A genome-wide analysis of annexins from parasitic organisms and their vectors
Open accessAbstract
In this study, we conduct an in-depth analysis of annexin proteins from a diverse range of invertebrate taxa, including the major groups that contain the parasites and vector organisms that are harmful to humans and domestic animals. Using structure-based amino acid sequence alignments and phylogenetic analyses, we present a classification for this protein group and assign names to sequences with ambiguous annotations in public databases. Our analyses reveal six distinct annexin clades, and the mapping of genes encoding annexins to the genome of the human blood fluke Schistosoma mansoni supports the hypothesis of gene duplication as a major evolutionary event in annexin genesis. This study illuminates annexin diversity from a novel perspective using contemporary phylogenetic hypotheses of eukaryote evolution, and will aid the consolidation of annexin protein identities in public databases and provide a foundation for future functional analysis and characterisation of these proteins in parasites of socioeconomic importance.
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Annexins have a patchy phylogenetic distribution in eukaryotes, with homologs detected in genomes of animals (group A and B), fungi (group C), plants (group D), and some protists of the Excavata and SAR supergroups (group E).
“The annexins have a patchy phylogenetic distribution in eukaryotes, but homologs have been detected in the genomes of animals (group A and B), fungi (group C), plants (group D), and some protists of the Excavata and SAR supergroups (group E) (3).”
From Comparative Cell Biology and Evolution of Annexins in Diplomonads (2016) · cites this paper as [3]
The Discussion reports annexins in animals, fungi, plants, Excavata, and some SAR lineages, consistent with a patchy distribution. It identifies Group E annexins in excavates but says SAR annexins are not yet categorised, so the claim’s assignment of SAR homologs to Group E is not supported. (LLM, conf=0.90)
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Additional file 1 of Molecular and functional characterization of Schistosoma japonicum annexin A13
Zhong, H., Hou, L., Qin, F., Ren, Y., Dong, B., Zhu, D., Li, H., Lu, K., Fu, Z., Liu, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26649381
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686278
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686293
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686290
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686266
Additional file 4 of Molecular and functional characterization of Schistosoma japonicum annexin A13
Zhong, H., Hou, L., Qin, F., Ren, Y., Dong, B., Zhu, D., Li, H., Lu, K., Fu, Z., Liu, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26649390
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686281
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686257
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686251
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686260
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686242
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686275
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686239
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686233
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686230
Additional file 2 of Molecular and functional characterization of Schistosoma japonicum annexin A13
Zhong, H., Hou, L., Qin, F., Ren, Y., Dong, B., Zhu, D., Li, H., Lu, K., Fu, Z., Liu, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26649384
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686254
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686287
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686284
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.25302974
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686227
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686236
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.25303187
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686269
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686272
Additional file 3 of Molecular and functional characterization of Schistosoma japonicum annexin A13
Zhong, H., Hou, L., Qin, F., Ren, Y., Dong, B., Zhu, D., Li, H., Lu, K., Fu, Z., Liu, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26649387
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686245
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686248
Brann, T., Beltramini, A., Chaparro, C., Berriman, M., Doyle, Sr., & Protasio, A. (2024) · Figshare · doi:10.6084/m9.figshare.26686263
Lakshmanan, B., Anand, A., Priya, M. N., Ambily, R., & Athira, C. P. (2026) · Gene Reports · doi:10.1016/j.genrep.2026.102588
Gao, L., Luo, W., Guo, Y., Yan, Y., Li, G., Yu, Q., Liu, M., Wang, E., Li, P., & Liu, T. (2026) · SSRN Electronic Journal · doi:10.2139/ssrn.7624294
- Authors
- Cantacessi, C., Seddon, J. M., Miller, T. L., Leow, C. Y., Thomas, L., Mason, L., Willis, C., Walker, G., Loukas, A., Gasser, R. B., Jones, M. K., & Hofmann, A.
- Affiliations
- James Cook University (AU)
- The University of Queensland (AU)
- Griffith University (AU)
- University of Otago (NZ)
- The University of Melbourne (AU)
- Corresponding author
- Jones, Malcolm K.
- Hofmann, Andreas
- ORCID
- Venue
- Scientific Reports
- Published
- 2013-10-11
- Volume
- 3
- Issue
- 1
- Pages
- 2893-2893
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC3795353
- OpenAlex
- W2069166753
- Cited by
- 46
- References
- 41
- Citations by year
- 2026: 2 · 2024: 14 · 2023: 4 · 2022: 1 · 2021: 8 · 2020: 2 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 1 · 2014: 3 · 2013: 1
- FWCI
- 1.34
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Scientific Reports (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- ResearchOnline - JCU (James Cook University) (submittedVersion)
- Griffith Research Online (submittedVersion)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc-nd)
- Funders
- Queensland Government
- Universiti Sains Malaysia
- Medical Research Council
- Australian Research Council
- National Health and Medical Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Phylogenetic Studies
- Life Sciences › Immunology and Microbiology › Parasitology › Parasites and Host Interactions
- Keywords
- annexins, gene duplication, Schistosoma mansoni, disease vectors, protein annotation, eukaryotic evolution, genome-wide analysis
- MeSH terms
- Animals, Chromosome Mapping, Humans, Invertebrates, Phylogeny, Annexins, Evolution, Molecular, Databases, Genetic, Genome-Wide Association Study
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