The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice
Open accessAbstract
Prevention of quality of life (QOL) deterioration is associated with the inhibition of geriatric diseases and the regulation of brain function. However, no substance is known that prevents the aging of both body and brain. It is known that polyamine concentrations in somatic tissues (including the brain) decrease with increasing age, and polyamine-rich foods enhance longevity in yeast, worms, flies, and mice, and protect flies from age-induced memory impairment. A main source of exogenous polyamines is the intestinal lumen, where they are produced by intestinal bacteria. We found that arginine intake increased the concentration of putrescine in the colon and increased levels of spermidine and spermine in the blood. Mice orally administered with arginine in combination with the probiotic bifidobacteria LKM512 long-term showed suppressed inflammation, improved longevity, and protection from age-induced memory impairment. This study shows that intake of arginine and LKM512 may prevent aging-dependent declines in QOL via the upregulation of polyamines.
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Cites
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Cited by
Gut microbiota, metabolites and host immunity
Rooks, M. G., & Garrett, W. S. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.42 · Cited by 3,409
An insight into gut microbiota and its functionalities
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Metabolic Control of Longevity
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Metadata
- Authors
- Kibe, R., Kurihara, S., Sakai, Y., Suzuki, H., Ooga, T., Sawaki, E., Muramatsu, K., Nakamura, A., Yamashita, A., Kitada, Y., Kakeyama, M., Benno, Y., & Matsumoto, M.
- Venue
- Scientific Reports
- Published
- 2014-04-01
- Volume
- 4
- Issue
- 1
- Pages
- 4548-4548
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W1974483460
- Cited by
- 271
- References
- 56
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- gold
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- Kibe, R., Kurihara, S., Sakai, Y., Suzuki, H., Ooga, T., Sawaki, E., Muramatsu, K., Nakamura, A., Yamashita, A., Kitada, Y., Kakeyama, M., Benno, Y., & Matsumoto, M. (2014). Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice. Scientific Reports. https://doi.org/10.1038/srep04548
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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