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Cited by 550Epigenetics and DNA MethylationGenomics and Chromatin DynamicsChromatin Remodeling and Cancer

Mapping Human Epigenomes

Open access
Rivera, Chloe M., Ren, Bing·2013·Cell
DOI 10.1016/j.cell.2013.09.011PMC PMC3838898
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Abstract

As the second dimension to the genome, the epigenome contains key information specific to every type of cells. Thousands of human epigenome maps have been produced in recent years thanks to rapid development of high throughput epigenome mapping technologies. In this review, we discuss the current epigenome mapping toolkit and utilities of epigenome maps. We focus particularly on mapping of DNA methylation, chromatin modification state, and chromatin structures, and emphasize the use of epigenome maps to delineate human gene regulatory sequences and developmental programs. We also provide a perspective on the progress of the epigenomics field and challenges ahead.

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Authors
Rivera, C. M., & Ren, B.
Affiliations
University of California San Diego (US)
Corresponding author
Ren, Bing
ORCID
Ren, Bing
Venue
Cell
Publisher
Elsevier BV
Published
2013-09
Volume
155
Issue
1
Pages
39-55
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2013.09.011
PMC
PMC3838898
OpenAlex
W2005986419
Cited by
550
References
32
Citations by year
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FWCI
5.70
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Human Genome Research Institute (U54HG006997)
  • National Institute of General Medical Sciences (T32GM008666)
  • National Institute of Environmental Health Sciences (U01ES017166)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords
human epigenome, epigenome mapping, DNA methylation, chromatin modification, chromatin structure, gene regulatory sequences, developmental programs
MeSH terms
Animals, Chromatin, Humans, Genome, Human, Sequence Analysis, DNA, DNA Methylation, Epigenesis, Genetic, Genome-Wide Association Study, Epigenomics, High-Throughput Nucleotide Sequencing

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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