Inhibitors of NF-κB signaling: 785 and counting

Activators and target genes of Rel/NF-κB transcription factors

Pahl, H. L. (1999) · Oncogene · doi:10.1038/sj.onc.1203239 · Cited by 3,727

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., & Karin, M. (1997) · Nature · doi:10.1038/41493 · Cited by 2,125

Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

Yuan, M., Konstantopoulos, N., Lee, J., Hansen, L., Li, Z.-W., Karin, M., & Shoelson, S. E. (2001) · Science · doi:10.1126/science.1061620 · Cited by 1,884

NF-κB and the immune response

Hayden, M. S., West, A. P., & Ghosh, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209943 · Cited by 1,178

Post-translational modifications regulating the activity and function of the nuclear factor kappa B pathway

Perkins, N. D. (2006) · Oncogene · doi:10.1038/sj.onc.1209937 · Cited by 674

Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance

Bubici, C., Papa, S., Dean, K., & Franzoso, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209936 · Cited by 399

Evolving functions of endothelial cells in inflammation

Pober, J. S., & Sessa, W. C. (2007) · Nature Reviews Immunology · doi:10.1038/nri2171 · Cited by 2,022

Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging

Salminen, A., Huuskonen, J., Ojala, J., Kauppinen, A., Kaarniranta, K., & Suuronen, T. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2007.09.002 · Cited by 581

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

Kell, D. B. (2009) · BMC Medical Genomics · doi:10.1186/1755-8794-2-2 · Cited by 554

Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance

Bubici, C., Papa, S., Dean, K., & Franzoso, G. (2006) · Oncogene · doi:10.1038/sj.onc.1209936 · Cited by 399

Targeting the NF-κB pathway in asthma and chronic obstructive pulmonary disease

Edwards, M. R., Bartlett, N. W., Clarke, D., Birrell, M., Belvisi, M., & Johnston, S. L. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.09.003 · Cited by 375

PROTACs: great opportunities for academia and industry (an update from 2020 to 2021)

He, M., Cao, C., Ni, Z., Liu, Y., Song, P., Hao, S., He, Y., Sun, X., & Rao, Y. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00999-9 · Cited by 283

Mesenchymal stem cell-derived exosomes: therapeutic opportunities and challenges for spinal cord injury

Liu, W.-Z., Ma, Z.-J., Li, J.-R., & Kang, X.-W. (2021) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02153-8 · Cited by 252

TF-PROTACs Enable Targeted Degradation of Transcription Factors

Liu, J., Chen, H., Kaniskan, H. Ü., Xie, L., Chen, X., Jin, J., & Wei, W. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c03852 · Cited by 247

Bilberry juice modulates plasma concentration of NF-κB related inflammatory markers in subjects at increased risk of CVD

Karlsen, A., Paur, I., Bøhn, S. K., Sakhi, A. K., Borge, G. I., Serafini, M., Erlund, I., Laake, P., Tonstad, S., & Blomhoff, R. (2010) · European Journal of Nutrition · doi:10.1007/s00394-010-0092-0 · Cited by 216

Lung inflammation caused by inhaled toxicants: A review

Wong, J., Magun, B., & Wood, L. (2016) · International Journal of Chronic Obstructive Pulmonary Disease · doi:10.2147/copd.s106009 · Cited by 193

NFκB/p53 crosstalk—a promising new therapeutic target

Schneider, G., & Krämer, O. H. (2011) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2010.10.003 · Cited by 87

Asiaticoside produces an antidepressant‑like effect in a chronic unpredictable mild stress model of depression in mice, involving reversion of inflammation and the PKA/pCREB/BDNF signaling pathway

Wang, L., Guo, T., Guo, Y., & Xu, Y. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11305 · Cited by 70

Double-Edged Swords as Cancer Therapeutics: Novel, Orally Active, Small Molecules Simultaneously Inhibit p53–MDM2 Interaction and the NF-κB Pathway

Zhuang, C., Miao, Z., Wu, Y., Guo, Z., Li, J., Yao, J., Xing, C., Sheng, C., & Zhang, W. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm401800k · Cited by 50

Targeting NF-κB and HIF-1 Pathways for the Treatment of Cancer: Part II

Wilczynski, J., Duechler, M., & Czyz, M. (2011) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-011-0132-3 · Cited by 41

Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks

Mallikarjun, V., & Swift, J. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.11.020 · Cited by 14