Cited by 264Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model OrganismsSirtuins and Resveratrol in Medicine

Impact of cellular senescence signature on ageing research

Sikora, Ewa, Arendt, Thomas, Bennett, Martin, Narita, Masashi·2011·Ageing Research Reviews

Abstract

Cellular senescence as the state of permanent inhibition of cell proliferation is a tumour-suppressive mechanism. However, due to the associated secretory phenotype senescence can also contribute to cancer and possibly other age-related diseases, such as obesity, diabetes, atherosclerosis and Alzheimer's disease. There are two major mechanisms of cellular senescence; replicative senescence depends on telomere erosion or dysfunction whilst stress-induced premature senescence (SIPS) is telomere-independent and also includes oncogene-induced senescence (OIS). The senescence phenotype is characterised by altered cellular morphology, increased activity for senescence-associated-β-galactosidase (SA-β-GAL), increased formation of senescence-associated heterochromatin foci (SAHF) and promyelocytic leukemia protein nuclear bodies (PML NBs), permanent DNA damage, chromosomal instability and an inflammatory secretome. Some of these markers have been identified in cells from age-related pathologies. However, to improve our understanding of the contribution of cellular senescence to organismal ageing and age-related disease, it is imperative to define an unequivocal signature of cellular senescence that is functionally connected with normal and pathological ageing. Herein, we describe the processes leading to senescence, and the current biomarkers of cellular senescence, with particular emphasis on the causal role of DNA damage responses involved in the process. We highlight the gaps in o…

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Crossref · 10.1016/j.arr.2010.10.002

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Authors
Sikora, E., Arendt, T., Bennett, M., & Narita, M.
Affiliations
  • Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
  • Leipzig University (DE)
  • University of Cambridge (GB)
  • Cancer Research UK (GB)
Corresponding author
Sikora, Ewa
Venue
Ageing Research Reviews
Publisher
Elsevier BV
Published
2011-01
Volume
10
Issue
1
Pages
146-152
ISSN
1568-1637 (ISSN-L)
OpenAlex
W1977970646
Cited by
264
References
102
Citations by year
2026: 7 · 2025: 5 · 2024: 13 · 2023: 11 · 2022: 11 · 2021: 13 · 2020: 14 · 2019: 17 · 2018: 21 · 2017: 19 · 2016: 19 · 2015: 25 · 2014: 23 · 2013: 33 · 2012: 24
FWCI
2.12
Type
journal article
Language
en
Open access
closed
Locations
  • Ageing Research Reviews (publishedVersion)
  • PubMed (publishedVersion)
Funders
British Heart Foundation (RG/08/009/25841)
Topics
  • Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
Keywords
cellular senescence, senescence biomarkers, replicative senescence, stress-induced premature senescence, oncogene-induced senescence, telomere shortening, DNA damage response, senescence-associated β-galactosidase, senescence-associated heterochromatin foci, PML nuclear bodies, senescence-associated secretory phenotype, age-related diseases, aging
MeSH terms
Aging, DNA Damage, Humans, Phenotype, Research, Biomarkers, Telomere, Cellular Senescence, Genomic Instability

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