Cited by 216Phytochemicals and Antioxidant ActivitiesPomegranate: compositions and health benefitsExercise and Physiological Responses

Bilberry juice modulates plasma concentration of NF-κB related inflammatory markers in subjects at increased risk of CVD

Karlsen, Anette, Paur, Ingvild, Bøhn, Siv K., Sakhi, Amrit K., Borge, Grethe I., Serafini, Mauro, Erlund, Iris, Laake, Petter +2 more·2010·European Journal of Nutrition

Abstract

Purpose Bilberries are abundant in polyphenols. Dietary polyphenols have been associated with strategies for prevention and treatment of chronic inflammatory diseases. We investigated the effect of bilberry juice on serum and plasma biomarkers of inflammation and antioxidant status in subjects with elevated levels of at least one risk factor for cardiovascular disease (CVD).Methods In a randomized controlled trial, participants consumed either bilberry juice (n = 31) or water (n = 31) for 4 weeks.Results Supplementation with bilberry juice resulted in significant decreases in plasma concentrations of C-reactive protein (CRP), interleukin (IL)-6, IL-15, and monokine induced by INF-gamma (MIG). Unexpectedly, an increase in the plasma concentration of tumor nuclear factor-alpha (TNF-alpha) was observed in the bilberry group. CRP, IL-6, IL15, MIG, and TNF-alpha are all target genes of nuclear factor- kappa B (NF-kappaB), -a transcription factor that is crucial in orchestrating inflammatory responses. Plasma quercetin and p-coumaric acid increased in the bilberry group, otherwise no differences were observed for clinical parameters, oxidative stress or antioxidant status. Furthermore, we studied the effect of polyphenols from bilberries on lipopolysaccharide (LPS)-induced NF-kappaB activation in a monocytic cell line. We observed that quercetin, epicatechin, and resveratrol inhibited NF-kappaB activation.Conclusions These findings suggest that supplementation with bilberry polyphenols may modulate the inflammation processes. Further testing of bilberry supplementation as a potential strategy in prevention and treatment of chronic inflammatory diseases is warranted.

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Crossref · 10.1007/s00394-010-0092-0

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  • FoxO proteins regulate genes involved in energy homeostasis, cell survival, and inflammatory responses including NF-kB.

    “FoxO proteins are transcription factors which regulate the expression of genes involved in energy homeostasis, cell survival and inflammatory responses including NF-kB (274 -278) .”
  • Sirtuin activation improves metabolic efficiency, strengthens cell stress defences, and dampens inflammatory activities by decreasing NF-kB activation.

    “As a consequence, metabolic efficiency is improved, cell defences against stress are strengthened and inflammatory activities are dampened, notably by decreasing the activation of NF-kB (271 -274) .”

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Authors
Karlsen, A., Paur, I., Bøhn, S. K., Sakhi, A. K., Borge, G. I., Serafini, M., Erlund, I., Laake, P., Tonstad, S., & Blomhoff, R.
Affiliations
  • University of Oslo (NO)
  • Nofima (NO)
  • Institut National de la Recherche Agronomique du Niger (NE)
  • Finnish Institute for Health and Welfare (FI)
  • Oslo University Hospital (NO)
Corresponding author
Blomhoff, Rune
Venue
European Journal of Nutrition
Published
2010-02-02
Volume
49
Issue
6
Pages
345-355
ISSN
  • 1436-6207 (ISSN-L)
  • 1436-6215
OpenAlex
W2102160308
Cited by
216
References
56
Citations by year
2026: 4 · 2025: 13 · 2024: 8 · 2023: 11 · 2022: 13 · 2021: 18 · 2020: 12 · 2019: 12 · 2018: 15 · 2017: 13 · 2016: 12 · 2015: 16 · 2014: 19 · 2013: 23 · 2012: 12
FWCI
10.39
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
Funders
Norges Forskningsråd
Topics
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
  • Health Sciences › Nursing › Nutrition and Dietetics › Pomegranate: compositions and health benefits
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
dietary polyphenols, NF-κB signaling, inflammatory markers, cardiovascular risk, C-reactive protein, interleukin-6, IL-15, monokine induced by interferon-gamma, TNF-α, quercetin, p-coumaric acid, epicatechin, resveratrol, antioxidant status, oxidative stress, functional food supplementation
MeSH terms
Adult, Aged, Anti-Inflammatory Agents, Non-Steroidal, Beverages, C-Reactive Protein, Cardiovascular Diseases, Female, Flavonoids, Fruit, Humans, Lipopolysaccharides, Male, Middle Aged, Monocytes, Phenols, Risk Factors, Biomarkers, Cytokines, NF-kappa B, Inflammation Mediators, Dietary Supplements, U937 Cells, Vaccinium myrtillus, Polyphenols

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