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Epigenome rejuvenation: HP1β mobility as a measure of pluripotent and senescent chromatin ground states

Manukyan, Maria, Singh, Prim B.·2014·Scientific Reports
DOI 10.1038/srep04789PMC PMC3999444
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  • The idea of inducing epigenetic transition to a 'youthful' state without the loss of cell identity, defined as 'epigenetic rejuvenation', was proposed for the first time in 2010.

    “The idea of inducing epigenetic transition to a 'youthful' state without the loss of cell identity, defined as 'epigenetic rejuvenation', was proposed for the first time in 2010 (refs.99-101).”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [100]

    The Abstract and Discussion describe epigenetic rejuvenation as returning an aged epigenome to a youthful state while maintaining differentiated functions. Both cite an earlier proposal, and the References identify a 2010 paper on epigenetic rejuvenation. Our copy does not establish that the idea was proposed for the first time in 2010. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

  • After 9 days of reprogramming with LIN28 added to OSKM, HP1b mobility was restored to levels found in young fibroblasts without sacrificing cell identity.

    “After 9 days of reprogramming, HP1b mobility, an indicator of active cell cycling, was restored to the same levels found in young fibroblasts without sacrificing cell identity 100 .”

    From Mechanisms, pathways and strategies for rejuvenation through epigenetic reprogramming (2023) · cites this paper as [100]

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Research works printed but not linked: 49

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Metadata

Authors
Manukyan, M., & Singh, P. B.
Venue
Scientific Reports
Publisher
Springer Science and Business Media LLC
Published
2014-04-25
Volume
4
Issue
1
ISSN
2045-2322
DOI
10.1038/srep04789
PMC
PMC3999444
Cited by
45
References
7
Language
en
Licence

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