Cited by 87NF-κB Signaling PathwaysCancer-related Molecular PathwaysSignaling Pathways in Disease

NFκB/p53 crosstalk—a promising new therapeutic target

Schneider, Günter, Krämer, Oliver H.·2011·Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Abstract

The transcription factors p53 and NFκB determine cellular fate and are involved in the pathogenesis of most-if not all-cancers. The crosstalk between these transcription factors becomes increasingly appreciated as an important mechanism operative during all stages of tumorigenesis, metastasis, and immunological surveillance. In this review, we summarize molecular mechanisms regulating cross-signaling between p53 and NFκB proteins and how dysregulated interactions between p53 and NFκB family members contribute to oncogenesis. We furthermore analyze how such signaling modules represent targets for the design of novel intervention strategies using established compounds and powerful combination therapies.

Integrity signals

Registry

Crossref · 10.1016/j.bbcan.2010.10.003

Cites

179 of 179 references verified0 citation errors · 0 not checkable

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Authors
Schneider, G., & Krämer, O. H.
Affiliations
  • TUM Klinikum (DE)
  • Friedrich Schiller University Jena (DE)
Corresponding author
Krämer, Oliver H.
Venue
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Publisher
Elsevier BV
Published
2011-01
Volume
1815
Issue
1
Pages
90-103
ISSN
0304-419X (ISSN-L)
OpenAlex
W2045487670
Cited by
87
References
182
Citations by year
2025: 1 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 6 · 2017: 1 · 2016: 6 · 2015: 6 · 2014: 10 · 2013: 9 · 2012: 14
FWCI
0.77
Type
journal article
Language
en
Open access
closed
Locations
  • Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (publishedVersion)
  • PubMed (publishedVersion)
  • mediaTUM – the media and publications repository of the Technical University Munich (Technical University Munich) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Keywords
NF-κB, p53, transcription factor crosstalk, carcinogenesis, metastasis, tumor surveillance, combination therapy, therapeutic target
MeSH terms
Animals, Cell Cycle, Humans, Neoplasm Metastasis, Neoplasms, Signal Transduction, Tumor Suppressor Protein p53, NF-kappa B, Apoptosis

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