Cell cycle inhibitors in normal and tumor stem cells.
Abstract
Emerging data suggest that stem cells may be one of the key elements in normal tissue regeneration and cancer development, although they are not necessarily the same entity in both scenarios. As extensively demonstrated in the hematopoietic system, stem cell repopulation is hierarchically organized and is intrinsically limited by the intracellular cell cycle inhibitors. Their inhibitory effects appear to be highly associated with the differentiation stage in stem/progenitor pools. While this negative regulation is important for maintaining homeostasis, especially at the stem cell level under physiological cues or pathological insults, it constrains the therapeutic use of adult stem cells in vitro and restricts endogenous tissue repair after injury. On the other hand, disruption of cell cycle inhibition may contribute to the formation of the so-called 'tumor stem cells' (TSCs) that are currently hypothesized to be partially responsible for tumorigenesis and recurrence of cancer after conventional therapies. Therefore, understanding how cell cycle inhibitors control stem cells may offer new strategies not only for therapeutic manipulations of normal stem cells but also for novel therapies selectively targeting TSCs.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The p16-Arf locus encodes 2 tumor suppressors, p16 and Arf.
“The p16-Arf locus encodes 2 tumor suppressors, p16 and Arf.10-12”
From Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner (2014) · cites this paper as [12]
Cites
Prospective identification of tumorigenic breast cancer cells
Al‐Hajj, M., Wicha, M. S., Benito‐Hernández, A., Morrison, S. J., & Clarke, M. F. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530291100 · Cited by 10,388 · see citing works
Stem cells, cancer, and cancer stem cells
Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738 · see citing works
Bonnet, D., & Dick, J. (1997) · Nature Medicine · doi:10.1038/nm0797-730 · Cited by 7,417 · see citing works
CDK inhibitors: positive and negative regulators of G1-phase progression
Sherr, C. J., & Roberts, J. M. (1999) · Genes & Development · doi:10.1101/gad.13.12.1501 · Cited by 6,115 · see citing works
Sherr, C. J. (1996) · Science · doi:10.1126/science.274.5293.1672 · Cited by 5,379 · see citing works
Subventricular zone astrocytes are neural stem cells in the adult mammalian brain
Doetsch, F., Caillé, I., Lim, D. A., García-Verdugo, J. M., & Alvarez-Buylla, A. (1999) · Cell · doi:10.1016/s0092-8674(00)80783-7 · Cited by 3,898 · see citing works
Osteoblastic cells regulate the haematopoietic stem cell niche
Calvi, L. M., Adams, G. B., Weibrecht, K. W., Weber, J. M., Olson, D. P., Knight, M. C., Martin, R. P., Schipani, E., Pajevic, P. D., Bringhurst, F. R., et al. (2003) · Nature · doi:10.1038/nature02040 · Cited by 3,452 · see citing works
Morgan, D. O. (1995) · Nature · doi:10.1038/374131a0 · Cited by 3,288 · see citing works
Inhibitors of mammalian G1 cyclin-dependent kinases.Preprint
Sherr, C. J., & Roberts, J. M. (1995) · Genes & Development · doi:10.1101/gad.9.10.1149 · Cited by 3,222 · see citing works
Checkpoints: Controls That Ensure the Order of Cell Cycle Events
Hartwell, L. H., & Weinert, T. A. (1989) · Science · doi:10.1126/science.2683079 · Cited by 3,053 · see citing works
Identification of the haematopoietic stem cell niche and control of the niche size
Zhang, J., Niu, C. S., Ye, L., Huang, H., He, X. C., Tong, W.-G., Ross, J., Haug, J., Johnson, T. J., Feng, J. Q., et al. (2003) · Nature · doi:10.1038/nature02041 · Cited by 2,948 · see citing works
G1 phase progression: Cycling on cue
Sherr, C. J. (1994) · Cell · doi:10.1016/0092-8674(94)90540-1 · Cited by 2,675 · see citing works
Wnt proteins are lipid-modified and can act as stem cell growth factors
Willert, K., Brown, J. D., Danenberg, E., Duncan, A. W., Weissman, I. L., Reya, T., Yates, J. R., & Nusse, R. (2003) · Nature · doi:10.1038/nature01611 · Cited by 2,257 · see citing works
G <sub>1</sub> Events and Regulation of Cell Proliferation
Pardee, A. B. (1989) · Science · doi:10.1126/science.2683075 · Cited by 2,182 · see citing works
A role for Wnt signalling in self-renewal of haematopoietic stem cells
Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159 · see citing works
Polyák, K., Lee, M.-H., Erdjument‐Bromage, H., Koff, A., Roberts, J. M., Tempst, P., & Massagué, J. (1994) · Cell · doi:10.1016/0092-8674(94)90572-x · Cited by 2,118 · see citing works
Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
Deng, C., Zhang, P., Wade Harper, J., Elledge, S. J., & Leder, P. (1995) · Cell · doi:10.1016/0092-8674(95)90039-x · Cited by 2,113 · see citing works
Definition of a consensus binding site for p53
El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985 · see citing works
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.
Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003) · Nature · doi:10.1038/nature01587 · Cited by 1,871 · see citing works
Vogelstein, B. (1992) · Cell · doi:10.1016/0092-8674(92)90421-8 · Cited by 1,862 · see citing works
Effects of an Rb mutation in the mouse
Jacks, T., Fazeli, A., Schmitt, E. M., Bronson, R. T., Goodell, M. A., & Weinberg, R. A. (1992) · Nature · doi:10.1038/359295a0 · Cited by 1,755 · see citing works
Applying the principles of stem-cell biology to cancer
Pardal, R., Clarke, M. F., & Morrison, S. J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc1232 · Cited by 1,616 · see citing works
Nakayama, K., Ishida, N., Shirane, M., Inomata, A., Inoue, T., SHISHIDO, N., Horii, I., Loh, D. Y., & Nakayama, K. (1996) · Cell · doi:10.1016/s0092-8674(00)81237-4 · Cited by 1,548 · see citing works
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27
Carrano, A. C., Eytan, E., Hershko, A., & Pagano, M. (1999) · Nature Cell Biology · doi:10.1038/12013 · Cited by 1,544 · see citing works
Fero, M. L., Rivkin, M. J., Tasch, M., Porter, P. L., Carow, C. E., Firpo, E. J., Polyák, K., Tsai, L., Broudy, V. C., Perlmutter, R. M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81239-8 · Cited by 1,459 · see citing works
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.
Lessard, J., & Sauvageau, G. (2003) · Nature · doi:10.1038/nature01572 · Cited by 1,452 · see citing works
Cotsarelis, G., Cheng, S.-Z., Dong, G., Sun, T., & Lavker, R. M. (1989) · Cell · doi:10.1016/0092-8674(89)90958-6 · Cited by 1,429 · see citing works
Morshead, C. M., Reynolds, B. A., Craig, C. G., McBurney, M. W., Staines, W. A., Morassutti, D., Weiss, S., & van der Kooy, D. (1994) · Neuron · doi:10.1016/0896-6273(94)90046-9 · Cited by 1,403 · see citing works
New functional activities for the p21 family of CDK inhibitors.
LaBaer, J., Garrett, M. D., Stevenson, L. F., Slingerland, J. M., Sandhu, C., Chou, H. S., Fattaey, A., & Harlow, E. (1997) · Genes & Development · doi:10.1101/gad.11.7.847 · Cited by 1,402 · see citing works
Hematopoietic Stem Cell Quiescence Maintained by p21 <sup>cip1/waf1</sup>
Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339 · see citing works
Self-citationBmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation
Molofsky, A. V., Pardal, R., Iwashita, T., Park, I.-K., Clarke, M. F., & Morrison, S. J. (2003) · Nature · doi:10.1038/nature02060 · Cited by 1,301 · see citing works
Capturing and profiling adult hair follicle stem cells
Morris, R. J., Liu, Y., Marles, L., Yang, Z., Trempus, C., Li, S., Lin, J. S., Sawicki, J. A., & Cotsarelis, G. (2004) · Nature Biotechnology · doi:10.1038/nbt950 · Cited by 1,283 · see citing works
Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance
Steinman, R., & Nussenzweig, M. (2002) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.231606698 · Cited by 1,278 · see citing works
Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis
Lee, E. Y.-H. P., Chang, C.-Y., Hu, N., Wang, Y.-C. J., Lai, C., Herrup, K., Lee, W., & Bradley, A. (1992) · Nature · doi:10.1038/359288a0 · Cited by 1,264 · see citing works
Radiation-induced cell cycle arrest compromised by p21 deficiency
Brugarolas, J., Chandrasekaran, C., Gordon, J. I., Beach, D., Jacks, T., & Hannon, G. J. (1995) · Nature · doi:10.1038/377552a0 · Cited by 1,242 · cited 2× · see citing works
“CKI knockout rodent models have been particularly useful in providing a feasible approach for studying the roles of cell cycle inhibitors in stem cell biology (Brugarolas et al., 1995; Nakayama et al., 1996; Franklin et al., 1998).”
BackgroundCheng, M., Olivier, P., Diehl, J. A., Fero, M., Roussel, M. F., Roberts, J. M., & Sherr, C. J. (1999) · The EMBO Journal · doi:10.1093/emboj/18.6.1571 · Cited by 1,142 · see citing works
Requirement for a functional Rb-1 gene in murine development
Clarke, A. R., Maandag, E. R., van ROON, M. A., van der Lugt, N. M. T., van der Valk, M., Hooper, M., Berns, A. J. M., & Rielef, H. T. (1992) · Nature · doi:10.1038/359328a0 · Cited by 1,006 · see citing works
The INK4a/ARF network in tumour suppression
Sherr, C. J. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35096061 · Cited by 984 · see citing works
Developmental potential and dynamic behavior of hematopoietic stem cells
Lemischka, I. R., Raulet, D. H., & Mulligan, R. C. (1986) · Cell · doi:10.1016/0092-8674(86)90566-0 · Cited by 880 · see citing works
Cheshier, S. H., Morrison, S. J., Liao, X., & Weissman, I. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3120 · Cited by 858 · see citing works
Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis
Sharpless, N. E., Bardeesy, N., Lee, K.-H., Carrasco, D., Castrillon, D. H., Aguirre, A. J., Wu, E. A., Horner, J. W., & DePinho, R. A. (2001) · Nature · doi:10.1038/35092592 · Cited by 848 · see citing works
The murine gene p27Kip1 is haplo-insufficient for tumour suppression
Fero, M. L., Randel, E., Gurley, K. E., Roberts, J. M., & Kemp, C. J. (1998) · Nature · doi:10.1038/24179 · Cited by 784 · see citing works
Proliferation and Differentiation of Progenitor Cells Throughout the Intact Adult Rat Spinal Cord
Horner, P. J., Power, A. E., Kempermann, G., Kuhn, H. G., Palmer, T. D., Winkler, J., Thal, L. J., & Gage, F. H. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-06-02218.2000 · Cited by 777 · see citing works
Zhang, P., Liégeois, N. J., Wong, C., Finegold, M. J., Hou, H., Thompson, J. C., Silverman, A., Harper, J. W., DePinho, R. A., & Elledge, S. J. (1997) · Nature · doi:10.1038/387151a0 · Cited by 750 · see citing works
Size Control in Animal Development
Conlon, I. J., & RAFF, M. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80563-2 · Cited by 743 · see citing works
The retinoblastoma tumour suppressor in development and cancer
Classon, M., & Harlow, E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc950 · Cited by 738 · see citing works
Signalling, cell cycle and pluripotency in embryonic stem cells
Burdon, T., Smith, A. T., & Savatier, P. (2002) · Trends in Cell Biology · doi:10.1016/s0962-8924(02)02352-8 · Cited by 710 · see citing works
HOXB4-Induced Expansion of Adult Hematopoietic Stem Cells Ex Vivo
Antonchuk, J., Sauvageau, G., & Humphries, R. K. (2002) · Cell · doi:10.1016/s0092-8674(02)00697-9 · Cited by 700 · see citing works
Passegue, E. A., Jamieson, C. H. M., Ailles, L., & Weissman, I. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2034201100 · Cited by 685 · see citing works
Requirement of p27 Kip1 for Restriction Point Control of the Fibroblast Cell Cycle
Coats, S., Flanagan, W. M., Nourse, J. L., & Roberts, J. M. (1996) · Science · doi:10.1126/science.272.5263.877 · Cited by 679 · see citing works
Sherr, C. J., & Weber, J. D. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)00038-6 · Cited by 654 · see citing works
Varnum‐Finney, B., Xu, L., Brashem‐Stein, C., Nourigat, C., Flowers, D. A., Bakkour, S., Pear, W. S., & Bernstein, I. D. (2000) · Nature Medicine · doi:10.1038/81390 · Cited by 642 · see citing works
Bmi1, stem cells, and senescence regulation
Park, I.-K., Morrison, S. J., & Clarke, M. F. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200420800 · Cited by 495 · see citing works
Resistance to Apoptosis Conferred by Cdk Inhibitors During Myocyte Differentiation
Wang, J., & Walsh, K. (1996) · Science · doi:10.1126/science.273.5273.359 · Cited by 490 · see citing works
Pathways governing G1/S transition and their response to DNA damage
Bartek, J. J., & Lukas, J. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02114-7 · Cited by 467 · see citing works
Progenitor cells from human brain after death
Palmer, T. D., Schwartz, P. H., Taupin, P., Kaspar, B. K., Stein, S. A., & Gage, F. H. (2001) · Nature · doi:10.1038/35075141 · Cited by 457 · see citing works
Aladjem, M. I., Spike, B. T., Rodewald, L. W., Hope, T. J., Klemm, M., Jaenisch, R., & Wahl, G. M. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70061-2 · Cited by 442 · see citing works
Drexler, H. (1998) · Leukemia · doi:10.1038/sj.leu.2401043 · Cited by 430 · see citing works
Stier, S., Cheng, T., Dombkowski, D., Carlesso, N., & Scadden, D. T. (2002) · Blood · doi:10.1182/blood.v99.7.2369 · Cited by 421 · see citing works
Self-citationFranklin, D. S., Godfrey, V., Lee, H., Kovalev, G. I., Schoonhoven, R., Chen-Kiang, S., Su, L., & Xiong, Y. (1998) · Genes & Development · doi:10.1101/gad.12.18.2899 · Cited by 409 · see citing works
Deregulated degradation of the cdk inhibitor p27 and malignant transformation
Bloom, J., & Pagano, M. (2002) · Seminars in Cancer Biology · doi:10.1016/s1044-579x(02)00098-6 · Cited by 374 · see citing works
Functional Isolation and Characterization of Human Hematopoietic Stem Cells
Berardi, A. C., Wang, A., Levine, J. D., Lopez, P., & Scadden, D. T. (1995) · Science · doi:10.1126/science.7528940 · Cited by 371 · see citing works
A Role for the Wnt Gene Family in Hematopoiesis: Expansion of Multilineage Progenitor Cells
Austin, T. W., Solar, G. P., Ziegler, F. C., Liem, L. M., & Matthews, W. (1997) · Blood · doi:10.1182/blood.v89.10.3624 · Cited by 358 · see citing works
Stem cell repopulation efficiency but not pool size is governed by p27kip1
Cheng, T., Rodrigues, N. P., Dombkowski, D., Stier, S., & Scadden, D. T. (2000) · Nature Medicine · doi:10.1038/81335 · Cited by 347 · see citing works
Self-citationde Nooij, J. C., Letendre, M. A., & Hariharan, I. K. (1996) · Cell · doi:10.1016/s0092-8674(00)81819-x · Cited by 318 · see citing works
Transforming growth factor-β: pleiotropic role in the regulation of hematopoiesis
Fortunel, N. O., Hatzfeld, A., & Hatzfeld, J. (2000) · Blood · doi:10.1182/blood.v96.6.2022.h8002022_2022_2036 · Cited by 314 · see citing works
Missero, C., Cunto, F. D., Kiyokawa, H., Koff, A., & Dotto, G. P. (1996) · Genes & Development · doi:10.1101/gad.10.23.3065 · Cited by 312 · see citing works
Franklin, D. S., Godfrey, V., O’Brien, D. A., Deng, C., & Xiong, Y. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.16.6147-6158.2000 · Cited by 298 · see citing works
In Vitro Self-Renewal Division of Hematopoietic Stem Cells
Ema, H., Takano, H., Sudo, K., & Nakauchi, H. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.9.1281 · Cited by 284 · see citing works
In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein
Krošl, J., Austin, P., Beslu, N., KROON, E. J., Humphries, R. K., & Sauvageau, G. (2003) · Nature Medicine · doi:10.1038/nm951 · Cited by 283 · see citing works
Yuan, Y., Shen, H., Franklin, D. S., Scadden, D. T., & Cheng, T. (2004) · Nature Cell Biology · doi:10.1038/ncb1126 · Cited by 269 · see citing works
Self-citationLatres, E., Malumbres, M., Sotillo, R., Martín, J., Ortega, S., Martín‐Caballero, J., Flores, J. M., Cordón‐Cardo, C., & Barbacid, M. (2000) · The EMBO Journal · doi:10.1093/emboj/19.13.3496 · Cited by 257 · see citing works
Identification of a Myc‐dependent step during the formation of active G1 cyclin‐cdk complexes.
Steiner, P., Philipp, A., Lukáš, J., Godden-Kent, D., Pagano, M., Mittnacht, S., Bártek, J., & Eilers, M. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00163.x · Cited by 246 · see citing works
Evidence that hematopoiesis may be a stochastic process in vivo
Abkowitz, J. L., Catlin, S. N., & Guttorp, P. M. (1996) · Nature Medicine · doi:10.1038/nm0296-190 · Cited by 246 · see citing works
Harrison, D., & Lerner, C. P. (1991) · Blood · doi:10.1182/blood.v78.5.1237.1237 · Cited by 242 · see citing works
Hatzfeld, J., Ml, L., Brown, E. L., Sookdeo, H. K., Lévesque, J.-P., O'Toole, T., Gurney, C. W., Clark, S., & Hatzfeld, A. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.4.925 · Cited by 227 · see citing works
The differential impact of p16INK4a or p19ARF deficiency on cell growth and tumorigenesis
Sharpless, N. E., Ramsey, M. R., Balasubramanian, P., Castrillon, D. H., & DePinho, R. A. (2004) · Oncogene · doi:10.1038/sj.onc.1207074 · Cited by 224 · cited 1× · see citing works
“…the above different groups, there are also specific collaborative effects between some of the CKIs or their related proteins, such as p16 and p19ARF (Sharpless et al., 2004) or p27 and p18 (Franklin et al., 1998) or p15 and p18 (Latres et al., 2000), indicating the crosstalk of different pathways.”
BackgroundMarshak, D. R., Gardner, R. L., & Gottlieb, D. J. (2001) · Medical Entomology and Zoology · Cited by 218 · see citing works
Harrison, D. E., Astle, C. M., & Lerner, C. P. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.3.822 · Cited by 205 · see citing works
Abrogation of p27 by cDNA Antisense Suppresses Quiescence (G0 State) in Fibroblasts
Rivard, N., L’Allemain, G., Bártek, J., & Pouysségur, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.31.18337 · Cited by 203 · see citing works
Doetsch, F. K., García‐Verdugo, J. M., Caillé, I., Álvarez-Buylla, A., Chao, M. V., & Casaccia‐Bonnefil, P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02255.2002 · Cited by 202 · see citing works
Kay, H. E. M. (1965) · The Lancet · doi:10.1016/s0140-6736(65)90763-4 · Cited by 197 · see citing works
Cardoso, A. A., Ml, L., Batard, P., Hatzfeld, A., Brown, E. L., Lévesque, J.-P., Sookdeo, H. K., Panterne, B., Sansilvestri, P., & Clark, S. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8707 · Cited by 178 · see citing works
p21/p53, Cellular Growth Control and Genomic Integrity
El‐Deiry, W. S. (1998) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-71941-7_6 · Cited by 173 · see citing works
Stem cells and cellular pedigrees – a conceptual introduction
Loeffler, M., & Potten, C. S. (1997) · Elsevier eBooks · doi:10.1016/b978-012563455-7/50002-7 · Cited by 169 · see citing works
Ellisen, L. W., Carlesso, N., Cheng, T., Scadden, D. T., & Haber, D. A. (2001) · The EMBO Journal · doi:10.1093/emboj/20.8.1897 · Cited by 166 · see citing works
Self-citationPawliuk, R., Eaves, C. J., & Humphries, R. K. (1996) · Blood · doi:10.1182/blood.v88.8.2852.bloodjournal8882852 · Cited by 158 · see citing works
A Role for p27/Kip1 in the Control of Cerebellar Granule Cell Precursor Proliferation
Miyazawa, K., Himi, T., Garcia, V., Yamagishi, H., Sato, S., & Ishizaki, Y. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-15-05756.2000 · Cited by 151 · see citing works
Uncoupling Cell Fate Determination from Patterned Cell Division in the Drosophila Eye
de Nooij, J. C., & Hariharan, I. K. (1995) · Science · doi:10.1126/science.270.5238.983 · Cited by 140 · see citing works
Inactivation of p27Kip1 by the viral E1A oncoprotein in TGFβ-treated cells
Mal, A. K., Poon, R. Y. C., Howe, P. H., Toyoshima, H., Hunter, T. R., & Harter, M. L. (1996) · Nature · doi:10.1038/380262a0 · Cited by 137 · see citing works
Cheng, L., Qasba, P., Vanguri, P., & Thiede, M. A. (2000) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(200007)184:1 · Cited by 136 · see citing works
Adhesion receptor expression by hematopoietic cell lines and murine progenitors
Becker, P. S., Nilsson, S. K., Li, Z., Berrios, V. M., Dooner, M. S., Cooper, C. L., Hsieh, C., & Quesenberry, P. J. (1999) · Experimental Hematology · doi:10.1016/s0301-472x(98)00037-x · Cited by 132 · see citing works
The chiaroscuro stem cell: a unified stem cell theory
Quesenberry, P. J., Colvin, G. A., & Lambert, J.-F. (2002) · Blood · doi:10.1182/blood-2002-04-1246 · Cited by 130 · see citing works
INK4d-Deficient Mice Are Fertile Despite Testicular Atrophy
Zindy, F., van Deursen, J., Grosveld, G. C., Sherr, C. J., & Roussel, M. F. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.1.372-378.2000 · Cited by 130 · see citing works
Hematopoietic stem cells for transplantation
Verfaillie, C. M. (2002) · Nature Immunology · doi:10.1038/ni0402-314 · Cited by 126 · see citing works
Oligodendrocyte precursor cells count time but not cell divisions before differentiation
Gao, F., Durand, B., & RAFF, M. C. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00060-1 · Cited by 120 · see citing works
Exit from G0 and entry into the cell cycle of cells expressing p21Sdi1 antisense RNA.
Nakanishi, M., Adami, G. R., Robetorye, R. S., Noda, A., Venable, S. F., Dimitrov, D., Pereira‐Smith, O. M., & Smith, J. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4352 · Cited by 119 · see citing works
Dao, M. A., Taylor, N. N., & Nolta, J. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13006 · Cited by 112 · see citing works
Uchida, N., Dykstra, B. J., Lyons, K., Leung, F. Y. K., & Eaves, C. J. (2003) · Experimental Hematology · doi:10.1016/j.exphem.2003.09.001 · Cited by 108 · see citing works
Shen, H., Cheng, T., Preffer, F. I., Dombkowski, D., Tomasson, M. H., Golan, D. E., Yang, O. O., Hofmann, W., Sodroski, J., Luster, A. D., et al. (1999) · Journal of Virology · doi:10.1128/jvi.73.1.728-737.1999 · Cited by 104 · see citing works
Self-citationOostendorp, R. A. J., Audet, J., & Eaves, C. J. (2000) · Blood · doi:10.1182/blood.v95.3.855.003k41_855_862 · Cited by 103 · see citing works
Mantel, C., Luo, Z., Canfield, J., Braun, S. E., Deng, C., & Broxmeyer, H. (1996) · Blood · doi:10.1182/blood.v88.10.3710.bloodjournal88103710 · Cited by 102 · see citing works
The relative quiescence of hematopoietic stem cells in nonhuman primates
Mahmud, N., Devine, S. M., Weller, K. P., Parmar, S., Sturgeon, C., Nelson, M. C., Hewett, T. A., & Hoffman, R. (2001) · Blood · doi:10.1182/blood.v97.10.3061 · Cited by 101 · see citing works
Haploinsufficiency of p18INK4c Sensitizes Mice to Carcinogen-Induced Tumorigenesis
Bai, F., Pei, X., Godfrey, V., & Xiong, Y. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.4.1269-1277.2003 · Cited by 99 · see citing works
Taniguchi, T., Endo, H., Chikatsu, N., Uchimaru, K., Asano, S., Fujita, T., Nakahata, T., & Motokura, T. (1999) · Blood · doi:10.1182/blood.v93.12.4167 · Cited by 96 · see citing works
Roy, V., & Verfaillie, C. M. (1999) · Experimental Hematology · doi:10.1016/s0301-472x(98)00031-9 · Cited by 93 · see citing works
Phelps, D. E., Hsiao, K., Li, Y., Hu, N., Franklin, D. S., Westphal, E., Lee, E. Y.-H. P., & Xiong, Y. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.4.2334 · Cited by 86 · see citing works
Cheng, T., Shen, H., Rodrigues, N. P., Stier, S., & Scadden, D. T. (2001) · Blood · doi:10.1182/blood.v98.13.3643 · Cited by 79 · see citing works
Self-citationYaroslavskiy, B. B., Watkins, S. C., Donnenberg, A. D., Patton, T., & Steinman, R. A. (1999) · Blood · doi:10.1182/blood.v93.9.2907.409a34_2907_2917 · Cited by 76 · see citing works
An Intrinsic Timer That Controls Cell-Cycle Withdrawal in Cultured Cardiac Myocytes
Burton, P. B. J., RAFF, M. C., Kerr, P., Yacoub, M. H., & Barton, P. J. R. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9524 · Cited by 74 · see citing works
Regulation of p21(WAF1) Expression During Normal Myeloid Differentiation
Steinman, R. A., Huang, J., Yaroslavskiy, B. B., Goff, J. P., Ball, E. D., & Nguyen, A. (1998) · Blood · doi:10.1182/blood.v91.12.4531 · Cited by 73 · see citing works
Ex vivo targeting of p21Cip1/Waf1 permits relative expansion of human hematopoietic stem cells
Stier, S., Cheng, T., Forkert, R., Lutz, C., Dombkowski, D., Zhang, J. L., & Scadden, D. T. (2003) · Blood · doi:10.1182/blood-2002-10-3053 · Cited by 65 · see citing works
Self-citationFortunel, N. O., Batard, P., Hatzfeld, A., Monier, M., Panterne, B., LEBKOWSKI, J. S., & Hatzfeld, J. (1998) · Journal of Cell Science · doi:10.1242/jcs.111.13.1867 · Cited by 63 · see citing works
Regenerative Response in Ischemic Brain Restricted by p21cip1/waf1
Qiu, J., Takagi, Y., Harada, J., Rodrigues, N. P., Moskowitz, M. A., Scadden, D. T., & Cheng, T. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031385 · Cited by 59 · see citing works
Self-citationRole of p53 in Hematopoietic Recovery After Cytotoxic Treatment
Wlodarski, P. K., Wasik, M. A., Ratajczak, M. Z., Sevignani, C., Hoser, G., Kawiak, J., Gewirtz, A. M., Calabretta, B., & Skórski, T. (1998) · Blood · doi:10.1182/blood.v91.8.2998.2998_2998_3006 · Cited by 53 · see citing works
p53‐independent DNA repair and cell cycle arrest in embryonic stem cells
Prost, S., Bellamy, C. O. C., Clarke, A. R., Wyllie, A. H., & Harrison, D. J. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00296-8 · Cited by 53 · see citing works
Cashman, J., Clark‐Lewis, I., Eaves, A., & Eaves, C. J. (1999) · Blood · doi:10.1182/blood.v94.11.3722 · Cited by 53 · see citing works
Karnezis, A. N., Dorokhov, M., Grompe, M., & Zhu, L. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200111933 · Cited by 50 · see citing works
A Role for the Wnt Gene Family in Hematopoiesis: Expansion of Multilineage Progenitor Cells
Austin, T. W., Solar, G. P., Ziegler, F. C., et al. (1997) · Blood · doi:10.1182/blood.v89.10.3624.3624_3624_3635 · Cited by 44 · see citing works
Braun, S. E., Mantel, C., Rosenthal, M. S., Cooper, S. H., Liu, L., Robertson, K. A., Hromas, R., & Broxmeyer, H. E. (1998) · Blood Cells Molecules and Diseases · doi:10.1006/bcmd.1998.0181 · Cited by 41 · see citing works
Stem Cells and CNS Development
Rao, M. S. (2001) · Humana Press eBooks · doi:10.1385/1592591078 · Cited by 37 · see citing works
Mouse epidermal stem cells proceed through the cell cycle
Dunnwald, M., Chinnathambi, S., Alexandrunas, D., & Bickenbach, J. R. (2003) · Journal of Cellular Physiology · doi:10.1002/jcp.10311 · Cited by 37 · see citing works
Uchida, N., Friera, A. M., He, D., Reitsma, M. J., Tsukamoto, A. S., & Weissman, I. L. (1997) · Blood · doi:10.1182/blood.v90.11.4354 · Cited by 36 · see citing works
Hatzfeld, A., Batard, P., Panterne, B., Taieb, F. E., & Hatzfeld, J. (1996) · Human Gene Therapy · doi:10.1089/hum.1996.7.2-207 · Cited by 30 · see citing works
Region-specific expression of cell cycle inhibitors in the adult brain
Legrier, M., Ducray, A., Propper, A. Y., & Kästner, A. (2001) · Neuroreport · doi:10.1097/00001756-200110080-00029 · Cited by 24 · see citing works
Tschan, M. P., Peters, U. R., Cajot, J., Betticher, D. C., Fey, M. F., & Tobler, A. (1999) · British Journal of Haematology · doi:10.1046/j.1365-2141.1999.01617.x · Cited by 21 · see citing works
Hirabayashi, Y., Matsuda, M., Aizawa, S., Kodama, Y., Kanno, J., & Inoue, T. (2002) · Experimental Biology and Medicine · doi:10.1177/153537020222700711 · Cited by 18 · see citing works
Marone, M., Pierelli, L., Mozzetti, S., Masciullo, V., Bonanno, G., Roberta Morosetti, A., Rutella, S., Battaglia, A., Rumi, C., Mancuso, S., et al. (2000) · British Journal of Haematology · doi:10.1046/j.1365-2141.2000.02227.x · Cited by 17 · see citing works
Taniguchi, T., Endo, H., Chikatsu, N., et al. (1999) · Blood · doi:10.1182/blood.v93.12.4167.412k05_4167_4178 · Cited by 10 · see citing works
Regulation of p21(WAF1) Expression During Normal Myeloid Differentiation
Steinman, R. A., Huang, J., Yaroslavskiy, B. B., et al. (1998) · Blood · doi:10.1182/blood.v91.12.4531.412k10_4531_4542 · Cited by 10 · see citing works
Stem Cells and CNS Development
Wikström, L., & Mercer, A. (2001) · Drug Discovery Today · doi:10.1016/s1359-6446(01)02041-4 · Cited by 3 · see citing works
Uchida, N., Friera, A. M., He, D., et al. (1997) · Blood · doi:10.1182/blood.v90.11.4354.4354_4354_4362 · Cited by 3 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells
Gao, M.-Q., Choi, Y.-P., Kang, S., Youn, J. H., & Cho, N. H. (2010) · Oncogene · doi:10.1038/onc.2010.35 · Cited by 389 · see citing works
Liver stem cells and hepatocellular carcinoma†
Mishra, L., Banker, T. P., Murray, J. C., Byers, S. W., Thenappan, A., He, A. R., Shetty, K., Johnson, L. B., & Reddy, E. P. (2008) · Hepatology · doi:10.1002/hep.22704 · Cited by 333 · see citing works
Cell-cycle restriction limits DNA damage and maintains self-renewal of leukaemia stem cells
Viale, A., Franco, F., Orleth, A., Cambiaghi, V., Giuliani, V., Bossi, D., Ronchini, C., Ronzoni, S., Muradore, I., Monestiroli, S., et al. (2008) · Nature · doi:10.1038/nature07618 · Cited by 303 · see citing works
Retention of Intrinsic Stem Cell Hierarchies in Carcinoma-Derived Cell Lines
Locke, M., Heywood, M., Fawell, S. C., & Mackenzie, I. C. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0931 · Cited by 258 · see citing works
Wu, C. X., Wang, X. Q., Chok, K., Man, K., Tsang, S. H. Y., Chan, A. C. Y., Wing, K., Xia, W. G., & Cheung, T. T. (2018) · Theranostics · doi:10.7150/thno.25487 · Cited by 228 · see citing works
Tumour stem cell-targeted treatment: elimination or differentiation
Massard, C., Deutsch, É., & Soria, J. (2006) · Annals of Oncology · doi:10.1093/annonc/mdl074 · Cited by 177 · see citing works
Hair follicle stem cells: Walking the maze
Tiede, S., Kloepper, J. E., Bodó, E., Tiwari, S., Kruse, C., & Paus, R. (2007) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2007.03.006 · Cited by 176 · see citing works
Shao, L., Feng, W., Li, H., Gardner, D., Luo, Y., Wang, Y., Liu, L., Meng, A., Sharpless, N. E., & Zhou, D. (2014) · Blood · doi:10.1182/blood-2013-07-515619 · Cited by 165 · see citing works
microRNAs regulate human embryonic stem cell division
Qi, J., Yu, J., Shcherbata, H. R., Mathieu, J., Wang, A. J., Seal, S., Zhou, W., Stadler, B., Bourgin, D., Wang, L., et al. (2009) · Cell Cycle · doi:10.4161/cc.8.22.10033 · Cited by 162 · see citing works
Cancer Stem Cells as Mediators of Treatment Resistance in Brain Tumors: Status and Controversies
Sakariassen, P. Ø., Immervoll, H., & Chekenya, M. (2007) · Neoplasia · doi:10.1593/neo.07658 · Cited by 157 · see citing works
Lee, E., Wang, J., Yumoto, K., Jung, Y., Cackowski, F. C., Decker, A. M., Li, Y., Franceschi, R. T., Pienta, K. J., & Taichman, R. S. (2016) · Neoplasia · doi:10.1016/j.neo.2016.07.007 · Cited by 151 · see citing works
Hoi, C. S. L., Lee, S. E., Lu, S.-Y., McDermitt, D. J., Osorio, K. M., Piskun, C. M., Peters, R. M., Paus, R., & Tumbar, T. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01308-09 · Cited by 116 · see citing works
Peng, D., Wang, H., Li, L., Ma, X., Chen, Y., Zhou, H., Luo, Y., Xiao, Y., & Liu, L. (2018) · Leukemia · doi:10.1038/s41375-018-0015-2 · Cited by 114 · see citing works
Hu, L., Ru, K., Zhang, L., Huang, Y.-T., Zhu, X., Liu, H., Zetterberg, A., Cheng, T., & Miao, W. (2014) · Biomarker Research · doi:10.1186/2050-7771-2-3 · Cited by 107 · see citing works
Self-citationMyeloid leukemia factor 1 regulates p53 by suppressing COP1 via COP9 signalosome subunit 3
Yoneda‐Kato, N., Tomoda, K., Umehara, M., Arata, Y., & Kato, J. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600656 · Cited by 100 · see citing works
Scl regulates the quiescence and the long-term competence of hematopoietic stem cells
Lacombe, J., Herblot, S., Rojas‐Sutterlin, S., Haman, A., Barakat, S., Iscove, N. N., Sauvageau, G., & Hoang, T. (2009) · Blood · doi:10.1182/blood-2009-01-201384 · Cited by 99 · see citing works
Sox2 Suppression by miR-21 Governs Human Mesenchymal Stem Cell Properties
Trohatou, O., Zagoura, D., Bitsika, V., Pappa, K. I., Antsaklis, A., Anagnou, N. P., & Roubelakis, M. G. (2013) · Stem Cells Translational Medicine · doi:10.5966/sctm.2013-0081 · Cited by 84 · see citing works
Park, C., Kim, G., Kim, G., Choi, B. T., Park, Y., & Choi, Y. H. (2006) · Oncology Reports · doi:10.3892/or.15.5.1225 · Cited by 83 · see citing works
Hematopoietic stem cell senescence and cancer therapy-induced long-term bone marrow injury.
Shao, L., Wang, Y., Chang, J., Luo, Y., Meng, A., & Zhou, D. (2013) · PubMed · doi:10.3978/j.issn.2218-676x.2013.07.03 · Cited by 79 · see citing works
A critical role for Apc in hematopoietic stem and progenitor cell survival
Qian, Z., Chen, L., Fernald, A. A., Williams, B. O., & Beau, M. M. L. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080578 · Cited by 75 · see citing works
The MicroRNA Pathway Plays a Regulatory Role in Stem Cell Division
Shcherbata, H. R., Hatfield, S. D., Ward, E. J., Reynolds, S., Fischer, K. A., & Ruohola‐Baker, H. (2006) · Cell Cycle · doi:10.4161/cc.5.2.2343 · Cited by 74 · see citing works
Cell cycle regulation of hematopoietic stem or progenitor cells
Hao, S., Chen, C., & Cheng, T. (2016) · International Journal of Hematology · doi:10.1007/s12185-016-1984-4 · Cited by 71 · see citing works
Self-citationZheng, Z. S., Jia, J., Zhang, X., Zara, J. N., Yin, W., Chiang, M., Liu, Y., Wang, J., Pang, S., Ting, K., et al. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.04.049 · Cited by 68 · see citing works
Kinetics of normal hematopoietic stem and progenitor cells in a Notch1-induced leukemia model
Hu, X., Shen, H., Tian, C., Yu, H. M., Zheng, G., XuFeng, R., Ju, Z., Xu, J., Wang, J., & Cheng, T. (2009) · Blood · doi:10.1182/blood-2009-06-227843 · Cited by 66 · see citing works
Self-citationNanotechnology in oncology: advances in biosynthesis, drug delivery, and theranostics
Ammar, M. M., Ali, R., Elaziz, N. A. A., Habib, H., Abbas, F. M., Yassin, M. T., Maniah, K., & Abdelaziz, R. (2025) · Discover Oncology · doi:10.1007/s12672-025-02664-3 · Cited by 63 · see citing works
Tong, J., Sun, T., Ma, S., Zhao, Y., Ju, M., Gao, Y., Zhu, P., Tan, P., Fu, R., Zhang, A., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.01.018 · Cited by 63 · see citing works
Self-citationWolfe, A. R., Debeb, B. G., Lacerda, L., Larson, R. A., Bambhroliya, A. B., Huang, X., Bertucci, F., Finetti, P., Birnbaum, D., Laere, S. V., et al. (2015) · Breast Cancer Research and Treatment · doi:10.1007/s10549-015-3645-3 · Cited by 62 · see citing works
Evolving Therapies and FAK Inhibitors for the Treatment of Cancer
Dunn, K. B., Heffler, M., & Golubovskaya, V. (2010) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152010794728657 · Cited by 58 · see citing works
Qiu, J., Takagi, Y., Harada, J., Topalkara, K., Wang, Y., Sims, J. R., Zheng, G., Huang, P., Ling, Y., Scadden, D. T., et al. (2009) · Stem Cells · doi:10.1002/stem.1 · Cited by 57 · see citing works
Self-citationTabruyn, S. P., Nguyen, N.-Q.-N., Cornet, A. M., MARTIAL, J. A., & Struman, I. (2005) · Molecular Endocrinology · doi:10.1210/me.2004-0515 · Cited by 52 · see citing works
Gao, Y., Yang, P., Shen, H., Yu, H. M., Song, X., Zhang, L., Zhang, P., Cheng, H., Xie, Z., Hao, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms7328 · Cited by 49 · see citing works
Self-citationThe SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs
Rodrı́guez, S., Wang, L., Mumaw, C. L., Srour, E. F., Celso, C. L., Nakayama, K. I., & Carlesso, N. (2011) · Blood · doi:10.1182/blood-2010-11-321521 · Cited by 46 · see citing works
Su, L. (2009) · Oncology Reports · doi:10.3892/or_00000599 · Cited by 46 · see citing works
Leukemia cell infiltration causes defective erythropoiesis partially through MIP-1α/CCL3
Wang, Y., Gao, A., Zhao, H., Lu, P., Cheng, H., Dong, F., Gong, Y., Ma, S., Zheng, Y., Zhang, H., et al. (2016) · Leukemia · doi:10.1038/leu.2016.81 · Cited by 39 · see citing works
Self-citationBayati, S., Bashash, D., Ahmadian, S., Safaroghli‐Azar, A., Alimoghaddam, K., Ghavamzadeh, A., & Ghaffari, S. H. (2016) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2016.09.006 · Cited by 39 · see citing works
Wang, L., Huang, J., Jiang, M., & Sun, L. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23030 · Cited by 38 · see citing works
Kanatsu‐Shinohara, M., Takashima, S., & Shinohara, T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914448107 · Cited by 38 · see citing works
Fu, H., Chuang, I., Yang, Y.-C., Chuang, P.-C., Lin, H., Ou, Y., Chien, C.-C. C., Huang, H., & Kang, H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19092541 · Cited by 35 · see citing works
DDAH1 Deficiency Attenuates Endothelial Cell Cycle Progression and Angiogenesis
Zhang, P., Xu, X., Hu, X., Wang, H., Fassett, J. T., Huo, Y., Chen, Y., & Bache, R. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079444 · Cited by 34 · see citing works
Bae, S.-J., & Choi, Y. H. (2006) · Phytotherapy Research · doi:10.1002/ptr.2020 · Cited by 34 · see citing works
Endogenous GAS6 and Mer receptor signaling regulate prostate cancer stem cells in bone marrow
Jung, Y., Decker, A. M., Wang, J., Lee, E., Kana, L. A., Yumoto, K., Cackowski, F. C., Rhee, J., Carmeliet, P., Buttitta, L., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.8365 · Cited by 34 · see citing works
DCAF1 controls T-cell function via p53-dependent and -independent mechanisms
Guo, Z., Kong, Q., Liu, C., Zhang, S., Zou, L., Yan, F., Whitmire, J. K., Xiong, Y., Chen, X., & Wan, Y. Y. (2016) · Nature Communications · doi:10.1038/ncomms10307 · Cited by 32 · see citing works
Han, X., Zhang, J., Peng, Y., Peng, M., Chen, X., Chen, H., Song, J., Hu, X., Ye, M., Li, J., et al. (2016) · Blood · doi:10.1182/blood-2016-09-739268 · Cited by 32 · see citing works
Zhou, Z.-H., Ping, Y., Yu, S., Liang, Y., Yao, X., Chen, J., Cui, Y., & Bian, X. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.02.033 · Cited by 31 · see citing works
Tian, C., Zheng, G., Cao, Z., Li, Q., Ju, Z., Wang, J., Yuan, W., & Cheng, T. (2013) · Cell Cycle · doi:10.4161/cc.23160 · Cited by 30 · see citing works
Self-citationExpansion of hematopoietic stem/progenitor cells
Wu, H., Xin‐Na, D., & Duan, H. (2008) · American Journal of Hematology · doi:10.1002/ajh.21262 · Cited by 30 · see citing works
The CDK inhibitors: potential targets for therapeutic stem cell manipulations?
Boyer, M. J., & Cheng, T. (2007) · Gene Therapy · doi:10.1038/sj.gt.3303064 · Cited by 30 · see citing works
Self-citationMolecular and Cellular Basis of Regeneration and Tissue Repair
Pajalunga, D., Mazzola, A., Franchitto, A., Puggioni, E. M. R., & Crescenzi, M. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-7425-z · Cited by 29 · see citing works
Sprouty1, a new target of the angiostatic agent 16K prolactin, negatively regulates angiogenesis
Sabatel, C., Cornet, A. M., Tabruyn, S. P., Malvaux, L., Castermans, K., MARTIAL, J. A., & Struman, I. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-231 · Cited by 27 · see citing works
Cheng, T. (2007) · Gene Therapy · doi:10.1038/sj.gt.3303066 · Cited by 26 · see citing works
Self-citationTrohatou, O., Zagoura, D., Orfanos, N. K., Pappa, K. I., Marinos, E., Anagnou, N. P., & Roubelakis, M. G. (2017) · Stem Cells and Development · doi:10.1089/scd.2016.0203 · Cited by 25 · see citing works
Fujita, M., Takeshita, H., & Sawa, H. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000407 · Cited by 25 · see citing works
Aberrant methylation and reduced expression of RASSF1A in Ewing sarcoma
Avigad, S., Shukla, S., Naumov, I., Cohen, I. J., Ash, S., Meller, I., Kollender, Y., Issakov, J., & Yaniv, I. (2009) · Pediatric Blood & Cancer · doi:10.1002/pbc.22115 · Cited by 25 · see citing works
Mishra, C. B., Mongre, R. K., Kumari, S., Jeong, D. K., & Tiwari, M. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.6b01007 · Cited by 24 · see citing works
Implications of a simple mathematical model to cancer cell population dynamics
Garner, A. L., Lau, Y. Y., Jordan, D. W., Uhler, M. D., & Gilgenbach, R. M. (2006) · Cell Proliferation · doi:10.1111/j.1365-2184.2006.00368.x · Cited by 24 · see citing works
Cancerous stem cells: deviant stem cells with cancer-causing misbehavior
Chandler, J. M., & Lagasse, E. (2010) · Stem Cell Research & Therapy · doi:10.1186/scrt13 · Cited by 23 · see citing works
Yuan, Y., Yu, H. M., Boyer, M. J., Song, X., Cao, S., Shen, H., & Cheng, T. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2945 · Cited by 22 · see citing works
Self-citationRegulating Quiescence: New Insights into Hematopoietic Stem Cell Biology
Passegue, E. A., & Wagers, A. J. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.03.002 · Cited by 21 · see citing works
Cul4A is required for hematopoietic stem-cell engraftment and self-renewal
Li, B., Jia, N., Waning, D. L., Yang, F., Haneline, L. S., & Chun, K. T. (2007) · Blood · doi:10.1182/blood-2006-12-064154 · Cited by 20 · see citing works
Pleiotropic p27Kip1, BCR-ABL and leukemic stem cell: the trio in concert
Sengupta, A., & Banerjee, S. (2007) · Leukemia · doi:10.1038/sj.leu.2404842 · Cited by 20 · see citing works
A molecular signaling map and its application
Li, J., & Mansmann, U. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.08.022 · Cited by 19 · see citing works
Sphere-induced reprogramming of RPE cells into dual-potential RPE stem-like cells
Chen, F., Liu, X., Chen, Y., Liu, J. Y., Lü, H., Wang, W., Lu, X., Dean, K. C., Gao, L., Kaplan, H. J., et al. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2019.102618 · Cited by 19 · see citing works
Salim, K., Guest, P. C., Skynner, H. A., Bilsland, J., Bonnert, T. P., McAllister, G., & Muñoz-Sanjuán, I. (2007) · Stem Cells and Development · doi:10.1089/scd.2006.00100 · Cited by 19 · see citing works
Tong, J., Sun, T., Ma, S., Zhao, Y., Ju, M., Gao, Y., Zhu, P., Tan, P., Fu, R., Zhang, A., et al. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.02.026 · Cited by 18 · see citing works
Self-citationGlasstetter, L. M., Oderinde, T. S., Mirchandani, M., Rajagopalan, K. S., Barsom, S. H., Thaler, R., Siddiqi, S., Zhu, X., Tang, H. R., Jordan, K. L., et al. (2023) · Stem Cell Research & Therapy · doi:10.1186/s13287-023-03372-x · Cited by 17 · see citing works
Mechanisms of action of hESC-secreted proteins that enhance human and mouse myogenesis
Yousef, H., Conboy, M. J., Mamiya, H., Zeiderman, M., Schlesinger, C., Schaffer, D. V., & Conboy, I. M. (2014) · Aging · doi:10.18632/aging.100659 · Cited by 16 · see citing works
Early hematopoiesis inhibition under chronic radiation exposure in humans
Akleyev, А. V., Akushevich, I. V., Dimov, G. P., Veremeyeva, G. A., Varfolomeyeva, T. A., Ukraintseva, S. V., & YASHIN, A. I. (2010) · Radiation and Environmental Biophysics · doi:10.1007/s00411-010-0269-1 · Cited by 16 · see citing works
Long non‐coding RNA MRPL23‐AS1 suppresses anoikis in salivary adenoid cystic carcinoma in vitro
Li, Y., Fu, M., Song, Y., Li, H., & Ge, X. (2022) · Oral Diseases · doi:10.1111/odi.14156 · Cited by 15 · see citing works
Tomiatti, V., Istvánffy, R., Pietschmann, E., Kratzat, S., Hoellein, A., Quintanilla-Fend, L., von Bubnoff, N. C. C., Peschel, C., Oostendorp, R. A. J., & Keller, U. B. (2014) · Oncogene · doi:10.1038/onc.2014.364 · Cited by 15 · see citing works
Cancer stem cells and brain tumors: uprooting the bad seeds
Lee, D. Y., & Gutmann, D. H. (2007) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.7.11.1581 · Cited by 15 · see citing works
Telomere dysfunction and cell cycle checkpoints in hematopoietic stem cell aging
Ju, Z., Zhang, J., Gao, Y., & Cheng, T. (2011) · International Journal of Hematology · doi:10.1007/s12185-011-0882-z · Cited by 14 · see citing works
Self-citationLi, Y., Pal, R., Sung, L., Feng, H., Miao, W., Cheng, S., Tian, C., & Cheng, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045212 · Cited by 11 · see citing works
Self-citationp19INK4d: More than Just a Cyclin-Dependent Kinase Inhibitor
Han, X., Kuang, Y., Chen, H., Liu, T., Zhang, J., & Liu, J. (2019) · Current Drug Targets · doi:10.2174/1389450120666190809161901 · Cited by 11 · see citing works
Proliferation of Multiple Cell Types in the Skeletal Muscle Tissue Elicited by Acute p21 Suppression
Biferi, M. G., Nicoletti, C., Falcone, G., Puggioni, E. M. R., Passaro, N., Mazzola, A., Pajalunga, D., Zaccagnini, G., Rizzuto, E., Auricchio, A., et al. (2015) · Molecular Therapy · doi:10.1038/mt.2015.27 · Cited by 11 · see citing works
The impact of tumor microenvironments on stem cells
Wang, L., Cheng, T., & Zheng, G. (2013) · Translational Cancer Research · doi:10.21037/1675 · Cited by 8 · see citing works
Self-citationOodi, A., Noruzinia, M., Roudkenar, M. H., Nikougoftar, M., Soltanpour, M. S., Khorshidfar, M., & Amirizadeh, N. (2012) · Hematology · doi:10.1179/1607845412y.0000000009 · Cited by 8 · see citing works
Assessing the prognostic value of stemness-related genes in breast cancer patients
Wang, W., Wang, H., Wang, M.-S., Huang, Y., Ma, Y.-Y., Qi, J., Shi, J., & Li, W. (2020) · Scientific Reports · doi:10.1038/s41598-020-73164-3 · Cited by 6 · see citing works
Preleukemic stem cells: leave it or not?
Su, M., Cheng, H., & Cheng, T. (2020) · Blood Science · doi:10.1097/bs9.0000000000000042 · Cited by 6 · see citing works
Self-citationCan precancerous stem cells be risk markers for malignant transformation in the oral mucosa?
Wang, S., Liu, Y., Yu, S., Bai, J., & Hao, C. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00441-0 · Cited by 5 · see citing works
p21/Zbtb18 repress the expression of cKit to regulate the self-renewal of hematopoietic stem cells
Wang, N., Yang, S., Li, Y., Gou, F., Lv, Y., Zhao, X., Wang, Y., Xu, C., Zhou, B., Dong, F., et al. (2024) · Protein & Cell · doi:10.1093/procel/pwae022 · Cited by 5 · see citing works
Self-citationEffects of Ethanol on the Regulation of Cell Cycle in Neural Stem Cells
Zawada, W. M., & Das, M. (2006) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195183139.003.0012 · Cited by 5 · see citing works
Amirizadeh, N., Oodi, A., Nikougoftar, M., & Soltanpour, M. S. (2013) · Hematology · doi:10.1179/1607845412y.0000000062 · Cited by 4 · see citing works
Czerwonka, A., Lemieszek, M. K., Karpińska, M. M., Matysiak, J., Niewiadomy, A., & Rzeski, W. (2018) · Medicinal Chemistry Research · doi:10.1007/s00044-018-2223-8 · Cited by 4 · see citing works
Novel Therapeutic Targets for Hepatocellular Carcinoma Treatment
Chen, Y., & Han, C. (2012) · InTech eBooks · doi:10.5772/28894 · Cited by 2 · see citing works
The Road to Commitment: Lineage Restriction Events in Hematopoiesis
Månsson, R., Zandi, S., Bryder, D., & Sigvardsson, M. (2009) · Springer eBooks · doi:10.1007/978-0-387-85816-6_2 · Cited by 2 · see citing works
Contribution of the Cancer Stem Cell Phenotype to Hepatocellular Carcinoma Resistance
Castven, D., Czauderna, C., & Marquardt, J. U. (2017) · Resistance to targeted anti-cancer therapeutics · doi:10.1007/978-3-319-56197-4_4 · Cited by 2 · see citing works
CANCER BIOLOGY, CANCER MODELS AND SOME NEW APPROACHES TO CARCINOGENESIS
Tan, W., Chen, C. W., & Zhang, L. J. (2008) · Series in Mathematical Biology and Medicine · doi:10.1142/9789812779489_0003 · Cited by 2 · see citing works
THE STEM (CLONOGENIC) CELLS OF CANCER: RETURNING TO THE EARLIER RECEIVED DATA
Чиссов, В. И., Сергеева, Н. С., Sviridova, I. K., & Пелевина, И. И. (2006) · CyberLeninK (CyberLeninka) · Cited by 1 · see citing works
Cell Cycle Control of Stem Cell Fate
Nacusi, L. P., & Sheaff, R. J. (2008) · WORLD SCIENTIFIC eBooks · doi:10.1142/9789812775771_0004 · Cited by 1 · see citing works
Franke, K., Vilne, B., da Costa, O. P., Rudelius, M., Peschel, C., Oostendorp, R. A. J., & Keller, U. B. (2015) · Oncotarget · doi:10.18632/oncotarget.5217 · Cited by 1 · see citing works
PKB/Akt kinase localization and role in stemness maintenance in cancer
Jain, M. V. (2016) · Linköping University Electronic Press eBooks · doi:10.3384/diss.diva-127477 · Cited by 1 · see citing works
Salim, K., Guest, P. C., Skynner, H. A., Bilsland, J., Bonnert, T. P., McAllister, G., & Muñoz-Sanjuán, I. (2007) · Stem Cells and Development · doi:10.1089/scd.2007.16.ft-2 · Cited by 1 · see citing works
GENETIC REGULATION OF HEMATOPOIETIC STEM CELL NUMBERS IN MICE
Liang, Y. (2005) · UKnowledge (University of Kentucky)
Implications of Developmental Switches for Hematopoietic Stem Cell Aging
Nygren, J., & Bryder, D. (2009) · Springer eBooks · doi:10.1007/978-1-4020-9063-9_31
Identification of Unique Hematopoietic Stem Cell Properties
Nygren, J. (2005) · Lund University Publications (Lund University)
The role of Diencephalon/Mesencephalon Homeobox 1 (Dmbx1) in Zebrafish Visual System Development
Wong, L. (2013) · TSpace (University of Toronto)
Fator de pluripotência OCT4A e agressividade de meduloblastoma humano
da Silva, P. B. G. (2017) · doi:10.11606/t.41.2017.tde-20032017-161403
Therapeutic targeting of the leukaemic fusion genes
Issa, H. (2019)
- Authors
- Cheng, T.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Cheng, Tao
- ORCID
- Cheng, Tao
- Venue
- Oncogene
- Published
- 2004-09-20
- Volume
- 23
- Issue
- 43
- Pages
- 7256-7266
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W1991227964
- Cited by
- 117
- References
- 128
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 14 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 4 · 2014: 5 · 2013: 8 · 2012: 4
- FWCI
- 0.83
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Society of Hematology
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL70561, R01HL070561)
- National Institute of Diabetes and Digestive and Kidney Diseases (K08DK002761, DK 02761)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- cell cycle inhibitors, stem cells, cancer stem cells, hematopoietic stem cells, stem cell differentiation, tissue regeneration, tumor recurrence, carcinogenesis, adult stem cell therapy, tissue homeostasis
- MeSH terms
- Animals, Cell Cycle, Cell Division, Humans, Neoplasm Proteins, Saccharomyces cerevisiae, Stem Cells, Neoplastic Stem Cells, Cyclins, Mice, Knockout, Cell Cycle Proteins, Cyclin-Dependent Kinases, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review