Impact of cellular senescence signature on ageing research
Abstract
Cellular senescence as the state of permanent inhibition of cell proliferation is a tumour-suppressive mechanism. However, due to the associated secretory phenotype senescence can also contribute to cancer and possibly other age-related diseases, such as obesity, diabetes, atherosclerosis and Alzheimer's disease. There are two major mechanisms of cellular senescence; replicative senescence depends on telomere erosion or dysfunction whilst stress-induced premature senescence (SIPS) is telomere-independent and also includes oncogene-induced senescence (OIS). The senescence phenotype is characterised by altered cellular morphology, increased activity for senescence-associated-β-galactosidase (SA-β-GAL), increased formation of senescence-associated heterochromatin foci (SAHF) and promyelocytic leukemia protein nuclear bodies (PML NBs), permanent DNA damage, chromosomal instability and an inflammatory secretome. Some of these markers have been identified in cells from age-related pathologies. However, to improve our understanding of the contribution of cellular senescence to organismal ageing and age-related disease, it is imperative to define an unequivocal signature of cellular senescence that is functionally connected with normal and pathological ageing. Herein, we describe the processes leading to senescence, and the current biomarkers of cellular senescence, with particular emphasis on the causal role of DNA damage responses involved in the process. We highlight the gaps in o…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Both normal and tumor cells undergo senescence in response to various insults that cause persistent DNA damage.
“Both normal and tumor cells undergo senescence in response to various insults that cause persistent DNA damage (Kuilman et al., 2010; Rodier and Campisi, 2011; Sikora et al., 2011; Ohtani and Hara, 2013)”
From Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 To Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution (2020) · cites this paper as Sikora et al., 2011
Cites
Hanahan, D., & Weinberg, R. A. (2000) · Cell · doi:10.1016/s0092-8674(00)81683-9 · Cited by 29,219 · see citing works
Mantovani, A., Allavena, P., Sica, A., & Balkwill, F. (2008) · Nature · doi:10.1038/nature07205 · Cited by 11,399 · see citing works
Inflammation and metabolic disorders
Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199 · see citing works
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508 · see citing works
A biomarker that identifies senescent human cells in culture and in aging skin in vivo.
Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., & Pereira-Smith, O. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.20.9363 · Cited by 7,477 · see citing works
The DNA-damage response in human biology and disease
Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092 · see citing works
Telomeres shorten during ageing of human fibroblasts
Harley, C. B., Futcher, A. B., & Greider, C. W. (1990) · Nature · doi:10.1038/345458a0 · Cited by 5,750 · see citing works
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358 · see citing works
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,178 · see citing works
Extension of Life-Span by Introduction of Telomerase into Normal Human Cells
Bodnar, A. G., Ouellette, M., Frolkis, M., Holt, S. E., Chiu, C.-P., Morin, G. B., Harley, C. B., Shay, J. W., Lichtsteiner, S., & Wright, W. E. (1998) · Science · doi:10.1126/science.279.5349.349 · Cited by 4,975 · see citing works
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
Bartkova, J., Hořejší, Z., Koed, K., Krämer, A., Tort, F., Zieger, K., Guldberg, P., Sehested, M., Nesland, J. M., Lukas, C., et al. (2005) · Nature · doi:10.1038/nature03482 · Cited by 2,688 · see citing works
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
Narita, M., Nuñez, S., Heard, E., Narita, M., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., & Lowe, S. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00401-x · Cited by 2,278 · see citing works
Self-citationPersistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
Rodier, F., Coppé, J.-P., Patil, C. K., Hoeijmakers, W. A. M., Muñoz, D. P., Raza, S. R., Freund, A., Campeau, E., Davalos, A. R., & Campisi, J. (2009) · Nature Cell Biology · doi:10.1038/ncb1909 · Cited by 2,232 · see citing works
BRAFE600-associated senescence-like cell cycle arrest of human naevi
Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature · doi:10.1038/nature03890 · Cited by 2,160 · see citing works
Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA
Blasco, M. A., Lee, H.-W., Hande, M. P., Samper, E., Lansdorp, P. M., DePinho, R. A., & Greider, C. W. (1997) · Cell · doi:10.1016/s0092-8674(01)80006-4 · Cited by 2,108 · see citing works
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
Chen, Z., Trotman, L. C., Shaffer, D., Lin, H.-K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., et al. (2005) · Nature · doi:10.1038/nature03918 · Cited by 1,993 · see citing works
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L.-V. F., Kolettas, E., Niforou, K., Zoumpourlis, V. C., et al. (2006) · Nature · doi:10.1038/nature05268 · Cited by 1,986 · see citing works
Olovnikov (1973) · doi:10.1016/0022-5193(73)90198-7 · Cited by 1,847 · see citing works
Atmospheric carbon dioxide concentrations over the past 60 million years
Pearson, P. N., & Palmer, M. R. (2000) · Nature · doi:10.1038/35021000 · Cited by 1,771 · see citing works
Senescence in premalignant tumours
Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguría, A., Zaballos, A., Flores, J. M., Barbacid, M., et al. (2005) · Nature · doi:10.1038/436642a · Cited by 1,482 · see citing works
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
Rudolph, K. L., Chang, S., Lee, H.-W., Blasco, M., Gottlieb, G. J., Greider, C., & DePinho, R. A. (1999) · Cell · doi:10.1016/s0092-8674(00)80580-2 · Cited by 1,349 · see citing works
Oncogene-induced senescence as an initial barrier in lymphoma development
Braig, M., Lee, S., Loddenkemper, C., Rudolph, C., Peters, A. H. F. M., Schlegelberger, B., Stein, H., Dörken, B., Jenuwein, T., & Schmitt, C. A. (2005) · Nature · doi:10.1038/nature03841 · Cited by 1,220 · see citing works
Molecular inflammation: Underpinnings of aging and age-related diseases
Chung, H. Y., Cesari, M., Anton, S., Marzetti, E., Giovannini, S., Seo, A. Y., Carter, C., Yu, B. P., & Leeuwenburgh, C. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2008.07.002 · Cited by 1,203 · see citing works
Living on a break: cellular senescence as a DNA-damage response
d'Adda di Fagagna, F. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2440 · Cited by 1,170 · see citing works
Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts
Parrinello, S., Samper, E., Krtolica, A., Goldstein, J., Melov, S., & Campisi, J. (2003) · Nature Cell Biology · doi:10.1038/ncb1024 · Cited by 1,116 · see citing works
Cellular Senescence in Aging Primates
Herbig, U., Ferreira, M., Condel, L., Carey, D., & Sedivy, J. M. (2006) · Science · doi:10.1126/science.1122446 · Cited by 1,101 · see citing works
Fat tissue, aging, and cellular senescence
Tchkonia, T., Morbeck, D. E., Von Zglinicki, T., Van Deursen, J., Lustgarten, J., Scrable, H., Khosla, S., Jensen, M. D., & Kirkland, J. L. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00608.x · Cited by 1,094 · see citing works
Cellular senescence as a tumor-suppressor mechanism
Campisi, J. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02151-1 · Cited by 936 · see citing works
Senescence-messaging secretome: SMS-ing cellular stress
Kuilman, T., & Peeper, D. S. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2560 · Cited by 909 · see citing works
A crucial role for adipose tissue p53 in the regulation of insulin resistance
Minamino, T., Orimo, M., Shimizu, I., Kunieda, T., Yokoyama, M., Ito, T., Nojima, A., Nabetani, A., Oike, Y., Matsubara, H., et al. (2009) · Nature Medicine · doi:10.1038/nm.2014 · Cited by 891 · see citing works
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
Pearson, M. A., Carbone, R., Sebastiani, C., Cioce, M., Fagioli, M., Saito, S., Higashimoto, Y., Appella, E., Minucci, S., Pandolfi, P. P., et al. (2000) · Nature · doi:10.1038/35018127 · Cited by 838 · see citing works
Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks
Sedelnikova, O. A., Horikawa, I., Zimonjic, D. B., Popescu, N. C., Bonner, W. M., & Barrett, J. C. (2004) · Nature Cell Biology · doi:10.1038/ncb1095 · Cited by 790 · see citing works
Loss of telomeric DNA during aging of normal and trisomy 21 human lymphocytes.
Vaziri, H., Schächter, F., Uchida, I. A., Wei, L., Zhu, X., Effros, R. B., Cohen, D., & Harley, C. (1993) · PubMed · Cited by 734 · see citing works
Senescence and immortalization: role of telomeres and telomerase
Shay, J. W., & Wright, W. E. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh296 · Cited by 729 · see citing works
Toussaint, O., Medrano, E. E., & von Zglinicki, T. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00180-7 · Cited by 713 · see citing works
DNA damage response and cellular senescence in tissues of aging mice
Wang, C., Jurk, D., Maddick, M., Nelson, G., Martin‐Ruiz, C., & Von Zglinicki, T. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00481.x · Cited by 696 · see citing works
Mantovani, A. (2008) · Nature · doi:10.1038/457036b · Cited by 646 · see citing works
Senescent cells as a source of inflammatory factors for tumor progression
Davalos, A. R., Coppe, J.-P., Campisi, J., & Desprez, P.-Y. (2010) · Cancer and Metastasis Reviews · doi:10.1007/s10555-010-9220-9 · Cited by 636 · see citing works
Matthews, C., Gorenne, I., Scott, S., Figg, N., Kirkpatrick, P., Ritchie, A., Goddard, M., & Bennett, M. (2006) · Circulation Research · doi:10.1161/01.res.0000233315.38086.bc · Cited by 615 · see citing works
Self-citationAccumulation of senescent cells in Mitotic tissue of aging primates
Jeyapalan, J. C., Ferreira, M., Sedivy, J. M., & Herbig, U. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.008 · Cited by 571 · see citing works
Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
Romanov, S. R., Kozakiewicz, B. K., Holst, C. R., Stampfer, M. R., Haupt, L. M., & Tlsty, T. D. (2001) · Nature · doi:10.1038/35054579 · Cited by 560 · see citing works
p16 <sup>INK4A</sup> is a robust <i>in vivo</i> biomarker of cellular aging in human skin
Ressler, S., Bartkova, J., Niederegger, H., Bartek, J., Scharffetter‐Kochanek, K., Jansen‐Dürr, P., & Wlaschek, M. (2006) · Aging Cell · doi:10.1111/j.1474-9726.2006.00231.x · Cited by 557 · see citing works
Vascular Cell Senescence: Contribution to Atherosclerosis
Minamino, T., & Komuro, I. (2007) · Circulation Research · doi:10.1161/01.res.0000256837.40544.4a · Cited by 542 · see citing works
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3
Gamerdinger, M., Hajieva, P., Kaya, A. M., Wolfrum, U., Hartl, F. U., & Behl, C. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.29 · Cited by 522 · see citing works
Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?
Herrup, K., & Yang, Y. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2124 · Cited by 507 · see citing works
Hallmarks of senescence in carcinogenesis and cancer therapy
Shay, J. W., & Roninson, I. B. (2004) · Oncogene · doi:10.1038/sj.onc.1207518 · Cited by 502 · see citing works
Inflammatory networks in ageing, age-related diseases and longevity
Vasto, S., Candore, G., Balistreri, C. R., Caruso, M., Colonna‐Romano, G., Grimaldi, M. P., Listı̀, F., Nuzzo, D., Lio, D., & Caruso, C. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.11.015 · Cited by 481 · see citing works
The immune system in extreme longevity
Sansoni, P., Vescovini, R., Fagnoni, F. F., Biasini, C., Zanni, F., Zanlari, L., Telera, A. R., Lucchini, G., Passeri, G., Monti, D., et al. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.06.008 · Cited by 442 · see citing works
Putting the stress on senescence
Serrano, M., & Blasco, M. A. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00278-7 · Cited by 413 · see citing works
Puzzles, promises and a cure for ageing
Vijg, J., & Campisi, J. (2008) · Nature · doi:10.1038/nature07216 · Cited by 407 · see citing works
Vascular endothelial senescence: from mechanisms to pathophysiology
Erusalimsky, J. D. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.91353.2008 · Cited by 399 · see citing works
Progeria syndromes and ageing: what is the connection?
Burtner, C. R., & Kennedy, B. K. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2944 · Cited by 386 · see citing works
Is β-Galactosidase Staining a Marker of Senescence in Vitro and in Vivo?
Severino, J., Allen, R. G., Balin, S., Balin, A., & Cristofalo, V. J. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.4875 · Cited by 370 · see citing works
Cellular senescence and organismal aging
Jeyapalan, J. C., & Sedivy, J. M. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.04.001 · Cited by 347 · see citing works
Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy
Davoli, T., Denchi, E. L., & de Lange, T. (2010) · Cell · doi:10.1016/j.cell.2010.01.031 · Cited by 298 · see citing works
BRAFE600 in benign and malignant human tumours
Michaloglou, C., Vredeveld, L. C. W., Mooi, W. J., & Peeper, D. S. (2007) · Oncogene · doi:10.1038/sj.onc.1210704 · Cited by 272 · see citing works
Cellular senescence in vivo: a barrier to tumorigenesis
Prieur, A., & Peeper, D. S. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.01.007 · Cited by 260 · see citing works
Short Telomeres are Sufficient to Cause the Degenerative Defects Associated with Aging
Armanios, M., Alder, J. K., Parry, E. M., Karim, B., Strong, M. A., & Greider, C. W. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.10.028 · Cited by 257 · see citing works
Hepatic polyploidy and liver growth control
Gupta, S. K. (2000) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0317 · Cited by 250 · see citing works
Sordet, O., Redon, C. E., Guirouilh‐Barbat, J., Smith, S. H., Solier, S., Douarre, C., Conti, C., Nakamura, A., Das, B. B., Nicolas, E., et al. (2009) · EMBO Reports · doi:10.1038/embor.2009.97 · Cited by 239 · see citing works
Cell aging in vivo and in vitro
Rubin, H. (1997) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00067-5 · Cited by 226 · see citing works
Shibata, K. R., Aoyama, T., Shima, Y., Fukiage, K., Otsuka, S., Furu, M., Kohno, Y., Ito, K., Fujibayashi, S., Neo, M., et al. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0225 · Cited by 216 · see citing works
Wagner, M., Hampel, B., Bernhard, D., Hala, M., Zwerschke, W., & Jansen‐Dürr, P. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00105-x · Cited by 203 · see citing works
Mortality and immortality at the cellular level. A review.
Hayflick, L. (1997) · PubMed · Cited by 202 · see citing works
Vascular smooth muscle cell senescence in atherosclerosis
GORENNE, I., KAVURMA, M., SCOTT, S., & BENNETT, M. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.06.004 · Cited by 196 · see citing works
Self-citationSenescent cells fail to express cdc2, cycA, and cycB in response to mitogen stimulation.
Stein, G. H., Drullinger, L. F., Robetorye, R. S., Pereira-Smith, O. M., & Smith, J. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.24.11012 · Cited by 185 · see citing works
Systemic Inflammation, Infection, ApoE Alleles, and Alzheimer Disease: A Position Paper
Finch, C. E., & Morgan, T. E. (2007) · Current Alzheimer Research · doi:10.2174/156720507780362254 · Cited by 180 · see citing works
Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells
Śliwińska, M. A., Mosieniak, G., Wolanin, K., Babik, A., Piwocka, K., Magalska, A., Szczepanowska, J., Fronk, J., & Sikora, E. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.04.011 · Cited by 179 · see citing works
Self-citationBoth telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence
Nakamura, A. J., Chiang, Y. J., Hathcock, K. S., Horikawa, I., Sedelnikova, O. A., Hodes, R. J., & Bonner, W. M. (2008) · Epigenetics & Chromatin · doi:10.1186/1756-8935-1-6 · Cited by 168 · see citing works
New model of health promotion and disease prevention for the 21st century
Butler, R. N., Miller, R. A., Perry, D. P., Carnes, B. A., Williams, T. F., Cassel, C. K., Brody, J. A., Bernard, M., Partridge, L., Kirkwood, T. B. L., et al. (2008) · BMJ · doi:10.1136/bmj.a399 · Cited by 162 · see citing works
Ye, X., Zerlanko, B. J., Zhang, R., Somaiah, N., Lipinski, M., Salomoni, P., & Adams, P. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01592-06 · Cited by 161 · see citing works
Cellular senescence and chromatin structure
Funayama, R., & Ishikawa, F. (2007) · Chromosoma · doi:10.1007/s00412-007-0115-7 · Cited by 150 · see citing works
ATM Activation in Normal Human Tissues and Testicular Cancer
Bártková, J., Bakkenist, C. J., Meyts, E. R., Skakkebæk, N. E., Sehested, M., Lukas, J., Kastan, M. B., & Bártek, J. (2005) · Cell Cycle · doi:10.4161/cc.4.6.1742 · Cited by 144 · see citing works
The p400 E1A-associated protein is a novel component of the p53 → p21 senescence pathwayPreprint
Chan, H. M., Narita, M., Lowe, S. W., & Livingston, D. M. (2005) · Genes & Development · doi:10.1101/gad.1280205 · Cited by 144 · see citing works
Self-citationMahmoudi, M., Gorenne, I., Mercer, J. R., Figg, N., Littlewood, T. D., & Bennett, M. R. (2008) · Circulation Research · doi:10.1161/circresaha.108.182899 · Cited by 139 · see citing works
Self-citationThe role of the DNA damage response in neuronal development, organization and maintenance
Barzilai, A., Biton, S., & Shiloh, Y. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.03.005 · Cited by 135 · see citing works
Senescence-associated beta-galactosidase activity expression in aging hippocampal neurons
Geng, Y.-Q., Guan, J.-T., Xu, X.-H., & Fu, Y.-C. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.05.011 · Cited by 129 · see citing works
Changes of telomere length with aging
Takubo, K., Aida, J., Izumiyama‐Shimomura, N., Ishikawa, N., Sawabe, M., Kurabayashi, R., Shiraishi, H., Arai, T., & Nakamura, K. (2010) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2010.00605.x · Cited by 103 · see citing works
DNA damage responses in neural cells: Focus on the telomere
Zhang, P., Dilley, C. M., & Mattson, M. P. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.052 · Cited by 103 · see citing works
Polyploidy: The Link Between Senescence and Cancer
Mosieniak, G., & Sikora, E. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210790883714 · Cited by 102 · see citing works
Self-citationBacterial intoxication evokes cellular senescence with persistent DNA damage and cytokine signalling
Blažková, H., Krejcikova, K., Moudrý, P., Frisan, T., Hodny, Z., & Bartek, J. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00862.x · Cited by 99 · see citing works
Connecting autophagy to senescence in pathophysiology
Young, A. R. J., & Narita, M. (2010) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.12.005 · Cited by 86 · see citing works
Self-citationUnexpected Pieces to the Senescence Puzzle
Cichowski, K. M., & Hahn, W. C. (2008) · Cell · doi:10.1016/j.cell.2008.05.027 · Cited by 80 · see citing works
Telomere-driven replicative senescence is a stress response
von Zglinicki, T., Petrie, J., & Kirkwood, T. B. L. (2003) · Nature Biotechnology · doi:10.1038/nbt0303-229b · Cited by 76 · see citing works
Micco, R. D., Cicalese, A., Fumagalli, M., Dobreva, M., Verrecchia, A., Pelicci, P. G., & di Fagagna, F. D. (2008) · Cell Cycle · doi:10.4161/cc.7.22.7152 · Cited by 76 · see citing works
Bandyopadhyay, D., Timchenko, N. A., Suwa, T., Hornsby, P. J., Campisi, J., & Medrano, E. E. (2001) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00098-5 · Cited by 72 · see citing works
Yang, D., McCrann, D. J., Nguyen, H. G., Hilaire, C. S., DePinho, R. A., Jones, M. R., & Ravid, K. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00274.x · Cited by 67 · see citing works
In vitro senescence of immune cells
Effros, R. B., Dagarag, M. D., & Valenzuela, H. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.09.004 · Cited by 62 · see citing works
Hubáčková, S., Nováková, Z., Krejčíková, K., Košař, M., Dobrovolná, J., Dušková, P., Hanzlíková, H., Vančurová, M., Baráth, P., Bártek, J., et al. (2010) · Cell Cycle · doi:10.4161/cc.9.15.12521 · Cited by 56 · see citing works
Yang, D., Liu, L., & Zheng, X. (2008) · Ageing Research Reviews · doi:10.1016/j.arr.2008.02.001 · Cited by 55 · see citing works
HUMAN DIPLOID FIBROBLAST CELLS IN SENESCENCE; CYCLING THROUGH POLYPLOIDY TO MITOTIC CELLS
Walen, K. H. (2006) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1290/0603019.1 · Cited by 49 · see citing works
Arendt, T., Mosch, B., & Morawski, M. (2009) · International Journal of Molecular Sciences · doi:10.3390/ijms10041609 · Cited by 48 · see citing works
Self-citationAlzheimer’s Disease and Genetics of Inflammation: A Pharmacogenomic Vision
Vasto, S., Candore, G., Duro, G., Lio, D., Grimaldi, M. P., & Caruso, C. (2007) · Pharmacogenomics · doi:10.2217/14622416.8.12.1735 · Cited by 46 · see citing works
Wojda, A., Ziętkiewicz, E., Mossakowska, M., Pawłowski, W., Skrzypczak, K., & Witt, M. (2006) · The Journals of Gerontology Series A · doi:10.1093/gerona/61.8.763 · Cited by 46 · see citing works
Chatoo, W., Abdouh, M., & Bernier, G. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3610 · Cited by 41 · see citing works
INFLAMMATION AND ALZHEIMER'S DISEASE
Gupta, A., & Pansari, K. (2003) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2003.tb11394.x · Cited by 31 · see citing works
PML links aberrant cytokine signaling and oncogenic stress to cellular senescence
Bourdeau, V. (2009) · Frontiers in bioscience · doi:10.2741/3256 · Cited by 30 · see citing works
Aging of chick embryo fibroblasts in vitro. V. Time course studies on polyploid nucleus accumulation
Kaji, K., & Matsuo, M. (1981) · Experimental Cell Research · doi:10.1016/0014-4827(81)90245-7 · Cited by 17 · see citing works
Flagged first, then by citations
2 of the 102 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Salminen, A., Kauppinen, A., & Kaarniranta, K. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2011.12.006 · Cited by 763 · see citing works
Sharma, R. K., Agarwal, A. K., Rohra, V. K., Assidi, M., Abu-Elmagd, M. M., & Turki, R. F. (2015) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-015-0028-x · Cited by 469 · see citing works
Georgakopoulou, E., Tsimaratou, K., Evangelou, K., Fernandez, M.-P., Zoumpourlis, V, Trougakos, I., Kletsas, D., Bartek, J., Serrano, M., & Gorgoulis, V. (2012) · Aging · doi:10.18632/aging.100527 · Cited by 390 · see citing works
Inflammaging decreases adaptive and innate immune responses in mice and humans
Frasca, D., & Blomberg, B. B. (2016) · Biogerontology · doi:10.1007/s10522-015-9578-8 · Cited by 357 · see citing works
Salminen, A., Ojala, J., Kaarniranta, K., Haapasalo, A., Hiltunen, M., & Soininen, H. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07738.x · Cited by 333 · see citing works
Bharadwaj, U., Kasembeli, M. M., Robinson, P., & Tweardy, D. J. (2020) · Pharmacological Reviews · doi:10.1124/pr.119.018440 · Cited by 314 · see citing works
“Both normal and tumor cells undergo senescence in response to various insults that cause persistent DNA damage (Kuilman et al., 2010; Rodier and Campisi, 2011; Sikora et al., 2011; Ohtani and Hara, 2013); senescence is characterized by the inability to proliferate despite sufficient nutrients and mitogens while mainta…”
BackgroundInfluentialMolecular mechanisms of aging and anti-aging strategies
Li, Y., Tian, X., Luo, J., Bao, T., Wang, S., & Wu, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01663-1 · Cited by 333 · see citing works
Persistent γH2AX: A promising molecular marker of DNA damage and aging
Siddiqui, M. S., François, M., Fenech, M. F., & Leifert, W. R. (2015) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2015.07.001 · Cited by 266 · see citing works
Olivieri, F., Lazzarini, R., Recchioni, R., Marcheselli, F., Rippo, M. R., Nuzzo, S., Albertini, M. C., Graciotti, L., Babini, L., Mariotti, S., et al. (2012) · AGE · doi:10.1007/s11357-012-9440-8 · Cited by 206 · see citing works
MicroRNAs linking inflamm-aging, cellular senescence and cancer
Olivieri, F., Rippo, M. R., Monsurrò, V., Salvioli, S., Capri, M., Procopio, A. D., & Franceschi, C. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2013.05.001 · Cited by 203 · see citing works
Assessing cell and organ senescence biomarkers
de Jesus, B. B., & Blasco, M. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.247866 · Cited by 187 · see citing works
Intrinsic skin aging: the role of oxidative stress.
Poljšak, B., Dahmane, R. G., & Godić, A. (2012) · PubMed · Cited by 184 · see citing works
Liu, J., Huang, K., Cai, G.-Y., Chen, X.-M., Yang, J.-R., Lin, L.-R., Yang, J., Huo, B.-G., Zhan, J., & He, Y.-N. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2013.10.002 · Cited by 181 · see citing works
Senescence in chronic liver disease: Is the future in aging?
Aravinthan, A. D., & Alexander, G. J. M. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.05.030 · Cited by 174 · see citing works
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2013) · Ageing Research Reviews · doi:10.1016/j.arr.2012.11.004 · Cited by 173 · see citing works
IL-6-STAT3 signaling and premature senescence
Kojima, H., Inoue, T., Kunimoto, H., & Nakajima, K. (2013) · JAK-STAT · doi:10.4161/jkst.25763 · Cited by 170 · see citing works
Frasca, D., Diaz, A., Romero, M., & Blomberg, B. B. (2017) · Experimental Gerontology · doi:10.1016/j.exger.2016.12.001 · Cited by 160 · see citing works
Mosieniak, G., Adamowicz, M., Alster, O., Jaskowiak, H., Szczepankiewicz, A. A., Wilczynski, G. M., Ciechomska, I. A., & Sikora, E. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.05.004 · Cited by 157 · see citing works
Self-citationPolyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence
Mosieniak, G., Śliwińska, M. A., Alster, O., Strzeszewska, A., Sunderland, P., Piechota, M. J., Waś, H., & Sikora, E. (2015) · Neoplasia · doi:10.1016/j.neo.2015.11.008 · Cited by 161 · see citing works
Self-citationIs senescence-associated β-galactosidase a marker of neuronal senescence?
Piechota, M. J., Sunderland, P., Wysocka, A., Nalberczak‐Skóra, M., Śliwińska, M. A., Radwańska, K., & Sikora, E. (2016) · Oncotarget · doi:10.18632/oncotarget.12752 · Cited by 156 · see citing works
Self-citationMicroglia change from a reactive to an age-like phenotype with the time in culture
Caldeira, C., Oliveira, A. F., Cunha, C., Vaz, A. R., Falcão, A. S., Fernandes, A., & Brites, D. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00152 · Cited by 156 · see citing works
Lee, K. S., Lin, S., Copland, D. A., Dick, A. D., & Liu, J. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02088-0 · Cited by 150 · see citing works
Impact of Advanced Paternal Age on Fertility and Risks of Genetic Disorders in Offspring
Kaltsas, A., Moustakli, E., Zikopoulos, A., Georgiou, I. A., Dimitriadis, F., Symeonidis, E. N., Markou, E., Michaelidis, T. M., Tien, D. M. B., Giannakis, I., et al. (2023) · Genes · doi:10.3390/genes14020486 · Cited by 149 · see citing works
Tăcutu, R., Budovsky, A., Yanai, H., & Fraifeld, V. E. (2011) · Aging · doi:10.18632/aging.100413 · Cited by 143 · see citing works
Xu, Z., Feng, W., Shen, Q., Yu, N., Yu, K., Wang, S., Chen, Z., Shioda, S., & Guo, Y. (2017) · Aging and Disease · doi:10.14336/ad.2016.0620 · Cited by 143 · see citing works
Bielak-Zmijewska, A., Wnuk, M., Przybylska, D., Grabowska, W., Lewinska, A., Alster, O., Korwek, Z., Cmoch, A., Myszka, A., Pikula, S., et al. (2014) · Biogerontology · doi:10.1007/s10522-013-9477-9 · Cited by 139 · see citing works
Self-citationThe Role of Curcumin in the Modulation of Ageing
Bielak-Żmijewska, A., Grabowska, W., Ciolko, A., Bojko, A., Mosieniak, G., Bijoch, Ł., & Sikora, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051239 · Cited by 143 · see citing works
Self-citationThe Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect?
Kordinas, V., Ioannidis, A., & Chatzipanagiotou, S. (2016) · Genes · doi:10.3390/genes7090060 · Cited by 139 · see citing works
Toll like receptor signaling in “inflammaging”: microRNA as new players
Olivieri, F., Rippo, M. R., Prattichizzo, F., Babini, L., Graciotti, L., Recchioni, R., & Procopio, A. D. (2013) · Immunity & Ageing · doi:10.1186/1742-4933-10-11 · Cited by 137 · see citing works
Sécher, T., Samba‐Louaka, A., Oswald, É., & Nougayrède, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0077157 · Cited by 134 · see citing works
Lewińska, A., Adamczyk‐Grochala, J., Kwasniewicz, E., Deręgowska, A., & Wnuk, M. (2017) · APOPTOSIS · doi:10.1007/s10495-017-1353-7 · Cited by 122 · see citing works
Effects of d ‐galactose‐induced ageing on the heart and its potential interventions
Bo‐Htay, C., Palee, S., Apaijai, N., Chattipakorn, S. C., & Chattipakorn, N. (2018) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13472 · Cited by 122 · see citing works
SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin
Chen, H., Liu, X., Zhu, W., Chen, H., Hu, X., Jiang, Z., Xu, Y., Wang, L., Zhou, Y., Chen, P., et al. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00103 · Cited by 118 · see citing works
A common signature of cellular senescence; does it exist?
Sikora, E., Bielak-Żmijewska, A., & Mosieniak, G. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101458 · Cited by 120 · see citing works
Self-citationKey Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation
Caldeira, C., Cunha, C., Vaz, A. R., Falcão, A. S., Barateiro, A., Seixas, E., Fernandes, A., & Brites, D. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00277 · Cited by 117 · see citing works
The STAT3-IGFBP5 axis is critical for IL-6/gp130-induced premature senescence in human fibroblasts
Kojima, H., Kunimoto, H., Inoue, T., & Nakajima, K. (2012) · Cell Cycle · doi:10.4161/cc.11.4.19172 · Cited by 114 · see citing works
Effects of (−)-epicatechin on molecular modulators of skeletal muscle growth and differentiation
Gutiérrez-Salmeán, G., Ciaraldi, T. P., Nogueira, L., Barboza, J., Taub, P. R., Hogan, M. C., Henry, R. R., Meaney, E., Villarreal, F. J., Ceballos, G. M., et al. (2013) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2013.09.007 · Cited by 113 · see citing works
Cellular Senescence - its role in cancer and the response to ionizing radiation
Sabin, R. J., & Anderson, R. M. (2011) · Genome Integrity · doi:10.1186/2041-9414-2-7 · Cited by 116 · see citing works
Kaarniranta, K., Kajdanek, J., Morawiec, J., Pawlowska, E., & Blasiak, J. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19082317 · Cited by 112 · see citing works
Noncancerous disease-targeting AIEgens
Duo, Y., Luo, G., Zhang, W., Wang, R., Xiao, G. G., Li, Z., Li, X., Chen, M., Yoon, J., & Tang, B. Z. (2023) · Chemical Society Reviews · doi:10.1039/d2cs00610c · Cited by 106 · see citing works
Conserved senescence associated genes and pathways in primary human fibroblasts detected by RNA-seq
Marthandan, S., Baumgart, M., Priebe, S., Groth, M., Schaer, J., Kaether, C., Guthke, R., Cellerino, A., Platzer, M., Diekmann, S., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154531 · Cited by 91 · see citing works
The role of myeloid-derived suppressor cells (MDSC) in the inflammaging process
Salminen, A., Kaarniranta, K., & Kauppinen, A. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.09.001 · Cited by 100 · see citing works
Morphological and Functional Characteristic of Senescent Cancer Cells
Sikora, E., Mosieniak, G., & Śliwińska, M. A. (2016) · Current Drug Targets · doi:10.2174/1389450116666151019094724 · Cited by 100 · see citing works
Self-citationWang, T., Wu, X., Rudaisat, M. A., Song, Y., & Cheng, H. (2020) · Journal of Cancer · doi:10.7150/jca.45176 · Cited by 97 · see citing works
Cellular Senescence in Ageing, Age-Related Disease and Longevity
Sikora, E., Bielak-Żmijewska, A., & Mosieniak, G. (2013) · Current Vascular Pharmacology · doi:10.2174/1570161111666131219094045 · Cited by 91 · see citing works
Self-citationSahardi, N. F. N. M., & Makpol, S. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/5054395 · Cited by 90 · see citing works
Lewińska, A., Adamczyk‐Grochala, J., Kwasniewicz, E., Deręgowska, A., & Wnuk, M. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2016.11.018 · Cited by 90 · see citing works
Błasiak, J., Piechota, M. J., Pawłowska, E., Szatkowska, M., Sikora, E., & Kaarniranta, K. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5293258 · Cited by 92 · see citing works
Self-citationmTOR Activity and Autophagy in Senescent Cells, a Complex Partnership
Cayo, Á., Segovia, R., Venturini, W., Moore‐Carrasco, R., Valenzuela, C. A., & Brown, N. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158149 · Cited by 92 · see citing works
Linton, P., & Thoman, M. L. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.06.017 · Cited by 86 · see citing works
Ma, C., Pi, C., Yang, Y. J., Lin, L., Shi, Y., Li, Y., Li, Y., & He, X. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170930 · Cited by 86 · see citing works
Metabolic requirements of human pro-inflammatory B cells in aging and obesity
Frasca, D., Diaz, A., Romero, M., Thaller, S. R., & Blomberg, B. B. (2019) · PLoS ONE · doi:10.1371/journal.pone.0219545 · Cited by 86 · see citing works
Myeloid-derived suppressor cells (MDSC): an important partner in cellular/tissue senescence
Salminen, A., Kauppinen, A., & Kaarniranta, K. (2018) · Biogerontology · doi:10.1007/s10522-018-9762-8 · Cited by 84 · see citing works
Wang, S., Wang, X., Cheng, Y., Ouyang, W., Sang, X., Liu, J., Su, Y., Liu, Y., Li, C., Yang, L., et al. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3632169 · Cited by 83 · see citing works
Mitterberger, M. C., Lechner, S., Mattesich, M., & Zwerschke, W. (2013) · The Journals of Gerontology Series A · doi:10.1093/gerona/glt043 · Cited by 82 · see citing works
Frasca, D. (2018) · Experimental Gerontology · doi:10.1016/j.exger.2017.07.002 · Cited by 82 · see citing works
Is DNA damage indispensable for stress-induced senescence?
Bielak-Żmijewska, A., Mosieniak, G., & Sikora, E. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.08.004 · Cited by 80 · see citing works
Self-citationToba, H., Cannon, P. L., Yabluchanskiy, A., Iyer, R. P., D'Armiento, J. M., & Lindsey, M. L. (2016) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00633.2016 · Cited by 76 · see citing works
Shokat, S., & Großkinsky, D. K. (2019) · Sustainability · doi:10.3390/su11174558 · Cited by 74 · see citing works
Salminen, A. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101280 · Cited by 76 · see citing works
Giménez‐Bastida, J. A., Ávila‐Gálvez, M. Á., Espı́n, J. C., & González‐Sarrías, A. (2020) · Food and Chemical Toxicology · doi:10.1016/j.fct.2020.111260 · Cited by 73 · see citing works
Cellular senescence: a hitchhiker’s guide
Aravinthan, A. D. (2015) · Human Cell · doi:10.1007/s13577-015-0110-x · Cited by 73 · see citing works
Yu, Y.-C., Yang, P., Chuah, Q.-Y., Huang, Y.-H., Peng, C.-W., Lee, Y., & Chiu, S.-J. (2013) · Scientific Reports · doi:10.1038/srep01675 · Cited by 71 · see citing works
Neuregulin-1 attenuates stress-induced vascular senescence
Shakeri, H., Gevaert, A. B., Schrijvers, D. M., Meyer, G. R. Y. D., Keulenaer, G. W. D., Guns, P., Lemmens, K., & Segers, V. F. M. (2018) · Cardiovascular Research · doi:10.1093/cvr/cvy059 · Cited by 70 · see citing works
Chaix, R., Fagny, M., Cosín‐Tomás, M., Alvarez-López, M., Lemée, L., Regnault, B., Davidson, R. J., Antoine Lutz, A., & Kaliman, P. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.11.003 · Cited by 74 · see citing works
Toba, H., Brás, L. E. D. C., Baicu, C. F., Zile, M. R., Lindsey, M. L., & Bradshaw, A. D. (2015) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00402.2014 · Cited by 69 · see citing works
High-order chromatin structure and the epigenome in SAHFs
Chandra, T., & Narita, M. (2012) · Nucleus · doi:10.4161/nucl.23189 · Cited by 71 · see citing works
Self-citationBerberine suppresses gero-conversion from cell cycle arrest to senescence
Zhao, H., Halicka, H. D., Li, J., & Darżynkiewicz, Z. (2013) · Aging · doi:10.18632/aging.100593 · Cited by 70 · see citing works
Centenarian lamins: rapamycin targets in longevity
Lattanzi, G., Ortolani, M., Columbaro, M., Prencipe, S., Mattioli, E., Lanzarini, C., Maraldi, N. M., Cenni, V., Garagnani, P., Salvioli, S., et al. (2013) · Journal of Cell Science · doi:10.1242/jcs.133983 · Cited by 69 · see citing works
The senescent hepatocyte gene signature in chronic liver disease
Aravinthan, A. D., Shannon, N. B., Heaney, J., Hoare, M., Marshall, A., & Alexander, G. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.09.011 · Cited by 65 · see citing works
Yasaei, H., Gilham, E., Pickles, J. C., Roberts, T. P. L., O’Donovan, M. R., & Newbold, R. F. (2012) · Oncogene · doi:10.1038/onc.2012.45 · Cited by 65 · see citing works
Korwek, Z., Sewastianik, T., Bielak-Żmijewska, A., Mosieniak, G., Alster, O., Moreno-Villaneuva, M., Bürkle, A., & Sikora, E. (2012) · DNA repair · doi:10.1016/j.dnarep.2012.08.006 · Cited by 59 · see citing works
Self-citationDing, D., Chou, H.-L., Hung, W.-T., Liu, H.-W., & Chu, T. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-59 · Cited by 61 · see citing works
Macromolecular Degradation Systems and Cardiovascular Aging
Nakayama, H., Nishida, K., & Otsu, K. (2016) · Circulation Research · doi:10.1161/circresaha.115.307495 · Cited by 55 · see citing works
Targeting normal and cancer senescent cells as a strategy of senotherapy
Sikora, E., Bielak-Żmijewska, A., & Mosieniak, G. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100941 · Cited by 57 · see citing works
Self-citationLee, H., Cha, H., & Park, J. H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21010343 · Cited by 56 · see citing works
Neuregulin-1, a potential therapeutic target for cardiac repair
Wang, Y., Wei, J.-L., Zhang, P., Zhang, X., Wang, Y., Chen, W., Zhao, Y., & Cui, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.945206 · Cited by 56 · see citing works
Pi, C., Yang, Y. J., Sun, Y., Wang, H., Sun, H., Ma, M., Lin, L., Shi, Y., Li, Y., Li, Y., et al. (2019) · Aging · doi:10.18632/aging.101993 · Cited by 56 · see citing works
Shang, D., Hong, Y., Xie, W., Tu, Z., & Xu, J. L. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00929 · Cited by 54 · see citing works
Senolytics: Eliminating Senescent Cells and Alleviating Intervertebral Disc Degeneration
Wu, Y., Shen, S., Shi, Y., Tian, N., Zhou, Y., & Zhang, X. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.823945 · Cited by 52 · see citing works
Activation-induced and damage-induced cell death in aging human T cells
Sikora, E. (2015) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2015.03.011 · Cited by 51 · see citing works
Self-citationWu, C.-L., Wang, Y., Jin, B., Chen, H., Xie, B., & Mao, Z.-B. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.661785 · Cited by 50 · see citing works
NOX4 downregulation leads to senescence of human vascular smooth muscle cells
Przybylska, D., Janiszewska, D., Goździk, A., Bielak-Żmijewska, A., Sunderland, P., Sikora, E., & Mosieniak, G. (2016) · Oncotarget · doi:10.18632/oncotarget.12079 · Cited by 51 · see citing works
Self-citationKomseli, E.-S., Pateras, I. S., Krejsgaard, T., Stawiski, K., Rizou, S. V., Polyzos, A., Roumelioti, F., Chiourea, M., Mourkioti, I., Paparouna, E., et al. (2018) · BMC Genomics · doi:10.1186/s12864-017-4375-1 · Cited by 49 · see citing works
Restorative Biological Processes and Health
Robles, T. F., & Carroll, J. (2011) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2011.00368.x · Cited by 51 · see citing works
Li, Q., Liu, X., & Wei, J. J. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.08.109 · Cited by 49 · see citing works
Wang, J., Wu, P., Chen, P. C.-H., Lee, C.-W., Chen, W., & Hung, S. (2016) · Stem Cells Translational Medicine · doi:10.5966/sctm.2015-0226 · Cited by 49 · see citing works
Ding, C., Min, J., Tan, Y., Zheng, L., Ma, R., Zhao, R., Zhao, H., Ding, Q., Chen, H., & Huo, D. (2024) · Advanced Materials · doi:10.1002/adma.202401361 · Cited by 48 · see citing works
Role of Cellular Senescence and NOX4-Mediated Oxidative Stress in Systemic Sclerosis Pathogenesis
Piera-Velázquez, S., & Jiménez, S. A. (2014) · Current Rheumatology Reports · doi:10.1007/s11926-014-0473-0 · Cited by 48 · see citing works
Manukyan, M., & Singh, P. B. (2014) · Scientific Reports · doi:10.1038/srep04789 · Cited by 49 · see citing works
Bo‐Htay, C., Shwe, T., Higgins, L., Palee, S., Shinlapawittayatorn, K., Chattipakorn, S. C., & Chattipakorn, N. (2019) · GeroScience · doi:10.1007/s11357-019-00132-9 · Cited by 53 · see citing works
Fujimura, K., Wakino, S., Minakuchi, H., Hasegawa, K., Hosoya, K., Komatsu, M., Kaneko, Y., Shinozuka, K., Washida, N., Kanda, T., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094373 · Cited by 45 · see citing works
Dehydroepiandrosterone reduces preadipocyte proliferation via androgen receptor
Fujioka, K., Kajita, K., Wu, Z., Hanamoto, T., Ikeda, T., Mori, I., Okada, H., Yamauchi, M., Uno, Y., Morita, H., et al. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00112.2011 · Cited by 43 · see citing works
Cheng, X. F., Yao, X., Xu, S., Pan, J., Yu, H., Bao, J., Guan, H., Lu, R., & Zhang, L. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.04.074 · Cited by 46 · see citing works
Label-free light-sheet microfluidic cytometry for the automatic identification of senescent cells
Lin, M., Liu, Q., Liu, C., Xu, Q., Shao, C., & Su, X. (2018) · Biomedical Optics Express · doi:10.1364/boe.9.001692 · Cited by 45 · see citing works
Parathyroid hormone ameliorates temporomandibular joint osteoarthritic‐like changes related to age
Cui, C., Zheng, L., Fan, Y., Zhang, J., Xu, R., Xie, J., & Zhou, X. (2020) · Cell Proliferation · doi:10.1111/cpr.12755 · Cited by 43 · see citing works
Frasca, D., Romero, M., Diaz, A., Garcia, D., Thaller, S. R., & Blomberg, B. B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041839 · Cited by 43 · see citing works
DNA double strand break responses and chromatin alterations within the aging cell
Klement, K., & Goodarzi, A. A. (2014) · Experimental Cell Research · doi:10.1016/j.yexcr.2014.09.003 · Cited by 43 · see citing works
Iron homeostasis and neurodegeneration in the ageing brain: Insight into ferroptosis pathways
Alrouji, M., Anwar, S., Venkatesan, K., Shahwan, M. J., Hassan, M. I., Islam, A., & Shamsi, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102575 · Cited by 44 · see citing works
Regulated expression of the lncRNA TERRA and its impact on telomere biology
Oliva-Rico, D., & Herrera, L. A. (2017) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2017.09.001 · Cited by 42 · see citing works
- Authors
- Sikora, E., Arendt, T., Bennett, M., & Narita, M.
- Affiliations
- Instytut Biologii Doświadczalnej im. Marcelego Nenckiego (PL)
- Leipzig University (DE)
- University of Cambridge (GB)
- Cancer Research UK (GB)
- Corresponding author
- Sikora, Ewa
- Venue
- Ageing Research Reviews
- Publisher
- Elsevier BV
- Published
- 2011-01
- Volume
- 10
- Issue
- 1
- Pages
- 146-152
- ISSN
- 1568-1637 (ISSN-L)
- OpenAlex
- W1977970646
- Cited by
- 264
- References
- 102
- Citations by year
- 2026: 7 · 2025: 5 · 2024: 13 · 2023: 11 · 2022: 11 · 2021: 13 · 2020: 14 · 2019: 17 · 2018: 21 · 2017: 19 · 2016: 19 · 2015: 25 · 2014: 23 · 2013: 33 · 2012: 24
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Ageing Research Reviews (publishedVersion)
- PubMed (publishedVersion)
- Funders
- British Heart Foundation (RG/08/009/25841)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- cellular senescence, senescence biomarkers, replicative senescence, stress-induced premature senescence, oncogene-induced senescence, telomere shortening, DNA damage response, senescence-associated β-galactosidase, senescence-associated heterochromatin foci, PML nuclear bodies, senescence-associated secretory phenotype, age-related diseases, aging
- MeSH terms
- Aging, DNA Damage, Humans, Phenotype, Research, Biomarkers, Telomere, Cellular Senescence, Genomic Instability
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review