The DOI matches its Crossref record; 78 of the 80 references it cites were found in a registry or an index.
The Wnt code: cnidarians signal the way
Abstract
Cnidarians are the simplest metazoans with a nervous system. They are well known for their regeneration capacity, which is based on the restoration of a signalling centre (organizer). Recent work has identified the canonical Wnt pathway in the freshwater polyp Hydra, where it acts in organizer formation and regeneration. Wnt signalling is also essential for cnidarian embryogenesis. In the sea anemone Nematostella vectensis 11 of the 12 known wnt gene subfamilies were identified. Different wnt genes exhibit serial and overlapping expression domains along the oral-aboral axis of the embryo (the 'wnt code'). This is reminiscent of the hox code (cluster) in bilaterian embryogenesis that is, however, absent in cnidarians. It is proposed that the common ancestor of cnidarians and bilaterians invented a set of wnt genes that patterned the ancient main body axis. Major antagonists of Wnt ligands (e.g. Dkk 1/2/4) that were previously known only from chordates, are also present in cnidarians and exhibit a similar conserved function. The unexpectedly high level of genetic complexity of wnt genes evolved in early multi-cellular animals about 650 Myr ago and suggests a radical expansion of the genetic repertoire, concurrent with the evolution of multi-cellularity and the diversification of eumetazoan body plans.
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“or even the formation of multiple polyp heads52.”
From Sequential actions of β-catenin and Bmp pattern the oral nerve net in Nematostella vectensis (2014) · cites this paper as [52]
Citations
Cites
The Wnt Signaling Pathway in Development and Disease
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Secreted antagonists of the Wnt signalling pathway
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Wnt signalling regulates adult hippocampal neurogenesis
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WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra
Hobmayer, B., Rentzsch, F., Kuhn, K., Happel, C. M., von Laue, C. C., Snyder, P., Rothbächer, U., & Holstein, T. W. (2000) · Nature · doi:10.1038/35025063 · Cited by 599
Unexpected complexity of the Wnt gene family in a sea anemone
Kusserow, A., Pang, K., Sturm, C., Hrouda, M., Lentfer, J., Schmidt, H. A., Technau, U., von Haeseler, A., Hobmayer, B., Martindale, M. Q., et al. (2005) · Nature · doi:10.1038/nature03158 · Cited by 599
Self-citationSecretion of Wnt Ligands Requires Evi, a Conserved Transmembrane Protein
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The genesis and evolution of homeobox gene clusters
García‐Fernàndez, J. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1723 · Cited by 490
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Towards an integrated view of Wnt signaling in development
van Amerongen, R., & Nusse, R. (2009) · Development · doi:10.1242/dev.033910 · Cited by 1,213
“Notably, a remarkably diverse Wnt repertoire is already present in Cnidarians, an ancient metazoan phylum that includes fresh water polyps and sea anemones (Guder et al., 2006).”
BackgroundFrizzled and LRP5/6 Receptors for Wnt/ -Catenin SignalingPreprint
MacDonald, B. T., & He, X. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a007880 · Cited by 640
“All of the above “core” Wnt/b-catenin signaling components are present in vertebrates and the well-studied fruit fly Drosophila and are also encoded in sequenced genomes of radial symmetric Cnidarians Hydra magnipapillata and Nematostella vectensis (Guder et al. 2006) and of the primitive metazoan sponge Amphimedon qu…”
BackgroundComparative Aspects of Animal Regeneration
Brockes, J. P., & Kumar, A. (2008) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.24.110707.175336 · Cited by 491
Apoptotic Cells Provide an Unexpected Source of Wnt3 Signaling to Drive Hydra Head Regeneration
Chera, S., Ghila, L., Dobretz, K., Wenger, Y., Bauer, C. R., Buzgariu, W., Martinou, J., & Galliot, B. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.07.014 · Cited by 424
“…Previous work showed the upregulation of Wnt3 expression several hours after mid-gastric section in endodermal epithelial cells (Hobmayer et al., 2000; Guder et al., 2006a), whereas this work identified an immediate and transient overproduction of Wnt3 protein by cells of the interstitial lineage.”
BackgroundResultInfluentialSclerostin and Dickkopf-1 as Therapeutic Targets in Bone Diseases
Ke, H. Z., Richards, W. G., Li, X., & Ominsky, M. S. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1060 · Cited by 409
Metadata
- Authors
- Guder, C., Philipp, I., Lengfeld, T., Watanabe, H., Hobmayer, B., & Holstein, T. W.
- Affiliations
- Heidelberg University (DE)
- Universität Innsbruck (AT)
- Corresponding author
- Holstein, T W
- Venue
- Oncogene
- Published
- 2006-12-04
- Volume
- 25
- Issue
- 57
- Pages
- 7450-7460
- ISSN
- 0950-9232 (ISSN-L)
- 1476-5594
- OpenAlex
- W1983253019
- Cited by
- 177
- References
- 80
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 9 · 2021: 8 · 2020: 1 · 2019: 11 · 2018: 9 · 2017: 6 · 2016: 11 · 2015: 8 · 2014: 15 · 2013: 7 · 2012: 14
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Oncogene (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Keywords
- Wnt signaling, Cnidaria, Nematostella vectensis, Hydra, regeneration, embryonic development, oral-aboral axis, Hox code, body plan evolution, gene family expansion
- MeSH terms
- Animals, Cnidaria, Hydra, Ligands, Models, Biological, Phylogeny, Sea Anemones, Signal Transduction, Evolution, Molecular, Body Patterning, Wnt Proteins, beta Catenin
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