Cited by 209Stress Responses and CortisolChild Abuse and TraumaNeuroendocrine regulation and behavior

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Cerebrospinal Fluid Corticotropin-Releasing Factor and Perceived Early-Life Stress in Depressed Patients and Healthy Control Subjects

Carpenter, Linda L, Tyrka, Audrey R, McDougle, Christopher J, Malison, Robert T, Owens, Michael J, Nemeroff, Charles B, Price, Lawrence H·2004·Neuropsychopharmacology

DOI 10.1038/sj.npp.1300375

Open this paper in CoChat — free account

Abstract

Previous studies have reported elevated concentrations of cerebrospinal fluid (CSF) corticotropin-releasing factor (CRF) in patients with major depression. Elevations of CSF CRF have also been reported in adult laboratory animals exposed to the stress of brief maternal deprivation or maternal neglect in the neonatal or preweaning period. The present study was designed to determine whether major depression and a history of perceived early adversity in childhood are independently associated with elevated CSF CRF concentrations in adults. In this case-control study, 27 medication-free adults with major depression and 25 matched controls underwent standardized lumbar puncture for collection of a single CSF sample at 1200. Subjects provided data about significant adverse early-life experiences and rated their global perceived level of stress during pre-school and preteen years on a six-point Likert scale. The mean difference in CSF CRF between depressed patients and controls did not reach statistical significance. In a regression model, perceived early-life stress was a significant predictor of CSF CRF, but depression was not. Perinatal adversity and perceived adversity in the preteen adversity years (ages 6-13 years) were both independently associated with decreasing CSF CRF concentrations. The relationship observed between perceived early-life stress and adult CSF CRF concentrations in this study closely parallels recent preclinical findings. More work is needed to elucidate the…

Integrity signals

Registry

Crossref · 10.1038/sj.npp.1300375

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A rating scale for depression
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817
Psychopharmacology: The Fourth Generation of Progress
Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985
Impact of child sexual abuse: A review of the research.
Browne, A., & Finkelhor, D. (1986) · Psychological Bulletin · doi:10.1037/0033-2909.99.1.66 · Cited by 2,718
Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood
Heim, C. (2000) · JAMA · doi:10.1001/jama.284.5.592 · Cited by 1,968
Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638
Elevated Concentrations of CSF Corticotropin-Releasing Factor-Like Immunoreactivity in Depressed Patients
Nemeroff, C. B., Widerlöv, E., Bissette, G., Walléus, H., Karlsson, I., Eklund, K., Kilts, C. D., Loosen, P. T., & Vale, W. (1984) · Science · doi:10.1126/science.6334362 · Cited by 1,485
Self-citation
Early Environmental Regulation of Forebrain Glucocorticoid Receptor Gene Expression: Implications for Adrenocortical Responses to Stress; pp. 49–60
Meaney, M. J., Diorio, J., Francis, D., Widdowson, J., LaPlante, P., Caldji, C., Sharma, S., Seckl, J. R., & Plotsky, P. M. (2010) · Developmental Neuroscience · doi:10.1159/000111395 · Cited by 878
Psychopharmacology: The Fourth Generation of Progress
Kramlinger, K. G. (1995) · Mayo Clinic Proceedings · doi:10.4065/70.10.1021-a · Cited by 779
Altered Pituitary-Adrenal Axis Responses to Provocative Challenge Tests in Adult Survivors of Childhood Abuse
Heim, C., Newport, D. J., Bonsall, R., Miller, A. H., & Nemeroff, C. B. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.4.575 · Cited by 746
Self-citation
Neuropsychopharmacology
Mathur, R. (2004) · Jaypee Brothers Medical Publishers (P) Ltd. eBooks · doi:10.5005/jp/books/10243_6 · Cited by 669

Show all 48 references

Research works printed but not linked: 3

Buske-Kirschbaum A, Jobst S, Wilkes C, Hellhammer DH (2000). American Psychosomatic Society, Vol. Abstract number 1392. Savannah, GA.
Hong SK, Gold PW, Herkenham M (1993). Hypothalamic paraventricular lesions decrease corticotropin-releasing hormone in the CSF and elevate TRH mRNA in the locus coeruleus (Abstract 31211). Soc Neurosci Abstr 19: 762.
Plotsky PM, Sanchez MM (2003). AAAS Annual Meeting. Denver, CO.

Sorted by citations

Effects of stress throughout the lifespan on the brain, behaviour and cognition
Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2639 · Cited by 6,256
Adverse childhood experiences, allostasis, allostatic load and age-related disease
Danese, A., & McEwen, B. S. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.08.019 · Cited by 2,140
The link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704
Self-citation
Association of <emph type="ital">FKBP5</emph> Polymorphisms and Childhood Abuse With Risk of Posttraumatic Stress Disorder Symptoms in Adults
Binder, E. B. (2008) · JAMA · doi:10.1001/jama.299.11.1291 · Cited by 1,362
Current research trends in early life stress and depression: Review of human studies on sensitive periods, gene–environment interactions, and epigenetics
Heim, C., & Binder, E. B. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.10.032 · Cited by 986
Effects of the social environment and stress on glucocorticoid receptor gene methylation: A systematic review
Turecki, G., & Meaney, M. J. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.11.022 · Cited by 796
Paradise lost: the neurobiological and clinical consequences of child abuse and neglect
Nemeroff, C. B. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.019 · Cited by 768
Self-citation
Posttraumatic stress disorder: a state-of-the-science review
Nemeroff, C. B., Bremner, J. D., Foa, E. B., Mayberg, H. S., North, C. S., & Stein, M. B. (2006) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.07.005 · Cited by 675
Self-citation
Influence of Child Abuse on Adult Depression: Moderation by the Corticotropin-Releasing Hormone Receptor Gene
Bradley, R. G., Binder, E. B., Epstein, M. P., Tang, Y., Nair, H. P., Liu, W., Gillespie, C. F., Berg, T., Evces, M., Newport, D. J., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.26 · Cited by 643
Self-citation
Neurobiological and psychiatric consequences of child abuse and neglect
Heim, C., Shugart, M., Craighead, W. E., & Nemeroff, C. B. (2010) · Developmental Psychobiology · doi:10.1002/dev.20494 · Cited by 613
Self-citation
Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application
Millan, M. J. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.11.006 · Cited by 569
Long term consequences of neonatal rearing on central corticotropin-releasing factor systems in adult male rat offspring
Plotsky, P. M., Thrivikraman, K. V., Nemeroff, C. B., Caldji, C., Sharma, S., & Meaney, M. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300769 · Cited by 522
Self-citation
Early life stress and development: potential mechanisms for adverse outcomes
Smith, K. E., & Pollak, S. D. (2020) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-020-09337-y · Cited by 500
Early Life Stress and Morphometry of the Adult Anterior Cingulate Cortex and Caudate Nuclei
Cohen, R. A., Grieve, S., Hoth, K. F., Paul, R. H., Sweet, L., Tate, D., Gunstad, J., Stroud, L., McCaffery, J., Hitsman, B., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.12.016 · Cited by 439
Annual Research Review: All mothers are not created equal: neural and psychobiological perspectives on mothering and the importance of individual differences
Barrett, J., & Fleming, A. S. (2011) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2010.02306.x · Cited by 433
Neurophysiologic effects of transcutaneous auricular vagus nerve stimulation (taVNS) via electrical stimulation of the tragus: A concurrent taVNS/fMRI study and review
Badran, B. W., Dowdle, L. T., Mithoefer, O. J., LaBate, N. T., Coatsworth, J., Brown, J. C., DeVries, W. H., Austelle, C. W., McTeague, L. M., & George, M. S. (2017) · Brain stimulation · doi:10.1016/j.brs.2017.12.009 · Cited by 399
The CRF system, stress, depression and anxiety—insights from human genetic studies
Binder, E. B., & Nemeroff, C. B. (2010) · Molecular Psychiatry · doi:10.1038/mp.2009.141 · Cited by 379
Self-citation
Rethinking Concepts and Categories for Understanding the Neurodevelopmental Effects of Childhood Adversity
Smith, K. E., & Pollak, S. D. (2020) · Perspectives on Psychological Science · doi:10.1177/1745691620920725 · Cited by 379
Corticotropin Releasing Factor (CRF) Receptor Signaling in the Central Nervous System: New Molecular Targets
Hauger, R., Risbrough, V. B., Brauns, O., & Dautzenberg, F. M. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706777950684 · Cited by 344
Hidden wounds? inflammatory links between childhood trauma and psychopathology
Danese, A., & Baldwin, J. R. (2017) · Annual Review of Psychology · doi:10.1146/annurev-psych-010416-044208 · Cited by 286
The Development of Persistent Pain and Psychological Morbidity After Motor Vehicle Collision: Integrating the Potential Role of Stress Response Systems Into a Biopsychosocial Model
McLean, S. A., Clauw, D. J., Abelson, J. L., & Liberzon, I. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000181276.49204.bb · Cited by 279
Interaction of childhood maltreatment with the corticotropin-releasing hormone receptor gene: effects on hypothalamic-pituitary-adrenal axis reactivity
Tyrka, A. R., Price, L. H., Gelernter, J., Schepker, C., Anderson, G. M., & Carpenter, L. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.05.012 · Cited by 264
Self-citation
Intergenerational Transmission of Maternal Childhood Maltreatment Exposure: Implications for Fetal Brain Development
Buss, C., Entringer, S., Moog, N. K., Toepfer, P., Fair, D. A., Simhan, H. N., Heim, C. M., & Wadhwa, P. D. (2017) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2017.03.001 · Cited by 250
Childhood parental loss and adult hypothalamic-pituitary-adrenal function
Tyrka, A. R., Wier, L., Price, L. H., Ross, N., Anderson, G. M., Wilkinson, C. W., & Carpenter, L. L. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.01.011 · Cited by 250
Self-citation
Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness?
Jeon, S. W., & Kim, Y. K. (2016) · World Journal of Psychiatry · doi:10.5498/wjp.v6.i3.283 · Cited by 247
The Neurobiological Toll of Child Abuse and Neglect
Neigh, G. N., Gillespie, C. F., & Nemeroff, C. B. (2009) · Trauma Violence & Abuse · doi:10.1177/1524838009339758 · Cited by 248
Self-citation
Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function
Anacker, C., O'Donnell, K. J., & Meaney, M. J. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.3/canacker · Cited by 237
Moderation of Adult Depression by a Polymorphism in the FKBP5 Gene and Childhood Physical Abuse in the General Population
Appel, K., Schwahn, C., Mahler, J., Schulz, A., Spitzer, C., Fenske, K., Stender, J., Barnow, S., John, U., Teumer, A., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.81 · Cited by 234
ERK/MAPK signalling in the developing brain: Perturbations and consequences
Iroegbu, J. D., Ijomone, O. K., Femi-Akinlosotu, O. M., & Ijomone, O. M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.009 · Cited by 212
Early-life adversity and brain development: Is the microbiome a missing piece of the puzzle?
O’Mahony, S. M., Clarke, G., Dinan, T. G., & Cryan, J. F. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.068 · Cited by 203
Psychological and neural mechanisms of trait mindfulness in reducing depression vulnerability
Paul, N. A., Stanton, S. J., Greeson, J. M., Smoski, M. J., & Wang, L. (2013) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nss070 · Cited by 193
Identifying key features of early stressful experiences that produce stress vulnerability and resilience in primates
Parker, K. J., & Maestripieri, D. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.09.003 · Cited by 167
Momentary relationship between cortisol secretion and symptoms in patients with fibromyalgia
McLean, S. A., Williams, D. A., Harris, R. E., Kop, W. J., Groner, K. H., Ambrose, K., Lyden, A. K., Gracely, R. H., Crofford, L. J., Geisser, M. E., et al. (2005) · Arthritis & Rheumatism · doi:10.1002/art.21372 · Cited by 187
The CRF Family of Neuropeptides and their Receptors - Mediators of the Central Stress Response
Dedic, N., Chen, A., & Deussing, J. M. (2017) · Current Molecular Pharmacology · doi:10.2174/1874467210666170302104053 · Cited by 187
Neurobehavioral foundation of environmental reactivity.
Moore, S. R., & Depue, R. A. (2015) · Psychological Bulletin · doi:10.1037/bul0000028 · Cited by 183
The clinical correlates of reported childhood sexual abuse: an association between age at trauma onset and severity of depression and PTSD in adults
Schoedl, A. F., Costa, M. C. P., Mari, J. J., Mello, M. F., Tyrka, A. R., Carpenter, L. L., & Price, L. H. (2010) · Journal of Child Sexual Abuse · doi:10.1080/10538711003615038 · Cited by 164
Self-citation
Early Life Stress, Mood, and Anxiety Disorders
Syed, S. A., & Nemeroff, C. B. (2017) · Chronic Stress · doi:10.1177/2470547017694461 · Cited by 174
Self-citation
Early Life Stress and Adult Emotional Experience: An International Perspective
Cohen, R. A., Hitsman, B. L., Paul, R. H., McCaffery, J. M., Stroud, L. R., Sweet, L. H., Gunstad, J., NIAURA, R. S., MacFarlane, A. C., Bryant, R. A., et al. (2006) · The International Journal of Psychiatry in Medicine · doi:10.2190/5r62-9pqy-0nel-tlpa · Cited by 148
Perinatal programming of emotional brain circuits: an integrative view from systems to molecules
Bock, J., Rether, K., Gröger, N., Xie, L., & Braun, K. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00011 · Cited by 152
Polymorphisms in CRHR1 and the serotonin transporter loci: Gene × Gene × Environment interactions on depressive symptoms
Ressler, K. J., Bradley, B., Mercer, K. B., Deveau, T. C., Smith, A. K., Gillespie, C. F., Nemeroff, C. B., Cubells, J. F., & Binder, E. B. (2010) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31052 · Cited by 140
“These observations in laboratory animals are consistent with the findings in humans where early life trauma is a strong predictor of CSF CRF concentration in adults [Carpenter et al., 2004; Lee et al., 2005, 2006].”
Self-citation
A review of physiological and behavioral monitoring with digital sensors for neuropsychiatric illnesses
Reinertsen, E., & Clifford, G. D. (2018) · Physiological Measurement · doi:10.1088/1361-6579/aabf64 · Cited by 136
Reversal by quercetin of corticotrophin releasing factor induced anxiety- and depression-like effect in mice
Bhutada, P., Mundhada, Y. R., Bansod, K. U., Ubgade, A., Quazi, M., Umathe, S. N., & Mundhada, D. R. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.04.025 · Cited by 128
Decline in serotonergic firing activity and desensitization of 5-HT1A autoreceptors after chronic unpredictable stress
Bambico, F. R., Nguyen, N.-T., & Gobbi, G. (2009) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2008.11.005 · Cited by 137
Effect of vagus nerve stimulation on cerebrospinal fluid monoamine metabolites, norepinephrine, and gamma-aminobutyric acid concentrations in depressed patients
Carpenter, L. L., Moreno, F. A., Kling, M. A., Anderson, G. M., Regenold, W. T., Labiner, D. M., & Price, L. H. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.06.025 · Cited by 123
Self-citation
Depressive Symptoms in Adults Separated from Their Parents as Children: A Natural Experiment during World War II
Pesonen, A., Räikkönen, K., Heinonen, K., Kajantie, E., Forsén, T., & Eriksson, J. G. (2007) · American Journal of Epidemiology · doi:10.1093/aje/kwm254 · Cited by 118
Childhood maltreatment, the corticotropin‐releasing hormone receptor gene and adult depression in the general population
Grabe, H., Schwahn, C., Appel, K., Mahler, J., Schulz, A., Spitzer, C., Fenske, K., Barnow, S., Lucht, M., Freyberger, H., et al. (2010) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31131 · Cited by 113
Violence, Stress, and Somatic Syndromes
Crofford, L. J. (2007) · Trauma Violence & Abuse · doi:10.1177/1524838007303196 · Cited by 110
Early Life Adversity as a Risk Factor for Fibromyalgia in Later Life
Low, L. A., & Schweinhardt, P. (2011) · Pain Research and Treatment · doi:10.1155/2012/140832 · Cited by 110
Cerebrospinal Fluid Corticotropin-Releasing Factor Concentration is Associated with Pain but not Fatigue Symptoms in Patients with Fibromyalgia
McLean, S. A., Williams, D. A., Stein, P. K., Harris, R. E., Lyden, A. K., Whalen, G., Park, K. M., Liberzon, I., Sen, A., Gracely, R. H., et al. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301200 · Cited by 101
Implications of genetic research on the role of the serotonin in depression: emphasis on the serotonin type 1A receptor and the serotonin transporter
Neumeister, A., Young, T. A., & Stastny, J. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1950-3 · Cited by 98
Epigenetic Risk Factors in PTSD and Depression
Raabe, F. J., & Spengler, D. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00080 · Cited by 100
Sensitizing effect of early adversity on depressive reactions to later proximal stress: Moderation by polymorphisms in serotonin transporter and corticotropin releasing hormone receptor genes in a 20-year longitudinal study
Starr, L. R., Hammen, C. L., Conway, C., Raposa, E. B., & Brennan, P. A. (2014) · Development and Psychopathology · doi:10.1017/s0954579414000996 · Cited by 102
Corticotropin-releasing hormone and the hypothalamic–pituitary–adrenal axis in psychiatric disease
Naughton, M., Dinan, T. G., & Scott, L. V. (2014) · Handbook of clinical neurology · doi:10.1016/b978-0-444-59602-4.00005-8 · Cited by 97
Childhood adversity and allostatic overload of the hypothalamic–pituitary–adrenal axis: A vulnerability model for depressive disorders
Wilkinson, P. O., & Goodyer, I. M. (2011) · Development and Psychopathology · doi:10.1017/s0954579411000472 · Cited by 95
Childhood Trauma and Personality Disorder: Positive Correlation With Adult CSF Corticotropin-Releasing Factor Concentrations
Lee, R., Geracioti, T. D., Kasckow, J. W., & Coccaro, E. F. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.5.995 · Cited by 84
Gene–Environment Interactions and Intermediate Phenotypes: Early Trauma and Depression
Hornung, O. P., & Heim, C. C. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00014 · Cited by 85
Animal models to improve our understanding and treatment of suicidal behavior
Gould, T. D., Georgiou, P., Brenner, L. A., Brundin, L., Can, A., Courtet, P., Donaldson, Z. R., Dwivedi, Y., Guillaume, S., Gottesman, I. I., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.50 · Cited by 85
Neurobiology of Stress-Induced Reproductive Dysfunction in Female Macaques
Bethea, C. L., Centeno, M. L., & Cameron, J. L. (2008) · Molecular Neurobiology · doi:10.1007/s12035-008-8042-z · Cited by 78
Early life stress and substance use disorders: The critical role of adolescent substance use
Kirsch, D. E., & Lippard, E. (2022) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2022.173360 · Cited by 86
From Hans Selye's Discovery of Biological Stress to the Identification of Corticotropin‐ Releasing Factor Signaling Pathways
Taché, Y., & Brunnhuber, S. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1410.007 · Cited by 76
Neurostructural imaging findings in children with post‐traumatic stress disorder: Brief review
Jackowski, A. P., de Araújo, C. M., Lacerda, A. L. T., Mari, J. D. J., & Kaufman, J. (2009) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.2008.01906.x · Cited by 71
Early life stress as an influence on limbic epilepsy: a hypothesis whose time has come?
Koe, A. S. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.024.2009 · Cited by 74
The Parental Brain
Numan, M. (2020) · doi:10.1093/oso/9780190848675.001.0001 · Cited by 106
Psychometric properties of the Perceived Stress Scale (PSS): measurement invariance between athletes and non-athletes and construct validity
Chiu, Y., Lu, F. J.-H., Lin, J.-H., Nien, C., Hsu, Y., & Liu, H. (2016) · PeerJ · doi:10.7717/peerj.2790 · Cited by 81
Developmental psychopathology and neurobiology of aggression
Gollan, J. K., Lee, R., & Coccaro, E. F. (2005) · Development and Psychopathology · doi:10.1017/s0954579405050546 · Cited by 68
Epigenetics and Suicidal Behavior Research Pathways
Turecki, G. (2014) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2014.06.011 · Cited by 65
The transgenerational transmission of childhood adversity: behavioral, cellular, and epigenetic correlates
Gröger, N., Matas, E., Gos, T., Lesse, A., Poeggel, G., Braun, K., & Bock, J. (2016) · Journal of Neural Transmission · doi:10.1007/s00702-016-1570-1 · Cited by 67
Maus-tratos na infância e psicopatologia no adulto: caminhos para a disfunção do eixo hipotálamo-pituitária-adrenal
Mello, M. F., Faria, A. A., Mello, A. F., Carpenter, L. L., Tyrka, A. R., & Price, L. H. (2009) · Brazilian Journal of Psychiatry · doi:10.1590/s1516-44462009000600002 · Cited by 65
Self-citation
Early-life Stress, Corticotropin-Releasing Factor, and Serotonin Transporter Gene: A Pilot Study
Coplan, J., Abdallah, C., Kaufman, J., Gelernter, J., Smith, E. L. P., Perera, T., Dwork, A., Kaffman, A., Gorman, J., Rosenblum, L. A., et al. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.07.011 · Cited by 41
Self-citation
Childhood trauma dependent anxious depression sensitizes HPA axis function
Menke, A., Lehrieder, D., Fietz, J., Leistner, C., Wurst, C., Stonawski, S., Reitz, J., Lechner, K., Busch, Y., Weber, H., et al. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.07.025 · Cited by 55
Reduced cortical thickness in veterans exposed to early life trauma
Corbo, V., Salat, D. H., Amick, M. M., Leritz, E. C., Milberg, W., & McGlinchey, R. E. (2014) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2014.04.013 · Cited by 57
Corticotropin-Releasing Factor and the Psychobiology of Early-Life Stress
Gillespie, C. F., & Nemeroff, C. B. (2007) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2007.00481.x · Cited by 51
Self-citation
Maternal regulation of the infant's hypothalamic‐pituitary‐adrenal axis stress response: Seymour ‘Gig’ Levine's legacy to neuroendocrinology
Suchecki, D. (2018) · Journal of Neuroendocrinology · doi:10.1111/jne.12610 · Cited by 50
CSF Corticotropin-Releasing Factor in Personality Disorder: Relationship with Self-Reported Parental Care
Lee, R. J., Gollan, J., Kasckow, J., Geracioti, T., & Coccaro, E. F. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301104 · Cited by 44
Early adversity contributes to chronic stress induced depression-like behavior in adolescent male rhesus monkeys
Zhang, Z.-Y., Mao, Y., Feng, X., Zheng, N., Lü, L., Ma, Y., Qin, D., & Hu, X. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.03.040 · Cited by 44
Overexpression of Forebrain CRH During Early Life Increases Trauma Susceptibility in Adulthood
Tóth, M., Flandreau, E. I., Deslauriers, J., Geyer, M. A., Mansuy, I. M., Pich, E. M., & Risbrough, V. B. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.338 · Cited by 40
Angst and the amygdala
Schulkin, J. A. (2006) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2006.8.4/jschulkin · Cited by 39
Posttraumatic Stress Disorder: A State-of-the-Science Review
Nemeroff, C. B., Bremner, J. D., Foa, E. B., Mayberg, H. S., North, C. S., & Stein, M. B. (2009) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/foc.7.2.foc254 · Cited by 39
Self-citation
Neuropeptide and Sigma Receptors as Novel Therapeutic Targets for the Pharmacotherapy of Depression
Paschos, K. A., Veletza, S. V., & Chatzaki, Ε. (2009) · CNS Drugs · doi:10.2165/11310830-000000000-00000 · Cited by 36
Maternal–Infant Response to Variable Foraging Demand in Nonhuman Primates
Coplan, J. D., Smith, E. L., Altemus, M. M., Mathew, S. J., Perera, T. D., Kral, J. G., Gorman, J. M., Owens, M. J., Nemeroff, C. B., & Rosenblum, L. A. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1364.057 · Cited by 37
Self-citation
Hypothalamic corticotrophin releasing hormone neurons in stress‐induced psychopathology: Revaluation of synaptic contributions
Stanton, L. M., Price, A. J., & Manning, E. E. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13268 · Cited by 40
Adult Anxiety Disorders in Relation to Trait Anxiety and Perceived Stress in Childhood
Mundy, E. A., Weber, M., Rauch, S. L., Killgore, W. D. S., Simon, N. M., Pollack, M. H., & Rosso, I. M. (2015) · Psychological Reports · doi:10.2466/02.10.pr0.117c17z6 · Cited by 45
Cerebrospinal fluid levels of glutamate and corticotropin releasing hormone in major depression before and after treatment.
Garakani, A., Martínez, J., Yehuda, R., & Gorman, J. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.06.037 · Cited by 32
Effect of early life social adversity on drug abuse vulnerability: Focus on corticotropin-releasing factor and oxytocin
Bardo, M. T., Hammerslag, L. R., & Malone, S. G. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108567 · Cited by 32
What factors contribute to the risk of depression in epilepsy?— T asmanian E pilepsy R egister M ood S tudy ( TERMS )
Lacey, C. J., Salzberg, M. R., & D'Souza, W. J. (2016) · Epilepsia · doi:10.1111/epi.13302 · Cited by 31
Individual differences in early adolescents’ latent trait cortisol (LTC): Relation to early adversity
Stroud, C. B., Chen, F. R., Doane, L. D., & Granger, D. A. (2016) · Developmental Psychobiology · doi:10.1002/dev.21410 · Cited by 30
Neuroimmune Mechanisms and Sex/Gender-Dependent Effects in the Pathophysiology of Mental Disorders
Kokkosis, A. G., & Tsirka, S. E. (2020) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.120.266163 · Cited by 29
The neurobiology of childhood trauma, from early physical pain onwards: as relevant as ever in today's fractured world
Campbell, K. A. (2022) · European Journal of Psychotraumatology · doi:10.1080/20008066.2022.2131969 · Cited by 40
Forebrain-Specific CRF Overproduction During Development is Sufficient to Induce Enduring Anxiety and Startle Abnormalities in Adult Mice
Tóth, M., Gresack, J. E., Bangasser, D. A., Plona, Z., Valentino, R. J., Flandreau, E. I., Mansuy, I. M., Merlo‐Pich, E., Geyer, M. A., & Risbrough, V. B. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.336 · Cited by 28
Hypothalamic—Pituitary— Adrenal Axis Dysregulation in Women With Irritable Bowel Syndrome in Response to Acute Physical Stress
FitzGerald, L., Kehoe, P., & Sinha, K. (2009) · Western Journal of Nursing Research · doi:10.1177/0193945909339320 · Cited by 27
Life course pathways to prenatal maternal stress
Kingston, D., Sword, W., Krueger, P., Hanna, S., & Markle‐Reid, M. (2012) · Journal of Obstetric, Gynecologic & Neonatal Nursing · doi:10.1111/j.1552-6909.2012.01381.x · Cited by 26
Cerebrospinal fluid proteome evaluation in major depressive disorder by mass spectrometry
Franzen, A. D., Lam, T. T., Williams, K. R., Nairn, A. C., Duman, R. S., Sathyanesan, M., Kumar, V., Carpenter, L. L., & Newton, S. S. (2020) · BMC Psychiatry · doi:10.1186/s12888-020-02874-9 · Cited by 25
Self-citation
Neurophysiologic Effects of Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) via Electrical Stimulation of the Tragus: A Concurrent taVNS/fMRI Study and Review
Badran, B. W., Dowdle, L. T., Mithoefer, O. J., LaBate, N. T., Coatsworth, J., Brown, J. C., DeVries, W. H., Austelle, C. W., McTeague, L. M., & George, M. S. (2022) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.20110 · Cited by 29
Altered Response to Neuroendocrine Challenge Linked to Indices of the Metabolic Syndrome in Healthy Adults
Tyrka, A. R., Walters, O. C., Price, L. H., Anderson, G., & Carpenter, L. L. (2012) · Hormone and Metabolic Research · doi:10.1055/s-0032-1306342 · Cited by 26
Self-citation
From Vulnerability to Neurotoxicity: A Developmental Approach to the Effects of Stress on the Brain and Behavior
LUPIEN, S. J., Ouellet‐Morin, I., Herba, C. M., Juster, R., & McEwen, B. S. (2016) · Epigenetics and human health · doi:10.1007/978-3-319-24493-8_1 · Cited by 29
The effects of stress in early life and adolescence on posttraumatic stress disorder, depression, and anxiety symptomatology in adulthood
Chaby, L. E., Zhang, L., & Liberzon, I. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2017.01.001 · Cited by 29
CSF-studies in neuropsychiatric disorders.
Raedler, T. J., & Wiedemann, K. (2006) · PubMed · Cited by 25
The neuroendocrinology of childhood trauma in personality disorder
Lee, R., Hempel, J., TenHarmsel, A., Liu, T., Mathé, A. A., & Klock, A. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.05.006 · Cited by 25
Early life stress and glutamate neurotransmission in major depressive disorder
Averill, L. A., Abdallah, C. G., Fenton, L. R., Fasula, M. K., Jiang, L., Rothman, D. L., Mason, G. F., & Sanacora, G. (2020) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2020.03.015 · Cited by 26
Prefrontal cortex VAMP1 gene network moderates the effect of the early environment on cognitive flexibility in children
Dalmaz, C., Barth, B., Pokhvisneva, I., Wang, Z., Patel, S. H., Quillfeldt, J. A., Filho, E. J. D. M., de Lima, R. M. S., Arcego, D. M., Sassi, R. B., et al. (2021) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2021.107509 · Cited by 24

Authors: Carpenter, L. L., Tyrka, A. R., McDougle, C. J., Malison, R. T., Owens, M. J., Nemeroff, C. B., & Price, L. H.
Affiliations: Brown University (US)
Indiana University School of Medicine (US)
Yale University (US)
Emory University (US)
Corresponding author: Carpenter, Linda L
ORCID: Carpenter, Linda L
Tyrka, Audrey R
McDougle, Christopher J
Malison, Robert T
Nemeroff, Charles B
Price, Lawrence H
Venue: Neuropsychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2003-12-31
Volume: 29
Issue: 4
Pages: 777-784
ISSN: 0893-133X (ISSN-L)
1740-634X
DOI: 10.1038/sj.npp.1300375
OpenAlex: W2005533083
Cited by: 209
References: 48
Citations by year: 2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 8 · 2021: 4 · 2020: 27 · 2019: 7 · 2018: 6 · 2017: 9 · 2016: 19 · 2015: 9 · 2014: 20 · 2013: 9 · 2012: 9
FWCI: 2.89
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: National Alliance for Research on Schizophrenia and Depression
National Institutes of Health (MH-42088)
National Institute of Mental Health (R01MH042088, P50MH058922, MH58922, MH42088)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Keywords: corticotropin-releasing factor, cerebrospinal fluid, major depressive disorder, childhood adversity, maternal deprivation, maternal neglect, perinatal adversity, neuroendocrine changes, stress hormones
MeSH terms: Adult, Corticotropin-Releasing Hormone, Depressive Disorder, Major, Major Depressive Disorder, Female, Humans, Life Change Events, Male, Middle Aged, Stress, Psychological, Linear Models, Case-Control Studies

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Cerebrospinal Fluid Corticotropin-Releasing Factor and Perceived Early-Life Stress in Depressed Patients and Healthy Control Subjects

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks