Brain‐derived neurotrophic factor expression is repressed during myogenic differentiation by miR‐206
Abstract
J. Neurochem. (2012) 120, 230–238. Brain‐derived neurotrophic factor (BDNF) is required for efficient skeletal‐muscle regeneration and perturbing its expression causes abnormalities in the proliferation and differentiation of skeletal muscle cells. In this study, we investigated the mechanism of BDNF suppression that occurs during myogenic differentiation. BDNF is expressed at the mRNA level as two isoforms that differ in the length of their 3′UTRs as a result of alternative cleavage and polyadenylation. Sequence analysis revealed the presence of three miR‐206 target sites in the long BDNF 3′UTR (BDNF‐L), whereas only one site was found in the short mRNA BDNF 3′UTR (BDNF‐S). miR‐206 is known to regulate the differentiation of C2C12 myoblasts and its expression is induced during the transition from myoblasts to myotubes. We thus examined whether miR‐206‐mediated suppression is responsible for the expression pattern of BDNF during myogenic differentiation. BDNF‐L was suppressed to a greater extent than BDNF‐S during differentiation of C2C12 myoblasts. Transfection of a miR‐206 precursor decreased activity of reporters representative of the BDNF‐L 3′UTR, but not BDNF‐S 3′UTR, and repressed endogenous BDNF mRNA levels. This suppression was found to be dependent on the presence of multiple miR‐206 target sites in the BDNF‐L 3′UTR. Conversely, suppression of miR‐206 levels resulted in de‐repression of BDNF 3′UTR reporter activity and increased endogenous BDNF‐L mRNA levels. A receptor for BDNF, p75 NTR, was also suppressed during differentiation and in response to miR‐206, but this appeared to not be entirely mediated via a miR‐206 target site its 3′UTR. Based on these observations, BDNF represents a novel target through which miR‐206 controls the initiation and maintenance of the differentiated state of muscle cells. These results further suggest that miR‐206 might play a role in regulating retrograde signaling of BDNF at the neuromuscular junction.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Stem cell quiescence is controlled at least in part by mechanisms that alter 3' UTR length and thus susceptibility to miRNA regulation.
“the importance of transcript 3′ UTRs as targets for miRNAs suggests that stem cell quiescence is controlled, at least in part, by mechanisms that alter 3′ UTR length and thus the susceptibility to regulation by miRNAs92–95.”
From Molecular regulation of stem cell quiescence (2013) · cites this paper as [93]
Cites
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · see citing works
Lewis, B. P., Burge, C. B., & Bartel, D. P. (2005) · Cell · doi:10.1016/j.cell.2004.12.035 · Cited by 11,855 · see citing works
Alternative isoform regulation in human tissue transcriptomes
Wang, E. T., Sandberg, R., Luo, S., Khrebtukova, I., Zhang, L., Mayr, C., Kingsmore, S. F., Schroth, G. P., & Burge, C. B. (2008) · Nature · doi:10.1038/nature07509 · Cited by 5,181 · see citing works
Mammalian microRNAs predominantly act to decrease target mRNA levels
Guo, H., Ingolia, N. T., Weissman, J. S., & Bartel, D. P. (2010) · Nature · doi:10.1038/nature09267 · Cited by 3,886 · see citing works
Regulation of mRNA Translation and Stability by microRNAs
Fabian, M. R., Sonenberg, N., & Filipowicz, W. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060308-103103 · Cited by 3,214 · see citing works
Identification of tissue-specific microRNAs from mouse
Lagos-Quintana, M., Rauhut, R., Yalcin, A., Meyer, J., Lendeckel, W., & Tuschl, T. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00809-6 · Cited by 2,859 · see citing works
Mayr, C., & Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.06.016 · Cited by 1,613 · see citing works
Sandberg, R., Neilson, J. R., Sarma, A., Sharp, P. A., & Burge, C. B. (2008) · Science · doi:10.1126/science.1155390 · Cited by 1,349 · see citing works
siRNAs can function as miRNAsPreprint
Doench, J. G., Petersen, C. P., & Sharp, P. A. (2003) · Genes & Development · doi:10.1101/gad.1064703 · Cited by 1,262 · see citing works
Mouse and rat <i>BDNF</i> gene structure and expression revisited
Aid, T., Kazantseva, A., Piirsoo, M., Palm, K., & Timmusk, T. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21139 · Cited by 943 · see citing works
Multiple promoters direct tissue-specific expression of the rat BDNF gene
Timmusk, T., Palm, K., Metsis, M., Reintam, T., Paalme, V., Saarma, M., & Persson, H. (1993) · Neuron · doi:10.1016/0896-6273(93)90335-o · Cited by 858 · see citing works
Muscle-specific microRNA miR-206 promotes muscle differentiation
Kim, H. K., Lee, Y. S., Sivaprasad, U., Malhotra, A., & Dutta, A. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200603008 · Cited by 762 · see citing works
Potentiation of developing neuromuscular synapses by the neurotrophins NT-3 and BDNF
Lohof, A. M., Ip, N. Y., & Poo, M.-M. (1993) · Nature · doi:10.1038/363350a0 · Cited by 755 · see citing works
DiStefano, P. S., Friedman, B., Radziejewski, C. H., Alexander, C., Boland, P. S., Schick, C., Lindsay, R. M., & Wiegand, S. J. (1992) · Neuron · doi:10.1016/0896-6273(92)90213-w · Cited by 742 · see citing works
MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice
Williams, A. H., Valdez, G., Moresi, V., Qi, X., McAnally, J., Elliott, J. L., Bassel‐Duby, R., Sanes, J. R., & Olson, E. N. (2009) · Science · doi:10.1126/science.1181046 · Cited by 738 · see citing works
Pruunsild, P., Kazantseva, A., Aid, T., Palm, K., & Timmusk, T. (2007) · Genomics · doi:10.1016/j.ygeno.2007.05.004 · Cited by 699 · see citing works
An, J. J., Gharami, K., Liao, G., Woo, N. H., Lau, A. G., Vanevski, F., Torre, E. R., Jones, K. R., Feng, Y., Lu, B., et al. (2008) · Cell · doi:10.1016/j.cell.2008.05.045 · Cited by 670 · see citing works
Ji, Z., Lee, J. Y., Pan, Z., Jiang, B., & Tian, B. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0900028106 · Cited by 595 · see citing works
MicroRNAs as Regulators of Differentiation and Cell Fate Decisions
Ivey, K. N., & Srivastava, D. (2010) · Cell Stem Cell · doi:10.1016/j.stem.2010.06.012 · Cited by 449 · see citing works
Brain-derived neurotrophic factor rescues developing avian motoneurons from cell death
Oppenheim, R. W., Yin, Q.-W., Prevette, D. M., & Yan, Q. (1992) · Nature · doi:10.1038/360755a0 · Cited by 447 · see citing works
Ozsolak, F., Kapranov, P., Foissac, S., Kim, S. W., Fishilevich, E., Monaghan, A. P., John, B., & Milos, P. M. (2010) · Cell · doi:10.1016/j.cell.2010.11.020 · Cited by 400 · see citing works
miR-206 and -486 Induce Myoblast Differentiation by Downregulating Pax7
Dey, B. K., Gagan, J. R., & Dutta, A. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01009-10 · Cited by 380 · see citing works
MicroRNA-1/206 Targets c-Met and Inhibits Rhabdomyosarcoma Development
Yan, D., Dong, X. D., Chen, X., Wang, L., Lu, C., Wang, J., Qu, J., & Tu, L. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.020511 · Cited by 270 · see citing works
Fu, Y., Sun, Y., Li, Y., Li, J., Rao, X., Chen, C., & Xu, A. (2011) · Genome Research · doi:10.1101/gr.115295.110 · Cited by 270 · see citing works
TGF-β Regulates miR-206 and miR-29 to Control Myogenic Differentiation through Regulation of HDAC4
Winbanks, C. E., Wang, B., Beyer, C., Koh, P., White, L. J., Kantharidis, P., & Gregorevic, P. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.192625 · Cited by 265 · see citing works
The Landscape of C. elegans 3′UTRs
Mangone, M., Manoharan, A. P., Thierry‐Mieg, D., Thierry‐Mieg, J., Han, T., Mackowiak, S. D., Mis, E. K., Zegar, C., Gutwein, M. R., Khivansara, V., et al. (2010) · Science · doi:10.1126/science.1191244 · Cited by 247 · see citing works
Mellios, N., Huang, H.-S., Grigorenko, A., Rogaev, E., & Akbarian, S. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn201 · Cited by 239 · see citing works
Lau, A. G., Irier, H. A., Gu, J., Tian, D., Ku, L., Liu, G., Xia, M., Fritsch, B., Zheng, J. Q., Dingledine, R. J., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002929107 · Cited by 225 · see citing works
BDNF is expressed in skeletal muscle satellite cells and inhibits myogenic differentiation
Mousavi, K., & Jasmin, B. J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5398-05.2006 · Cited by 210 · see citing works
Self-citationClow, C., & Jasmin, B. J. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-02-0154 · Cited by 175 · see citing works
Self-citationPro-BDNF–induced synaptic depression and retraction at developing neuromuscular synapses
Yang, F., Je, H.-S., Ji, Y., Nagappan, G., Hempstead, B., & Lu, B. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200811147 · Cited by 130 · see citing works
Neurotrophin and Trk-mediated Signaling in the Neuromuscular System
Pitts, E. V., Potluri, S., Hess, D. M., & Balice‐Gordon, R. J. (2006) · International Anesthesiology Clinics · doi:10.1097/00004311-200604420-00004 · Cited by 82 · see citing works
The role of neurotrophins in muscle under physiological and pathological conditions
Chevrel, G., Hohlfeld, R., & Sendtner, M. (2005) · Muscle & Nerve · doi:10.1002/mus.20444 · Cited by 82 · see citing works
Baron, P., Scarpini, E. A., Meola, G., Santilli, I. M., Conti, G. M., Pleasure, D., & Scarlato, G. (1994) · Muscle & Nerve · doi:10.1002/mus.880170304 · Cited by 33 · see citing works
Regulation of the p75 Neurotrophin Receptor in a Rat Myogenic Cell Line (L6)
Rende, M., Brizi, E., Sorci, G., Bianchi, R., Provenzano, C., Bruno, R., & Donato, R. (1999) · The Histochemical Journal · doi:10.1023/a:1003851024732 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Molecular regulation of stem cell quiescence
Cheung, T. H., & Rando, T. A. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3591 · Cited by 1,148 · see citing works
Pedersen, B. K. (2013) · Comprehensive physiology · doi:10.1002/cphy.c120033 · Cited by 516 · see citing works
Muscle-specific microRNAs in skeletal muscle development
Horak, M., Novák, J., & Vašků, J. B. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.12.013 · Cited by 476 · see citing works
Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise
Schnyder, S., & Handschin, C. (2015) · Bone · doi:10.1016/j.bone.2015.02.008 · Cited by 419 · see citing works
Translational control by changes in poly(A) tail length: recycling mRNAs
Weill, L., Belloc, E., Bava, F.-A., & Méndez, R. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2311 · Cited by 328 · see citing works
Cattaneo, A., Cattane, N., Begni, V, Pariante, C. M., & Riva, M. A. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.214 · Cited by 244 · see citing works
MiR-206, a Key Modulator of Skeletal Muscle Development and Disease
Ma, G., Wang, Y., Li, Y., Cui, L., Zhao, Y., Zhao, B., & Li, K. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.10921 · Cited by 231 · see citing works
Role of BDNF epigenetics in activity-dependent neuronal plasticity
Karpova, N. N. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.002 · Cited by 200 · see citing works
MicroRNA-206: A Potential Circulating Biomarker Candidate for Amyotrophic Lateral Sclerosis
Toivonen, J. M., Manzano, R., Oliván, S., Zaragoza, P., García‐Redondo, A., & Osta, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0089065 · Cited by 186 · see citing works
Roles of the canonical myomiRs miR-1, -133 and -206 in cell development and disease
Mitchelson, K. R. (2015) · World Journal of Biological Chemistry · doi:10.4331/wjbc.v6.i3.162 · Cited by 176 · see citing works
miR-1, miR-10b, miR-155, and miR-191 are novel regulators of BDNF
Varendi, K., Kumar, A., Härma, M.-A., & Andressoo, J.-O. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1628-x · Cited by 144 · see citing works
Brain-derived neurotrophic factor
Benarroch, E. E. (2015) · Neurology · doi:10.1212/wnl.0000000000001507 · Cited by 135 · see citing works
microRNA-206 in Rat Medial Prefrontal Cortex Regulates BDNF Expression and Alcohol Drinking
Tapocik, J. D., Barbier, E., Flanigan, M. E., Solomon, M. G., Pincus, A. B., Pilling, A., Sun, H., Schank, J. R., King, C. E., & Heilig, M. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0445-14.2014 · Cited by 135 · see citing works
Tapocik, J. D., Solomon, M., Flanigan, M. E., Meinhardt, M. W., Barbier, E., Schank, J. R., Schwandt, M. L., Sommer, W. H., & Heilig, M. A. (2012) · The Pharmacogenomics Journal · doi:10.1038/tpj.2012.17 · Cited by 101 · see citing works
Therapeutic Potentials of BDNF/TrkB in Breast Cancer; Current Status and Perspectives
Tajbakhsh, A., Mokhtari‐Zaer, A., Rezaee, M., Afzaljavan, F., Rivandi, M., Hassanian, S. M., Ferns, G. A., Pasdar, A., & Avan, A. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25943 · Cited by 93 · see citing works
Epigenetics, microRNA, and addiction
Kenny, P. J. (2014) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2014.16.3/pkenny · Cited by 90 · see citing works
The Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations
Leuchtmann, A. B., Adak, V., Dilbaz, S., & Handschin, C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.709807 · Cited by 84 · see citing works
Early diagnosis of Alzheimer's disease from elevated olfactory mucosal miR-206 level.
Moon, J., Lee, S.-T., Kong, I. G., Byun, J.-I., Sunwoo, J.-S., Shin, J.-W., Shim, J.-Y., Park, J.-H., Jeon, D., Jung, K.-H., et al. (2016) · Scientific Reports · doi:10.1038/srep20364 · Cited by 69 · see citing works
Yang, X., Yang, Q., Wang, X., Luo, C., Wan, Y., Li, J., Liu, K., Zhou, M., & Zhang, C. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-014-8312-z · Cited by 69 · see citing works
The role of microRNAs in skeletal muscle health and disease
McCarthy, J. J. (2015) · Frontiers in bioscience · doi:10.2741/4298 · Cited by 67 · see citing works
Allen, M., Bird, C. W., Feng, W., Liu, G., Li, W., Perrone‐Bizzozero, N. I., & Feng, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055718 · Cited by 68 · see citing works
Gao, Y., Su, J., Guo, W., Polich, E. D., Magyar, D. P., Xing, Y., Li, H., Smrt, R. D., Chang, Q., & Zhao, X. (2015) · Stem Cells · doi:10.1002/stem.1950 · Cited by 65 · see citing works
Pedersen, B. K. (2013) · Comprehensive physiology · doi:10.1002/j.2040-4603.2013.tb00522.x · Cited by 59 · see citing works
MicroRNA-206: a Promising Theranostic Marker
Novák, J., Kružliak, P., Vašků, J. B., Slabý, O., & Novák, M. (2014) · Theranostics · doi:10.7150/thno.7552 · Cited by 58 · see citing works
Regulatory networks between neurotrophins and miRNAs in brain diseases and cancers
Shi, J. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2014.135 · Cited by 58 · see citing works
Papathanassoglou, E. D. E., Miltiadous, P., & Karanikola, M. N. K. (2014) · Biological Research For Nursing · doi:10.1177/1099800414555411 · Cited by 53 · see citing works
Reprogramming of mPFC transcriptome and function in alcohol dependence
Heilig, M. A., Barbier, E., Johnstone, A. L., Tapocik, J. D., Meinhardt, M. W., Pfarr, S., Wahlestedt, C., & Sommer, W. H. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12344 · Cited by 50 · see citing works
Xie, B., Liu, Z., Jiang, L., Liu, W., Song, M. L., Zhang, Q., Zhang, R., Cui, D., Wang, X., & Xu, S. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160468 · Cited by 51 · see citing works
Brain-derived neurotrophic factor and early-life stress: Multifaceted interplay
Bondar, N. P., & Merkulova, T. I. (2016) · Journal of Biosciences · doi:10.1007/s12038-016-9648-3 · Cited by 48 · see citing works
MiRNA-206 and BDNF genes interacted in bipolar I disorder.
Wang, Z., Zhang, C., Huang, J., Yuan, C., Hong, W., Chen, J., Yu, S., Xu, L., Gao, K., & Fang, Y. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.03.047 · Cited by 44 · see citing works
Post-Transcriptional Regulation in Skeletal Muscle Development, Repair, and Disease
Weskamp, K., Olwin, B. B., & Parker, R. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.12.002 · Cited by 45 · see citing works
Alternative Polyadenylation in Stem Cell Self-Renewal and Differentiation
Sommerkamp, P., Cabezas‐Wallscheid, N., & Trumpp, A. (2021) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2021.04.006 · Cited by 39 · see citing works
Maggio, S., Canonico, B., Ceccaroli, P., Polidori, E., Cioccoloni, A., Giacomelli, L., Marini, C. F., Annibalini, G., Gervasi, M., Benelli, P., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24033039 · Cited by 39 · see citing works
Is Brain-Derived Neurotrophic Factor a Metabolic Hormone in Peripheral Tissues?
Iu, E. C. Y., & Chan, C. B. (2022) · Biology · doi:10.3390/biology11071063 · Cited by 37 · see citing works
cAMP-inducible coactivator CRTC3 attenuates brown adipose tissue thermogenesis
Yoon, Y., Tsai, W., de Velde, S. V., Chen, Z., Lee, K., Morgan, D. A., Rahmouni, K., Matsumura, S., Wiater, E., Song, Y., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805257115 · Cited by 35 · see citing works
A New Player in Depression: MiRNAs as Modulators of Altered Synaptic Plasticity
Gao, Y., Yong-qian, Z., Wang, H., Deng, Y., & Li, N. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094555 · Cited by 37 · see citing works
Short-term Preoperative Dietary Restriction Is Neuroprotective in a Rat Focal Stroke Model
Mätlik, K., Airavaara, M., Anttila, J. E., Vose, S. C., Planken, A., Saarma, M., Mitchell, J. R., & Andressoo, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093911 · Cited by 33 · see citing works
Amirouche, A., Tadesse, H., Miura, P., Bélanger, G., Lunde, J. A., Côté, J., & Jasmin, B. J. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1350 · Cited by 32 · see citing works
Self-citationMcKay, B. R., Nederveen, J. P., Fortino, S. A., Snijders, T., Joanisse, S., Kumbhare, D. A., & Parise, G. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2019-0501 · Cited by 33 · see citing works
MotomiRs: miRNAs in Motor Neuron Function and Disease
Hawley, Z. C. E., Campos‐Melo, D., Droppelmann, C. A., & Strong, M. J. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00127 · Cited by 33 · see citing works
All's well that ends well: alternative polyadenylation and its implications for stem cell biology
Mueller, A. A., Cheung, T. H., & Rando, T. A. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.12.008 · Cited by 32 · see citing works
MicroRNAs and Synaptic Plasticity: From Their Molecular Roles to Response to Therapy
Mohammadi, A. H., Seyedmoalemi, S., Moghanlou, M., Akhlagh, S. A., Talaei, S. A., Hamblin, M. R., Jafari, A., & Mirzaei, H. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02907-2 · Cited by 33 · see citing works
From microRNA target validation to therapy: lessons learned from studies on BDNF
Varendi, K., Mätlik, K., & Andressoo, J. (2015) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-1836-z · Cited by 31 · see citing works
MicroRNAs involved in skeletal muscle development and their roles in rhabdomyosarcoma pathogenesis
Novák, J., Vinklárek, J., Vašků, J. B., & Slabý, O. (2013) · Pediatric Blood & Cancer · doi:10.1002/pbc.24664 · Cited by 30 · see citing works
The miR206-JunD Circuit Mediates the Neurotoxic Effect of Methylmercury in Cortical Neurons
Guida, N., Valsecchi, V., Laudati, G., Serani, A., Mascolo, L., Molinaro, P., Montuori, P., Renzo, G. D., Canzoniero, L. M. T., & Formisano, L. (2018) · Toxicological Sciences · doi:10.1093/toxsci/kfy051 · Cited by 29 · see citing works
The Yin and Yang of nucleic acid-based therapy in the brain
Gustincich, S., Zucchelli, S., & Mallamaci, A. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.11.001 · Cited by 27 · see citing works
Amirouche, A., Jahnke, V. E., Lunde, J. A., Koulmann, N., Freyssenet, D. G., & Jasmin, B. J. (2016) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00185.2016 · Cited by 27 · see citing works
Self-citationHalievski, K., Xu, Y., Haddad, Y. W., Tang, Y. P., Yamada, S., Katsuno, M., Adachi, H., Sobue, G., Breedlove, S. M., & Jordan, C. L. (2020) · The Journal of Physiology · doi:10.1113/jp279208 · Cited by 26 · see citing works
Yao, Y., Wang, X., & Gao, J. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s256319 · Cited by 26 · see citing works
Pucci, M., Bonaventura, M. V. M. D., Wille‐Bille, A., Fernández, M. S., Maccarrone, M., Pautassi, R. M., Cifani, C., & D’Addario, C. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.004 · Cited by 24 · see citing works
Piovesana, R., Faroni, A., Taggi, M., Matera, A., Soligo, M., Canipari, R., Manni, L., Reid, A. J., & Tata, A. M. (2020) · Scientific Reports · doi:10.1038/s41598-020-63645-w · Cited by 25 · see citing works
Solomon, M. G., Griffin, W. C., Lopez, M. F., & Becker, H. C. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.02.012 · Cited by 24 · see citing works
Mammalian Target of Rapamycin at the Crossroad Between Alzheimer’s Disease and Diabetes
Liang, H., Nie, J., Skike, C. E. V., Valentine, J. M., & Orr, M. E. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-3540-2_10 · Cited by 24 · see citing works
Legaard, G. E., & Pedersen, B. K. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-814593-7.00013-x · Cited by 24 · see citing works
- Invited Review - Physiological Roles of Adipokines, Hepatokines, and Myokines in Ruminants
Roh, S., Suzuki, Y., Gotoh, T., Tatsumi, R., & Katoh, K. (2015) · Asian-Australasian Journal of Animal Sciences · doi:10.5713/ajas.16.0001r · Cited by 23 · see citing works
BDNF Modulation by microRNAs: An Update on the Experimental Evidence
de Assis, G. G., & Murawska‐Ciałowicz, E. (2024) · Cells · doi:10.3390/cells13100880 · Cited by 25 · see citing works
An alanine expanded PABPN1 causes increased utilization of intronic polyadenylation sites
Abbassi‐Daloii, T., Yousefi, S., de Klerk, E., Grossouw, L. M., Riaz, M., Hoen, P. A. C. ’., & Raz, V. (2017) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-017-0007-x · Cited by 21 · see citing works
Yu, L., Liao, Q., Zeng, X., Lv, Z., Zheng, H., Zhao, Y. C., Sun, X., & Wu, Z. (2014) · European Journal of Clinical Microbiology & Infectious Diseases · doi:10.1007/s10096-014-2087-x · Cited by 21 · see citing works
Evidence for the Contribution of the miR-206/BDNF Pathway in the Pathophysiology of Depression
Zheng, Y., & Jin, X. (2024) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyae039 · Cited by 21 · see citing works
Effect of intravenous injection of antagomiR-1 on brain ischemia
Talebi, A., Rahnema, M., & Bigdeli, M. R. (2019) · Molecular Biology Reports · doi:10.1007/s11033-018-04580-y · Cited by 19 · see citing works
MicroRNAs in the regeneration of skeletal muscle
Yu, X. (2012) · Frontiers in bioscience · doi:10.2741/4124 · Cited by 15 · see citing works
Li, T., Yu, S., Zhou, C., Wang, K., & Wan, Y. (2019) · Journal of drug targeting · doi:10.1080/1061186x.2019.1616744 · Cited by 15 · see citing works
RetractedZhao, H., Li, P., & Wang, J. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.954364 · Cited by 14 · see citing works
Targeting MicroRNAs Involved in the BDNF Signaling Impairment in Neurodegenerative Diseases
You, H. J., Park, J. H., Pareja-Galeano, H., Lucía, A., & Shin, J. I. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-016-8407-9 · Cited by 13 · see citing works
Shrestha, S., Phay, M., Kim, H. H., Pouladvand, P., Lee, S. J., & Yoo, S. (2018) · FEBS Open Bio · doi:10.1002/2211-5463.12581 · Cited by 12 · see citing works
Jatwani, A., & Tulsawani, R. (2021) · High Altitude Medicine & Biology · doi:10.1089/ham.2020.0172 · Cited by 11 · see citing works
Yuan, M., Hong, Z., Wu, W., Hu, L., & Chen, H. (2012) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4456 · Cited by 10 · see citing works
Comprehensive analysis of lncRNA‑miRNA‑mRNA regulatory networks for Alzheimer’s disease
Li, F., Lin, Z., & Tian, G. (2022) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2022-025 · Cited by 9 · see citing works
Brain neurotrophic factor BDNF: new data, functions and questions
Zhivkovich, M., Ermolaeva, E. V., Soboleva, A. V., Samoilova, E. M., Chudakova, D. A., & Baklaushev, V. P. (2024) · Genes and Cells · doi:10.17816/gc623163 · Cited by 8 · see citing works
Tristetraprolin is a novel regulator of BDNF
Kumar, A., Mätlik, K., Peränen, J., & Andressoo, J. (2014) · SpringerPlus · doi:10.1186/2193-1801-3-502 · Cited by 8 · see citing works
Barden, J., Kosloski, O., Jadidian, A., & Akaaboune, M. (2024) · Journal of Cell Science · doi:10.1242/jcs.262303 · Cited by 7 · see citing works
Laiferová, N. A., Nemec, M., Vernerová, L., Balážová, M., Vokurková, M., Oreská, S., Klein, M., Špiritović, M., Tomčík, M., Vencovský, J., et al. (2022) · Clinical and Experimental Rheumatology · doi:10.55563/clinexprheumatol/69z7za · Cited by 6 · see citing works
Kyung, J., Kim, D., Shin, K., Park, D., Hong, S., Kim, T. M., Choi, E., & Kim, Y.-B. (2023) · Cells · doi:10.3390/cells12232711 · Cited by 7 · see citing works
Peregud, D., Panchenko, L. F., & Gulyaeva, N. V. (2016) · Neurochemical Journal · doi:10.1134/s1819712416040085 · Cited by 6 · see citing works
Pedersen, B. K. (2016) · Springer eBooks · doi:10.1007/978-3-319-11251-0_31 · Cited by 4 · see citing works
Choi, J. J., Shin, E. J., Han, W. M., Anderson, S. E., Mohiuddin, M., Lee, N. H., Trần, T. H., Nakhai, S. A., Jeong, H., Shcherbina, A., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.24.113456 · Cited by 4 · see citing works
Sun, H., Miao, Q., Wan, B., Liao, J., Tian, N., Chang, Z., Yin, J., & Zhang, X. (2025) · Journal of Nutrition · doi:10.1016/j.tjnut.2025.07.018 · Cited by 3 · see citing works
MicroRNAs in Skeletal Muscle Differentiation
Sun, H., Cao, Y., Zhao, Y. F., Lu, L., Zhou, L., Wang, L., Chen, X., & Wang, H. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405544-5.00017-4 · Cited by 3 · see citing works
de Freitas, R. M., Felipe, S. M. D. S., Ribeiro, J. K. C., Araújo, V. R., Martin, C. P. S., Oliveira, M. A. F., Martins, S. D., Pontes, J. P. A., Alves, J. O., Soares, P. M., et al. (2022) · Brazilian Journal of Biology · doi:10.1590/1519-6984.256691 · Cited by 2 · see citing works
Kyung, J., Kim, D., Shin, K., Park, D., Hong, S., Kim, T. M., Choi, E., & Kim, Y.-B. (2023) · Preprints.org · doi:10.20944/preprints202307.0748.v1 · Cited by 2 · see citing works
MicroRNAs in Skeletal Muscle Differentiation
Sun, H., Cao, Y., Zhao, Y. F., Lu, L., Zhou, L., Wang, L., Chen, X., & Wang, H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-820719-2.00013-2 · Cited by 1 · see citing works
The importance of runny nose tests in Alzheimer’s disease
Özkan, K. (2019) · Demiroglu Science University Florence Nightingale Journal of Medicine · doi:10.5606/fng.btd.2019.020 · Cited by 1 · see citing works
Identification of key mi RNA s in unilateral mastication‐induced disruption of cartilage homeostasis
Wu, M., Wang, X., Shuai, J., Deng, L., Lu, H., Zhou, Y., & Wu, M. (2023) · Oral Diseases · doi:10.1111/odi.14504 · Cited by 1 · see citing works
MicroRNAs in Alcohol Abuse and Toxicity
Miranda, R. C., & Balaraman, S. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405941-2.00024-9 · Cited by 1 · see citing works
Pedersen, B. K. (2015) · Springer eBooks · doi:10.1007/978-3-319-12125-3_31-1 · Cited by 1 · see citing works
T r anslational research Epigenetics, microRNA, and addiction
Kenny, P. J. (2014)
THE ROLE OF MUSCLE-DERIVED NEUROTROPHIC FACTORS IN SPINAL BULBAR MUSCULAR ATROPHY
Halievski, K. (2016) · Michigan State University Libraries · doi:10.25335/eggx-0g86
Shrestha, S. (2025) · Library, Museums and Press - UDSpace (University of Delaware) · doi:10.58088/zxdw-5t26
Malvandi, A. M., Gerosa, L., Maroni, P., Orlando, M. E., Mohammadipour, A., & Lombardi, G. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106569
The Role of Epigenetics in Demisexuality: A Higher-Order Adaptive Network Model
Pulchny, K. K., Hendrikse, S. C. F., & Jan Treur, A. (2026) · Lecture notes in networks and systems · doi:10.1007/978-3-032-20752-4_10
Jalaiei, A., Darabi, A. H. K., Sakkaki, E., Rezazadeh, M., & Ghafouri‐Fard, S. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12067-4 · Cited by 1 · see citing works
- Authors
- Miura, P., Amirouche, A., Clow, C., Bélanger, G., & Jasmin, B. J.
- Affiliations
- University of Ottawa (CA)
- Corresponding author
- Jasmin, Bernard J
- Venue
- Journal of Neurochemistry
- Publisher
- Wiley
- Published
- 2011-12-06
- Volume
- 120
- Issue
- 2
- Pages
- 230-238
- ISSN
- 0022-3042 (ISSN-L)
- 1471-4159
- OpenAlex
- W1523993111
- Cited by
- 92
- References
- 36
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 7 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 3 · 2016: 12 · 2015: 11 · 2014: 15 · 2013: 8 · 2012: 4
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurochemistry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- brain-derived neurotrophic factor, miR-206, myogenesis, skeletal muscle, 3' untranslated region, microRNA binding sites, p75 neurotrophin receptor, C2C12 myoblasts, neuromuscular junction, retrograde signaling, muscle regeneration
- MeSH terms
- Animals, Cell Differentiation, Cell Line, Transformed, Enzyme Inhibitors, Enzyme-Linked Immunosorbent Assay, Gene Expression Regulation, Mutation, RNA, Messenger, Transfection, Brain-Derived Neurotrophic Factor, 3' Untranslated Regions, Receptor, Nerve Growth Factor, Muscle Development, Myoblasts, MicroRNAs, Mice, RNA Isoforms
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
