Early diagnosis of Alzheimer's disease from elevated olfactory mucosal miR-206 level.
Open accessAbstract
MicroRNA-206, which suppresses the expression of brain-derived neurotrophic factor, is known to be elevated in the brains of Alzheimer's disease (AD) patients. We performed intranasal biopsy of the olfactory epithelia of early dementia patients (n = 24) and cognitively healthy controls (n = 9). Patients with significant depression (n = 8) were analyzed separately, as their cognitive impairments were thought to be caused by their depression. Real-time PCR was performed on the biopsied tissues. The relative microRNA-206 level exhibited a 7.8-fold increase (P = 0.004) in the mild cognitive impairment group (CDR 0.5; n = 13) and a 41.5-fold increase (P < 0.001) in the CDR 1 group (n = 11). However, this level was not increased in the depression group, even in those with cognitive decline. Using the optimal cutoff value, the sensitivity/specificity for diagnosing CDR 0.5 and CDR 1 dementia were 87.5%/94.1% and 90.9%/93.3%, respectively. In ROC analysis, the AUCs were 0.942 and 0.976 in the CDR 0.5 and CDR 1 groups, respectively. The olfactory mucosal microRNA-206 level and cognitive assessment scores were significantly correlated in the non-depressed subjects with cognitive impairment. In conclusion, the olfactory mucosal microRNA-206 level can be easily measured, and it can be utilized as an excellent biomarker for the diagnosis of early AD, including mild cognitive impairment.
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MiR-206 can suppress the production of BDNF following transcription.
“MiR-206 can suppress the production of BDNF following transcription, which is vital for the regulation and participation in MMD [34].”
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- Authors
- Moon, J., Lee, S.-T., Kong, I. G., Byun, J.-I., Sunwoo, J.-S., Shin, J.-W., Shim, J.-Y., Park, J.-H., Jeon, D., Jung, K.-H., Jung, K.-Y., Kim, D.-Y., Lee, S. K., Kim, M., & Chu, K.
- Affiliations
- Seoul National University (KR)
- Hallym University Sacred Heart Hospital (KR)
- CHA University (KR)
- Corresponding author
- Kim, Manho
- Chu, Kon
- ORCID
- Venue
- Scientific Reports
- Published
- 2016-02-04
- Volume
- 6
- Issue
- 1
- Pages
- 20364-20364
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4740889
- OpenAlex
- W2418165897
- Cited by
- 69
- References
- 64
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 8 · 2023: 2 · 2022: 8 · 2021: 6 · 2020: 7 · 2019: 9 · 2018: 8 · 2017: 9 · 2016: 2 · 2014: 1
- FWCI
- 8.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Keywords
- Alzheimer's disease, miR-206, olfactory epithelium, early diagnosis, mild cognitive impairment, dementia, biomarkers, brain-derived neurotrophic factor, depression, cognitive impairment
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cognition Disorders, Female, Humans, Male, Middle Aged, Olfactory Mucosa, ROC Curve, Biomarkers, Case-Control Studies, Area Under Curve, MicroRNAs, Early Diagnosis, Real-Time Polymerase Chain Reaction
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