Cited by 292Estrogen and related hormone effectsNuclear Receptors and SignalingGenomics and Chromatin Dynamics

Nuclear receptors: integration of multiple signalling pathways through phosphorylation

Rochette-Egly, Cécile·2003·Cellular Signalling

Abstract

Nuclear receptors (NRs) orchestrate the transcription of specific gene networks in response to binding of their cognate ligand. They also act as mediators in a variety of signalling pathways through integrating diverse phosphorylation events. NR phosphorylation concerns all three major domains, the N-terminal activation function (AF-1), the ligand-binding and the DNA binding domains. Often, phosphorylation of NRs by kinases that are associated with general transcription factors (e.g. cdk7 within TFIIH), or activated in response to a variety of signals (MAPKs, Akt, PKA, PKC), facilitates the recruitment of coactivators or of components of the transcription machinery and, therefore, cooperates with the ligand to enhance transcription activation. But phosphorylation can also contribute to the termination of the ligand response through inducing DNA dissociation or NR degradation or through decreasing ligand affinity. These different modes of regulation reveal an unexpected complexity of the dynamics of NR-mediated transcription. In addition, deregulation of NR phosphorylation may impact their action in certain diseases or cancers.

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Crossref · 10.1016/s0898-6568(02)00115-8

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Authors
Rochette-Egly, C.
Venue
Cellular Signalling
Publisher
Elsevier BV
Published
2003-04
Volume
15
Issue
4
Pages
355-366
ISSN
0898-6568 (ISSN-L)
OpenAlex
W2056128228
Cited by
291
References
136
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 2 · 2019: 7 · 2018: 5 · 2017: 8 · 2016: 7 · 2015: 12 · 2014: 15 · 2013: 21 · 2012: 10
FWCI
2.14
Type
journal article
Language
en
Open access
closed
Locations
  • Cellular Signalling (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords
nuclear receptors, phosphorylation, transcriptional regulation, transcriptional coactivator, ligand-binding domain, DNA-binding domain, mitogen-activated protein kinase, Akt, protein kinase A, protein kinase C, CDK7, TFIIH, transcription termination, ligand dissociation, cancer
MeSH terms
Animals, Cell Nucleus, DNA-Binding Proteins, Hormones, Humans, Neoplasms, Phosphorylation, Protein Binding, RNA, Messenger, Transcription, Genetic, Signal Transduction, Down-Regulation, Up-Regulation, Protein Serine-Threonine Kinases, Receptors, Cytoplasmic and Nuclear

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