Cited by 498Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia ResearchAcute Lymphoblastic Leukemia research

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Hox genes in hematopoiesis and leukemogenesis

Argiropoulos, B, Humphries, R K·2007·Oncogene

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Abstract

Gene expression analyses, gene targeting experiments and retroviral overexpression studies in the murine bone marrow transplantation model have provided strong correlative evidence for the involvement of clustered Hox genes in normal hematopoiesis. The data strongly support the hypothesis that the role of Hox genes in normal hematopoiesis is primarily at the level of hematopoietic stem cell function. A large body of evidence now links Hox genes to leukemic transformation including dysregulated HOX expression in leukemic patient samples, their involvement as oncogenic fusion proteins with NUP98 and their requirement for the oncogenicity of Mll fusions. In recent years, much attention has been devoted to the identification and characterization of leukemic stem cells. Given the documented role of Hox genes in hematopoiesis and leukemogenesis, we propose that Hox-dependent pathways are closely linked to the self-renewal program crucial to the origin and function of leukemic stem cells.

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Authors: Argiropoulos, B., & Humphries, R. K.
Affiliations: BC Cancer Agency (CA)
Corresponding author: Humphries, R K
ORCID: Argiropoulos, B
Humphries, R K
Venue: Oncogene
Publisher: Springer Science and Business Media LLC
Published: 2007-10-15
Volume: 26
Issue: 47
Pages: 6766-6776
ISSN: 0950-9232 (ISSN-L)
1476-5594
DOI: 10.1038/sj.onc.1210760
OpenAlex: W1976021347
Cited by: 492
References: 143
Citations by year: 2026: 8 · 2025: 11 · 2024: 18 · 2023: 16 · 2022: 18 · 2021: 18 · 2020: 11 · 2019: 22 · 2018: 20 · 2017: 28 · 2016: 28 · 2015: 27 · 2014: 38 · 2013: 43 · 2012: 38
FWCI: 4.80
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Oncogene (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Health Sciences › Medicine › Hematology › Acute Myeloid Leukemia Research
Health Sciences › Medicine › Hematology › Acute Lymphoblastic Leukemia research
Keywords: Hox genes, hematopoiesis, leukemogenesis, hematopoietic stem cells, leukemia stem cells, MLL fusion, self-renewal, bone marrow transplantation, fusion oncogenes
MeSH terms: Animals, Genes, Homeobox, Hematopoiesis, Humans, Leukemia, Homeodomain Proteins

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Hox genes in hematopoiesis and leukemogenesis

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