Hox genes in hematopoiesis and leukemogenesis

Molecular classification of cancer: class discovery and class prediction by gene expression monitoring

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Identification of human brain tumour initiating cells

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Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

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A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

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A role for Wnt signalling in self-renewal of haematopoietic stem cells

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Hox genes in vertebrate development

Krumlauf, R. K. (1994) · Cell · doi:10.1016/0092-8674(94)90290-9 · Cited by 2,079

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.

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Isolation and In vitro Propagation of Tumorigenic Breast Cancer Cells with Stem/Progenitor Cell Properties

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MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

Armstrong, S. A., Staunton, J. E., Silverman, L. B., Pieters, R., den Boer, M. L., Minden, M. D., Sallan, S. E., Lander, E. S., Golub, T. R., & Korsmeyer, S. J. (2001) · Nature Genetics · doi:10.1038/ng765 · Cited by 1,721

Hox transcription factor regulation of adult bone-marrow-derived cell behaviour during tissue repair and regeneration

Mahdipour, E., & Mace, K. A. (2011) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2011.579096 · Cited by 17

Lessons Learned: HIV Points the Way Towards Precision Treatment of Mixed-Lineage Leukemia

Čermáková, K., Weydert, C., Christ, F., Rijck, J. D., & Debyser, Z. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.05.005 · Cited by 14

Transcriptional regulation of the proto‐oncogene Zfp521 by SPI1 (PU.1) and HOXC13

Yu, M., Aldallal, S., Al‐Haj, L., Panjwani, S., McCartney, A. S., Edwards, S. M., Manjunath, P., Walker, C., Awgulewitsch, A., & Hentges, K. E. (2016) · genesis · doi:10.1002/dvg.22963 · Cited by 14

HOXB9 Expression Correlates with Histological Grade and Prognosis in LSCC

Sun, C., Han, C., Wang, P., Jin, Y., Sun, Y., & Qu, L. (2017) · BioMed Research International · doi:10.1155/2017/3680305 · Cited by 14

The miR-17∼92 cluster contributes to MLL leukemia through the repression of MEIS1 competitor PKNOX1

Mian, Y. A., & Zeleznik‐Le, N. J. (2016) · Leukemia Research · doi:10.1016/j.leukres.2016.04.006 · Cited by 13

High expression of miR-25 predicts favorable chemotherapy outcome in patients with acute myeloid leukemia

Niu, M., Yuan, F., Zhang, N., Shao, T., Zhang, H., Wang, R., Yao, Y., Yao, R., Wu, Q., Cao, J., et al. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0843-9 · Cited by 13

HOXC10 Suppresses Browning to Maintain White Adipocyte Identity

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Gene expression analysis reveals HOX gene upregulation in trisomy 8 AML

Kok, C. H., Brown, A. L., Ekert, P. G., & D’Andrea, R. J. (2010) · Leukemia · doi:10.1038/leu.2010.85 · Cited by 13

The role of aberrant transcription factor in the progression of chronic myeloid leukemia

Zhang, S. (2008) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428190802163305 · Cited by 13

Expression of a retinoic acid signature in circulating CD34 cells from coronary artery disease patients

Kraan, T. C. T. M. V. D. P., Schirmer, S. H., Fledderus, J. O., Moerland, P. D., Baggen, J. M. C., Leyen, T. A., van der Laan, A. M., Piek, J. J., van Royen, N., & Horrevoets, A. J. G. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-388 · Cited by 13

CCI-007, a novel small molecule with cytotoxic activity against infant leukemia with MLL rearrangements

Somers, K., Chudakova, D. A., Middlemiss, S., Wen, V. W., Clifton, M., Kwek, A., Liu, B., Mayoh, C., Bongers, A., Karsa, M., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.10022 · Cited by 13

Enforced expression of Hoxa5 in haematopoietic stem cells leads to aberrant erythropoiesis in vivo

Yang, D., Zhang, X., Dong, Y., Liu, X., Wang, T., Wang, X., Geng, Y., Fang, S., Zheng, Y., Chen, X., et al. (2015) · Cell Cycle · doi:10.4161/15384101.2014.992191 · Cited by 13

Single-Cell Multiomics Reveals Distinct Cell States at the Top of the Human Hematopoietic HierarchyPreprint

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c‐Met inhibition in a HOXA9/Meis1 model of CN‐AML

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Genetic and molecular distinctions in spinal ependymomas: A review

Connolly, I. D., Ali, R., Li, Y., & Gephart, M. H. (2015) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2015.10.011 · Cited by 11

Down-regulation of HOXA4, HOXA7, HOXA10, HOXA11 and MEIS1 during monocyte-macrophage differentiation in THP-1 cells.

Martino, V., Bianchera, A., Reia, L., Bussolati, O., Fazzina, R., Marino, F., Montemurro, L., Tonelli, R., Pession, A., Gazzola, G., et al. (2009) · Molecular Medicine Reports · doi:10.3892/mmr_00000090 · Cited by 12

A systematic survey of HOX and TALE expression profiling in human cancers

Jia, Y. Y., Bleicher, F., & Merabet, S. (2018) · The International Journal of Developmental Biology · doi:10.1387/ijdb.180286fb · Cited by 11

Mutations that collaborate with IL-7Ra signaling pathways to drive ALL

Rodrigues, G. O. L., Cramer, S. D., Winer, H. Y., Hixon, J. A., Li, W., Yunes, J. A., & Durum, S. K. (2021) · Advances in Biological Regulation · doi:10.1016/j.jbior.2021.100788 · Cited by 11

Hox B4 as potential marker of non-differentiated cells in human cervical cancer cells

de la Rosa, A. P. B., Briones-Cerecero, E., Lugo-Melchor, O. Y., León‐Rodríguez, A. D., Santos, L., Castelo-Ruelas, J., Valdivia, A., Piña‐Sánchez, P., Chagolla‐López, A., Hernández-Cueto, D., et al. (2011) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-011-1081-2 · Cited by 11

The Prognostic Relevance of BAALC and ERG Expression Levels in Cytogenetically Normal Pediatric Acute Myeloid Leukemia

Aref, S., Khodary, T. A., Abouzeid, T., Sadiek, A. E., Menshawy, N. E., & Ashery, R. A. (2014) · Indian Journal of Hematology and Blood Transfusion · doi:10.1007/s12288-014-0395-z · Cited by 10

Systematic characterization of the HOXA9 downstream targets in MLL-r leukemia by noncoding CRISPR screens

Wright, S., Zhao, X., Rosikiewicz, W., Mryncza, S., Hyle, J. W., Qi, W., Liu, Z., Yi, S., Cheng, Y., Xu, B., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43264-5 · Cited by 8

A case of congenital bone marrow failure with radio-ulnar synostosis

Yoshida, H., Hashii, Y., Okuda, T., Kusuki, S., Sato, E., Inoue, A., Kawakami, C., Yabe, M., Ohta, H., & Ozono, K. (2010) · International Journal of Hematology · doi:10.1007/s12185-010-0494-z · Cited by 10

Hox genes and animal regeneration

Novikova, E. L., Бакаленко, Н. И., Nesterenko, A. Y., & Kulakova, M. A. (2016) · Russian Journal of Developmental Biology · doi:10.1134/s106236041604007x · Cited by 10

The Development of Inhibitors Targeting the Mixed Lineage Leukemia 1 (MLL1)-WD Repeat Domain 5 Protein (WDR5) Protein- Protein Interaction

Ye, X., Chen, G., Jin, J., Zhang, B., Wang, Y., Cai, Z., & Ye, F. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867326666190528080514 · Cited by 10

Regulation of Hox Activity: Insights from Protein Motifs

Merabet, S., Sambrani, N., Pradel, J., & Graba, Y. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6673-5_1 · Cited by 10

Adult Stem and Progenitor Cells

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SET‐NUP214 and MLL cooperatively regulate the promoter activity of the HoxA10 gene

Çiğdem, S., Saito, S., Nishikata, D., Nagata, K., & Okuwaki, M. (2021) · Genes to Cells · doi:10.1111/gtc.12886 · Cited by 9

HOX genes regulate Rac1 activity in hematopoietic cells through control of Vav2 expression

Breitinger, C., Maethner, E., García-Cuéllar, M.-P., Schambony, A., Fischer, K., Schilling, K., & Slany, R. K. (2012) · Leukemia · doi:10.1038/leu.2012.166 · Cited by 9

Therapeutic targeting of WDR5-MLL1 by EMBOW-derived peptides suppresses leukemia progression

Zhang, M., Chen, M., Li, P., & Min, J. (2025) · Cell chemical biology · doi:10.1016/j.chembiol.2025.10.002 · Cited by 8

Bioinformatic Analyses of Broad H3K79me2 Domains in Different Leukemia Cell Line Data Sets

Sharma, P., Sattarifard, H., Fatemiyan, N., Lakowski, T. M., & Davie, J. (2022) · Cells · doi:10.3390/cells11182830 · Cited by 8

Single-Cell RNA Sequencing ofSox17-Expressing Lineages Reveals Distinct Gene Regulatory Networks and Dynamic Developmental Trajectories

Trinh, L. T., Osipovich, A. B., Liu, B., Shrestha, S., Cartailler, J., Wright, C. V. E., & Magnuson, M. A. (2023) · Stem Cells · doi:10.1093/stmcls/sxad030 · Cited by 11

HOXA9 Regulome and Pharmacological Interventions in Leukemia

Aryal, S., & Lu, R. (2024) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-62731-6_18 · Cited by 8

Hox‐driven conditional immortalization of myeloid and lymphoid progenitors: Uses, advantages, and future potential

Lail, S. S., Arnold, C. R., de Almeida, L. G. N., McKenna, N. T., Chiriboga, J. A., Dufour, A., Warren, A. L., & Yates, R. M. (2022) · Traffic · doi:10.1111/tra.12869 · Cited by 8

Enhanced expression of the EVI1 gene in NUP98/HOXA-expressing leukemia cells

Eguchi‐Ishimae, M., Eguchi, M., Ohyashiki, K., Yamagata, T., & Mitani, K. (2009) · International Journal of Hematology · doi:10.1007/s12185-009-0267-8 · Cited by 8

Low HOXC10 expression in liver cancer regulates proliferation via a mechanism involving miR‑221 and the MAPK signaling pathway

Ma, K., Zhao, C., Guo, K. Y., Fu, Z., Che, C., Dong, B., Pang, C., Zhang, S., Liu, W., Yang, Z., et al. (2020) · Oncology Letters · doi:10.3892/ol.2020.11988 · Cited by 7

HOXA13 serves as a biomarker to predict neoadjuvant therapy efficacy in advanced colorectal cancer patients

Liu, S., Zhang, R., Yang, Z., Wang, Y., Guo, X., Zhao, Y., Lin, H., Xiang, Y., Ding, C., Dong, Z., et al. (2022) · Acta Biochimica et Biophysica Sinica · doi:10.3724/abbs.2022182 · Cited by 7

Homeoprotein Hbx4 represses the expression of the adhesion molecule DdCAD-1 governing cytokinesis and development

Kim, J., Seo, J., Yim, H., & Kang, S. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.04.052 · Cited by 7

Regulation of hematopoiesis

Buckley, S., & Verfaillie, C. M. (2011) · Elsevier eBooks · doi:10.1016/b978-0-7020-3147-2.00004-3 · Cited by 7

Cytogenetics and Molecular Genetics

Harrison, C. J., Moorman, A. V., Schwab, C. J., Iacobucci, I., & Mullighan, C. G. (2017) · Springer eBooks · doi:10.1007/978-3-319-39708-5_4 · Cited by 7

The clinical significance of CDX2 in leukemia: A new perspective for leukemia research

Darvishi, M., Mashati, P., & Khosravi, A. (2018) · Leukemia Research · doi:10.1016/j.leukres.2018.07.021 · Cited by 7

Upregulation of HOXA13 as a potential tumorigenesis and progression promoter of LUSC based on qRT-PCR and bioinformatics.

Zhang, R., Deng, Y., Zhang, Y., Zhai, G., He, R., Hu, X., Wei, D., Feng, Z., & Chen, G. (2017) · PubMed Central · Cited by 7

There and Back Again: Hox Clusters Use Both DNA Strands

Novikova, E. L., & Kulakova, M. A. (2021) · Journal of Developmental Biology · doi:10.3390/jdb9030028 · Cited by 7

Human NUP98-IQCG fusion protein induces acute myelomonocytic leukemia in mice by dysregulating the Hox/Pbx3 pathway

Pan, M., Zhang, Q. Y., Wang, Y., Liu, P., Ren, R., Huang, J., Chen, L., Xi, X. D., Chen, Z., & Chen, S. J. (2015) · Leukemia · doi:10.1038/leu.2015.347 · Cited by 7

In Vivo Chemical Screening in Zebrafish Embryos Identified FDA-Approved Drugs That Induce Differentiation of Acute Myeloid Leukemia Cells

Wei, X., Wang, W., Yin, Q., Li, H., Ahmed, A., Ullah, R., Li, W., & Jing, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25147798 · Cited by 6

Genome-wide association study reveals the underlying regulatory mechanisms of red blood traits in Anadara granosa

He, X., Liao, Y., Yu, G., Wang, S., & Bao, Y. (2024) · BMC Genomics · doi:10.1186/s12864-024-10857-3 · Cited by 7

Statistical Test of Expression Pattern (STEPath): a new strategy to integrate gene expression data with genomic information in individual and meta-analysis studies

Martini, P. G. V., Risso, D., Sales, G., Romualdi, C., Lanfranchi, G., & Cagnin, S. (2011) · BMC Bioinformatics · doi:10.1186/1471-2105-12-92 · Cited by 6

The antagonistic duality of NPM1 mutations in AML

Khan, I., & Gartel, A. L. (2022) · Blood Advances · doi:10.1182/bloodadvances.2022007420 · Cited by 6

Characterization of Leukemia-Inducing Genes Using a Proto-Oncogene/Homeobox Gene Retroviral Human cDNA Library in a Mouse In Vivo Model

Jang, S. H., Lee, S., & Chung, H. Y. (2015) · PLoS ONE · doi:10.1371/journal.pone.0143240 · Cited by 6

NUP98-HOXA10hd-Expanded Hematopoietic Stem Cells Efficiently Reconstitute Bone Marrow of Mismatched Recipients and Induce Tolerance

Even, Y., Bennett, J. L., Sekulovic, S., So, L., Yi, L., McNagny, K. M., Humphries, R. K., & Rossi, F. M. V. (2010) · Cell Transplantation · doi:10.3727/096368910x545068 · Cited by 6

Could Targeting NPM1c+ Misfolding Be a Promising Strategy for Combating Acute Myeloid Leukemia?

Florio, D., & Marasco, D. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020811 · Cited by 5

Therapeutic targeting and HSC proliferation by small molecules and biologicals

Albayrak, E., & Kocabaş, F. (2023) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2022.11.012 · Cited by 5

Hematopoietic Stem Cells

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Npm1 haploinsufficiency in collaboration with MEIS1 is sufficient to induce AML in mice

Muranyi, A., Ammer, T., Kechter, A., Rawat, V. P. S., Sinha, A., González-Menéndez, I., Quintanilla‐Martínez, L., Azoitei, A., Güneş, Ç., Mupo, A., et al. (2022) · Blood Advances · doi:10.1182/bloodadvances.2022007015 · Cited by 6

Biomarkers of disease recurrence in stage I testicular germ cell tumours

Lesko, P., Chovanec, M., & Mego, M. (2022) · Nature Reviews Urology · doi:10.1038/s41585-022-00624-y · Cited by 5

MicroRNAs shaping cellular reprogramming

Chakraborty, S., & Ghosh, Z. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815669-8.00004-x · Cited by 5

Acute Myeloid Leukemia in an Infant with t(8;19)(p11.2;q13) Translocation: Case Report and a Review of the Literature

Eason, A. C., Bunting, S. T., Peterson, J. F., Saxe, D., & Sabnis, H. S. (2019) · Case Reports in Hematology · doi:10.1155/2019/4198415 · Cited by 5

Cell-type specificcis-regulatory networks

Polychronidou, M., & Lohmann, I. (2013) · Fly · doi:10.4161/fly.22939 · Cited by 5

Brief Report: Ectopic Expression of Nup98-HoxA10 Augments Erythroid Differentiation of Human Embryonic Stem Cells

Ji, J., Risueño, R. M., Hong, S., Allan, D., Rosten, P., Humphries, R. K., & Bhatia, M. (2011) · Stem Cells · doi:10.1002/stem.622 · Cited by 5

Differential expression of human homeodomain TGIFLX in brain tumor cell lines.

Raoofian, R., Noori–Daloii, M. R., Rad, S. S., Modarressi, M. H., Ghaffari, S. H., Mojarrad, M., Abolhasani, F., & Heidari, M. (2013) · PubMed · Cited by 5

Rituximab maintenance therapy in diffuse large B-cell lymphoma: is XY the most important variable?

Lunning, M. A., & Armitage, J. O. (2015) · Haematologica · doi:10.3324/haematol.2015.129924 · Cited by 5

HLX in AML: novel prognostic and therapeutic target

Pandolfi, A., & Steidl, U. G. (2012) · Oncotarget · doi:10.18632/oncotarget.705 · Cited by 6

NUPA10hd-immortalized and genetically engineered progenitors allow studying dendritic cell immune functions

Samson, G. P. B., Anslinger, N., Legler, D. F., & Finke, D. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1658429 · Cited by 4

Inability of HOXB4 to enhance self-renewal of malignant B cells: Favorable profile for the expansion of autologous hematopoietic stem cells

Fournier, M., Rondeau, I. S., Larochelle, F., Hassawi, M., Shestakova, E. A., Roy, D., & Bijl, J. J. (2014) · Experimental Hematology · doi:10.1016/j.exphem.2014.01.011 · Cited by 4

Antiaging in a Bottle: Bioactive Competency of Plasma-Generated Nitric Oxide Water for Modulation of Aging-Related Signature in Human Dermal Cells

Jaiswal, A., Kaushik, N., Acharya, T. R., Uhm, H. S., Choi, E. H., & Kaushik, N. K. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c14051 · Cited by 4

AF10 Plays a Key Role in the Survival of Uncommitted Hematopoietic Cells

Chamorro-García, R., Cervera, M., & Arredondo, J. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051626 · Cited by 4

Mutated NPM1 in combination with overexpression of Meis1 or Hoxa9 is not sufficient to induce acute myeloid leukemia

Wiktorin, H. G., Nilsson, T., Jansson, A., Palmqvist, L., & Martner, A. (2015) · Experimental Hematology and Oncology · doi:10.1186/s40164-016-0053-2 · Cited by 4

Gene Transcription as a Therapeutic Target in Leukemia

Khamidullina, A. I., Varlamova, E. A., Hammoud, N. A., Yastrebova, M. A., & Bruter, A. V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147340 · Cited by 4

HSC and miRNA Regulation with Implication for Foetal Haemoglobin Induction in Beta Haemoglobinopathies

Okeke, C., Silas, U., Nnodu, O., & Clementina, O. (2022) · Current Stem Cell Research & Therapy · doi:10.2174/1574888x17666220221104711 · Cited by 4

MicroRNA target homeobox messenger RNA in HIV induced hematopoietic inhibition

Koka, P. S., & Ramdass, B. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1382789 · Cited by 4

MiR-340 Is a Biomarker for Selecting Treatment Between Chemotherapy and Allogeneic Transplantation in Acute Myeloid Leukemia

Niu, M., Zhang, N., Wang, R., Shao, T., Yuan, F., Shen, Y., Liu, X., Zhao, K., Zhu, S., Xu, L., et al. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01058 · Cited by 4

A Novel Translocation InvolvingRUNX1andHOXAGene Clusters in a Case of Acute Myeloid Leukemia with t(7;21)(p15;q22)

Moon, Y., Horsman, D. E., Humphries, R. K., & Park, G. (2013) · Immune Network · doi:10.4110/in.2013.13.5.222 · Cited by 4

Modulating the malignancy of Hox proteins

Kyba, M. (2017) · Blood · doi:10.1182/blood-2016-11-751909 · Cited by 4

KMT 2 A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Brock, L., Benzien, L., Lange, S., Hühns, M., Runge, A., Roolf, C., Sekora, A., Knuebel, G., Escobar, H. M., Junghanß, C., et al. (2025) · Molecular Oncology · doi:10.1002/1878-0261.13792 · Cited by 3

NUP214 in Acute Myeloid Leukemia

Bruserud, Ø., & Reikvam, H. (2025) · Cells · doi:10.3390/cells14181461 · Cited by 3

Combining menin and MEK inhibition to target poor prognosis KMT2A -rearranged RAS pathway–mutant acute myeloid leukemia

Scheidegger, N. K., Schneider, C., Alexe, G., Wang, Y.-C., Alonzo, T. A., Basanthakumar, A. T., Bourgeois, W., Dudkiewicz-Garbicz, J., Khalid, D., Merickel, L. A., et al. (2026) · Blood Advances · doi:10.1182/bloodadvances.2025016208 · Cited by 4

Differential transcriptional control of hematopoiesis in congenital and cyclic neutropenia patients harboring ELANE mutations

Zeidler, A., Borbaran-Bravo, N., Dannenmann, B., Ritter, M. U., Nasri, M., Klimiankou, M., Kandabarau, S., Zahabi, A., König, J., Zeidler, C., et al. (2023) · Haematologica · doi:10.3324/haematol.2023.284033 · Cited by 3

Transcriptomics profiling reveal the heterogeneity of white and brown adipocyte

Zhang, Z., Xu, L., Zhang, L., Lu, J., Peng, Z., Guo, X., & Gao, J. (2023) · Journal of Bioenergetics and Biomembranes · doi:10.1007/s10863-023-09990-7 · Cited by 4

Unraveling MLL1-fusion leukemia: Epigenetic revelations from an iPS cell point mutation

Kobrossy, L., Xu, W., Zhang, C., Feng, W., Turner, C. E., & Cosgrove, M. S. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107825 · Cited by 3

HOXA1 Contributes to Bronchial Epithelial Cell Cycle Progression by Regulating p21/CDKN1A

McCluskey, E., Velli, S. K., Kaminski, R., Markward, T., Leming, H., Yu, D., & Sajjan, U. S. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052332 · Cited by 5

Coordinated regulation of self-renewal and cell cycle during human lympho-myeloid lineage restriction

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Principles of Hematopoietic Stem Cell Biology

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