The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease
Open accessAbstract
Although attempts have been made to reveal the relationships between bacteria and human health, little is known about the species and function of the microbial community associated with oral diseases. In this study, we report the sequencing of 16 metagenomic samples collected from dental swabs and plaques representing four periodontal states. Insights into the microbial community structure and the metabolic variation associated with periodontal health and disease were obtained. We observed a strong correlation between community structure and disease status, and described a core disease-associated community. A number of functional genes and metabolic pathways including bacterial chemotaxis and glycan biosynthesis were over-represented in the microbiomes of periodontal disease. A significant amount of novel species and genes were identified in the metagenomic assemblies. Our study enriches the understanding of the oral microbiome and sheds light on the contribution of microorganisms to the formation and succession of dental plaques and oral diseases.
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Cites
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Self-citationA framework for human microbiome research
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Cited by
Periodontitis: facts, fallacies and the future
Slots, J. (2017) · Periodontology 2000 · doi:10.1111/prd.12221 · Cited by 1,153
The oral microbiome and the immunobiology of periodontal disease and caries
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Pathogens and host immunity in the ancient human oral cavity
Warinner, C., Rodrigues, J. F. M., Vyas, R., Trachsel, C., Shved, N., Grossmann, J., Radini, A., Hancock, Y., Tito, R. Y., Fiddyment, S., et al. (2014) · Nature Genetics · doi:10.1038/ng.2906 · Cited by 618
Role of Oral Microbiome Signatures in Diagnosis and Prognosis of Oral Cancer
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“A number of useful genes and metabolic pathways such as bacterial chemotaxis, flagellar assembly, and toxin biosynthesis were found to be enriched in the microbiomes of periodontal disease.(46) Periodontitis-associated microorganisms induce inflammation and destruction of tissue through degradation of collagen and rel…”
BackgroundChen, H., & Jiang, W. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00508 · Cited by 317
Metadata
- Authors
- Wang, J., Qi, J., Zhao, H., He, S., Zhang, Y., Wei, S., & Zhao, F.
- Venue
- Scientific Reports
- Published
- 2013-05-15
- Volume
- 3
- Issue
- 1
- Pages
- 1843-1843
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2055921002
- Cited by
- 242
- References
- 9
- FWCI
- 25.10
- Type
- journal article
- Language
- en
- Open access
- gold
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