The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs
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Citations
Cites
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218 · cited 4×
“…drug-induced SLP also indicates that some genes other than p53 or p21 play an essential role in this response. p16 was shown to be involved in accelerated senescence of normal cells (Serrano et al., 1997), but HT1080 and HCT116 cells are p16-de®cient (Whitaker et al., 1995; Myohanen et al., 1998).”
BackgroundInfluentialRequirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
Bunz, F., Dutriaux, A., Lengauer, C., Waldman, T., Zhou, S., Brown, J. P., Sedivy, J. M., Kinzler, K. W., & Vogelstein, B. (1998) · Science · doi:10.1126/science.282.5393.1497 · Cited by 2,803
Senescence of human fibroblasts induced by oncogenic Raf
Zhu, J., Woods, D., McMahon, M., & Bishop, J. M. (1998) · Genes & Development · doi:10.1101/gad.12.19.2997 · Cited by 826
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
Waldman, T., Lengauer, C., Kinzler, K. W., & Vogelstein, B. (1996) · Nature · doi:10.1038/381713a0 · Cited by 728
Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells.
Chen, Q., & Ames, B. N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.10.4130 · Cited by 641
Robles, S. J., & Adami, G. R. (1998) · Oncogene · doi:10.1038/sj.onc.1201862 · Cited by 498
Research works printed but not linked: 25
- Campisi J. . 1997 Eur. J. Cancer 33: 703–709. · DOI · Paper page
- Chang B-D and Roninson IB. . 1996 Gene 183: 137–142. · DOI
- DiLeonardo A, Linke SP, Clarkin K and Wahl GM. . 1994 Genes Dev. 8: 2540–2551. · DOI · Paper page
- el-Deiry WS, Tokino T, Velculescu VE, Levy DB, Parsons R, Trent JM, Lin D, Mercer WE, Kinzler KW and Vogelstein B. . 1993 Cell 75: 817–825. · DOI · Paper page
- Harper JW, Adami G, Wei N, Keyomarsi K and Elledge S. . 1993 Cell 75: 805–816. · DOI · Paper page
- Hendry JH and West CML. . 1997 Int. J. Radiat. Biol. 71: 709–719. · DOI
- Holt SE, Aisner DL, Shay JW and Wright WE. . 1997 Proc. Natl. Acad. Sci. USA 94: 10687–10692. · DOI
- Horan PK and Slezak SE. . 1989 Nature 340: 167–168. · DOI · Paper page
- Kandel ES, Chang BD, Schott B, Shtil AA, Gudkov AV and Roninson IB. . 1997 Somatic Cell Mol. Genet. 23: 325–340. · DOI
- Liu LF. . 1989 Annu. Rev. Biochem. 58: 351–375. · DOI · Paper page
- Lowe SW, Ruley HE, Jacks T and Housman DE. . 1993 Cell 74: 957–968. · DOI · Paper page
- Miller DA and Rosman GJ. . 1989 Biotechniques 7: 980–986. · DOI
- Ossovskaya VS, Mazo IA, Chernov MV, Chernova OB, Strezoska Z, Kondratov R, Stark GR, Chumakov PM and Gudkov AV. . 1996 Proc. Natl. Acad. Sci. USA 93: 10309–10314. · DOI
- Pear WS, Nolan GP, Scott ML and Baltimore D. . 1993 Proc. Natl. Acad. Sci. USA 90: 8392–8396. · DOI · Paper page
- Pellegata NS, Antoniono RJ, Redpath JL and Stanbridge EJ. . 1996 Proc. Natl. Acad. Sci. USA 93: 15209–15214. · DOI
- Pereira-Smith OM and Smith JR. . 1988 Proc. Natl. Acad. Sci. USA 85: 6042–6046. · DOI · Paper page
- Perry ME, Rolfe M, McIntyre P, Commane M and Stark GR. . 1992 Mutat. Res. 276: 189–197. · DOI
- Schott B, Iraj ES and Roninson IB. . 1996 Somatic Cell Mol. Genet. 22: 292–309. · doi:10.1007/bf02369568
- Shay JW. . 1997 J. Cell Physiol. 173: 266–270. · DOI
- Sugrue MM, Shin DY, Lee SW and Aaronson SA. . 1997 Proc. Natl. Acad. Sci. USA 94: 9648–9653. · DOI · Paper page
- Uhrbom L, Nister M and Westermark B. . 1997 Oncogene 15: 505–514. · DOI
- Waldman T, Zhang Y, Dillehay L, Yu J, Kinzler K, Vogelstein B and Williams J. . 1997 Nature Medicine 3: 1034–1036. · DOI · Paper page
- Wang Y, Blandino G, Oren M and Givol D. . 1998b Oncogene 17: 1923–1930. · DOI
- Weinberg RA. . 1997 Cell 88: 573–575. · DOI
- Xu H-J, Zhou Y, Ji W, Perng G-S, Kruzelock R, Kong C-T, Bast RC, Mills GB, Li J and Hu S-X. . 1997 Oncogene 15: 2589–2596. · DOI · Paper page
Cited by
Coppé, J.-P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P.-Y., & Campisi, J. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060301 · Cited by 302
“Many human tumor cells retain the ability to senesce, in culture and in vivo, in response to DNA-damaging chemotherapeutic agents [48,49].”
BackgroundThe essence of senescence: Figure 1.
Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038
The Cell–Cycle Arrest and Apoptotic Functions of p53 in Tumor Initiation and Progression
Chen, J. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026104 · Cited by 1,222
Exploiting senescence for the treatment of cancer
Wang, L., Lankhorst, L., & Bernards, R. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-022-00450-9 · Cited by 867
Therapy-induced senescence in cancer.
Ewald, J. A., Desotelle, J. A., Wilding, G., & Jarrard, D. F. (2010) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djq364 · Cited by 824
Metadata
- Authors
- Chang, B.-D., Xuan, Y., Broude, E. V., Zhu, H., Schott, B., Fang, J., & Roninson, I. B.
- Venue
- Oncogene
- Published
- 1999-08-26
- Volume
- 18
- Issue
- 34
- Pages
- 4808-4818
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W2315283231
- Cited by
- 386
- References
- 8
- FWCI
- 7.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- www.springer.com/tdm (vor)
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- CoChat. (2026). Citation check: Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. https://app.cochat.ai/papers/10.1038/sj.onc.1203078
- The paper
- Chang, B.-D., Xuan, Y., Broude, E. V., Zhu, H., Schott, B., Fang, J., & Roninson, I. B. (1999). Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs. Oncogene. https://doi.org/10.1038/sj.onc.1203078
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
