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Cited by 367Neuroendocrine regulation and behaviorOlfactory and Sensory Function StudiesNeurotransmitter Receptor Influence on Behavior

The V1a Vasopressin Receptor Is Necessary and Sufficient for Normal Social Recognition: A Gene Replacement Study

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Bielsky, Isadora F., Hu, Shuang-Bao, Ren, Xianghui, Terwilliger, Ernest F., Young, Larry J.·2005·Neuron
DOI 10.1016/j.neuron.2005.06.031
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Abstract

Vasopressin modulates many social and nonsocial behaviors, including emotionality. We have previously reported that male mice with a null mutation in the V1a receptor (V1aR) exhibit a profound impairment in social recognition and changes in anxiety-like behavior. Using site-specific injections of a V1aR-specific antagonist, we demonstrate that the lateral septum, but not the medial amygdala, is critical for social recognition. Reexpressing V1aR in the lateral septum of V1aR knockout mice (V1aRKO) using a viral vector resulted in a complete rescue of social recognition. Furthermore, overexpression of the V1aR in the lateral septum of wild-type (wt) mice resulted in a potentiation of social recognition behavior and a mild increase in anxiety-related behavior. These results demonstrate that the V1aR in the lateral septum plays a critical role in the neural processing of social stimuli required for complex social behavior.

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  • Social discrimination is a complex behavior, and several other signaling molecules have been shown to play a role in social discrimination, including oxytocin and arginine vasopressin.

    “social discrimination is a complex behavior, and several other signaling molecules have been shown to play a role in social discrimination, including oxytocin [35–37] and arginine vasopressin [24, 38–40].”

    From Sex-specific effects of neonatal progestin receptor antagonism on juvenile social play behavior in rats (2021) · cites this paper as [24]

  • AVP expression within the BST and CMA is involved in a number of social behaviors, including social play behavior.

    “AVP expression within the bed nucleus of the striaterminalis (BST) and the centromedial amygdala (CMA) is known to be involved in a number of social behaviors, [18][19][20] including social play behavior.21”

    From Neonatal MeCP2 is important for the organization of sex differences in vasopressin expression (2012) · cites this paper as [19]

  • Mice with reduced AVP release in the LS or lacking AVP V1aR have selective deficits in social memory, and re-introduction of AVP or V1aR in the LS rescues social memory.

    “Mice with reduced AVP release in the LS, or that are lacking AVP V1aR entirely, have similarly selective deficits in social memory, and re-introduction of AVP or V1aR respectively in the LS results in rescue of social memory (Bielsky et al 2004; Bielsky et al 2005; Lukas et al 2011).”

    From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Bielsky et al 2005

  • Mice with impairments in either the oxytocin or vasopressin system show deficits in distinguishing between familiar and novel conspecifics.

    “For example, mice with impairments in either system show deficits in distinguishing between familiar and novel conspecifics (74,94,95).”

    From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [94]

  • Bed nucleus of the stria terminalis vasopressin cell ablation impairs social recognition in males, likely through its projection to the lateral septum, and restoration of BNST-LS vasopressin signaling in Magel2-KO mice ameliorated social discrimination deficits.

    “For example, BNST AVP cell ablation impairs social recognition in males, likely through its projection to the LS (94, 108, 109), and restoration of BNST-LS AVP signaling in Magel2-KO mice ameliorated social discrimination deficits (110).”

    From Oxytocin, Vasopressin, and Social Behavior: From Neural Circuits to Clinical Opportunities (2022) · cites this paper as [94]

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Authors
Bielsky, I. F., Hu, S.-B., Ren, X., Terwilliger, E. F., & Young, L. J.
Affiliations
  • Emory University (US)
  • National Institutes of Health (US)
  • Beth Israel Deaconess Medical Center (US)
Corresponding author
Bielsky, Isadora F.
ORCID
Young, Larry J.
Venue
Neuron
Publisher
Elsevier BV
Published
2005-08
Volume
47
Issue
4
Pages
503-513
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2005.06.031
OpenAlex
W2058147277
Cited by
367
References
64
Citations by year
2026: 8 · 2025: 11 · 2024: 8 · 2023: 15 · 2022: 17 · 2021: 17 · 2020: 5 · 2019: 15 · 2018: 18 · 2017: 19 · 2016: 18 · 2015: 19 · 2014: 20 · 2013: 24 · 2012: 18
FWCI
27.70
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1f31mh070112-01)
  • National Institute of Mental Health (MH-64692, K02MH064692, MH 56897, MH070112, R01MH056538, MH056538)
  • National Center for Research Resources (RR-00 165, P51RR000165)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
vasopressin V1a receptor, social recognition, lateral septum, medial amygdala, gene replacement, anxiety-like behavior, emotionality, social behavior
MeSH terms
Amygdala, Animals, Anxiety Disorders, Behavior, Animal, Female, Genetic Vectors, Habituation, Psychophysiologic, Male, Mice, Inbred C57BL, Mutation, Septal Nuclei, Sexual Behavior, Animal, Smell, Social Behavior, Transfection, Receptors, Vasopressin, Mice, Knockout, Recognition, Psychology, Mice, Antidiuretic Hormone Receptor Antagonists

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