Impacts of infection with different toxigenic Clostridium difficile strains on faecal microbiota in children

Ling, Zongxin; Liu, Xia; Jia, Xiaoyun; Cheng, Yiwen; Luo, Yueqiu; Yuan, Li; Wang, Yuezhu; Zhao, Chunna; Guo, Shu; Li, Lanjuan; Xu, Xiwei; Xiang, Charlie

doi:10.1038/srep07485

Cited by 158Clostridium difficile and Clostridium perfringens researchGut microbiota and healthBacterial Identification and Susceptibility Testing

Impacts of infection with different toxigenic Clostridium difficile strains on faecal microbiota in children

Open access

Ling, Zongxin, Liu, Xia, Jia, Xiaoyun, Cheng, Yiwen, Luo, Yueqiu, Yuan, Li, Wang, Yuezhu, Zhao, Chunna +4 more·2014·Scientific Reports

DOI 10.1038/srep07485PMC PMC4265774

Open this paper in CoChat — free account Open PDF

Abstract

Increasing evidence suggests that altered intestinal microbial composition and function result in an increased risk of Clostridium difficile-associated diarrhoea (CDAD); however, the specific changes of intestinal microbiota in children suffering from CDAD and their associations with C. difficile strain toxigenicity are poorly understood. High-throughput pyrosequencing showed that reduced faecal bacterial diversity and dramatic shifts of microbial composition were found in children with CDAD. The Firmicutes/Bacteroidetes ratio was increased significantly in patients with CDAD, which indicated that dysbiosis of faecal microbiota was closely associated with CDAD. C. difficile infection resulted in an increase in lactate-producing phylotypes, with a corresponding decrease in butyrate-producing bacteria. The decrease in butyrate and lactate buildup impaired intestinal colonisation resistance, which increased the susceptibility to C. difficile colonisation. Strains of C. difficile which were positive for both toxin A and toxin B reduced faecal bacterial diversity to a greater degree than strains that were only toxin B-positive, and were associated with unusually abundant Enterococcus, which implies that the C. difficile toxins have different impacts on the faecal microbiota of children. Greater understanding of the relationships between disruption of the normal faecal microbiota and colonisation with C. difficile that produces different toxins might lead to improved treatment.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1038/srep07485

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

The high efficacy rate of FMT in rCDI is not observed under other conditions where the characteristics of donors, recipients, and working protocols appear to largely impact clinical outcomes.
“This concept is supported by evidence that the high efficacy rate of FMT in rCDI is not observed under other conditions where the characteristics of donors, 26,39 recipients, 41,42 and working protocols, 43 appear to largely impact clinical outcomes.”
From Key determinants of success in fecal microbiota transplantation: From microbiome to clinic (2023) · cites this paper as [39]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Metagenomic biomarker discovery and explanation
Segata, N., Izard, J., Waldron, L., Gevers, D., Miropolsky, L., Garrett, W. S., & Huttenhower, C. (2011) · Genome Biology · doi:10.1186/gb-2011-12-6-r60 · Cited by 16,192 · see citing works
An obesity-associated gut microbiome with increased capacity for energy harvest
Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413 · see citing works
Duodenal Infusion of Donor Feces for Recurrent Clostridium difficile
van Nood, E., Vrieze, A., Nieuwdorp, M., Fuentes, S., Zoetendal, E. G., de Vos, W. M., Visser, C. E., Kuijper, E. J., Bartelsman, J. F. W. M., Tijssen, J. G. P., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1205037 · Cited by 3,708 · see citing works
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910 · see citing works
Colonic Health: Fermentation and Short Chain Fatty Acids
Wong, J. M. W., de Souza, R., Kendall, C. W. C., Emam, A., & Jenkins, D. J. A. (2006) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200603000-00015 · Cited by 2,739 · see citing works
Microbiota and SCFA in lean and overweight healthy subjects
Schwiertz, A., Taras, D., Schäfer, K., Beijer, S., Bos, N. A., Donus, C., & Hardt, P. D. (2010) · Obesity · doi:10.1038/oby.2009.167 · Cited by 2,457 · see citing works
A Population-Based Study
Christakis, D., Richards, J. A., Zimmerman, F. J., Garrison, M. M., Xu, D., & Yapanel, U. H. (2009) · Cited by 2,290 · see citing works
Prebiotic effects: metabolic and health benefits
Roberfroid, M. B., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R. A., Rowland, I. R., Wolvers, D. A. W., Watzl, B., Szajewska, H., Stahl, B., et al. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003363 · Cited by 2,098 · see citing works
Impacts of biodiversity on the emergence and transmission of infectious diseases
Keesing, F., Belden, L. K., Daszak, P., Dobson, A., Harvell, C. D., Holt, R. D., Hudson, P., Jolles, A., Jones, K. E., Mitchell, C. E., et al. (2010) · Nature · doi:10.1038/nature09575 · Cited by 2,043 · see citing works
The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age
Mariat, D., Firmesse, O., Levenez, F., Guimarăes, V., Sokol, H., Doré, J., Corthier, G., & Furet, J.-P. (2009) · BMC Microbiology · doi:10.1186/1471-2180-9-123 · Cited by 1,755 · see citing works
The gut microbiota suppresses insulin-mediated fat accumulation via the short-chain fatty acid receptor GPR43
Kimura, I., Ozawa, K., Inoue, D., Imamura, T., Kimura, K., Maeda, T., Terasawa, K., Kashihara, D., Hirano, K., Tani, T., et al. (2013) · Nature Communications · doi:10.1038/ncomms2852 · Cited by 1,512 · see citing works
Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians
Biagi, E., Nylund, L., Candela, M., Ostan, R., Bucci, L., Pini, E., Nikkïla, J., Monti, D., Satokari, R., Franceschi, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010667 · Cited by 1,483 · see citing works
Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and Europe
Warny, M., Pépin, J., Fang, A., Killgore, G., Thompson, A. D., Brazier, J., Frost, E. H., & McDonald, L. C. (2005) · The Lancet · doi:10.1016/s0140-6736(05)67420-x · Cited by 1,423 · see citing works
Gut Microbiota and Metabolic Endotoxemia in Young Obese Mexican Subjects
Radilla-Vázquez, R. B., Parra‐Rojas, I., Martínez-Hernández, N. E., Márquez‐Sandoval, F., Illades‐Aguiar, B., & Castro-Alarcón, N. (2016) · Obesity Facts · doi:10.1159/000442479 · Cited by 1,200 · see citing works
Lactate-Utilizing Bacteria, Isolated from Human Feces, That Produce Butyrate as a Major Fermentation Product
Duncan, S. H., Louis, P., & Flint, H. J. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.10.5810-5817.2004 · Cited by 1,124 · see citing works
Decreased Diversity of the Fecal Microbiome in RecurrentClostridium difficile–Associated Diarrhea
Chang, J. Y., Antonopoulos, D. A., Kalra, A., Tonelli, A., Khalife, W. T., Schmidt, T. M., & Young, V. B. (2008) · The Journal of Infectious Diseases · doi:10.1086/525047 · Cited by 1,010 · see citing works
Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection
Theriot, C. M., Koenigsknecht, M. J., Carlson, P. E., Hatton, G. E., Nelson, A. M., Li, B., Huffnagle, G. B., Z. Li, J., & Young, V. B. (2014) · Nature Communications · doi:10.1038/ncomms4114 · Cited by 974 · see citing works
Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation
de La Serre, C. B., Ellis, C. L., Lee, J., Hartman, A. L., Rutledge, J. C., & Raybould, H. E. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00098.2010 · Cited by 949 · see citing works
The role of toxin A and toxin B in Clostridium difficile infection
Kuehne, S. A., Cartman, S. T., Heap, J. T., Kelly, M. L., Cockayne, A., & Minton, N. P. (2010) · Nature · doi:10.1038/nature09397 · Cited by 853 · see citing works
Gut microbiota composition and development of atopic manifestations in infancy: the KOALA Birth Cohort Study
Penders, J., Thijs, C., van den Brandt, P. A., Kummeling, I., Snijders, B., Stelma, F., Adams, H., van Ree, R., & Stobberingh, E. E. (2007) · Gut · doi:10.1136/gut.2006.100164 · Cited by 844 · see citing works
Toxin B is essential for virulence of Clostridium difficile
Lyras, D., O’Connor, J. R., Howarth, P. M., Sambol, S. P., Carter, G. P., Phumoonna, T., Poon, R., Adams, V., Vedantam, G., Johnson, S., et al. (2009) · Nature · doi:10.1038/nature07822 · Cited by 745 · see citing works
Emergence and global spread of epidemic healthcare-associated Clostridium difficile
He, M., Miyajima, F., Roberts, P., Ellison, L., Pickard, D., Martin, M. J., Connor, T. R., Harris, S. R., Fairley, D., Bamford, K. B., et al. (2012) · Nature Genetics · doi:10.1038/ng.2478 · Cited by 729 · see citing works
Long-term follow-up of colonoscopic fecal microbiota transplant for recurrent Clostridium difficile infection
Brandt, L. J., Aroniadis, O. C., Mellow, M., Kanatzar, A., Kelly, C., Park, T., Stollman, N., Rohlke, F., & Surawicz, C. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2012.60 · Cited by 672 · see citing works
High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota
Zoetendal, E. G., Rajilić-Stojanović, M. D., & de Vos, W. M. (2008) · Gut · doi:10.1136/gut.2007.133603 · Cited by 672 · see citing works
Changes in the Composition of the Human Fecal Microbiome After Bacteriotherapy for Recurrent Clostridium difficile-associated Diarrhea
Khoruts, A., Dicksved, J., Jansson, J. K., & Sadowsky, M. J. (2010) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e3181c87e02 · Cited by 649 · see citing works
Regulation of intestinal inflammation by microbiota following allogeneic bone marrow transplantation
Jenq, R. R., Ubeda, C., Taur, Y., Menezes, C. C., Khanin, R., Dudakov, J. A., Liu, C., West, M. L., Singer, N. V., Equinda, M. J., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20112408 · Cited by 626 · see citing works
Intestinal colonization resistance
Lawley, T. D., & Walker, A. W. (2013) · Immunology · doi:10.1111/j.1365-2567.2012.03616.x · Cited by 610 · see citing works
BACTERIOTHERAPY FOR CHRONIC RELAPSING CLOSTRIDIUM DIFFICILE DIARRHOEA IN SIX PATIENTS
Tvede, M., & Rask-Madsen, J. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92749-9 · Cited by 595 · see citing works
Intestinal dysbiosis and depletion of butyrogenic bacteria in Clostridium difficile infection and nosocomial diarrhea.
Antharam, V. C., Li, E. C., Ishmael, A., Sharma, A., Mai, V., Rand, K. H., & Wang, G. P. (2013) · Journal of Clinical Microbiology · doi:10.1128/jcm.00845-13 · Cited by 485 · see citing works
Fecal Microbiota Transplantation for the Treatment of Clostridium difficile Infection: A Systematic Review
Cammarota, G., Ianiro, G., & Gasbarrini, A. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000046 · Cited by 428 · see citing works
Comparison of the Fecal Microbiota of Healthy Horses and Horses with Colitis by High Throughput Sequencing of the V3-V5 Region of the 16S rRNA Gene
Costa, M., Arroyo, L. G., Allen‐Vercoe, E., Stämpfli, H. R., Kim, P. T., Sturgeon, A., & Weese, J. S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041484 · Cited by 426 · see citing works
Influence of antibiotic exposure in the early postnatal period on the development of intestinal microbiota
Tanaka, S., Kobayashi, T., Songjinda, P., Tateyama, A., Tsubouchi, M., Kiyohara, C., Shirakawa, T., Sonomoto, K., & Nakayama, J. (2009) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2009.00553.x · Cited by 396 · see citing works
Diarrhea in young children from low-income countries leads to large-scale alterations in intestinal microbiota composition
Pop, M., Walker, A. W., Paulson, J. N., Lindsay, B. R., Antonio, M., Hossain, M. A., Oundo, J. O., Tamboura, B., Mai, V., Astrovskaya, I., et al. (2014) · Genome biology · doi:10.1186/gb-2014-15-6-r76 · Cited by 376 · see citing works
Altered Fecal Microbiota Composition Associated with Food Allergy in Infants
Ling, Z., Li, Z., Liu, X., Cheng, Y., Luo, Y., Tong, X., Li, Y., Wang, Y., Sun, J., Li, L., et al. (2014) · Applied and Environmental Microbiology · doi:10.1128/aem.00003-14 · Cited by 375 · see citing works
Self-citation
Multiplex PCR Targetingtpi(Triose Phosphate Isomerase),tcdA(Toxin A), andtcdB(Toxin B) Genes for Toxigenic Culture ofClostridium difficile
Lemée, L., Dhalluin, A., Testelin, S., Mattrat, M.-A., Maillard, K. I., Lemeland, J., & Pons, J.-L. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.12.5710-5714.2004 · Cited by 338 · see citing works
Gut bacterial microbiota and obesity
Million, M., Lagier, J., Yahav, D., & Paul, M. (2013) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12172 · Cited by 290 · see citing works
Bacteriotherapy for chronic relapsing Clostridium difficile in six patients
Tvede, M. (1989) · The Lancet · Cited by 290 · see citing works
Large clostridial cytotoxins — a family of glycosyltransferases modifying small GTP-binding proteins
VONEICHELSTREIBER, C., Boquet, P., Sauerborn, M., & Thelestam, M. (1996) · Trends in Microbiology · doi:10.1016/0966-842x(96)10061-5 · Cited by 256 · see citing works
Characterization of a Toxin A-Negative, Toxin B-Positive Strain of Clostridium difficile Responsible for a Nosocomial Outbreak of Clostridium difficile -Associated Diarrhea
Alfa, M. J., Kabani, A. M., Lyerly, D. M., Moncrief, S., Neville, L. M., Albarrak, A. M., Harding, G., Dyck, B., Olekson, K., & Embil, J. M. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.7.2706-2714.2000 · Cited by 242 · see citing works
Clostridium difficile Infections among Hospitalized Children, United States, 1997–2006
Zilberberg, M. D., Tillotson, G., & McDonald, L. C. (2010) · Emerging infectious diseases · doi:10.3201/eid1604.090680 · Cited by 240 · see citing works
Interaction between the intestinal microbiota and host in Clostridium difficile colonization resistance
Britton, R. A., & Young, V. B. (2012) · Trends in Microbiology · doi:10.1016/j.tim.2012.04.001 · Cited by 236 · see citing works
Clostridium difficile Carriage in Elderly Subjects and Associated Changes in the Intestinal Microbiota
Rea, M. C., O’Sullivan, Ó., Shanahan, F., O’Toole, P. W., Stanton, C., Ross, R. P., & Hill, C. (2011) · Journal of Clinical Microbiology · doi:10.1128/jcm.05176-11 · Cited by 224 · see citing works
Importance of Toxin A, Toxin B, and CDT in Virulence of an Epidemic Clostridium difficile Strain
Kuehne, S. A., Collery, M. M., Kelly, M. L., Cartman, S. T., Cockayne, A., & Minton, N. P. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit426 · Cited by 220 · see citing works
The Epidemiology of Clostridium difficile Infection in Children: A Population-Based Study
Khanna, S., Baddour, L. M., Huskins, W. C., Kammer, P. P., Faubion, W. A., Zinsmeister, A. R., Harmsen, W. S., & Pardi, D. S. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit075 · Cited by 208 · see citing works
Clostridium difficile Carriage in Healthy Infants in the Community: A Potential Reservoir for Pathogenic Strains
Rousseau, C., Poilane, I., de Pontual, L., Maherault, A.-C., Monnier, A. L., & Collignon, A. (2012) · Clinical Infectious Diseases · doi:10.1093/cid/cis637 · Cited by 192 · see citing works
Toward an understanding of changes in diversity associated with fecal microbiome transplantation based on 16S rRNA gene deep sequencing
Shahinas, D., Silverman, M., Sittler, T., Chiu, C., Kim, P., Allen-Vercoe, E., Weese, S., Wong, A., Low, D. E., & Pillai, D. R. (2012) · mBio · doi:10.1128/mbio.00338-12 · Cited by 191 · see citing works
A Hospital Outbreak of Clostridium difficile Disease Associated with Isolates Carrying Binary Toxin Genes
McEllistrem, M. C., Carman, R. J., Gerding, D. N., Genheimer, C. W., & Zheng, L. (2004) · Clinical Infectious Diseases · doi:10.1086/427113 · Cited by 173 · see citing works
Characterization of the Sporulation Initiation Pathway of Clostridium difficile and Its Role in Toxin Production
Underwood, S., Guan, S., Subhash, V. V., Baines, S. D., Graham, L., Lewis, R. J., Wilcox, M. H., & Stephenson, K. (2009) · Journal of Bacteriology · doi:10.1128/jb.00882-09 · Cited by 165 · see citing works
Comparative Metagenomic Study of Alterations to the Intestinal Microbiota and Risk of NosocomialClostridum difficile–Associated Disease
Manges, A. R., Labbe, A., Loo, V. G., Atherton, J., Behr, M. A., Masson, L., Tellis, P. A., & Brousseau, R. (2010) · The Journal of Infectious Diseases · doi:10.1086/657319 · Cited by 151 · see citing works
Clostridium difficile Colonization in Early Infancy Is Accompanied by Changes in Intestinal Microbiota Composition
Rousseau, C., Levenez, F., Fouqueray, C., Dore, J. M., Collignon, A., & Lepage, P. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.01507-10 · Cited by 138 · see citing works
Toxins, Butyric Acid, and Other Short-Chain Fatty Acids Are Coordinately Expressed and Down-Regulated by Cysteine in Clostridium difficile
Karlsson, S., Lindberg, A., Norin, E. L., BURMAN, L. G., & Åkerlund, T. (2000) · Infection and Immunity · doi:10.1128/iai.68.10.5881-5888.2000 · Cited by 135 · see citing works
Pyrosequencing analysis of the human microbiota of healthy Chinese undergraduates
Ling, Z., Liu, X., Luo, Y., Yuan, L., Nelson, K. E., Wang, Y., Xiang, C., & Li, L. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-390 · Cited by 127 · see citing works
Self-citation
Obesity as a Risk Factor for Clostridium difficile Infection
Bishara, J., Farah, R. E., Mograbi, J., Khalaila, W., Abu‐Elheja, O., Mahamid, M., & Nseir, W. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cit280 · Cited by 109 · see citing works
Clostridium difficile in children: Colonisation and disease
Enoch, D., Butler, M. J., Pai, S., Aliyu, S. H., & Karas, J. A. (2011) · Journal of Infection · doi:10.1016/j.jinf.2011.05.016 · Cited by 102 · see citing works
Outcomes in community‐acquired Clostridium difficile infection
Khanna, S., Pardi, D. S., Aronson, S. L., Kammer, P. P., & Baddour, L. M. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04984.x · Cited by 83 · see citing works
Lack of association of tcdC type and binary toxin status with disease severity and outcome in toxigenic Clostridium difficile
Goldenberg, S. D., & French, G. L. (2011) · Journal of Infection · doi:10.1016/j.jinf.2011.03.001 · Cited by 82 · see citing works
Bacteriotherapy for the treatment of intestinal dysbiosis caused by Clostridium difficile infection
Adamu, B. O., & Lawley, T. D. (2013) · Current Opinion in Microbiology · doi:10.1016/j.mib.2013.06.009 · Cited by 39 · see citing works
Clostridium difficile
Curry, S. R. (2010) · Clinics in Laboratory Medicine · doi:10.1016/j.cll.2010.04.001 · Cited by 33 · see citing works
Clostridium difficile
Snow, M. (2011) · Nursing · doi:10.1097/01.nurse.0000399594.28533.35 · Cited by 10 · see citing works

Flagged first, then by citations

Sorted by citations

The Human Microbiota in Health and Disease
Wang, B., Yao, M., Lv, L., Ling, Z., & Li, L. (2017) · Engineering · doi:10.1016/j.eng.2017.01.008 · Cited by 861 · see citing works
Self-citation
Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma
Ren, Z., Li, A., Jiang, J., Zhou, L., Yu, Z., Lu, H., Xie, H., Chen, X., Shao, L., Zhang, R., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315084 · Cited by 772 · see citing works
Self-citation
Interaction of the microbiota with the human body in health and diseases
Altveş, S., Yıldız, H. K., & Vural, H. C. (2019) · Bioscience of Microbiota Food and Health · doi:10.12938/bmfh.19-023 · Cited by 398 · see citing works
Dietary fucoidan modulates the gut microbiota in mice by increasing the abundance of Lactobacillus and Ruminococcaceae
Shang, Q., Shan, X., Cai, C., Hao, J., Li, G., & Yu, G. (2016) · Food & Function · doi:10.1039/c6fo00309e · Cited by 359 · see citing works
Key determinants of success in fecal microbiota transplantation: From microbiome to clinic
Porcari, S., Benech, N., Valles-Colomer, M., Segata, N., Gasbarrini, A., Cammarota, G., Sokol, H., & Ianiro, G. (2023) · Cell Host & Microbe · doi:10.1016/j.chom.2023.03.020 · Cited by 331 · see citing works
Antibiotic use and microbiome function
Ferrer, M., Méndez–García, C., Rojo, D., Barbas, C., & Moyá, A. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.09.007 · Cited by 300 · see citing works
Dietary fucoidan improves metabolic syndrome in association with increased Akkermansia population in the gut microbiota of high-fat diet-fed mice
Shang, Q., Song, G., Zhang, M., Shi, J., Xu, C., Hao, J., Li, G., & Yu, G. (2017) · Journal of Functional Foods · doi:10.1016/j.jff.2016.11.002 · Cited by 258 · see citing works
Xiexin Tang improves the symptom of type 2 diabetic rats by modulation of the gut microbiota
Wei, X., Tao, J., Xiao, S., Jiang, S., Shang, E., Zhu, Z., Qian, D., & Duan, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-22094-2 · Cited by 255 · see citing works
Gut microbial profile analysis by MiSeq sequencing of pancreatic carcinoma patients in China
Ren, Z., Jiang, J., Xie, H., Li, A., Lu, H., Xu, S., Zhou, L., Zhang, H., Cui, G., Chen, X., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18820 · Cited by 228 · see citing works
Self-citation
The Potential Role of Gut Microbiota in Alzheimer’s Disease: From Diagnosis to Treatment
Varesi, A., Pierella, E., Romeo, M., Piccini, G. B., Alfano, C., Bjørklund, G., Oppong, A., Ricevuti, G., Esposito, C., Chirumbolo, S., et al. (2022) · Nutrients · doi:10.3390/nu14030668 · Cited by 225 · see citing works
Prebiotic Effect of Fructooligosaccharides from Morinda officinalis on Alzheimer’s Disease in Rodent Models by Targeting the Microbiota-Gut-Brain Axis
Chen, D., Yang, X., Yang, J., Lai, G., Yong, T., Tang, X., Shuai, O., Zhou, G., Xie, Y., & Wu, Q. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00403 · Cited by 227 · see citing works
Comparative In silico Analysis of Butyrate Production Pathways in Gut Commensals and Pathogens
Anand, S., Kaur, H., & Mande, S. S. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.01945 · Cited by 225 · see citing works
Characterizing bacterial communities in tilapia pond surface sediment and their responses to pond differences and temporal variations
Fan, L., Barry, K., Hu, G., Meng, S., Song, C., Qiu, L., Zheng, Y., Wu, W., Jianhong, Q., Chen, J., et al. (2016) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-016-2144-y · Cited by 199 · see citing works
Alterations in the Fecal Microbiota of Patients with HIV-1 Infection: An Observational Study in A Chinese Population
Ling, Z., Jin, C., Xie, T., Cheng, Y., Li, L., & Wu, N. (2016) · Scientific Reports · doi:10.1038/srep30673 · Cited by 185 · see citing works
Self-citation
The oral microbiota – a mechanistic role for systemic diseases
Jia, G., Zhi, A., Lai, P. F. H., Wang, G., Xia, Y., Xiong, Z., Zhang, H., Che, N., & Ai, L. (2018) · BDJ · doi:10.1038/sj.bdj.2018.217 · Cited by 183 · see citing works
Carrageenan-induced colitis is associated with decreased population of anti-inflammatory bacterium, Akkermansia muciniphila , in the gut microbiota of C57BL/6J mice
Shang, Q., Sun, W., Shan, X., Jiang, H., Cai, C., Hao, J., Li, G., & Yu, G. (2017) · Toxicology Letters · doi:10.1016/j.toxlet.2017.07.904 · Cited by 178 · see citing works
Microbiota assemblages of water, sediment, and intestine and their associations with environmental factors and shrimp physiological health
Huang, F., Pan, L., Song, M., Tian, C., & Gao, S. (2018) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-018-9229-5 · Cited by 177 · see citing works
Alterations of the Human Gut Microbiome in Chronic Kidney Disease
Ren, Z., Fan, Y., Li, A., Shen, Q., Wu, J., Ren, L., Lu, H., Ding, S., Ren, H., Liu, C., et al. (2020) · Advanced Science · doi:10.1002/advs.202001936 · Cited by 173 · see citing works
Self-citation
Roles and Mechanisms of Gut Microbiota in Patients With Alzheimer’s Disease
Wu, S., Liu, X., Jiang, R., Yan, X., & Ling, Z. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.650047 · Cited by 146 · see citing works
Self-citation
Tongue coating microbiome data distinguish patients with pancreatic head cancer from healthy controls
Lu, H., Ren, Z., Li, A., Li, J., Xu, S., Zhang, H., Jiang, J., Yang, J., Luo, Q., Zhou, K., et al. (2019) · Journal of Oral Microbiology · doi:10.1080/20002297.2018.1563409 · Cited by 142 · see citing works
Self-citation
Blood-Based Biomarkers for Alzheimer’s Disease Diagnosis and Progression: An Overview
Varesi, A., Carrara, A., Pires, V. G., Floris, V., Pierella, E., Savioli, G., Prasad, S., Esposito, C., Ricevuti, G., Chirumbolo, S., et al. (2022) · Cells · doi:10.3390/cells11081367 · Cited by 142 · see citing works
Probiotics, prebiotics, and synbiotics regulate the intestinal microbiota differentially and restore the relative abundance of specific gut microorganisms
Li, C., Niu, Z., Zou, M., Liu, S., Wang, M., Gu, X., Lu, H., Tian, H., & Jha, R. (2020) · Journal of Dairy Science · doi:10.3168/jds.2019-18003 · Cited by 141 · see citing works
The modulatory effect of (-)-epigallocatechin 3-O-(3-O-methyl) gallate (EGCG3″Me) on intestinal microbiota of high fat diet-induced obesity mice model
Cheng, M., Zhang, X., Miao, Y., Cao, J., Wu, Z., & Weng, P. (2016) · Food Research International · doi:10.1016/j.foodres.2016.12.008 · Cited by 137 · see citing works
Gut Microbiota as a Prospective Therapeutic Target for Curcumin: A Review of Mutual Influence
Zam, W. (2018) · Journal of Nutrition and Metabolism · doi:10.1155/2018/1367984 · Cited by 117 · see citing works
Oral Administration of a Select Mixture of Bacillus Probiotics Affects the Gut Microbiota and Goblet Cell Function following Escherichia coli Challenge in Newly Weaned Pigs of Genotype MUC4 That Are Supposed To Be Enterotoxigenic E. coli F4ab/ac Receptor Negative
Zhang, W., Zhu, Y., Zhou, D. B., Wu, Q., Song, D., Dicksved, J., & Wang, J. (2016) · Applied and Environmental Microbiology · doi:10.1128/aem.02747-16 · Cited by 113 · see citing works
Effects of Oligosaccharides From Morinda officinalis on Gut Microbiota and Metabolome of APP/PS1 Transgenic Mice
Yang, X., Diling, C., Yang, J. T., Ting, L., Guoyan, H., Hualun, L., Xiaocui, T., Lai, G., Shuai, O., Chaoqun, Z., et al. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00412 · Cited by 108 · see citing works
MICROBIOTA INSIGHTS IN CLOSTRIDIUM DIFFICILE INFECTION AND INFLAMMATORY BOWEL DISEASE
Rodriguez, C., Romero, E., Garrido‐Sánchez, L., Alcaín‐Martínez, G., Andrade, R., Taminiau, B., Daube, G., & García‐Fuentes, E. (2020) · Gut Microbes · doi:10.1080/19490976.2020.1725220 · Cited by 105 · see citing works
Modulation of Gut Microbiome Composition and Function in Experimental Colitis Treated with Sulfasalazine
Zheng, H., Chen, M., Li, Y., Wang, Y., Lin, W., Liao, Z., Wang, M., Ma, F., Liao, Q., & Xie, Z. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01703 · Cited by 102 · see citing works
Self-citation
Decreased Diversity of the Oral Microbiota of Patients with Hepatitis B Virus-Induced Chronic Liver Disease: A Pilot Project
Ling, Z., Liu, X., Cheng, Y., Jiang, X., Jiang, H., Wang, Y., & Li, L. (2015) · Scientific Reports · doi:10.1038/srep17098 · Cited by 102 · see citing works
Self-citation
Immunomodulatory Activities of a Fungal Protein Extracted from Hericium erinaceus through Regulating the Gut Microbiota
Diling, C., Chaoqun, Z., Yang, J., Jian, L., Su, J., Yizhen, X., & Lai, G. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00666 · Cited by 103 · see citing works
Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Clostridium difficile Infections
Baktash, A., Terveer, E. M., Zwittink, R. D., Hornung, B., Corver, J., Kuijper, E. J., & Smits, W. K. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.01242 · Cited by 102 · see citing works
Effects of high ambient temperature on the community structure and composition of ileal microbiome of broilers
Wang, X. J., Feng, J., Zhang, M. H., Li, X. M., Ma, D., & Chang, S. S. (2018) · Poultry Science · doi:10.3382/ps/pey032 · Cited by 100 · see citing works
Extracts fromHericium erinaceusrelieve inflammatory bowel disease by regulating immunity and gut microbiota
Diling, C., Yang, X., Chaoqun, Z., Yang, J., Xiaocui, T., Jun, C., Shuai, O., & Yizhen, X. (2017) · Oncotarget · doi:10.18632/oncotarget.20689 · Cited by 90 · see citing works
Chinese yam (Dioscorea opposita Thunb.) alleviates antibiotic-associated diarrhea, modifies intestinal microbiota, and increases the level of short-chain fatty acids in mice
Zhang, N., Liang, T., Jin, Q., Shen, C., Zhang, Y., & Jing, P. (2019) · Food Research International · doi:10.1016/j.foodres.2019.04.016 · Cited by 88 · see citing works
The Gut Microbiome in Inflammatory Bowel Disease: Lessons Learned From Other Immune-Mediated Inflammatory Diseases
Knox, N., Forbes, J. D., Peterson, C.-L., Domselaar, G. V., & Bernstein, C. N. (2019) · The American Journal of Gastroenterology · doi:10.14309/ajg.0000000000000305 · Cited by 84 · see citing works
Salmonella enterica Serovar Typhimurium Exploits Inflammation to Modify Swine Intestinal Microbiota
Drumo, R., Pesciaroli, M., Ruggeri, J., Tarantino, M., Chirullo, B., Pistoia, C., Petrucci, P., Martinelli, N., Moscati, L., Manuali, E., et al. (2016) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2015.00106 · Cited by 78 · see citing works
Identification of key taxa that favor intestinal colonization of Clostridium difficile in an adult Chinese population
Gu, S., Chen, Y., Zhang, X., Lu, H., Lv, T., Shen, P., Lv, L., Zheng, B., Jiang, X., & Li, L. (2015) · Microbes and Infection · doi:10.1016/j.micinf.2015.09.008 · Cited by 77 · see citing works
Self-citation
Structural and functional changes within the gut microbiota and susceptibility to Clostridium difficile infection
Ross, C. L., Spinler, J. K., & Savidge, T. (2016) · Anaerobe · doi:10.1016/j.anaerobe.2016.05.006 · Cited by 74 · see citing works
Sulfated polysaccharide from sea cucumber modulates the gut microbiota and its metabolites in normal mice
Zhu, Z., Zhu, B., Sun, Y., Ai, C., Wu, S., Wang, L., Song, S., & Liu, X. (2018) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2018.08.098 · Cited by 76 · see citing works
Self-citation
Skin microbiota of first cousins affected by psoriasis and atopic dermatitis
Drago, L., Grandi, R. D., Altomare, G. F., Pigatto, P. D. M., Rossi, O., & Toscano, M. (2016) · Clinical and Molecular Allergy · doi:10.1186/s12948-016-0038-z · Cited by 76 · see citing works
Gleaning Insights from Fecal Microbiota Transplantation and Probiotic Studies for the Rational Design of Combination Microbial Therapies
Hudson, L. E., Anderson, S. E., Corbett, A. H., & Lamb, T. J. (2016) · Clinical Microbiology Reviews · doi:10.1128/cmr.00049-16 · Cited by 76 · see citing works
Depth-resolved microbial community analyses in two contrasting soil cores contaminated by antimony and arsenic
Xiao, E., Krumins, V., Xiao, T., Dong, Y., Tang, S., Ning, Z., Huang, Z., & Sun, W. (2016) · Environmental Pollution · doi:10.1016/j.envpol.2016.11.071 · Cited by 73 · see citing works
Characterization of the Human Oropharyngeal Microbiomes in SARS‐CoV‐2 Infection and Recovery Patients
Gao, M., Wang, H., Luo, H., Sun, Y., Wang, L., Ding, S., Ren, H., Gang, J., Rao, B., Liu, S., et al. (2021) · Advanced Science · doi:10.1002/advs.202102785 · Cited by 72 · see citing works
Changes in the gastrointestinal microbiota of children with acute lymphoblastic leukaemia and its association with antibiotics in the short term
Bai, L., Zhou, P., Li, D., & Ju, X. (2017) · Journal of Medical Microbiology · doi:10.1099/jmm.0.000568 · Cited by 72 · see citing works
Interactions of Dihydromyricetin, a Flavonoid from Vine Tea ( Ampelopsis grossedentata ) with Gut Microbiota
Li, F., Zhao, X., Tong, Q., Zhou, X., Chen, J., Xiong, W., Fang, J., Wang, W., & Shi, C. (2018) · Journal of Food Science · doi:10.1111/1750-3841.14128 · Cited by 69 · see citing works
Subchronic oral mercury caused intestinal injury and changed gut microbiota in mice
Zhao, Y., Zhou, C., Wu, C., Guo, X., Hu, G., Wu, Q., Xu, Z. Q., Li, G., Cao, H., Li, L., et al. (2020) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2020.137639 · Cited by 67 · see citing works
Self-citation
Diversity of the microbial community and cultivable protease-producing bacteria in the sediments of the Bohai Sea, Yellow Sea and South China Sea
Jiang, Z., Chen, M., Huang, J., Guo, X., Zhang, Y., Liu, D., Wu, R., He, H., & Wang, J. (2019) · PLoS ONE · doi:10.1371/journal.pone.0215328 · Cited by 65 · see citing works
Changes in the Intestinal Microbiota of Gibel Carp (Carassius gibelio) Associated with Cyprinid herpesvirus 2 (CyHV-2) Infection
She, R., Li, T.-T., Luo, D., Li, J., Yin, L.-Y., Li, H., Liu, Y.-M., Li, X.-Z., & Yan, Q. (2017) · Current Microbiology · doi:10.1007/s00284-017-1294-y · Cited by 63 · see citing works
Potential prebiotic activities of soybean peptides Maillard reaction products on modulating gut microbiota to alleviate aging-related disorders in D-galactose-induced ICR mice
Zhang, Z., He, S., Cao, X., Ye, Y., Yang, L., Wang, J., Liu, H., & Sun, H. (2019) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103729 · Cited by 62 · see citing works
The preventive effects of probiotic Akkermansia muciniphila on D-galactose/AlCl3 mediated Alzheimer's disease-like rats
He, X., Yan, C., Zhao, S., Zhao, Y., Huang, R., & Li, Y. (2022) · Experimental Gerontology · doi:10.1016/j.exger.2022.111959 · Cited by 59 · see citing works
Correlating microbial community profiles with geochemical conditions in a watershed heavily contaminated by an antimony tailing pond
Xiao, E., Krumins, V., Tang, S., Xiao, T., Ning, Z., Lan, X., & Sun, W. (2016) · Environmental Pollution · doi:10.1016/j.envpol.2016.04.087 · Cited by 58 · see citing works
Effects of High Carbohydrate Diet-Modulated Microbiota on Gut Health in Chinese Perch
Zhang, Y., Liang, X., He, S., Xu, C., Wang, J., Li, J., Zhu, Q.-S., Zhang, Z., Li, L., & Alam, M. S. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.575102 · Cited by 49 · see citing works
Self-citation
Bacterioplankton community analysis in tilapia ponds by Illumina high-throughput sequencing
Li, F., Barry, K., Hu, G., Meng, S., Song, C., Wu, W., Chen, J. Z., & Xu, P. (2015) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-015-1962-7 · Cited by 48 · see citing works
Characterization of the microbial community composition and the distribution of Fe-metabolizing bacteria in a creek contaminated by acid mine drainage
Sun, W., Xiao, E., Krumins, V., Dong, Y., Xiao, T., Ning, Z., Chen, H., & Xiao, Q. (2016) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-016-7653-y · Cited by 48 · see citing works
A Meta-Transcriptomics Survey Reveals Changes in the Microbiota of the Chinese Mitten Crab Eriocheir sinensis Infected with Hepatopancreatic Necrosis Disease
Shen, H., Zang, Y., Song, K., Ma, Y., Dai, T., & Serwadda, A. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00732 · Cited by 48 · see citing works
Clostridioides difficile and Gut Microbiota: From Colonization to Infection and Treatment
Spigaglia, P. (2024) · Pathogens · doi:10.3390/pathogens13080646 · Cited by 51 · see citing works
Clostridium butyricumCombined withBifidobacterium infantisProbiotic Mixture Restores Fecal Microbiota and Attenuates Systemic Inflammation in Mice with Antibiotic-Associated Diarrhea
Ling, Z., Liu, X., Cheng, Y., Luo, Y., Li, Y., Li, L., & Xiang, C. (2015) · BioMed Research International · doi:10.1155/2015/582048 · Cited by 45 · see citing works
Self-citation
Deterministic processes dominate soil methanotrophic community assembly in grassland soils
Kou, Y., Wei, K., Li, C., Wang, Y., Tu, B., Wang, J., Li, X., & Yao, M. (2019) · Geoderma · doi:10.1016/j.geoderma.2019.114004 · Cited by 45 · see citing works
Self-citation
A metagenomic analysis of the modulatory effect of Cyclocarya paliurus flavonoids on the intestinal microbiome in a high‐fat diet‐induced obesity mouse model
Cheng, L., Chen, Y., Zhang, X., Zheng, X., Cao, J., Wu, Z., Qin, W., & Cheng, K. (2019) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.9622 · Cited by 43 · see citing works
Clostridioides difficile Infection
Stewart, D. B. (2020) · Clinics in Colon and Rectal Surgery · doi:10.1055/s-0040-1701228 · Cited by 43 · see citing works
Warming facilitates microbial reduction and release of arsenic in flooded paddy soil and arsenic accumulation in rice grains
Yuan, H., Wan, Q., Huang, Y., Chen, Z., He, X., Gustave, W., Manzoor, M., Liu, X., Tang, X., Ma, L. Q., et al. (2020) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2020.124913 · Cited by 43 · see citing works
Self-citation
Anti-obesity effects of Grifola frondosa through the modulation of lipid metabolism via ceramide in mice fed a high-fat diet
Jiang, X., Hao, J., Liu, Z., Ma, X., Feng, Y., Teng, L., Li, Y., & Wang, D. (2021) · Food & Function · doi:10.1039/d1fo00666e · Cited by 42 · see citing works
Defined Nutrient Diets Alter Susceptibility to Clostridium difficile Associated Disease in a Murine Model
Moore, J. H., Pinheiro, C. C. D., Zaenker, E. I., Bolick, D. T., Kolling, G. L., van Opstal, E. J., Noronha, F. J., de Medeiros, P. H. Q. S., Rodriguez, R. S., Lima, A. Â. M., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0131829 · Cited by 42 · see citing works
Fine-tuning the gut ecosystem: the current landscape and outlook of artificial microbiome therapeutics
Porcari, S., Fusco, W. G., Spivak, I., Fiorani, M., Gasbarrini, A., Elinav, E., Cammarota, G., & Ianiro, G. (2024) · The Lancet. Gastroenterology & hepatology · doi:10.1016/s2468-1253(23)00357-6 · Cited by 42 · see citing works
Vancomycin Treatment Alters Humoral Immunity and Intestinal Microbiota in an Aged Mouse Model ofClostridium difficileInfection
van Opstal, E. J., Kolling, G. L., Moore, J. H., Coquery, C. M., Wade, N. S., Loo, W. M., Bolick, D. T., Shin, J. H., Erickson, L. D., & Warren, C. A. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw071 · Cited by 39 · see citing works
Diversity and characterization of bacteria associated with the deep-sea hydrothermal vent crab Austinograea sp. comparing with those of two shallow-water crabs by 16S ribosomal DNA analysis
Zhang, N., Song, C., Wang, M., Liu, Y., Hui, M., & Cui, Z. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187842 · Cited by 39 · see citing works
Probiotics as adjunctive therapy for preventing Clostridium difficile infection – What are we waiting for?
Spinler, J. K., Ross, C. L., & Savidge, T. (2016) · Anaerobe · doi:10.1016/j.anaerobe.2016.05.007 · Cited by 39 · see citing works
Microbiota and pathogen ‘pas de deux’: setting up and breaking down barriers to intestinal infection
McKenney, E. S., & Kendall, M. M. (2016) · Pathogens and Disease · doi:10.1093/femspd/ftw051 · Cited by 39 · see citing works
Akebia Saponin D Regulates the Metabolome and Intestinal Microbiota in High Fat Diet-Induced Hyperlipidemic Rats
Zhou, P., Yang, X., Yang, Z., Huang, W., Kou, J., & Li, F. (2019) · Molecules · doi:10.3390/molecules24071268 · Cited by 35 · see citing works
Butyrolactone‐I, an efficient α‐glucosidase inhibitor, improves type 2 diabetes with potent TNF‐α–lowering properties through modulating gut microbiota in db/db mice
Wu, W. D., Liu, L., Zhu, H., Sun, Y., Wu, Y., Liao, H., Gui, Y., Li, L., Liu, L., Sun, F., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201901061r · Cited by 35 · see citing works
Self-citation
Protective Effect of Carvacrol against Gut Dysbiosis and Clostridium difficile Associated Disease in a Mouse Model
Mooyottu, S., Flock, G. H., Upadhyay, A., Upadhyaya, I., Maas, K. R., & Venkitanarayanan, K. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00625 · Cited by 34 · see citing works
Fecal microbiota transplantation for recurrent C. difficile infection in patients with inflammatory bowel disease: A systematic review and meta-analysis
Porcari, S., Baunwall, S. M. D., Occhionero, A. S., Ingrosso, M. R., Ford, A. C., Hvas, C. L., Gasbarrini, A., Cammarota, G., & Ianiro, G. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103036 · Cited by 33 · see citing works
Increased age and proton pump inhibitors are associated with severe Clostridium difficile infections in children
Chang, T., Hsu, W.-Y., Yang, T.-I., Lu, C., Hsueh, P., Chen, J., Lee, P., Huang, L., & Chang, L. (2018) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2018.09.002 · Cited by 33 · see citing works
Effects of microcystin-LR on gut microflora in different gut regions of mice
Chen, J., Xie, P., Lin, J., He, J., Zeng, C., & Chen, J. (2015) · The Journal of Toxicological Sciences · doi:10.2131/jts.40.485 · Cited by 33 · see citing works
Astaxanthin From Haematococcus pluvialis Prevents High-Fat Diet-Induced Hepatic Steatosis and Oxidative Stress in Mice by Gut-Liver Axis Modulating Properties
Wang, M., Xu, W., Yu, J., Liu, Y., Ma, H., Ji, C., Zhang, C., Xue, J., Li, R., & Cui, H. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.840648 · Cited by 32 · see citing works
Dietary Keratan Sulfate from Shark Cartilage Modulates Gut Microbiota and Increases the Abundance of Lactobacillus spp.
Shang, Q., Li, Q., Zhang, M., Song, G., Shi, J., Jiang, H., Cai, C., Hao, J., Li, G., & Yu, G. (2016) · Marine Drugs · doi:10.3390/md14120224 · Cited by 32 · see citing works
Spatial distribution of planktonic bacterial and archaeal communities in the upper section of the tidal reach in Yangtze River
Fan, L., Song, C., Meng, S., Qiu, L., Zheng, Y., Wu, W., Jianhong, Q., Li, D., Zhang, C., Hu, G., et al. (2016) · Scientific Reports · doi:10.1038/srep39147 · Cited by 32 · see citing works
Enrofloxacin Shifts Intestinal Microbiota and Metabolic Profiling and Hinders Recovery from Salmonella enterica subsp. enterica Serovar Typhimurium Infection in Neonatal Chickens
Ma, B., Mei, X., Lei, C., Cui, L., Gao, Y., Kong, L., Zhai, X., & Wang, H. (2020) · mSphere · doi:10.1128/msphere.00725-20 · Cited by 31 · see citing works
Bacterial Gut Microbiota and Infections During Early Childhood
George, S., Aguilera, X., Gallardo, P., Farfán, M. J., Lucero, Y., Torres, J. P., Vidal, R. M., & O’Ryan, M. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.793050 · Cited by 33 · see citing works
Huoxiang Zhengqi alleviates azoxymethane/dextran sulfate sodium-induced colitis-associated cancer by regulating Nrf2/NF-κB/NLRP3 signaling
Dong, M., Liu, H., Cao, T., Li, L., Sun, Z. H., Qiu, Y., & Wang, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1002269 · Cited by 30 · see citing works
Self-citation
Deoxycholic Acid and Lithocholic Acid Alleviate Liver Injury and Inflammation in Mice with Klebsiella pneumoniae-Induced Liver Abscess and Bacteremia
Zheng, Y., Yue, C., Zhang, H., Chen, H., Liu, Y., & Li, J. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s298495 · Cited by 28 · see citing works
Fecal Microbiota Transplantation Increases Colonic IL-25 and Dampens Tissue Inflammation in Patients with Recurrent Clostridioides difficile
Jan, N., Hays, R. A., Oakland, D. N., Kumar, P., Ramakrishnan, G., Behm, B. W., Petri, W. A., & Marie, C. S. (2021) · mSphere · doi:10.1128/msphere.00669-21 · Cited by 28 · see citing works
Influence of Novel Highly Pathogenic Avian Influenza A (H5N1) Virus Infection on Migrating Whooper Swans Fecal Microbiota
Zhao, N., Wang, S., Li, H., Liu, S., Li, M., Luo, J., Su, W., & He, H. (2018) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2018.00046 · Cited by 28 · see citing works
Porcine deltacoronavirus infection alters bacterial communities in the colon and feces of neonatal piglets
Li, H., Li, B., Liang, Q., Jin, X., Tang, L., Ding, Q., Wang, Z., & Wei, Z. (2020) · MicrobiologyOpen · doi:10.1002/mbo3.1036 · Cited by 27 · see citing works
Nutraceuticals Induced Changes in the Broiler Gastrointestinal Tract Microbiota
Szilágyi-Tolnai, E., Fauszt, P., Fidler, G., Pesti‐Asbóth, G., Szilágyi, E., Stágel, A., Kónya, J., Szabó, J., Stündl, L., Babinszky, L., et al. (2021) · mSystems · doi:10.1128/msystems.01124-20 · Cited by 27 · see citing works
The Water Extract of Ampelopsis grossedentata Alleviates Oxidative Stress and Intestinal Inflammation
Wang, Z., Jiang, Q., Li, P., Shi, P., Liu, C., Wang, W., Huang, K., Yin, Y., & Huang, P. (2023) · Antioxidants · doi:10.3390/antiox12030547 · Cited by 27 · see citing works
Escherichia�coli O101‑induced diarrhea develops gut microbial dysbiosis in rats
Sun, X., Gao, Y., Wang, X., Hu, G., Wang, Y., Feng, B., Hu, Y., Mu, X., Zhang, Y., & Dong, H. (2018) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2018.6997 · Cited by 27 · see citing works
Self-citation
Changes in the Fecal Microbiota Associated with a Broad-Spectrum Antimicrobial Administration in Hospitalized Neonatal Foals with Probiotics Supplementation
Freccero, F., Lanci, A., Mariella, J., Viciani, E., Quercia, S., Castagnetti, A., & Castagnetti, C. (2021) · Animals · doi:10.3390/ani11082283 · Cited by 26 · see citing works
Characterization of Gut Microbiota in Hospitalized Patients with Clostridioides difficile Infection
Vakili, B., Fateh, A., Aghdaei, H. A., Sotoodehnejadnematalahi, F., & Siadat, S. D. (2020) · Current Microbiology · doi:10.1007/s00284-020-01980-x · Cited by 26 · see citing works
Microbiological and metabolic pathways analysing the mechanisms of alfalfa polysaccharide and sulfated alfalfa polysaccharide in alleviating obesity
Li, Z., Sang, R., Feng, G., Feng, Y., Zhang, R., & Yan, X. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.130334 · Cited by 25 · see citing works
Hypoimmunity and intestinal bacterial imbalance are closely associated with blue body syndrome in cultured Penaeus vannamei
Liang, Q., Li, Z., Ou, M., Wu, X., Qiao, X.-L., Wei, W., Liu, Y., Ye, J., & Wang, W. (2020) · Aquaculture · doi:10.1016/j.aquaculture.2020.735118 · Cited by 25 · see citing works
Fecal Microbiome Data Distinguish Liver Recipients With Normal and Abnormal Liver Function From Healthy Controls
Lu, H., Ren, Z., Li, A., Zhang, H., Xu, S., Jiang, J., Zhou, L., Ling, Q., Wang, B., Cui, G., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.01518 · Cited by 25 · see citing works
Self-citation
Consortium of Probiotics Attenuates Colonization of Clostridioides difficile
Li, X., Chu, Q., Huang, Y., Xiao, Y., Song, L., Zhu, S., Kang, Y., Lu, S., Xu, J., & Ren, Z. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02871 · Cited by 25 · see citing works
Metabolic regulation of Ganoderma lucidum extracts in high sugar and fat diet-induced obese mice by regulating the gut-brain axis
Diling, C., Guo, Y., Qi, L., Xiaocui, T., Liu, Y., Jiaxin, F., Zhu, X., Zeng, M., Shuai, O., Dongdong, W., et al. (2020) · Journal of Functional Foods · doi:10.1016/j.jff.2019.103639 · Cited by 24 · see citing works
PM2.5 exposure significantly improves the exacerbation of A549 tumor-bearing CB17-SCID mice
Yang, B., & Xiao, C. (2018) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2018.04.025 · Cited by 24 · see citing works
Response of microbial communities to elevated thallium contamination in river sediments
Rasool, A., & Xiao, T. (2018) · Geomicrobiology Journal · doi:10.1080/01490451.2018.1481159 · Cited by 21 · see citing works
Amelioration of Growth Performance, Lipid Accumulation, and Intestinal Health in Mice by a Cooked Mixture of Lean Meat and Resistant Starch
Wang, X., Pan, Q., Ma, F., Li, P., Xu, B., & Chen, C. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201801364 · Cited by 21 · see citing works
Cyprinid herpesvirus 2 infection changes microbiota and metabolites in the gibel carp (Carassius auratus gibelio) midgut
Chen, P., Zhang, M., Zhang, Y., Li, J., Wan, X., Lv, T., Chen, Y., Zhao, Z., Ma, Z., Zhu, Z., et al. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1017165 · Cited by 20 · see citing works
Active and Secretory IgA-Coated Bacterial Fractions Elucidate Dysbiosis in Clostridium difficile Infection
Džunková, M., Moyá, A., Vázquez-Castellanos, J. F., Artacho, A., Chen, X., Kelly, C. P., & D’Auria, G. (2016) · mSphere · doi:10.1128/msphere.00101-16 · Cited by 20 · see citing works
Evaluation of dietary Haematococcus pluvialis in pilot-scale farming of Litopenaeus vannamei: Effects on production performance, physiological health, bacterial communities, and eukaryotic plankton
Huang, F., Xue, D., Li, Z., Dong, S., Jiang, F., Hu, Z., & Zheng, Y. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.738858 · Cited by 19 · see citing works

Characterization of Circulating Clostridium difficile Strains, Host Response and Intestinal Microbiome in Hospitalized Children With Diarrhea
Lees, E. A., Carrol, E. D., Ellaby, N. A. F., Roberts, P., Corless, C. E., Lenzi, L., Darby, A. C., O’Brien, S. J., Cunliffe, N. A., Turner, M. A., et al. (2019) · The Pediatric Infectious Disease Journal · doi:10.1097/inf.0000000000002559 · Cited by 15 · see citing works
Decreased Fecal Bacterial Diversity and Altered Microbiome in Children Colonized With Clostridium difficile
Chen, L. A., Hourigan, S. K., Grigoryan, Z., Gao, Z., Clemente, J. C., Rideout, J. R., Chirumamilla, S. R., Rabidazeh, S., Saeed, S. A., Elson, C. O., et al. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002210 · Cited by 12 · see citing works
Composition of gut microbiota in patients with toxigenic Clostridioides (Clostridium) difficile: Comparison between subgroups according to clinical criteria and toxin gene load
Han, S., Yi, J., Kim, J., Lee, S., & Moon, H. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212626 · Cited by 48 · see citing works
Children gut microbiota exhibits a different composition and metabolic profile after in vitro exposure to Clostridioides difficile and increases its sporulation
Horvat, S., Mahnič, A., Makuc, D., Pečnik, K., Plavec, J., & Rupnik, M. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1042526 · Cited by 8 · see citing works
The Gut Microbiome and Butyrate Differentiate Clostridioides difficile Colonization and Infection in Children
Nicholson, M. R., Ma, S., Strickland, B. A., Cecala, M. C., Zhang, L., Reasoner, S. A., Guiberson, E. R., Munneke, M. J., Shilts, M. H., Skaar, E. P., et al. (2025) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiaf631 · Cited by 1 · see citing works

Authors: Ling, Z., Liu, X., Jia, X., Cheng, Y., Luo, Y., Yuan, L., Wang, Y., Zhao, C., Guo, S., Li, L., Xu, X., & Xiang, C.
Affiliations: First Affiliated Hospital Zhejiang University (CN)
Capital Medical University (CN)
Chinese National Human Genome Center at Shanghai (CN)
Corresponding author: Li, Lanjuan
Xu, Xiwei
Xiang, Charlie
ORCID: Ling, Zongxin
Liu, Xia
Jia, Xiaoyun
Cheng, Yiwen
Wang, Yuezhu
Li, Lanjuan
Xiang, Charlie
Venue: Scientific Reports
Publisher: Springer Science and Business Media LLC
Published: 2014-12-15
Volume: 4
Issue: 1
Pages: 7485-7485
ISSN: 2045-2322 (ISSN-L)
DOI: 10.1038/srep07485
PMC: PMC4265774
OpenAlex: W2156456403
Cited by: 158
References: 60
Citations by year: 2026: 1 · 2025: 10 · 2024: 8 · 2023: 12 · 2022: 20 · 2021: 14 · 2020: 17 · 2019: 17 · 2018: 18 · 2017: 13 · 2016: 22 · 2015: 6
FWCI: 9.57
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0 (tdm)
creativecommons.org/licenses/by-nc-sa/4.0 (vor)
Locations: Scientific Reports (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion, cc-by-nc-sa)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China
National Key Research and Development Program of China
Natural Science Foundation of Zhejiang Province
Topics: Health Sciences › Medicine › Infectious Diseases › Clostridium difficile and Clostridium perfringens research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Bacterial Identification and Susceptibility Testing
Keywords: Clostridium difficile, Clostridium difficile-associated diarrhea, fecal microbiota, gut dysbiosis, children, toxin A, toxin B, Firmicutes/Bacteroidetes ratio, bacterial diversity, butyrate-producing bacteria, lactate-producing bacteria, Enterococcus, colonization resistance
MeSH terms: Bacterial Toxins, Child, Preschool, Diarrhea, Enterocolitis, Pseudomembranous, Feces, Humans, Intestines, RNA, Ribosomal, 16S, Case-Control Studies, Clostridioides difficile, Sequence Analysis, DNA, Real-Time Polymerase Chain Reaction, Microbiota

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Impacts of infection with different toxigenic Clostridium difficile strains on faecal microbiota in children

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks