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Cited by 209Stress Responses and CortisolChild Abuse and TraumaNeuroendocrine regulation and behavior

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Cerebrospinal Fluid Corticotropin-Releasing Factor and Perceived Early-Life Stress in Depressed Patients and Healthy Control Subjects

Carpenter, Linda L, Tyrka, Audrey R, McDougle, Christopher J, Malison, Robert T, Owens, Michael J, Nemeroff, Charles B, Price, Lawrence H·2004·Neuropsychopharmacology
DOI 10.1038/sj.npp.1300375
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Abstract

Previous studies have reported elevated concentrations of cerebrospinal fluid (CSF) corticotropin-releasing factor (CRF) in patients with major depression. Elevations of CSF CRF have also been reported in adult laboratory animals exposed to the stress of brief maternal deprivation or maternal neglect in the neonatal or preweaning period. The present study was designed to determine whether major depression and a history of perceived early adversity in childhood are independently associated with elevated CSF CRF concentrations in adults. In this case-control study, 27 medication-free adults with major depression and 25 matched controls underwent standardized lumbar puncture for collection of a single CSF sample at 1200. Subjects provided data about significant adverse early-life experiences and rated their global perceived level of stress during pre-school and preteen years on a six-point Likert scale. The mean difference in CSF CRF between depressed patients and controls did not reach statistical significance. In a regression model, perceived early-life stress was a significant predictor of CSF CRF, but depression was not. Perinatal adversity and perceived adversity in the preteen adversity years (ages 6-13 years) were both independently associated with decreasing CSF CRF concentrations. The relationship observed between perceived early-life stress and adult CSF CRF concentrations in this study closely parallels recent preclinical findings. More work is needed to elucidate the…

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Research works printed but not linked: 3

  1. Buske-Kirschbaum A, Jobst S, Wilkes C, Hellhammer DH (2000). American Psychosomatic Society, Vol. Abstract number 1392. Savannah, GA.
  2. Hong SK, Gold PW, Herkenham M (1993). Hypothalamic paraventricular lesions decrease corticotropin-releasing hormone in the CSF and elevate TRH mRNA in the locus coeruleus (Abstract 31211). Soc Neurosci Abstr 19: 762.
  3. Plotsky PM, Sanchez MM (2003). AAAS Annual Meeting. Denver, CO.

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Metadata

Authors
Carpenter, L. L., Tyrka, A. R., McDougle, C. J., Malison, R. T., Owens, M. J., Nemeroff, C. B., & Price, L. H.
Affiliations
  • Brown University (US)
  • Indiana University School of Medicine (US)
  • Yale University (US)
  • Emory University (US)
Corresponding author
Carpenter, Linda L
ORCID
Venue
Neuropsychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2003-12-31
Volume
29
Issue
4
Pages
777-784
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
DOI
10.1038/sj.npp.1300375
OpenAlex
W2005533083
Cited by
209
References
48
Citations by year
2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 27 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 19 · 2015: 9 · 2014: 20 · 2013: 9 · 2012: 9
FWCI
2.89
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Neuropsychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Alliance for Research on Schizophrenia and Depression
  • National Institutes of Health (MH-42088)
  • National Institute of Mental Health (R01MH042088, P50MH058922, MH58922, MH42088)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords
corticotropin-releasing factor, cerebrospinal fluid, major depressive disorder, childhood adversity, maternal deprivation, maternal neglect, perinatal adversity, neuroendocrine changes, stress hormones
MeSH terms
Adult, Corticotropin-Releasing Hormone, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Life Change Events, Male, Middle Aged, Stress, Psychological, Linear Models, Case-Control Studies

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