive behavioural therapy as a feasible treatment of adult-onset, focal, isolated, idiopathic cervical dystonia
Wadon, M. E., MacIver, C., Winter, M., & Peall, K. J. (2021) · Clinical Parkinsonism & Related Disorders · doi:10.1016/j.prdoa.2021.100121 · Cited by 11 · see citing works
Parkinsonismo reversible y dependiente de la dosis inducido por venlafaxina
García-Parajuá, P., Iniesta, I. A., & Magariños, M. (2003) · Medicina Clínica · doi:10.1016/s0025-7753(03)75202-6 · Cited by 8 · see citing works
Prevalence of Potential Pharmacological Interactions in Patients Undergoing Systemic Chemotherapy in a Tertiary Hospital
Amorim, E. D. T., Camargo, B., & Schuelter‐Trevisol, F. (2022) · Hospital Pharmacy · doi:10.1177/00185787211073464 · Cited by 7 · see citing works
SLC6A3, HTR2C and HTR6 Gene Polymorphisms and the Risk of Haloperidol-Induced Parkinsonism
Erjavec, G. N., Grubor, M., Živković, M., Božina, N., Šagud, M., Perković, M. N., Mihaljević-Peleš, A., Pivac, N., & Štrac, D. Š. (2022) · Biomedicines · doi:10.3390/biomedicines10123237 · Cited by 8 · see citing works
Serotonin Syndrome Triggered by Overuse of Caffeine and Complicated With Neuroleptic Malignant Syndrome: A Case Report
Ohta, R., & Sano, C. (2022) · Cureus · doi:10.7759/cureus.22468 · Cited by 5 · see citing works
Psychogenic movement disorder after a venlafaxine‐induced dystonia
Fonseca, L., Rodrigues, M., & Machado, Á. S. (2009) · Movement Disorders · doi:10.1002/mds.22910 · Cited by 5 · see citing works
New insights about the antidepressant-like effects of riparin A in a chronic murine model of depression
da Silva, C. P., Oliveira, D. D., Benincasa, B. I., Barbar, B., Perri, R. G. B., Fachin, A. L., Falconi‐Sobrinho, L. L., & Beleboni, R. O. (2024) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000781 · Cited by 4 · see citing works
When More Is Less: Overuse of Medical Services Harms Patients
Brownlee, S., Cassel, C. K., & Saini, V. (2014) · Springer eBooks · doi:10.1007/978-1-4939-0407-5_1 · Cited by 4 · see citing works
Clinical assessment of antipsychotic-induced extrapyramidal symptoms in nursing home residents with schizophrenia
Woźniak, K., & Kłoszewska, I. (2016) · Psychiatria i Psychologia Kliniczna · doi:10.15557/pipk.2016.0002 · Cited by 3 · see citing works
Polypharmacy in Psychiatry Practice, Volume II
Ritsner, M. S. (2013) · Springer eBooks · doi:10.1007/978-94-007-5799-8 · Cited by 3 · see citing works
Antidepressants in Schizophrenia: A Place for Them?
Terevnikov, V., & Joffe, G. (2012) · Springer eBooks · doi:10.1007/978-94-007-5805-6_9 · Cited by 1 · see citing works
"Non-Pharmacological Interventions for Chronic Pain and Depression: any Possible Applications of Multisensory Feedback Approaches Based on Body Representation? "
Martini, M. (2017) · Psychology and Behavioral Science International Journal · doi:10.19080/pbsij.2017.02.555599 · Cited by 1 · see citing works
Diagnóstico tardío en la rotura traumática del páncreas y el conducto pancreático
Ramírez‐Duque, N., Morillo, J. S. G., Álvarez, J. A., & Puente, M. (2003) · Medicina Clínica · doi:10.1016/s0025-7753(03)73832-9
The Effects of Acute Tryptophan Depletion on Movement, Mood, and Cognition in Patients with Parkinson’s Disease and Healthy Older Persons
Mace, J. L. (2007) · Otago University Research Archive (University of Otago)
Current Awareness
(2001) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.549
Current Awareness
(2001) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.374
Current Awareness
(2001) · Human Psychopharmacology Clinical and Experimental · doi:10.1002/hup.275
Parkinsonian Consequences in Patients Treated with Psychotropics-Why Does It Affect the Elderly More so than the Young?
(2022) · New Advances in Brain & Critical Care · doi:10.33140/nabcc.02.01.02
A comprehensive review on the role of dopamine in the pathophysiology of tardive dyskinesia
Kandasamy, K., Paramanandham, A., Kumari, G. R. S., & Ramalingam, K. (2023) · International Journal of Research in Medical Sciences · doi:10.18203/2320-6012.ijrms20233065
Mild motor signs in major depressive disorder: prevalence and clinical profile
Luca, A., Serretti, A., Barlati, S., Buson, L., Menesello, V., Magistrali, A., Silva, R. C., Perusi, G., Nibbio, G., Bignotti, S., et al. (2026) · The European Journal of Psychiatry · doi:10.1016/j.ejpsy.2026.100342
Aging in Schizophrenia: Clinical, Biological, and Psychosocial Perspectives
Morén, C., Pérez‐Toribio, A., Rubio-Contreras, E., Alvaro, P., Rosa-Castillo, A., & Pedregosa-Fauste, S. (2026) · Geriatrics · doi:10.3390/geriatrics11050133
Characteristics of Tremorogenesis and Tremorolytic Agents in a Pharmacological Rodent Model of Parkinsonism: Evidence from Behavioral, Neurochemical, and Electrophysiological Studies
Podurgiel, S. J. (2015) · OpenCommons at University of Connecticut (University of Connecticut)

Authors: Govoni, S., Racchi, M., Masoero, E., Zamboni, M., & Ferini-Strambi, L.
Affiliations: University of Pavia (IT)
IRCCS Ospedale San Raffaele (IT)
Corresponding author: Govoni, S
ORCID: Govoni, S
Racchi, M
Zamboni, M
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2001-03-01
Volume: 6
Issue: 2
Pages: 134-142
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/sj.mp.4000801
OpenAlex: W2312829777
Cited by: 35
References: 75
Citations by year: 2026: 2 · 2024: 1 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 2
FWCI: 0.24
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Molecular Psychiatry (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: extrapyramidal symptoms, antidepressants, older adults, parkinsonism, motor side effects, psychotropic drugs, neurotransmitters, neural circuits, aging, drug interactions
MeSH terms: Aged, Antidepressive Agents, Basal Ganglia Diseases, Depression, Drug Interactions, Humans

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Extrapyramidal symptoms and antidepressant drugs: neuropharmacological aspects of a frequent interaction in the elderly

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks