NFκB/p53 crosstalk—a promising new therapeutic target
Abstract
The transcription factors p53 and NFκB determine cellular fate and are involved in the pathogenesis of most-if not all-cancers. The crosstalk between these transcription factors becomes increasingly appreciated as an important mechanism operative during all stages of tumorigenesis, metastasis, and immunological surveillance. In this review, we summarize molecular mechanisms regulating cross-signaling between p53 and NFκB proteins and how dysregulated interactions between p53 and NFκB family members contribute to oncogenesis. We furthermore analyze how such signaling modules represent targets for the design of novel intervention strategies using established compounds and powerful combination therapies.
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PXN822 did not stabilize the p53 R172H mutant in the murine pancreatic ductal adenocarcinoma cell lines PPT-3107 and PPT-5436.
“The p53mutant R172H was not stabilized by the PXN822 treatment in PPT-3107 and PPT-5436 cells”
From Mdm2 inhibitors synergize with topoisomerase II inhibitors to induce p53-independent pancreatic cancer cell death (2013) · cites this paper as [24]
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Fighting Cancer with Red Wine? Molecular Mechanisms of Resveratrol
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Conditional ablation of Ikkb inhibits melanoma tumor development in mice
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Self-citationDepletion of Mutant p53 and Cytotoxicity of Histone Deacetylase Inhibitors
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Mutant p53 initiates a feedback loop that involves Egr-1/EGF receptor/ERK in prostate cancer cells
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The value of proteasome inhibition in cancer
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Contradictory functions of NF-κB in liver physiology and cancer
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Activated p53 induces NF-κB DNA binding but suppresses its transcriptional activation
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Cancer cells suppress p53 in adjacent fibroblasts
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The p53 Family Protein p73 Provides New Insights into Cancer Chemosensitivity and Targeting
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Cooperation of two mutant p53 alleles contributes to Fas resistance of prostate carcinoma cells.
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ARF the Integrator: Linking NF-?B, p53 and Checkpoint Kinases
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The diverse and complex roles of NF-κB subunits in cancer
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p53 and NF-κB Coregulate Proinflammatory Gene Responses in Human Macrophages
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p53 and the Carcinogenicity of Chronic InflammationPreprint
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HDAC1 and HDAC2 integrate the expression of p53 mutants in pancreatic cancer
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Self-citationRegulation of p53 and Rb Links the Alternative NF-κB Pathway to EZH2 Expression and Cell Senescence
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Temozolomide Treatment Induces lncRNA MALAT1 in an NF-κB and p53 Codependent Manner in Glioblastoma
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Acetylation modulates the STAT signaling code
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Self-citationp53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors
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Self-citationHistone deacetylase 2 controls p53 and is a critical factor in tumorigenesis
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Self-citationDissecting Major Signaling Pathways throughout the Development of Prostate Cancer
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The Bad, the Good, and the Ugly about Oxidative Stress
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- Authors
- Schneider, G., & Krämer, O. H.
- Affiliations
- TUM Klinikum (DE)
- Friedrich Schiller University Jena (DE)
- Corresponding author
- Krämer, Oliver H.
- Venue
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 1815
- Issue
- 1
- Pages
- 90-103
- ISSN
- 0304-419X (ISSN-L)
- OpenAlex
- W2045487670
- Cited by
- 87
- References
- 182
- Citations by year
- 2025: 1 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 6 · 2017: 1 · 2016: 6 · 2015: 6 · 2014: 10 · 2013: 9 · 2012: 14
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (publishedVersion)
- PubMed (publishedVersion)
- mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
- Keywords
- NF-κB, p53, transcription factor crosstalk, carcinogenesis, metastasis, tumor surveillance, combination therapy, therapeutic target
- MeSH terms
- Animals, Cell Cycle, Humans, Neoplasm Metastasis, Neoplasms, Signal Transduction, Tumor Suppressor Protein p53, NF-kappa B, Apoptosis
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