The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Ultrasound modulates ion channel currents
Open accessAbstract
Transcranial focused ultrasound (US) has been demonstrated to stimulate neurons in animals and humans, but the mechanism of this effect is unknown. It has been hypothesized that US, a mechanical stimulus, may mediate cellular discharge by activating mechanosensitive ion channels embedded within cellular membranes. To test this hypothesis, we expressed potassium and sodium mechanosensitive ion channels (channels of the two-pore-domain potassium family (K2P) including TREK-1, TREK-2, TRAAK; Na V 1.5) in the Xenopus oocyte system. Focused US (10 MHz, 0.3–4.9 W/cm 2) modulated the currents flowing through the ion channels on average by up to 23%, depending on channel and stimulus intensity. The effects were reversible upon repeated stimulation and were abolished when a channel blocker (ranolazine to block Na V 1.5, BaCl 2 to block K2P channels) was applied to the solution. These data reveal at the single cell level that focused US modulates the activity of specific ion channels to mediate transmembrane currents. These findings open doors to investigations of the effects of US on ion channels expressed in neurons, retinal cells, or cardiac cells, which may lead to important medical applications. The findings may also pave the way to the development of sonogenetics: a non-invasive, US-based analogue of optogenetics.
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Cites
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Cited by
Folloni, D., Verhagen, L., Mars, R. B., Fouragnan, E., Constans, C., Aubry, J.-F., Rushworth, M. F. S., & Sallet, J. (2019) · Neuron · doi:10.1016/j.neuron.2019.01.019 · Cited by 401
Transcranial focused ultrasound neuromodulation of the human primary motor cortex
Legon, W., Bansal, P., Tyshynsky, R., Ai, L., & Mueller, J. K. (2018) · Scientific Reports · doi:10.1038/s41598-018-28320-1 · Cited by 328
Low-intensity ultrasound neuromodulation: An overview of mechanisms and emerging human applications
Fomenko, A., Neudorfer, C., Dallapiazza, R. F., Kalia, S. K., & Lozano, A. M. (2018) · Brain Stimulation · doi:10.1016/j.brs.2018.08.013 · Cited by 322
Ultrasound-responsive systems as components for smart materials
Athanassiadis, A. G., Ma, Z., Moreno-Gomez, N., Melde, K., Choi, E., Goyal, R., & Fischer, P. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00622 · Cited by 293
Qiu, Z., Guo, J., Kala, S., Zhu, J., Xian, Q., Qiu, W., Li, G., Zhu, T., Meng, L., Zhang, R., et al. (2019) · iScience · doi:10.1016/j.isci.2019.10.037 · Cited by 266
Metadata
- Authors
- Kubanek, J., Shi, J., Marsh, J., Chen, D., Deng, C., & Cui, J.
- Venue
- Scientific Reports
- Published
- 2016-04-26
- Volume
- 6
- Issue
- 1
- Pages
- 24170-24170
- ISSN
- 2045-2322 (ISSN-L)
- OpenAlex
- W2342931385
- Cited by
- 353
- References
- 53
- FWCI
- 10.34
- Type
- journal article
- Language
- en
- Open access
- gold
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