Cited by 631Wnt/β-catenin signaling in development and cancerSignaling Pathways in DiseaseUbiquitin and proteasome pathways

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β-Catenin destruction complex: insights and questions from a structural perspective

Kimelman, D, Xu, W·2006·Oncogene

DOI 10.1038/sj.onc.1210055

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Abstract

At the heart of the canonical Wnt signaling pathway is the beta-catenin destruction complex, which functions in the absence of Wnt signaling to keep the cytosolic and nuclear levels of beta-catenin very low by promoting the phosphorylation and ubiquitination of beta-catenin. Structural studies, combined with other experimental approaches, have begun to provide important insights into the mechanism of the destruction complex. We suggest a working model for the destruction complex based on the existing structural and experimental data, and focus on the questions that this model and other studies have raised about the function of the complex in both the normal and Wnt-inhibited states.

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Self-citation
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Chronic myeloid leukemia stem cells and developing therapies
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“GSK3b-mediated phosphorylation of b-catenin increases its ubiquitination and proteasomal turnover, thereby reducing expression of bcatenin regulated genes controlling cell cycle and survival [111].”
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“Then, nuclear β-catenin binds to the transcription factors of the T cell factor/lymphocyte enhancer factor (TCF/LEF) family (Kimelman and Xu, 2006; Ring et al., 2014) and promotes the transcription of Wnt/β-catenin pathway target genes, including cMYC, cyclin D1, survivin, bcl-2, Rac1, Rho, and…”
Background
Wnt7b Inhibits Osteoclastogenesis via AKT Activation and Glucose Metabolic Rewiring
Wu, F., Li, B., Hu, X., Yu, F., Shi, Y., & Ye, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.771336 · Cited by 8
Multivalent Interaction of Beta-Catenin With its Intrinsically Disordered Binding Partner Adenomatous Polyposis Coli
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“The BDC comprises five different proteins: two structural proteins, APC and axin, three kinases [glycogen synthase kinase 3β (GSK3β) and casein kinase 1α and casein kinase 1ε (CK1α, CK1ε)], and protein phosphatase 2A (PP2A).”
BackgroundInfluential
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90K Glycoprotein Promotes Degradation of Mutant β-Catenin Lacking the ISGylation or Phosphorylation Sites in the N-terminus
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unc-37/ Groucho and lsy-22/ AES repress Wnt target genes in C. elegans asymmetric cell divisionsPreprint
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Long non-coding RNA AC122108.1 promotes lung adenocarcinoma brain metastasis and progression through the Wnt/β-catenin pathway by directly binding to aldolase A
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Dalbinol, a rotenoid fromAmorpha fruticosa L., exerts anti-proliferative activity by facilitating β-catenin degradation in hepatocellular carcinoma cells
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Protein Phosphatase Signaling in Cardiac Myocytes
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Cooperation of FGF/MEK/ERK and Wnt/β-catenin pathway regulators to promote the proliferation and pluripotency of mouse embryonic stem cells in serum- and feeder-free conditions
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“2006; Kimelman 2006; MacDonald and He 2009).”
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microRNA-133b represses the progression of lung cancer through inhibiting SOX9/β-catenin signaling pathway.
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To β or Not to β: Lack of Correlation Between APC Mutation and β-Catenin Nuclear Localization in Colorectal Cancer
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Background
Parallel and Sequential Pathways of Molecular Recognition of a Tandem-Repeat Protein and Its Intrinsically Disordered Binding Partner
Smith, B. M., Rowling, P. J. E., Dobson, C. M., & Itzhaki, L. S. (2021) · Biomolecules · doi:10.3390/biom11060827 · Cited by 6
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Background
Near-membrane ensemble elongation in the proline-rich LRP6 intracellular domain may explain the mysterious initiation of the Wnt signaling pathway
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Background
Human‐Centric, Three Dimensional Micro Light‐Emitting Diodes for Cosmetic and Medical Phototherapy
Nam, K. Y., Kim, M. S., An, J., Min, S., Lee, J. H., Park, J. S., Huh, C., Yun, S. H., & Lee, K. J. (2025) · Advanced Science · doi:10.1002/advs.202416716 · Cited by 5
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“The core components of the destruction complex consist of Ade-nomatous Polyposis Coli (APC), axis inhibition protein 1 and 2 (AXIN1 and AXIN2) and the kinases glycogen synthase kinase 3 (GSK3) and casein kinase 1 α (CK1 α ) [2, 3].”
Wnt/β-catenin signaling regulates pathogenesis of human middle ear cholesteatoma.
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WNT3a Signaling Inhibits Aromatase Expression in Breast Adipose Fibroblasts—A Possible Mechanism Supporting the Loss of Estrogen Responsiveness of Triple-Negative Breast Cancers
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Background
NUAK1 acts as a novel regulator of PD-L1 via activating GSK-3β/β-catenin pathway in hepatocellular carcinoma
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A Selective GSK3β Inhibitor, Tideglusib, Decreases Intermittent Access and Binge Ethanol Self‐Administration in C57BL/6J Mice
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OptoLRP6 Illuminates Wnt Signaling in Early Embryo Development
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“9 When cells are stimulated by the Wnt ligand binding to Frz and LRP6, components of the destruction complex translocate to the membrane and are downregulated, thus stabilizing b -catenin.”
Background
Testis- specific Y-encoded- like protein 1 and cholesterol metabolism: Regulation of CYP1B1 expression through Wnt signaling
Zhu, X., Gao, H., Qin, S., Liu, D., Cairns, J., Gu, Y., Yu, J., Weinshilboum, R. M., & Wang, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1047318 · Cited by 5
“Specifically, β-catenin is a downstream target of Wnt signaling (Kimelman and Xu, 2006).”
Background
Comparative evaluation of curcumin and curcumin loaded- dendrosome nanoparticle effects on the viability of SW480 colon carcinoma and Huh7 hepatoma cells
Esmatabadi, M. J. D., Sarkandi, M., Zade, H. M., Khaledi, G., Montazeri, M., Shekarabi, H. S. Z., Hormoz, Y. A., & Asgari, E. A. (2015) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 5
Ruling Out a Suspect: the Role of β-Catenin Mutation in Benign Parathyroid Neoplasia
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Authors: Kimelman, D., & Xu, W.
Affiliations: University of Washington (US)
Corresponding author: Kimelman, D
ORCID: Kimelman, D
Xu, W
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2006-12-04
Volume: 25
Issue: 57
Pages: 7482-7491
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1210055
OpenAlex: W2072335762
Cited by: 628
References: 72
Citations by year: 2026: 8 · 2025: 21 · 2024: 23 · 2023: 27 · 2022: 41 · 2021: 52 · 2020: 19 · 2019: 25 · 2018: 37 · 2017: 40 · 2016: 28 · 2015: 36 · 2014: 51 · 2013: 33 · 2012: 40
FWCI: 1.99
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Cancer Institute (CA 90351, R01CA090351)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD027262, HD27262)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: β-catenin destruction complex, Wnt/β-catenin signaling, β-catenin phosphorylation, β-catenin ubiquitination, protein complex structure, Wnt signaling inhibition
MeSH terms: Animals, Cell Nucleus, Colonic Neoplasms, Cytosol, Humans, Models, Biological, Phosphorylation, Protein Conformation, Stem Cells, Ubiquitin, beta Catenin

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β-Catenin destruction complex: insights and questions from a structural perspective

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