Application of high-throughput sequencing in understanding human oral microbiome related with health and disease
Open accessAbstract
The oral microbiome is one of most diversity habitat in the human body and they are closely related with oral health and disease. As the technique developing, high-throughput sequencing has become a popular approach applied for oral microbial analysis. Oral bacterial profiles have been studied to explore the relationship between microbial diversity and oral diseases such as caries and periodontal disease. This review describes the application of high-throughput sequencing for characterization of oral microbiota and analyzing the changes of the microbiome in the states of health or disease. Deep understanding the knowledge of microbiota will pave the way for more effective prevent dentistry and contribute to the development of personalized dental medicine.
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An ever-growing number of specific microbial taxa have been associated with both oral and systemic diseases.
“Amid this complexity, an ever-growing number of specific microbial taxa have been associated with both oral and systemic diseases[181,182].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [181]
Local variation in site-specific core microbial members speaks to heterogeneity of influences bacterial communities experience, including host factors such as age, diet, geography and oral health.
“Local variation in site-specific “core” microbial members speaks to the heterogeneity of influences bacterial communities experience, including host factors such as age, diet, geography and oral health[180–182].”
From Enterosalivary nitrate metabolism and the microbiome: Intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health (2017) · cites this paper as [181]
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- Authors
- Chen, H., & Jiang, W.
- Affiliations
- Zhejiang University (CN)
- Corresponding author
- Chen, Hui
- ORCID
- Venue
- Frontiers in Microbiology
- Publisher
- Frontiers Media SA
- Published
- 2014-10-13
- Volume
- 5
- Pages
- 508-508
- ISSN
- 1664-302X (ISSN-L)
- PMC
- PMC4195358
- OpenAlex
- W2155553719
- Cited by
- 317
- References
- 57
- Citations by year
- 2026: 7 · 2025: 24 · 2024: 19 · 2023: 30 · 2022: 45 · 2021: 45 · 2020: 53 · 2019: 47 · 2018: 17 · 2017: 12 · 2016: 12 · 2015: 6
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Microbiology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Keywords
- oral microbiota, next-generation sequencing, oral health, oral diseases, dental caries, periodontal disease, microbial diversity, preventive dentistry
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