The DOI matches its Crossref record; 51 of the 52 references it cites were found in a registry or an index.
Profound Impairment in Social Recognition and Reduction in Anxiety-Like Behavior in Vasopressin V1a Receptor Knockout Mice
Abstract
Considerable evidence suggests that arginine vasopressin (AVP) is critically involved in the regulation of many social and nonsocial behaviors, including emotionality. The existence of two AVP receptors in the brain, namely the V1a and V1b subtypes, and the lack of clear pharmacological data using selective agonists or antagonists, make it difficult to determine which receptor is responsible for the AVP-mediated effects on behavior. Here we report the behavioral effects of a null mutation in the V1a receptor (V1aR) in male mice. Male mice lacking functional V1aR (V1aRKO) exhibit markedly reduced anxiety-like behavior and a profound impairment in social recognition. V1aRKO performed normally on spatial and nonsocial olfactory learning and memory tasks. Acute central administration of AVP robustly stimulated stereotypical scratching and autogrooming in wild-type (WT), but not V1aRKO males. AVP and oxytocin (OT) mRNA and OT receptor-binding levels were similar in WT and V1aRKO mice. Given the current findings, the V1aR may provide a novel potential pharmacological target for social and affective disorders including autism, and anxiety disorders.
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In the citing paper
“The OT and AVP systems are also involved in more subtle aspects of social cognition, including recognising individuals as familiar (8,9).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [9]
In the citing paper
“V1aR and V1bR are both expressed in the brain and are the most well-known mediators of the effects of VP in the brain on social behavior.”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Bielsky et al., 2004
In the citing paper
“V1aR has been implicated in pair bonding, maternal care, aggression, social recognition, and social play”
From Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior (2016) · cites this paper as Bielsky et al., 2004
In the citing paper
“Finally, oxytocin can also bind to AVPR1A receptors25, which have also been linked to social functioning26.”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [26]
Citations
Cites
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Behavioural despair in rats: A new model sensitive to antidepressant treatments
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Social amnesia in mice lacking the oxytocin gene
Ferguson, J. N., Young, L. J., Hearn, E. F., Matzuk, M. M., Insel, T. R., & Winslow, J. T. (2000) · Nature Genetics · doi:10.1038/77040 · Cited by 1,130
Self-citationOxytocin in the Medial Amygdala is Essential for Social Recognition in the Mouse
Ferguson, J. N., Aldag, J. M., Insel, T. R., & Young, L. J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08278.2001 · Cited by 1,043
Self-citationA role for central vasopressin in pair bonding in monogamous prairie voles
Winslow, J. T., Hastings, N., Carter, C. S., Harbaugh, C. R., & Insel, T. R. (1993) · Nature · doi:10.1038/365545a0 · Cited by 948 · cited 1×
“…paternal behavior, social recognition, aggression, and affiliation, as well as anxiety-like behavior (Ferris et al, 1984, 1986; Le Moal et al, 1987; Winslow et al, 1993; Landgraf et al, 1995; Bamshad and Albers 1996; Liebsch et al, 1996; Everts and Koolhaas, 1997; Young et al, 1999; Parker and…”
BackgroundOxytocin is required for nursing but is not essential for parturition or reproductive behavior.
Nishimori, K., Young, L. J., Guo, Q., Wang, Z., Insel, T. R., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11699 · Cited by 734
Self-citationVasopressinergic control of pituitary adrenocorticotropin secretion comes of age
Antoni, F. A. (1993) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1993.1004 · Cited by 636
The neuroendocrine basis of social recognition
Ferguson, J. N., Young, L. J., & Insel, T. R. (2002) · Frontiers in Neuroendocrinology · doi:10.1006/frne.2002.0229 · Cited by 494
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Self-citationGriebel, G., Simiand, J., Serradeil-Le Gal, C., Wagnon, J., Pascal, M., Scatton, B., Maffrand, J.-P., & Soubrié, P. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.092012099 · Cited by 471
Cited by
Sorted by citations
Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine
Meyer-Lindenberg, A., Domes, G., Kirsch, P., & Heinrichs, M. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3044 · Cited by 1,688
The neurobiology of pair bonding.
Young, L. J., & Wang, Z. (2004) · Nature Neuroscience · doi:10.1038/nn1327 · Cited by 1,523
Self-citationOxytocin: The Great Facilitator of Life
Lee, H.-J., Macbeth, A. H., Pagani, J., & Young, W. S. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.001 · Cited by 1,037
The hippocampal CA2 region is essential for social memory
Hitti, F. L., & Siegelbaum, S. A. (2014) · Nature · doi:10.1038/nature13028 · Cited by 976
Vasopressin and Oxytocin Excite Distinct Neuronal Populations in the Central Amygdala
Huber, D., Veinante, P., & Stoop, R. (2005) · Science · doi:10.1126/science.1105636 · Cited by 804
Metadata
- Authors
- Bielsky, I. F., Hu, S.-B., Szegda, K. L., Westphal, H., & Young, L. J.
- Affiliations
- Emory University (US)
- National Institutes of Health (US)
- Corresponding author
- Bielsky, Isadora F
- ORCID
- Young, Larry J
- Venue
- Neuropsychopharmacology
- Published
- 2003-11-26
- Volume
- 29
- Issue
- 3
- Pages
- 483-493
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- OpenAlex
- W2084931825
- Cited by
- 531
- References
- 52
- Citations by year
- 2026: 16 · 2025: 13 · 2024: 14 · 2023: 20 · 2022: 26 · 2021: 24 · 2020: 15 · 2019: 20 · 2018: 19 · 2017: 26 · 2016: 21 · 2015: 21 · 2014: 35 · 2013: 30 · 2012: 25
- FWCI
- 32.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (9876754)
- National Institutes of Health (NIH-R01, IBN-9876754, RR‐00165)
- National Institute of Mental Health (K02MH064692, R01 MH56897, K02 MH64692, R01MH056897)
- National Center for Research Resources (RR-00 165, P51RR000165)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- vasopressin, vasopressin V1a receptor, knockout mice, social recognition, anxiety-like behavior, oxytocin, social behavior, emotionality, autism spectrum disorder, anxiety disorders, stereotypy, olfactory learning and memory
- MeSH terms
- Animals, Anxiety, Female, Genotype, Male, Mice, Inbred C57BL, Social Behavior, Receptors, Vasopressin, Mice, Knockout, Maze Learning, Recognition, Psychology, Mice
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