Nuclear receptors: integration of multiple signalling pathways through phosphorylation
Abstract
Nuclear receptors (NRs) orchestrate the transcription of specific gene networks in response to binding of their cognate ligand. They also act as mediators in a variety of signalling pathways through integrating diverse phosphorylation events. NR phosphorylation concerns all three major domains, the N-terminal activation function (AF-1), the ligand-binding and the DNA binding domains. Often, phosphorylation of NRs by kinases that are associated with general transcription factors (e.g. cdk7 within TFIIH), or activated in response to a variety of signals (MAPKs, Akt, PKA, PKC), facilitates the recruitment of coactivators or of components of the transcription machinery and, therefore, cooperates with the ligand to enhance transcription activation. But phosphorylation can also contribute to the termination of the ligand response through inducing DNA dissociation or NR degradation or through decreasing ligand affinity. These different modes of regulation reveal an unexpected complexity of the dynamics of NR-mediated transcription. In addition, deregulation of NR phosphorylation may impact their action in certain diseases or cancers.
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RARs and RXRs are phosphoproteins.
“For several years, RARs and RXRs have been known to be phosphoproteins ( 129 ).”
From Vitamin A and retinoid signaling: genomic and nongenomic effects (2013) · cites this paper as [129]
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- Authors
- Rochette-Egly, C.
- Venue
- Cellular Signalling
- Publisher
- Elsevier BV
- Published
- 2003-04
- Volume
- 15
- Issue
- 4
- Pages
- 355-366
- ISSN
- 0898-6568 (ISSN-L)
- OpenAlex
- W2056128228
- Cited by
- 291
- References
- 136
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 2 · 2019: 7 · 2018: 5 · 2017: 8 · 2016: 7 · 2015: 12 · 2014: 15 · 2013: 21 · 2012: 10
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Cellular Signalling (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- nuclear receptors, phosphorylation, transcriptional regulation, transcriptional coactivator, ligand-binding domain, DNA-binding domain, mitogen-activated protein kinase, Akt, protein kinase A, protein kinase C, CDK7, TFIIH, transcription termination, ligand dissociation, cancer
- MeSH terms
- Animals, Cell Nucleus, DNA-Binding Proteins, Hormones, Humans, Neoplasms, Phosphorylation, Protein Binding, RNA, Messenger, Transcription, Genetic, Signal Transduction, Down-Regulation, Up-Regulation, Protein Serine-Threonine Kinases, Receptors, Cytoplasmic and Nuclear
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