Cited by 631Wnt/β-catenin signaling in development and cancerSignaling Pathways in DiseaseUbiquitin and proteasome pathways

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β-Catenin destruction complex: insights and questions from a structural perspective

Kimelman, D, Xu, W·2006·Oncogene

DOI 10.1038/sj.onc.1210055

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Abstract

At the heart of the canonical Wnt signaling pathway is the beta-catenin destruction complex, which functions in the absence of Wnt signaling to keep the cytosolic and nuclear levels of beta-catenin very low by promoting the phosphorylation and ubiquitination of beta-catenin. Structural studies, combined with other experimental approaches, have begun to provide important insights into the mechanism of the destruction complex. We suggest a working model for the destruction complex based on the existing structural and experimental data, and focus on the questions that this model and other studies have raised about the function of the complex in both the normal and Wnt-inhibited states.

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Authors: Kimelman, D., & Xu, W.
Affiliations: University of Washington (US)
Corresponding author: Kimelman, D
ORCID: Kimelman, D
Xu, W
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2006-12-04
Volume: 25
Issue: 57
Pages: 7482-7491
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1210055
OpenAlex: W2072335762
Cited by: 628
References: 72
Citations by year: 2026: 8 · 2025: 21 · 2024: 23 · 2023: 27 · 2022: 41 · 2021: 52 · 2020: 19 · 2019: 25 · 2018: 37 · 2017: 40 · 2016: 28 · 2015: 36 · 2014: 51 · 2013: 33 · 2012: 40
FWCI: 1.99
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Cancer Institute (CA 90351, R01CA090351)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD027262, HD27262)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Keywords: β-catenin destruction complex, Wnt/β-catenin signaling, β-catenin phosphorylation, β-catenin ubiquitination, protein complex structure, Wnt signaling inhibition
MeSH terms: Animals, Cell Nucleus, Colonic Neoplasms, Cytosol, Humans, Models, Biological, Phosphorylation, Protein Conformation, Stem Cells, Ubiquitin, beta Catenin

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β-Catenin destruction complex: insights and questions from a structural perspective

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