Hox genes in hematopoiesis and leukemogenesis

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

Golub, T. R., Slonim, D. K., Tamayo, P., Huard, C., Gaasenbeek, M., Mesirov, J. P., Coller, H., Loh, M. L., Downing, J. R., Caligiuri, M. A., et al. (1999) · Science · doi:10.1126/science.286.5439.531 · Cited by 11,516

Identification of human brain tumour initiating cells

Singh, S. K., Hawkins, C. E., Clarke, I. D., Squire, J. A., Bayani, J., Hide, T., Henkelman, R. M., Cusimano, M. D., & Dirks, P. B. (2004) · Nature · doi:10.1038/nature03128 · Cited by 7,564

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

Bonnet, D. A., & Dick, J. E. (1997) · Nature Medicine · doi:10.1038/nm0797-730 · Cited by 7,197

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

O'Brien, C. A., Pollett, A. F., Gallinger, S., & Dick, J. E. (2006) · Nature · doi:10.1038/nature05372 · Cited by 4,174

A role for Wnt signalling in self-renewal of haematopoietic stem cells

Reya, T., Duncan, A. W., Ailles, L., Domen, J., Scherer, D. C., Willert, K., Hintz, L., Nusse, R., & Weissman, I. L. (2003) · Nature · doi:10.1038/nature01593 · Cited by 2,159

Hox genes in vertebrate development

Krumlauf, R. K. (1994) · Cell · doi:10.1016/0092-8674(94)90290-9 · Cited by 2,079

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

Yeoh, A. E. J., Ross, M. E., Shurtleff, S. A., Williams, W. K., Patel, D. H., Mahfouz, R. A., Behm, F. G., Raimondi, S. C., Relling, M. V., Patel, A. R., et al. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00032-6 · Cited by 1,914

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.

Park, I.-K., Qian, D., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003) · Nature · doi:10.1038/nature01587 · Cited by 1,871

Isolation and In vitro Propagation of Tumorigenic Breast Cancer Cells with Stem/Progenitor Cell Properties

Ponti, D., Costa, A., Zaffaroni, N., Pratesi, G., Petrangolini, G., Coradini, D., Pilotti, S., Pierotti, M. A., & Daidone, M. G. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0626 · Cited by 1,725

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

Armstrong, S. A., Staunton, J. E., Silverman, L. B., Pieters, R., den Boer, M. L., Minden, M. D., Sallan, S. E., Lander, E. S., Golub, T. R., & Korsmeyer, S. J. (2001) · Nature Genetics · doi:10.1038/ng765 · Cited by 1,721

Interactions between lineage‐associated transcription factors govern haematopoietic progenitor states

Kuciński, I., Wilson, N. K., Hannah, R., Kinston, S., Cauchy, P., Lenaerts, A., Grosschedl, R., & Göttgens, B. (2020) · The EMBO Journal · doi:10.15252/embj.2020104983 · Cited by 29

HOXC9 directly regulates distinct sets of genes to coordinate diverse cellular processes during neuronal differentiation

Wang, X., Choi, J.-H., Ding, J., Yang, L., Ngoka, L. C. M., Lee, E. J., Zha, Y., Mao, L., Jin, B., Ren, M., et al. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-830 · Cited by 30

It’s All About MEis: Menin-MLL Inhibition Eradicates NPM1-Mutated and MLL-Rearranged Acute Leukemias in Mice

Gundry, M. C., Goodell, M. A., & Brunetti, L. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.02.011 · Cited by 30

Epigenetic Modifiers in Normal and Malignant Hematopoiesis

Haladyna, J. N., Yamauchi, T., Neff, T., & Bernt, K. M. (2015) · Epigenomics · doi:10.2217/epi.14.88 · Cited by 30

HOX genes in normal, engineered and malignant hematopoiesis

Collins, E. M., & Thompson, A. (2018) · The International Journal of Developmental Biology · doi:10.1387/ijdb.180206at · Cited by 30

MicroRNA-708 is a novel regulator of the Hoxa9 program in myeloid cells

Schneider, E. M., Pochert, N., Rueß, C., MacPhee, L., Escano, L., Miller, C. V., Krowiorz, K., Malmberg, E. D., Heravi‐Moussavi, A., Lorzadeh, A., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0651-1 · Cited by 29

Glimpse into Hox and tale regulation of cell differentiation and reprogramming

Cerdá‐Esteban, N., & Spagnoli, F. M. (2013) · Developmental Dynamics · doi:10.1002/dvdy.24075 · Cited by 29

A role for BMP-induced homeobox geneMIXL1in acute myelogenous leukemia and identification of type I BMP receptor as a potential target for therapy

Raymond, A., Liu, B., Hong, L., Wei, C., Guindani, M., Lu, Y., Liang, S., John, L. S. S., Molldrem, J., & Nagarajan, L. (2014) · Oncotarget · doi:10.18632/oncotarget.2564 · Cited by 31

Geminin deletion from hematopoietic cells causes anemia and thrombocytosis in mice

Shinnick, K. M., Eklund, E. A., & McGarry, T. J. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43556 · Cited by 28

Zebrafish hoxd4a Acts Upstream of meis1.1 to Direct Vasculogenesis, Angiogenesis and Hematopoiesis

Amali, A. A., Sie, L., Winkler, C., & Featherstone, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058857 · Cited by 28

Elongation Factor ELL (Eleven-Nineteen Lysine-rich Leukemia) Acts as a Transcription Factor for Direct Thrombospondin-1 Regulation

Zhou, J., Feng, X., Ban, B., Liu, J., Wang, Z., & Xiao, W. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.010439 · Cited by 28

Breaking the Dimensionality Barrier

Bagwell, C. B. (2010) · Methods in molecular biology · doi:10.1007/978-1-61737-950-5_2 · Cited by 27

Pbx1 restrains myeloid maturation while preserving lymphoid potential in hematopoietic progenitors

Ficara, F., Crisafulli, L., Lin, C., Iwasaki, M., Smith, K. S., Zammataro, L., & Cleary, M. (2013) · Journal of Cell Science · doi:10.1242/jcs.125435 · Cited by 33

Hoxa6 potentiates short-term hemopoietic cell proliferation and extended self-renewal

Dickson, G. J., Kwasniewska, A., Mills, K., Lappin, T. R. J., & Thompson, A. (2009) · Experimental Hematology · doi:10.1016/j.exphem.2008.10.015 · Cited by 28

Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells

Dassé, E., Volpe, G., Walton, D. S., Wilson, N. K., Pozzo, W. D., O’Neill, L. P., Slany, R. K., Frampton, J., & Dumon, S. (2012) · Blood Cancer Journal · doi:10.1038/bcj.2012.20 · Cited by 27

Reprogramming of HeLa cells upon DNMT3L overexpression mimics carcinogenesis

Gopinathan, G., Ramakrishna, G., & Khosla, S. (2009) · Epigenetics · doi:10.4161/epi.4.5.9239 · Cited by 27

The Corepressor Rcor1 Is Essential for Normal Myeloerythroid Lineage Differentiation

Yao, H., Goldman, D. C., Fan, G., Mandel, G., & Fleming, W. (2015) · Stem Cells · doi:10.1002/stem.2086 · Cited by 24

Novel Insights into the Genetic Controls of Primitive and Definitive Hematopoiesis from Zebrafish Models

Sood, R. B., & Liu, P. (2012) · Advances in Hematology · doi:10.1155/2012/830703 · Cited by 26

The HOX–Apoptosis Regulatory Interplay in Development and Disease

Domsch, K., Papagiannouli, F., & Lohmann, I. (2015) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2015.07.014 · Cited by 26

The Hox transcription factor Ubx stabilizes lineage commitment by suppressing cellular plasticity in Drosophila

Domsch, K., Carnesecchi, J., Disela, V., Friedrich, J., Trost, N., Ermakova, O. V., Polychronidou, M., & Lohmann, I. (2019) · eLife · doi:10.7554/elife.42675 · Cited by 27

Paediatric Strategy Forum for medicinal product development of epigenetic modifiers for children

Pearson, A. D. J., Stegmaier, K., Bourdeaut, F., Reaman, G. H., Heenen, D. L., Meyers, M. L., Armstrong, S. A., Brown, P. A., Carvalho, D. D. D., Jabado, N., et al. (2020) · European Journal of Cancer · doi:10.1016/j.ejca.2020.08.014 · Cited by 26

HOXA4 Induces Expansion of Hematopoietic Stem Cells In Vitro and Confers Enhancement of Pro-B-Cells In Vivo

Fournier, M., Lebert‐Ghali, C., Krosl, G., & Bijl, J. J. (2011) · Stem Cells and Development · doi:10.1089/scd.2011.0259 · Cited by 26

Clinical and laboratory studies of 17 patients with acute myeloid leukemia harboring t(7;11)(p15;p15) translocation

Wei, S., Wang, S., Qiu, S., Qi, J., Mi, Y., Lin, D., Zhou, C., Liu, B., Li, W., Wang, Y., et al. (2013) · Leukemia Research · doi:10.1016/j.leukres.2013.05.020 · Cited by 26

Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes

Konrad, T. A., Karger, A., Hackl, H., Schwarzinger, I., Herbacek, I., & Wieser, R. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0109042 · Cited by 25

The posteriorHOXDlocus: Its contribution to phenotype and malignancy of Ewing sarcoma

von Heyking, K., Roth, L., Ertl, M., Schmidt, O., Calzada‐Wack, J., Neff, F., Lawlor, E. R., Burdach, S. E. G., & Richter, G. H. S. (2016) · Oncotarget · doi:10.18632/oncotarget.9702 · Cited by 25

Transcriptional memory of cells of origin overrides β‐catenin requirement of MLL cancer stem cells

Siriboonpiputtana, T., Zeisig, B. B., Zarowiecki, M., Fung, T. K., Mallardo, M., Tsai, C., Lau, P. N. I., Hoang, Q. C., Veiga, P., Barnes, J. L., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201797994 · Cited by 25

The Ins and Outs of Autophagy and Metabolism in Hematopoietic and Leukemic Stem Cells: Food for Thought

Ianniciello, A., Rattigan, K. M., & Helgason, G. V. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00120 · Cited by 25

Deciphering The Potential Role of Hox Genes in Pancreatic Cancer

Kuo, T., Cheng, K., Chen, L., & Hung, W. (2019) · Cancers · doi:10.3390/cancers11050734 · Cited by 25

Genomic profiling of pediatric ALK‐positive anaplastic large cell lymphoma: A Children's Cancer and Leukaemia Group Study

Youssif, C., Goldenbogen, J., Hamoudi, R., Carreras, J., Viskaduraki, M., Cui, Y., Bacon, C. M., Burke, G. A. A., & Turner, S. D. (2009) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20701 · Cited by 25

Identification of leukemia stem cells in acute myeloid leukemia and their clinical relevance

Hoang, V. T., Zepeda-Moreno, A., & Ho, A. D. (2012) · Biotechnology Journal · doi:10.1002/biot.201100350 · Cited by 20

Oddballs: Acute Leukemias of Mixed Phenotype and Ambiguous Origin

Steensma, D. P. (2011) · Hematology/Oncology Clinics of North America · doi:10.1016/j.hoc.2011.09.014 · Cited by 25

Structure-based design of ester compounds to inhibit MLL complex catalytic activity by targeting mixed lineage leukemia 1 (MLL1)–WDR5 interaction

Li, D., Wang, Z., Chen, W., Xie, Y.-Y., You, Q., & Guo, X. (2016) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2016.09.073 · Cited by 24

Hematopoietic Differentiation of Human Pluripotent Stem Cells: HOX and GATA Transcription Factors as Master Regulators

Alsayegh, K. N., Cortés-Medina, L. V., Ramos‐Mandujano, G., Badraiq, H., & Li, M. (2019) · Current Genomics · doi:10.2174/1389202920666191017163837 · Cited by 27

Zebrafish brd2a and brd2bare paralogous members of the bromodomain-ET (BET) family of transcriptional coregulators that show structural and expression divergence

DiBenedetto, A. J., Guinto, J. B., Ebert, T., Bee, K. J., Schmidt, M. M., & Jackman, T. R. (2008) · BMC Developmental Biology · doi:10.1186/1471-213x-8-39 · Cited by 24

Higher-order orchestration of hematopoiesis: Is cohesin a new player?

Panigrahi, A. K., & Pati, D. (2012) · Experimental Hematology · doi:10.1016/j.exphem.2012.09.010 · Cited by 24

Insulin-like growth factor 1 is a direct HOXA9 target important for hematopoietic transformation

Steger, J., Füller, E., García-Cuéllar, M.-P., Hetzner, K., & Slany, R. K. (2014) · Leukemia · doi:10.1038/leu.2014.287 · Cited by 23

ZNF521 sustains the differentiation block in MLL-rearranged acute myeloid leukemia

Germanò, G., Morello, G., Aveic, S., Pinazza, M., Minuzzo, S. A., Frasson, C., Persano, L., Bonvini, P., Viola, G., Bresolin, S., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.15387 · Cited by 21

Acute myeloid leukemia with NUP98–HOXC13 fusion and FLT3 internal tandem duplication mutation: case report and literature review

Tos̆ić, N., Stojiljković, M., Čolović, N., Čolović, M., & Pavlović, S. (2009) · Cancer Genetics and Cytogenetics · doi:10.1016/j.cancergencyto.2009.03.007 · Cited by 23

Leukemogenic properties of NUP98-PMX1 are linked to NUP98 and homeodomain sequence functions but not to binding properties of PMX1 to serum response factor

Hirose, K., Abramovich, C., Argiropoulos, B., & Humphries, R. K. (2008) · Oncogene · doi:10.1038/onc.2008.210 · Cited by 23

Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression

Liu, Y., Li, Q., Song, L., Gong, C., Tang, S., Budinich, K. A., Vanderbeck, A., Mathias, K. M., Wertheim, G. B. W., Nguyen, S. C., et al. (2024) · Cancer Discovery · doi:10.1158/2159-8290.cd-23-0876 · Cited by 23

HOXC9 overexpression is associated with gastric cancer progression and a prognostic marker for poor survival in gastric cancer patients

Zhao, X.-F., Yang, Y.-S., & Park, Y. K. (2020) · International Journal of Clinical Oncology · doi:10.1007/s10147-020-01772-0 · Cited by 22

Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo

Yu, H., Neale, G. A. M., Zhang, H., Lee, H. M., Ma, Z., Zhou, S., Forget, B. G., & Sorrentino, B. P. (2014) · Blood · doi:10.1182/blood-2013-10-534735 · Cited by 22

The homeodomain region controls the phenotype of HOX-induced murine leukemia

Breitinger, C., Maethner, E., García-Cuéllar, M.-P., & Slany, R. K. (2012) · Blood · doi:10.1182/blood-2011-10-384685 · Cited by 22

Genome‐wide methylation analysis in vestibular schwannomas shows putative mechanisms of gene expression modulation and global hypomethylation at the HOX gene cluster

Torres‐Martín, M., Lassaletta, L., de Campos, J. M., Isla, A., Pinto, G. R., Burbano, R. M. R., Meléndez, B., Castresana, J. S., & REY, J. A. (2014) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22232 · Cited by 23

Role of the HOXA cluster in HSC emergence and blood cancer

Abuhantash, M. A., Collins, E. M., & Thompson, A. (2021) · Biochemical Society Transactions · doi:10.1042/bst20210234 · Cited by 21

Transcription factor abnormalities in B-ALL leukemogenesis and treatment

Yin, H., Wang, J., Tan, Y., Jiang, M., Zhang, H., & Meng, G. (2023) · Trends in cancer · doi:10.1016/j.trecan.2023.06.004 · Cited by 23

Oncogenic deregulation of NKL homeobox geneMSX1in mantle cell lymphoma

Nagel, S., Ehrentraut, S., Meyer, C., Kaufmann, M., Drexler, H. G., & MacLeod, R. A. F. (2013) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2013.864762 · Cited by 21

Identification of novel target genes of nerve growth factor (NGF) in human mastocytoma cell line (HMC-1 (V560G c-Kit)) by transcriptome analysis

Dutta, P., Koch, A., Breyer, B., Schneider, H., Dittrich‐Breiholz, O., Kracht, M., & Tamura, T. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-196 · Cited by 21

Loss of quiescence and self-renewal capacity of hematopoietic stem cell in an in vitro leukemic niche

Vanegas, N.-D. P., & Vernot, J. (2017) · Experimental Hematology and Oncology · doi:10.1186/s40164-016-0062-1 · Cited by 23

The Generic Facet of Hox Protein Function

Saurin, A. J., Delfini, M.-C., Maurel-Zaffran, C., & Graba, Y. (2018) · Trends in Genetics · doi:10.1016/j.tig.2018.08.006 · Cited by 21

Hyperexpression of HOXC13, located in the 12q13 chromosomal region, in well-differentiated and dedifferentiated human liposarcomas

Cantile, M., Galletta, F., Franco, R., Aquino, G., Scognamiglio, G., Marra, L., Cerrone, M., Malzone, G., MANNA, A., Apice, G., et al. (2013) · Oncology Reports · doi:10.3892/or.2013.2760 · Cited by 21

Promoter methylation and expression levels of selected hematopoietic genes in pediatric B-cell acute lymphoblastic leukemia

Musialik‐Świetlińska, E., Bujko, M., Kober, P., Wypych, A., Gawle‐Krawczyk, K., Matysiak, M. J., & SIEDLECKI, J. A. (2015) · Blood Research · doi:10.5045/br.2015.50.1.26 · Cited by 20

Characterization of the Six1 homeobox gene in normal mammary gland morphogenesis

Coletta, R. D., McCoy, E. L., Burns, V., Kawakami, K., McManaman, J. L., Wysolmerski, J. J., & Ford, H. L. (2010) · BMC Developmental Biology · doi:10.1186/1471-213x-10-4 · Cited by 20

Genetic expression profiles of adult and pediatric ependymomas: Molecular pathways, prognostic indicators, and therapeutic targets

Nagasawa, D. T., Trang, A., Choy, W., Spasic, M., Yew, A. Y., Zarinkhou, G., Garcia, H. M., & Yang, I. (2013) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2012.12.006 · Cited by 20

POU1F1 is a novel fusion partner of NUP98 in acute myeloid leukemia with t(3;11)(p11;p15)

Lisboa, S., Cerveira, N., Bizarro, S., Correia, C., Vieira, J., Torres, L., Mariz, J., & Teixeira, M. R. (2013) · Molecular Cancer · doi:10.1186/1476-4598-12-5 · Cited by 20

Transcriptome Profiling of Pediatric Core Binding Factor AML

Hsu, C.-H., Nguyen, C. D., Yan, C., Ries, R. E., Chen, Q.-R., Hu, Y., Ostronoff, F., Stirewalt, D. L., Komatsoulis, G. A., Levy, S., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138782 · Cited by 20

Prognostic significance of HOXB4 inde novoacute myeloid leukemia

Umeda, S., Yamamoto, K., Murayama, T., Hidaka, M., Kurata, M., Ohshima, T., Suzuki, S., Sugawara, E., Kawano, F., & Kitagawa, M. (2012) · Hematology · doi:10.1179/102453312x13376952196250 · Cited by 20

Early T Cell Differentiation

Tremblay, C. S., Hoàng, T., & Hoang, T. (2010) · Progress in molecular biology and translational science · doi:10.1016/s1877-1173(10)92006-1 · Cited by 20

Rare cytogenetic abnormalities and alteration of microRNAs in acute myeloid leukemia and response to therapy

Shahjahani, M., Khodadi, E., Seghatoleslami, M., Asl, J. M., Golchin, N., Zaieri, Z. D., & Saki, N. (2015) · Oncology Reviews · doi:10.4081/oncol.2015.261 · Cited by 19

Therapeutic targeting of leukemia stem cells in acute myeloid leukemia

Barbosa, K., & Deshpande, A. J. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1204895 · Cited by 20

Zebrafish mll Gene Is Essential for Hematopoiesis

Wan, X., Hu, B., Liu, J., Feng, X., & Xiao, W. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.253252 · Cited by 19

Promoter DNA methylation and expression levels of HOXA4, HOXA5 and MEIS1 in acute myeloid leukemia

Musialik‐Świetlińska, E., Bujko, M., Kober, P., Grygorowicz, M. A., Libura, M. A., Przestrzelska, M., Juszczyński, P., Borg, K., Florek, I., Jakóbczyk, M., et al. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3196 · Cited by 19

Ex vivo expansion of normal and chronic myeloid leukemic stem cells without functional alteration using a NUP98HOXA10homeodomain fusion gene

Sloma, I., Imren, S., Beer, P. A., Zhao, Y., Lecault, V., Leung, D., Raghuram, K., Brimacombe, C. A., Lambie, K., Piret, J. M., et al. (2012) · Leukemia · doi:10.1038/leu.2012.196 · Cited by 19

Transcriptional control of leukemogenesis by the chromatin reader SGF29

Barbosa, K., Deshpande, A. J., Perales, M., Xiang, P., Murad, R., Pramod, A. B., Minkina, A., Robertson, N., Schischlik, F., Lei, X., et al. (2023) · Blood · doi:10.1182/blood.2023021234 · Cited by 20

Revumenib for patients with acute leukemia: a new tool for differentiation therapy

Salman, M. Y., & Stein, E. M. (2024) · Haematologica · doi:10.3324/haematol.2022.282621 · Cited by 18

The significance of spliceosome mutations in chronic lymphocytic leukemia

Rozovski, U., Keating, M. J., & Estrov, Z. E. (2012) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2012.742528 · Cited by 20

The Homeodomain Transcription Factor Hoxa2 Interacts with and Promotes the Proteasomal Degradation of the E3 Ubiquitin Protein Ligase RCHY1

Bergiers, I., Bridoux, L., Nguyen, N., Twizere, J., & Rezsöhazy, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0080387 · Cited by 20

Control of DNA replication: A new facet of Hox proteins?

Miotto, B., & Graba, Y. (2010) · BioEssays · doi:10.1002/bies.201000048 · Cited by 18

Normal and Pathological V(D)J Recombination: Contribution to the Understanding of Human Lymphoid Malignancies

Dadi, S., Noir, S. L., Asnafi, V., Beldjord, K., & Macintyre, E. A. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-0296-2_15 · Cited by 18

Disturbing the histone code in leukemia: translocations and mutations affecting histone methyl transferases

Chopra, M., & Bohlander, S. K. (2014) · Cancer Genetics · doi:10.1016/j.cancergen.2014.10.005 · Cited by 18

De Novo Generation of Human Hematopoietic Stem Cells from Pluripotent Stem Cells for Cellular Therapy

Ding, J., Li, Y., & Larochelle, A. (2023) · Cells · doi:10.3390/cells12020321 · Cited by 17

Mechanism of Action of HOXB4 on the Hematopoietic Differentiation of Embryonic Stem Cells

Forrester, L. M., & Jackson, M. (2012) · Stem Cells · doi:10.1002/stem.1036 · Cited by 17

Acute lymphoblastic leukaemia

Andersson, A., Moorman, A. V., Harrison, C. J., & Mullighan, C. G. (2016) · Wiley eBooks · doi:10.1002/9781118527948.ch5 · Cited by 20

Aberrant expression of homeobox gene SIX1 in Hodgkin lymphoma

Nagel, S., Meyer, C., Kaufmann, M., Drexler, H. G., & MacLeod, R. A. F. (2015) · Oncotarget · doi:10.18632/oncotarget.5556 · Cited by 16

Epigenetically induced ectopic expression of UNCX impairs the proliferation and differentiation of myeloid cells

Daniele, G., Simonetti, G., Fusilli, C., Iacobucci, I., Lonoce, A., Palazzo, A. J., Lomiento, M., Mammoli, F., Marsano, R. M., Marasco, E., et al. (2017) · Haematologica · doi:10.3324/haematol.2016.163022 · Cited by 16

Differential responses of lineages-committed hematopoietic progenitors and altered expression of self-renewal and differentiation-related genes in 1,4-benzoquinone (1,4-BQ) exposure

Chow, P. W., Rajab, N. F., Chua, K. H., Chan, K. M., & Hamid, Z. A. (2017) · Toxicology in Vitro · doi:10.1016/j.tiv.2017.10.001 · Cited by 16

Brd4 regulates the expression of essential autophagy genes and Keap1 in AML cells

Huang, M., Zhu, L., Garcia, J. S., Li, M. X., Gentles, A. J., & Mitchell, B. S. (2018) · Oncotarget · doi:10.18632/oncotarget.24432 · Cited by 16

The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells

Liu, T., Kong, W.-X., Tang, X.-Y., Xu, M., Wang, Q.-H., Zhang, B., Hu, L., & Chen, H. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0721-8 · Cited by 17

Drosophila Hox genes induce melanized pseudo-tumors when misexpressed in hemocytes

Ponrathnam, T., Saini, R., Banu, S., & Mishra, R. K. (2021) · Scientific Reports · doi:10.1038/s41598-021-81472-5 · Cited by 15

Importance of Bcl-2-family proteins in murine hematopoietic progenitor and early B cells

Kurschat, C., Metz, A., Kirschnek, S., & Häcker, G. A. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04079-8 · Cited by 17

Fine‐tuning the stimulation of MLL1 methyltransferase activity by a histone H3‐based peptide mimetic

Avdic, V., Zhang, P., Lanouette, S., Voronova, A., Skerjanc, I. S., & Couture, J.-F. (2010) · The FASEB Journal · doi:10.1096/fj.10-171959 · Cited by 16

Expression level of Pre B cell leukemia homeobox 2 correlates with poor prognosis of gastric adenocarcinoma and esophageal squamous cell carcinoma

Morii (2010) · International Journal of Oncology · doi:10.3892/ijo_00000541 · Cited by 16

Dangerous liaisons: cooperation between Pbx3, Meis1 and Hoxa9 in leukemia

Thorne, R., & Milne, T. A. (2015) · Haematologica · doi:10.3324/haematol.2015.129932 · Cited by 15

A Pilot Study Using a Multistaged Integrated Analysis of Gene Expression and Methylation to Evaluate Mechanisms for Evening Fatigue in Women Who Received Chemotherapy for Breast Cancer

Flowers, E., Flentje, A., Levine, J. D., Olshen, A. B., Hammer, M. J., Paul, S. M., Conley, Y. P., Miaskowski, C. A., & Kober, K. M. (2019) · Biological Research For Nursing · doi:10.1177/1099800418823286 · Cited by 17

Bladder cancer variants share aggressive features including a CA125+ cell state and targetable TM4SF1 expression

Yang, H., Song, H., Yip, E., Gilpatrick, T., Chang, K., Allegakoen, P., Lu, K. L., Hui, K. S. F., Pham, J. H., Kasap, C., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59888-8 · Cited by 15

LSD1 inhibition modulates transcription factor networks in myeloid malignancies

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KMT2A-rearranged acute lymphoblastic leukaemia

Kotecha, R. S., Pieters, R., & Stutterheim, J. (2024) · EJC Paediatric Oncology · doi:10.1016/j.ejcped.2024.100204 · Cited by 15

A Multiplex CRISPR-Screen Identifies PLA2G4A as Prognostic Marker and Druggable Target for HOXA9 and MEIS1 Dependent AML

Hassan, J. J., Lieske, A., Dörpmund, N., Klatt, D., Hoffmann, D., Kleppa, M., Kustikova, O. S., Stahlhut, M., Schwarzer, A., Schambach, A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179411 · Cited by 15

Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease

Fraschilla, I. R., Amatullah, H., Rahman, R., & Jeffrey, K. L. (2022) · Cell Host & Microbe · doi:10.1016/j.chom.2022.08.018 · Cited by 18

Isolation, Maintenance and Expansion of Adult Hematopoietic Stem/Progenitor Cells and Leukemic Stem Cells

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Differential Hox Expression in Murine Embryonic Stem Cell Models of Normal and Malignant Hematopoiesis

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Hox Genes

Deutsch, J. S. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6673-5 · Cited by 15

A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention

Sampietro, M. L., Trompet, S., Verschuren, J. J. W., Talens, R. P., Deelen, J., Heijmans, B. T., de Winter, R. J., Tio, R. A., Doevendans, P. A., Ganesh, S. K., et al. (2011) · Human Molecular Genetics · doi:10.1093/hmg/ddr389 · Cited by 14

Deregulated HOX genes in ameloblastomas are located in physical contiguity to keratin genes

Schiavo, G., D’Antò, V., Cantile, M., Procino, A., Giovanni, S. D., Valletta, R., Terracciano, L., Baumhoer, D., Jundt, G., & Cillo, C. (2011) · Journal of Cellular Biochemistry · doi:10.1002/jcb.23248 · Cited by 14

Meningioma 1 is indispensable for mixed lineage leukemia-rearranged acute myeloid leukemia

Sharma, A., Jyotsana, N., Gabdoulline, R. R., Heckl, D., Kuchenbauer, F. C., Slany, R. K., Ganser, A., & Heuser, M. (2019) · Haematologica · doi:10.3324/haematol.2018.211201 · Cited by 14

The fusion partner specifies the oncogenic potential of NUP98 fusion proteins

Saw, J., Curtis, D. J., Hussey, D. J., Dobrovic, A., Aplan, P. D., & Slape, C. I. (2013) · Leukemia Research · doi:10.1016/j.leukres.2013.09.013 · Cited by 14

The C. elegans SoxC protein SEM-2 opposes differentiation factors to promote a proliferative blast cell fate in the postembryonic mesoderm

Tian, C., Shi, H., Colledge, C. J., Stern, M., Waterston, R., & Liu, J. (2011) · Development · doi:10.1242/dev.062240 · Cited by 14

Isolated Hoxa9 overexpression predisposes to the development of lymphoid but not myeloid leukemia

Beachy, S., Onozawa, M., Silverman, D. A., Chung, Y., Rivera, M., & Aplan, P. (2013) · Experimental Hematology · doi:10.1016/j.exphem.2013.02.006 · Cited by 13

Association of TGIFLX/Y mRNA expression with prostate cancer

Ashtiani, Z. O., Ayati, M., Modarresi, M. H., Raoofian, R., Goulian, B. S., Greene, W. K., & Heidari, M. (2008) · Medical Oncology · doi:10.1007/s12032-008-9086-7 · Cited by 14

Mechanisms of mixed-lineage leukemia

Muntean, A. G. (2013) · International Journal of Hematologic Oncology · doi:10.2217/ijh.13.20 · Cited by 14

Hox regulation of normal and leukemic hematopoietic stem cells

Abramovich, C., & Humphries, R. K. (2005) · Current Opinion in Hematology · doi:10.1097/01.moh.0000160737.52349.aa · Cited by 164

Hox Genes: From Leukemia to Hematopoietic Stem Cell Expansion

Abramovich, C., Pineault, N., OHTA, H., & Humphries, R. K. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1349.014 · Cited by 81

The Role of HOX Homeobox Genes in Normal and Leukemic Hematopoiesis

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HOXandNon‐HOXHomeobox Genes in Leukemic Hematopoiesis

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Leukemogenic Transformation by Anterior HOXA-Cluster Genes.

Buhl, S., Maethner, E., & Slany, R. K. (2009) · Blood · doi:10.1182/blood.v114.22.2962.2962