Cited by 363Treatment of Major DepressionNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

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Synaptic plasticity and mood disorders

Duman, R S·2002·Molecular Psychiatry

DOI 10.1038/sj.mp.4001016

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Abstract

Recent studies demonstrate that the molecular elements known to regulate neuronal plasticity in models of learning and memory are also involved in the actions of drugs used for the treatment of depression and bipolar disorder. This includes up-regulation of transcription factors, such as the cAMP response element binding protein and neurotrophic factors, such as brain derived neurotrophic factor. These findings raise the possibility that regulation of neural plasticity in specific neuronal circuits is integrally involved in the therapeutic intervention of mood disorders. Atypical antipsychotic drugs, including clozapine and olanzapine, are also effective for the treatment of bipolar disorder, and are used as add-on medication for unipolar depression. The possibility that these atypical antipsychotic drugs also influence the molecular determinants of synaptic plasticity that are involved in the response to drugs used for the treatment of mood disorders, is discussed.

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Mammalian neural stem cells.
Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111
Subgenual prefrontal cortex abnormalities in mood disorders
Drevets, W. C., Price, J. L., Simpson, J. R., Todd, R. D., Reich, T., Vannier, M., & Raichle, M. E. (1997) · Nature · doi:10.1038/386824a0 · Cited by 2,693
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129
Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments
Nibuya, M., Morinobu, S., & Duman, R. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-11-07539.1995 · Cited by 2,109
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
Hippocampal atrophy in recurrent major depression
Sheline, Y. I., Wang, P. W., Gado, M. H., Csernansky, J. G., & Vannier, M. W. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.9.3908 · Cited by 1,932
Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms
Bonni, A., Brunet, A., West, A. E., Datta, S. R., Takasu, M. A., & Greenberg, M. E. (1999) · Science · doi:10.1126/science.286.5443.1358 · Cited by 1,908
Stress and cognitive function
McEwen, B. S., & Sapolsky, R. M. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80028-x · Cited by 1,889
Hippocampal Volume Reduction in Major Depression
Bremner, J. D., Narayan, M., Anderson, E. R., Staib, L. H., Miller, H. L., & Charney, D. S. (2000) · American Journal of Psychiatry · doi:10.1176/ajp.157.1.115 · Cited by 1,670

Show all 46 references

Research works printed but not linked: 4

Thome J, Sakai N, Shin KH, Steffen C, Impey S, Storm DR et al. Regulation of cAMP-response-element promoter activity by antidepressant treatment in CRE-lacZ transgenic mice Soc Neurosci 1998 24: 1844
Shirayama Y, Chen ACH, Duman RS . Antidepressant-like effects of BDNF and NT-3 in behavioral models of depression Soc Neurosci 2000 26: 1042
Jacobs B, Fornal CA . Chronic fluoxetine treatment increases hippocampal neurogenesis in rats: a novel theory of depression Soc Neurosci Abstracts, Miami, FL 1999
Kim J-E, Nakagawa S, Duman RS . Chronic administration of rolipram, a cAMP phosphodiesterase-4 inhibitor, upregulates neurogenesis in the adult mouse hippocampus Soc Neurosci Abs 2000 26: 2316

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Chang, Y.-H., Lee, S.-Y., Chen, S., Tzeng, N., Wang, T., Lee, I. H., Chen, P. S., Huang, S., Yang, Y. K., Ko, H.-C., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.08.017 · Cited by 36
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Ende, G., Demirakça, T., & Tost, H. (2006) · Progress in brain research · doi:10.1016/s0079-6123(06)56027-3 · Cited by 37
Dietary restriction changes behaviours in brain‐derived neurotrophic factor heterozygous mice: role of serotonergic system
Koizumi, H., Hashimoto, K., & Iyo, M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05094.x · Cited by 37
Down-regulation of the Trk-B signal pathway: the possible pathogenesis of major depression
Tsai, S. (2003) · Medical Hypotheses · doi:10.1016/s0306-9877(03)00299-8 · Cited by 37
Intracellular Signalling Pathways and Mood Disorders
Fišar, Z., & Hroudová, J. (2010) · Folia Biologica · doi:10.14712/fb2010056040135 · Cited by 36
Calcineurin (protein phosphatase 2B) is involved in the mechanisms of action of antidepressants
Crozatier, C., Farley, S., Mansuy, I. M., Dumas, S., Bruno Giros, A., & Tzavara, E. T. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.030 · Cited by 36
Drug-Induced Decrease of Protein Kinase A Activity Reveals Alteration in BDNF Expression of Bipolar Affective Disorder
Karege, F., Schwald, M., & Kouaissi, R. E. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300384 · Cited by 35
Repeated Quinpirole Treatment Increases cAMP-Dependent Protein Kinase Activity and CREB Phosphorylation in Nucleus Accumbens and Reverses Quinpirole-Induced Sensorimotor Gating Deficits in Rats
Culm, K. E., Lugo‐Escobar, N., Hope, B. T., & Hammer, R. P. (2004) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300483 · Cited by 36
Getting balance: Drugs for bipolar disorder share target
Coyle, J. T., & Manji, H. K. (2002) · Nature Medicine · doi:10.1038/nm0602-557 · Cited by 35
The possible role of tissue-type plasminogen activator and the plasminogen system in the pathogenesis of major depression
Tsai, S. (2005) · Medical Hypotheses · doi:10.1016/j.mehy.2005.10.009 · Cited by 35
Peripheral brain-derived neurotrophic factor changes along treatment with extended release quetiapine during acute mood episodes: An open-label trial in drug-free patients with bipolar disorder
Grande, I., Kapczinski, F. P., Stertz, L., Colpo, G. D., Kunz, M., Ceresér, K. M., Kauer‐Sant’Anna, M., Frey, B. N., Vieta, E., & Magalhães, P. V. D. S. (2012) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2012.08.017 · Cited by 33
Candidate genes for panic disorder: insight from human and mouse genetic studies
Gratacòs, M., Sahún, I., Gallego, X., Amador‐Arjona, A., Estivill, X., & Dierssen, M. (2007) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2007.00318.x · Cited by 33
Recent developments in the psychobiology and pharmacotherapy of depression: optimising existing treatments and novel approaches for the future
Farvolden, P., Kennedy, S. H., & Lam, R. W. M. (2003) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.12.1.65 · Cited by 33
Benefits and Challenges of Ultra-Fast, Short-Acting Psychedelics in the Treatment of Depression
Ramaekers, J. G., Reckweg, J. T., & Mason, N. L. (2025) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20230890 · Cited by 35
Biological and Behavioral Patterns of Post-Stroke Depression in Rats
Ifergane, G., Boyko, M., Frank, D., Shiyntum, H. N., Grinshpun, J., Kuts, R., Geva, A. B., Kaplan, Z., Zeldetz, V., & Cohen, H. (2018) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2017.302 · Cited by 32
The P11, tPA/plasminogen system and brain-derived neurotrophic factor: Implications for the pathogenesis of major depression and the therapeutic mechanism of antidepressants
Tsai, S. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.06.005 · Cited by 32
Atypical antipsychotics in the treatment of mood disorders
Vieta, E. (2003) · Current Opinion in Psychiatry · doi:10.1097/00001504-200301000-00006 · Cited by 33
Rethinking the role of TRKB in the action of antidepressants and psychedelics
Brunello, C. A., Cannarozzo, C., & Castrén, E. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2024.08.011 · Cited by 31
Men navigating inward and outward through depression.
Ramirez, J., & Badger, T. (2014) · Archives of Psychiatric Nursing · doi:10.1016/j.apnu.2013.10.001 · Cited by 35
Sub-chronic administration of rimonabant causes loss of antidepressive activity and decreases doublecortin immunoreactivity in the mouse hippocampus
Lee, S., Kim, D. H., Yoon, S., & Ryu, J. H. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.10.017 · Cited by 31
Insulin receptor substrate-2 in the ventral tegmental area regulates behavioral responses to cocaine.
Iñiguez, S. D., Warren, B. L., Neve, R. L., Nestler, E. J., Russo, S. J., & Bolaños‐Guzmán, C. A. (2008) · Behavioral Neuroscience · doi:10.1037/a0012893 · Cited by 30
Vascular Endothelial Growth Factor and Brain-Derived Neurotrophic Factor in Quetiapine Treated First-Episode Psychosis
Murphy, B., Pang, T. Y., Hannan, A. J., Proffitt, T., McConchie, M., Kerr, M., Markulev, C., O’Donnell, C. P., McGorry, P. D., & Berger, G. E. (2014) · Schizophrenia Research and Treatment · doi:10.1155/2014/719395 · Cited by 30
Depression, antidepressants, and peripheral blood components.
Fišar, Z., & Raboch, J. (2008) · PubMed · Cited by 30
Knockdown of FSTL1 inhibits microglia activation and alleviates depressive-like symptoms through modulating TLR4/MyD88/NF-κB pathway in CUMS mice
Xiao, X., Zhang, H., Ning, W., Yang, Z. R., Wang, Y., & Zhang, T. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114060 · Cited by 29
Mechanisms of action of brain insulin against neurodegenerative diseases
Ramalingam, M., & Kim, S. (2014) · Journal of Neural Transmission · doi:10.1007/s00702-013-1147-1 · Cited by 30
The correlation between plasma brain-derived neurotrophic factor and cognitive function in bipolar disorder is modulated by the BDNF Val66Met polymorphism
Lee, S.-Y., Wang, T., Chen, S., Chang, Y.-H., Chen, P. S., Huang, S., Tzeng, N., Wang, L., Lee, I. H., Chen, K. C., et al. (2016) · Scientific Reports · doi:10.1038/srep37950 · Cited by 27
A new synthetic varacin analogue, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride (TC-2153), decreased hereditary catalepsy and increased the BDNF gene expression in the hippocampus in mice
Kulikov, A. V., Tikhonova, M. A., Kulikova, E. A., Volcho, K. P., Khomenko, T. M., Salakhutdinov, N. F., & Popova, N. K. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2594-8 · Cited by 28
Cannabinoids and monoamine neurotransmission with focus on monoamine oxidase
Fišar, Z. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.12.010 · Cited by 28
Pro-apoptotic Action of Corticosterone in Hippocampal Organotypic Cultures
Kurek, A., Kucharczyk, M. W., Detka, J., Ślusarczyk, J., Trojan, E., Głombik, K., Bojarski, B., Ludwikowska, A., Lasoń, W., & Budziszewska, B. (2016) · Neurotoxicity Research · doi:10.1007/s12640-016-9630-8 · Cited by 26
Toward a complex system understanding of bipolar disorder: A chaotic model of abnormal circadian activity rhythms in euthymic bipolar disorder
Hadaeghi, F., Golpayegani, M. R., Jafari, S., & Murray, G. (2016) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/0004867416642022 · Cited by 26

Authors: Duman, R. S.
Affiliations: Yale University (US)
Corresponding author: Duman, R S
ORCID: Duman, R S
Venue: Molecular Psychiatry
Publisher: Springer Science and Business Media LLC
Published: 2002-01
Volume: 7
Issue: S1
Pages: S29-S34
ISSN: 1359-4184 (ISSN-L)
1476-5578
DOI: 10.1038/sj.mp.4001016
OpenAlex: W1983914274
Cited by: 363
References: 46
Citations by year: 2026: 2 · 2025: 10 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 4 · 2020: 11 · 2019: 6 · 2018: 12 · 2017: 7 · 2016: 10 · 2015: 8 · 2014: 12 · 2013: 18 · 2012: 21
FWCI: 3.26
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Molecular Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (2P01 MH25642, MH-45481, P01MH025642)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: synaptic plasticity, mood disorders, depression, bipolar disorder, CREB, brain-derived neurotrophic factor, neurotrophic factors, transcription factors, atypical antipsychotics, clozapine, olanzapine, neural circuits, antidepressant mechanism
MeSH terms: Antidepressive Agents, Depressive Disorder, Humans, Synaptic Transmission, Neuronal Plasticity, Cyclic AMP Response Element-Binding Protein, Brain-Derived Neurotrophic Factor, Mood Disorders

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