Exosomal microRNA miR-1246 induces cell motility and invasion through the regulation of DENND2D in oral squamous cell carcinoma
Open accessAbstract
Metastasis is associated with poor prognosis in cancers. Exosomes, which are packed with RNA and proteins and are released in all biological fluids, are emerging as an important mediator of intercellular communication. However, the function of exosomes remains poorly understood in cancer metastasis. Here, we demonstrate that exosomes isolated by size-exclusion chromatography from a highly metastatic human oral cancer cell line, HOC313-LM, induced cell growth through the activation of ERK and AKT as well as promoted cell motility of the poorly metastatic cancer cell line HOC313-P. MicroRNA (miRNA) array analysis identified two oncogenic miRNAs, miR-342-3p and miR-1246, that were highly expressed in exosomes. These miRNAs were transferred to poorly metastatic cells by exosomes, which resulted in increased cell motility and invasive ability. Moreover, miR-1246 increased cell motility by directly targeting DENN/MADD Domain Containing 2D (DENND2D). Taken together, our findings support the metastatic role of exosomes and exosomal miRNAs, which highlights their potential for applications in miRNA-based therapeutics.
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Extracellular miRNAs can exert biological functions in recipient cells to regulate their activity, thereby acting as intercellular signaling molecules.
“Many studies have also demonstrated that extracellular miRNAs can exert biological functions in recipient cells to regulate their activity, thereby acting as intercellular signaling molecules.”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [136]
miR-342-3p and miR-1246 secreted from a highly metastatic human oral cancer cell line induce metastasis in a poorly metastatic cancer cell line.
“miRNAs, specifically miR-342–3p and miR-1246, secreted from a highly metastatic human oral cancer cell line, were found to induce metastasis in a poorly metastatic cancer cell line (136).”
From Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation (2018) · cites this paper as [136]
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Cites
Hallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590 · see citing works
Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012
Ferlay, J., Soerjomataram, I., Dikshit, R., Eser, S., Mathers, C., Rebelo, M., Parkin, D. M., Forman, D., & Bray, F. (2015) · International Journal of Cancer · doi:10.1002/ijc.29210 · Cited by 28,766 · see citing works
Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J. J., & Lötvall, J. O. (2007) · Nature Cell Biology · doi:10.1038/ncb1596 · Cited by 12,834 · see citing works
Tumour exosome integrins determine organotropic metastasis
Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., et al. (2015) · Nature · doi:10.1038/nature15756 · Cited by 5,101 · see citing works
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715 · see citing works
Communication by Extracellular Vesicles: Where We Are and Where We Need to Go
Tkach, M., & Théry, C. (2016) · Cell · doi:10.1016/j.cell.2016.01.043 · Cited by 3,444 · see citing works
Extracellular vesicles: biology and emerging therapeutic opportunities
EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3978 · Cited by 3,254 · see citing works
Glypican-1 identifies cancer exosomes and detects early pancreatic cancer
Melo, S. A., Luecke, L. B., Kahlert, C., Fernandez, A. F., Gammon, S. T., Kaye, J., LeBleu, V. S., Mittendorf, E. A., Weitz, J., Rahbari, N., et al. (2015) · Nature · doi:10.1038/nature14581 · Cited by 2,880 · see citing works
MicroRNAs and other non-coding RNAs as targets for anticancer drug development
Ling, H. Y., Fabbri, M., & Călin, G. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4140 · Cited by 1,465 · see citing works
Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes.
Montecalvo, A., Larregina, A. T., Shufesky, W. J., Beer Stolz, D., Sullivan, M. L. G., Karlsson, J. M., Baty, C. J., Gibson, G. A., Erdos, G., Wang, Z., et al. (2012) · Blood · doi:10.1182/blood-2011-02-338004 · Cited by 1,262 · see citing works
Single‐step isolation of extracellular vesicles by size‐exclusion chromatography
Böing, A. N., van der Pol, E., Grootemaat, A. E., Coumans, F. A. W., Sturk, A., & Nieuwland, R. (2014) · Journal of Extracellular Vesicles · doi:10.3402/jev.v3.23430 · Cited by 1,228 · see citing works
Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth
Zhang, L., Zhang, S., Yao, J., Lowery, F. J., Zhang, Q., Huang, W.-C., Li, P., Li, M., Wang, X., Zhang, C., et al. (2015) · Nature · doi:10.1038/nature15376 · Cited by 1,080 · see citing works
Rivera, C. (2015) · PubMed Central · doi:10.5281/zenodo.192487 · Cited by 829 · see citing works
Tominaga, N., Kosaka, N., Ono, M., Katsuda, T., Yoshioka, Y., Tamura, K., Lötvall, J., Nakagama, H., & Ochiya, T. (2015) · Nature Communications · doi:10.1038/ncomms7716 · Cited by 724 · see citing works
A Novel Urine Exosome Gene Expression Assay to Predict High-grade Prostate Cancer at Initial Biopsy
McKiernan, J., Donovan, M. J., O’Neill, V., Bentink, S., Noerholm, M., Belzer, S. K., Skog, J., Kattan, M. W., Partin, A. W., Andriole, G. L., et al. (2016) · JAMA Oncology · doi:10.1001/jamaoncol.2016.0097 · Cited by 679 · see citing works
Baranyai, T., Herczeg, K., Onódi, Z., Voszka, I., Módos, K., Marton, N., Nagy, G., Mäger, I., Wood, M. J. A., Andaloussi, S. E., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145686 · Cited by 677 · see citing works
Ono, M., Kosaka, N., Tominaga, N., Yoshioka, Y., Takeshita, F., Takahashi, R.-U., Yoshida, M., Tsuda, H., Tamura, K., & Ochiya, T. (2014) · Science Signaling · doi:10.1126/scisignal.2005231 · Cited by 663 · see citing works
Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia
Yuyama, K., Sun, H., Mitsutake, S., & Igarashi, Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.324616 · Cited by 591 · see citing works
Mechanisms Governing Metastatic Dormancy and Reactivation
Giancotti, F. G. (2013) · Cell · doi:10.1016/j.cell.2013.10.029 · Cited by 586 · see citing works
miR-200–containing extracellular vesicles promote breast cancer cell metastasis
Le, M. T. N., Hamar, P., Guo, C., Basar, E., Perdigão-Henriques, R., Balaj, L., & Lieberman, J. (2014) · Journal of Clinical Investigation · doi:10.1172/jci75695 · Cited by 450 · see citing works
SCS macrophages suppress melanoma by restricting tumor-derived vesicle–B cell interactions
Pucci, F., Garris, C., Lai, C. P., Newton, A., Pfirschke, C., Engblom, C., Álvarez, D., Sprachman, M. M., Evavold, C. L., Magnuson, A. M., et al. (2016) · Science · doi:10.1126/science.aaf1328 · Cited by 348 · see citing works
Emerging biomarkers in head and neck cancer in the era of genomics
Kang, H., Kiess, A. P., & Chung, C. H. (2014) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2014.192 · Cited by 311 · see citing works
Hong, C., Funk, S., Müller, L., Boyiadzis, M. M., & Whiteside, T. L. (2016) · Journal of Extracellular Vesicles · doi:10.3402/jev.v5.29289 · Cited by 310 · see citing works
Exosomes as divine messengers: are they the Hermes of modern molecular oncology?
Braicu, C., Tomuleasa, C., Monroig-Bosque, P. D. C., Cucuianu, A., Berindan‐Neagoe, I., & Călin, G. A. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.130 · Cited by 296 · see citing works
YAP is a candidate oncogene for esophageal squamous cell carcinoma
Muramatsu, T., Imoto, I., Matsui, T., Kozaki, K., Haruki, S., Sudol, M., Shimada, Y., Tsuda, H., Kawano, T., & Inazawa, J. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq254 · Cited by 227 · see citing works
Downregulation of miR-342 is associated with tamoxifen resistant breast tumors
Cittelly, D. M., Das, P. M., Spoelstra, N. S., Edgerton, S. M., Richer, J. K., Thor, A. D., & Jones, F. E. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-317 · Cited by 191 · see citing works
miR-655 Is an EMT-Suppressive MicroRNA Targeting ZEB1 and TGFBR2
Harazono, Y., Muramatsu, T., Endo, H., Uzawa, N., Kawano, T., Harada, K., Inazawa, J., & Kozaki, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062757 · Cited by 117 · see citing works
Yuan, D., Xu, J., Wang, J., Pan, Y., Fu, J., Bai, Y., Zhang, J., & Shao, C. (2016) · Oncotarget · doi:10.18632/oncotarget.9017 · Cited by 98 · see citing works
Kojima, T., Shimazui, T., Hinotsu, S., Joraku, A., Oikawa, T., Kawai, K., Horie, R., Suzuki, H., Nagashima, R., Yoshikawa, K., et al. (2008) · Oncogene · doi:10.1038/onc.2008.391 · Cited by 92 · see citing works
Li, S., Moffett, H. F., Lü, J., Werner, L. L., Zhang, H., Ritz, J., Neuberg, D. S., Wucherpfennig, K. W., Brown, J. R., & Novina, C. D. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016956 · Cited by 84 · see citing works
miR-342-3p affects hepatocellular carcinoma cell proliferation via regulating NF-κB pathway
Zhao, L., & Zhang, Y. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.12.119 · Cited by 79 · see citing works
Circulating Serum miRNAs as Diagnostic Markers for Colorectal Cancer
Zekri, A. N., Youssef, A. S. E.-D., Lotfy, M. M., Gabr, R. M., Ahmed, O. S., Nassar, A. A.-M., Hussein, N., Omran, D., Medhat, E., Eid, S., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0154130 · Cited by 79 · see citing works
MicroRNA-1246 promotes growth and metastasis of colorectal cancer cells involving CCNG2 reduction
Wang, S., Zeng, Y., Zhou, J., Nie, S., Peng, Q., Gong, J., & Huo, J. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4557 · Cited by 78 · see citing works
miR-181a Targets RGS16 to Promote Chondrosarcoma Growth, Angiogenesis, and Metastasis
Sun, X., Charbonneau, C., Lei, W., Chen, Q., & Terek, R. M. (2015) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0697 · Cited by 70 · see citing works
Zhou, P., Ma, L., Zhou, J., Jiang, M., Rao, E., Zhao, Y., & Guo, F. (2016) · International Journal of Oncology · doi:10.3892/ijo.2016.3392 · Cited by 62 · see citing works
Zhang, T., Hu, Y., Ju, J., Hou, L., Li, Z., Xiao, D., Li, Y., Yao, J., Wang, C., Zhang, Y., et al. (2016) · Scientific Reports · doi:10.1038/srep19346 · Cited by 56 · see citing works
miR-634 Activates the Mitochondrial Apoptosis Pathway and Enhances Chemotherapy-Induced Cytotoxicity
Fujiwara, N., Inoue, J., Kawano, T., Tanimoto, K., Kozaki, K., & Inazawa, J. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0257 · Cited by 54 · see citing works
Muramatsu, T., Kozaki, K., Imoto, S., Yamaguchi, R., Tsuda, H., Kawano, T., Fujiwara, N., Morishita, M., Miyano, S., & Inazawa, J. (2016) · Oncogene · doi:10.1038/onc.2016.71 · Cited by 44 · see citing works
MiR-30a-5p is induced by Wnt/β-catenin pathway and promotes glioma cell invasion by repressing NCAM
Wang, Z., Dai, X., Chen, Y., Sun, C., Zhu, Q., Zhao, H., Liu, G., Huang, Q., & Lan, Q. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.08.007 · Cited by 43 · see citing works
Liu, W. M., Laux, H., Henry, J. Y., Bolton, T. B., Dalgleish, A. G., & Galustian, C. (2009) · Molecular Biology Reports · doi:10.1007/s11033-009-9614-3 · Cited by 31 · see citing works
Hibino, S., Kanda, M., Oya, H., Takami, H., Shimizu, D., Nomoto, S., Hishida, M., Niwa, Y., Koike, M., Yamada, S., et al. (2013) · Oncology Reports · doi:10.3892/or.2013.2901 · Cited by 27 · see citing works
Suppression of non-small cell lung cancer proliferation and tumorigenicity by DENND2D
Ling, B., Zheng, H., Fu, G., Yuan, J., Shi, T., Chen, S., Liu, Y., Liu, Y., Cao, Y. W., Zheng, S., et al. (2012) · Lung Cancer · doi:10.1016/j.lungcan.2012.10.012 · Cited by 18 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The biology <b>,</b> function <b>,</b> and biomedical applications of exosomes
Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770 · see citing works
Overview of MicroRNA Biogenesis, Mechanisms of Actions, and Circulation
O'Brien, J., Hayder, H., Zayed, Y., & Peng, C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00402 · Cited by 5,287 · see citing works
Oral squamous cell carcinomas: state of the field and emerging directions
Tan, Y., Wang, Z., Xu, M., Li, B., Huang, Z., Qin, S., Nice, E. C., Tang, J., & Huang, C. (2023) · International Journal of Oral Science · doi:10.1038/s41368-023-00249-w · Cited by 924 · see citing works
Qian, M., Wang, S., Guo, X., Wang, J., Zhang, Z., Qiu, W., Gao, X., Chen, Z., Xu, J., Zhao, R., et al. (2020) · Oncogene · doi:10.1038/s41388-019-0996-y · Cited by 345 · see citing works
Li, X. J., Ren, Z. J., Tang, J. H., & Yu, Q. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485780 · Cited by 268 · see citing works
Exosomal miRNAs in tumor microenvironment
Tan, S., Xia, L., Yi, P., Han, Y., Tang, L., Pan, Q., Tian, Y., Rao, S., Oyang, L., Liang, J., et al. (2020) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-020-01570-6 · Cited by 211 · see citing works
Emerging Function and Clinical Values of Exosomal MicroRNAs in Cancer
Wang, M., Yu, F., Ding, H., Wang, Y., Li, P., & Wang, K. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.04.027 · Cited by 196 · see citing works
Fatima, F., & Nawaz, M. (2017) · Non-Coding RNA · doi:10.3390/ncrna3010010 · Cited by 144 · see citing works
Exosomes and Their Role in Cancer Progression
Osaki, M., & Okada, F. (2019) · Yonago acta medica · doi:10.33160/yam.2019.06.002 · Cited by 134 · see citing works
Extracellular Vesicle-derived circular RNAs confers chemoresistance in Colorectal cancer
Hon, K. W., Mutalib, N. A., Abdullah, N. M. A., Jamal, R., & Abu, N. (2019) · Scientific Reports · doi:10.1038/s41598-019-53063-y · Cited by 133 · see citing works
An ARF6–Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles
Clancy, J. W., Zhang, Y., Sheehan, C. S., & D’Souza‐Schorey, C. (2019) · Nature Cell Biology · doi:10.1038/s41556-019-0345-y · Cited by 126 · see citing works
Qiu, W., Guo, X., Li, B., Wang, J., Qi, Y., Chen, Z., Zhao, R., Deng, L., Qian, M., Wang, S., et al. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.06.023 · Cited by 129 · see citing works
Miceli, R. T., Chen, T.-Y., Nose, Y., Tichkule, S., Brown, B., Fullard, J. F., Saulsbury, M. D., Heyliger, S. O., Gnjatic, S., Kyprianou, N., et al. (2024) · Journal of Extracellular Vesicles · doi:10.1002/jev2.70005 · Cited by 129 · see citing works
Exosome-mediated delivery of MALAT1 induces cell proliferation in breast cancer
Zhang, P., Zhou, H., Lu, K., Lu, Y., Wang, Y., & Feng, T. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s155134 · Cited by 129 · see citing works
Exosomal miRNA in chemoresistance, immune evasion, metastasis and progression of cancer
Kulkarni, B., Kirave, P., Gondaliya, P., Jash, K., Jain, A. K., Tekade, R. K., & Kalia, K. (2019) · Drug Discovery Today · doi:10.1016/j.drudis.2019.06.010 · Cited by 126 · see citing works
Mutschelknaus, L., Azimzadeh, O., Heider, T., Winkler, K., Vetter, M. H. F., Kell, R., Tapio, S., Merl‐Pham, J., Huber, S. M., Edalat, L., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12403-6 · Cited by 125 · see citing works
Exosomal miR-1246 in serum as a potential biomarker for early diagnosis of gastric cancer
Shi, Y., Wang, Z., Zhu, X., Chen, L., Ma, Y., Wang, J., Yang, X., & Liu, Z. (2019) · International Journal of Clinical Oncology · doi:10.1007/s10147-019-01532-9 · Cited by 125 · see citing works
Research progress of CTC, ctDNA, and EVs in cancer liquid biopsy
Wang, X., Wang, L., Lin, H., Zhu, Y., Huang, D., Lai, M., Xi, X., Huang, J., Zhang, W., & Zhong, T. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1303335 · Cited by 112 · see citing works
Sheller‐Miller, S., Choi, K., Choi, C., & Menon, R. (2019) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2019.06.010 · Cited by 110 · see citing works
Xie, C., Du, L., Guo, F., Li, X., & Cheng, B. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03526-7 · Cited by 107 · see citing works
Tabata, E., Kashimura, A., Kikuchi, A., Masuda, H., Miyahara, R., Hiruma, Y., Wakita, S., Ohno, M., Sakaguchi, M., Sugahara, Y., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-19940-8 · Cited by 102 · see citing works
Xie, C., Ji, N., Tang, Z., Li, J., & Chen, Q. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0985-3 · Cited by 102 · see citing works
Yue, K., Zhang, P., Zheng, M., Cao, X., Cao, Y., Zhang, Y., Zhang, Y.-F., Wu, H., Lu, Z., Liang, L., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2100-5 · Cited by 92 · see citing works
Bierbaumer, L., Schwarze, U. Y., Gruber, R., & Neuhaus, W. (2018) · Tissue Barriers · doi:10.1080/21688370.2018.1479568 · Cited by 91 · see citing works
RETRACTED: miR-1246 Targets CCNG2 to Enhance Cancer Stemness and Chemoresistance in Oral Carcinomas
Lin, S., Peng, C., Liao, Y., Chou, M., Hsieh, P., & Yu, C. (2018) · Cancers · doi:10.3390/cancers10080272 · Cited by 86 · see citing works
RetractedThe Role of Cancer-Derived Exosomes in Tumorigenicity & Epithelial-to-Mesenchymal Transition
Blackwell, R. H., Foreman, K. E., & Gupta, G. N. (2017) · Cancers · doi:10.3390/cancers9080105 · Cited by 82 · see citing works
The Role of Exosomal microRNA in Cancer Drug Resistance
Guo, Q.-R., Wang, H., Yan, Y.-D., Liu, Y., Su, C., Chen, H., Yan, Y., Adhikari, R., Wu, Q., & Zhang, J. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00472 · Cited by 81 · see citing works
Exosomal miRNAs: the tumor's trojan horse in selective metastasis
Bayat, M., & Nahand, J. S. (2024) · Molecular Cancer · doi:10.1186/s12943-024-02081-0 · Cited by 77 · see citing works
The Emerging Role of Exosomes in Diagnosis, Prognosis, and Therapy in Head and Neck Cancer
Hofmann, L., Ludwig, S., Vahl, J. M., Brunner, C., Hoffmann, T. K., & Theodoraki, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114072 · Cited by 72 · see citing works
MicroRNAs as Modulators of Oral Tumorigenesis—A Focused Review
Rishabh, K., Khadilkar, S., Kumar, A., Kalra, I., Kumar, A. P., & Kunnumakkara, A. B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052561 · Cited by 70 · see citing works
Wang, W., Jo, H., Park, S., Kim, H., Kim, S. I., Han, Y., Lee, J., Seol, A., Kim, J., Lee, M., et al. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215735 · Cited by 67 · see citing works
A Looking-Glass of Non-Coding RNAs in Oral Cancer
Irimie, A. I., Braicu, C., Sonea, L., Zimța, A., Cojocneanu, R., Tonchev, K., Mehterov, N. H., Diudea, D., Buduru, S. D., & Berindan‐Neagoe, I. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122620 · Cited by 67 · see citing works
Exosomes and cancer: From oncogenic roles to therapeutic applications
Mohammadi, S., Yousefi, F., Shabaninejad, Z., Movahedpour, A., Mahjoubin‐Tehran, M., Shafiee, A., Moradizarmehri, S., Hajighadimi, S., Savardashtaki, A., & Mirzaei, H. (2019) · IUBMB Life · doi:10.1002/iub.2182 · Cited by 66 · see citing works
A Review on the Role of miR-1246 in the Pathoetiology of Different Cancers
Ghafouri‐Fard, S., Khoshbakht, T., Hussen, B. M., Taheri, M. N., & Samadian, M. M. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2021.771835 · Cited by 66 · see citing works
Siriwardena, B. S. M. S., Tsunematsu, T., Qi, G., Ishimaru, N., & Kudo, Y. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051462 · Cited by 64 · see citing works
The Emerging Role of Exosomes in Oral Squamous Cell Carcinoma
Lu, Y., Zheng, Z., Yuan, Y., Pathak, J. L., Yang, X., Wang, L., Ye, Z., Cho, W. C. S., Zeng, M., & Wu, L. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.628103 · Cited by 64 · see citing works
Extracellular miR-224 as a prognostic marker for clear cell renal cell carcinoma
Fujii, N., Hirata, H., Ueno, K., Mori, J., Oka, S., Shimizu, K., Kawai, Y., Inoue, R., Yamamoto, Y., Matsumoto, H., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.22436 · Cited by 63 · see citing works
The origin of exosomal miR-1246 in human cancer cells
Xu, Y., Hannafon, B. N., Khatri, U., Gin, A. L., & Ding, W. (2019) · RNA Biology · doi:10.1080/15476286.2019.1585738 · Cited by 64 · see citing works
The role of exosomal non-coding RNAs in cancer metastasis
Wang, J.-P., Tang, Y.-Y., Fan, C.-M., Guo, C. J., Zhou, Y., Li, Z., Li, X.-L., Li, Y., Li, G.-Y., Xiong, W., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.23552 · Cited by 61 · see citing works
Huang, Y., Chen, L., Feng, Z.-M., Chen, W., Yan, S., Yang, R., Xiao, J., Gao, J., Zhang, D., & Ke, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.647763 · Cited by 58 · see citing works
Recruitment of DNA to tumor-derived microvesicles
Clancy, J. W., Sheehan, C. S., Boomgarden, A. C., & D’Souza‐Schorey, C. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110443 · Cited by 58 · see citing works
Moraes, J. A., Encarnação, C. C., Franco, V. A., Botelho, L. G. X., Rodrigues, G. P., Ramos-Andrade, I., Barja‐Fidalgo, C., & Renovato‐Martins, M. (2021) · Cancers · doi:10.3390/cancers13133328 · Cited by 57 · see citing works
Sirkisoon, S. R., Wong, G. L., Aguayo, N. R., Doheny, D. L., Zhu, D., Regua, A. T., Arrigo, A., Manore, S. G., Wagner, C. J., Thomas, A., et al. (2022) · Cancer Letters · doi:10.1016/j.canlet.2022.215726 · Cited by 58 · see citing works
Exosomes in Head and Neck Squamous Cell Carcinoma
Cheng, X., Song, F., Zheng, Y., Lv, J., Wang, Q. F., & Xu, N. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.00894 · Cited by 58 · see citing works
Xia, Y., Wei, K., Hu, L., Zhou, C., Lu, Z., Zhan, G., Pan, X., Pan, C., Wang, J., Wen, W. X., et al. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29578 · Cited by 58 · see citing works
Extracellular vesicles: important collaborators in cancer progression
Sato, S., & Weaver, A. M. (2018) · Essays in Biochemistry · doi:10.1042/ebc20170080 · Cited by 56 · see citing works
Potential Markers from Serum-Purified Exosomes for Detecting Oral Squamous Cell Carcinoma Metastasis
Li, C., Zhou, Y., Liu, J., Su, X., Qin, H., Huang, S.-H., Huang, X., & Zhou, N. (2019) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-18-1122 · Cited by 56 · see citing works
Tűzesi, Á., Kling, T., Wenger, A., Lunavat, T. R., Jang, S. C., Rydenhag, B., Lötvall, J. O., Pollard, S. M., Danielsson, A., & Carén, H. (2017) · Oncotarget · doi:10.18632/oncotarget.21621 · Cited by 54 · see citing works
Bhat, A., Yadav, J., Thakur, K., Aggarwal, N., Tripathi, T., Chhokar, A., Singh, T., Jadli, M., & Bharti, A. C. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02026-3 · Cited by 53 · see citing works
Huang, Q., Yang, J., Zheng, J., Hsueh, C., Guo, Y., & Zhou, L. F. (2018) · Oncology Reports · doi:10.3892/or.2018.6672 · Cited by 52 · see citing works
Liu, D., Upton, F. M., Rees, E., Limb, C., Jiao, L. R., Krell, J., & Frampton, A. E. (2020) · Cancers · doi:10.3390/cancers12113156 · Cited by 51 · see citing works
Current Status, Opportunities, and Challenges of Exosomes in Oral Cancer Diagnosis and Treatment
Liu, H., Huang, Y., Huang, M., Huang, Z., Wang, Q., Qing, L., Li, L., Xu, S., & Jia, B. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s365594 · Cited by 51 · see citing works
The Potential Roles of Extracellular Vesicles in Cigarette Smoke‐Associated Diseases
Ryu, A., Kim, D. H., Kim, E., & Lee, M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/4692081 · Cited by 51 · see citing works
Dilsiz, N. (2021) · Future Science OA · doi:10.2144/fsoa-2021-0102 · Cited by 50 · see citing works
Exosomes and other extracellular vesicles in oral and salivary gland cancers
Zhan, C., Yang, X., Yin, X., & Hou, J. L. (2019) · Oral Diseases · doi:10.1111/odi.13172 · Cited by 48 · see citing works
Diagnostic and therapeutic role of microRNAs in oral cancer (Review)
Wang, J., Lv, N., Lu, X., Yuan, R., Chen, Z., & Yu, J. (2020) · Oncology Reports · doi:10.3892/or.2020.7854 · Cited by 48 · see citing works
Otmani, K., Rouas, R., & Lewalle, P. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.913951 · Cited by 47 · see citing works
Li, X., He, J., Shao, M., Cui, B., Peng, F., Li, J., Ran, Y., Jin, D., Kong, J., Chang, J., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.06.151 · Cited by 47 · see citing works
Wang, X., Guo, J., Yu, P., Guo, L., Mao, X., Wang, J., Miao, S., & Sun, J. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-01840-x · Cited by 47 · see citing works
Xu, R., Li, H., Wu, S., Qu, J., Yuan, H., Zhou, Y., & Lu, Q. (2019) · International Urology and Nephrology · doi:10.1007/s11255-019-02210-5 · Cited by 43 · see citing works
Exosomal miR-196a-1 Promotes Gastric Cancer Cell Invasion and Metastasis By Targeting SFRP1
Feng, C., She, J., Chen, X., Zhang, Q., Zhang, X., Wang, Y., Ye, J., Shi, J., Tao, J., Feng, M., et al. (2019) · Nanomedicine · doi:10.2217/nnm-2019-0053 · Cited by 44 · see citing works
Exosomes in head and neck cancer: Roles, mechanisms and applications
Cao, J., Zhang, M., Xie, F., Lou, J., Zhou, X., Zhang, L., Fang, M., & Zhou, F. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.07.005 · Cited by 43 · see citing works
SRSF1 regulates exosome microRNA enrichment in human cancer cells
Xu, Y., Xu, X., Gin, A. L., Nshimiyimana, J. D., Mooers, B. H. M., Caputi, M., Hannafon, B. N., & Ding, W. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00615-9 · Cited by 41 · see citing works
Ali, N. M., Yeap, S. K., Ho, W. Y., Boo, L., Kỳ, H., Satharasinghe, D. A., Tan, S. W., Cheong, S. K., Huang, H. D., Lan, K.-C., et al. (2020) · Pharmaceuticals · doi:10.3390/ph14010008 · Cited by 41 · see citing works
Ueta, E., Tsutsumi, K., Kato, H., Matsushita, H., Shiraha, H., Fujii, M., Matsumoto, K., Horiguchi, S., & Okada, H. (2021) · Scientific Reports · doi:10.1038/s41598-021-91804-0 · Cited by 43 · see citing works
The Role of MicroRNAs in Recurrence and Metastasis of Head and Neck Squamous Cell Carcinoma
Yang, C. X., Sedhom, W. G., Song, J. I., & Lu, S. (2019) · Cancers · doi:10.3390/cancers11030395 · Cited by 40 · see citing works
Rezaee, M., Mohammadi, F., Keshavarzmotamed, A., Yahyazadeh, S., Vakili, O., Milasi, Y. E., Veisi, V., Dehmordi, R. M., Asadi, S., Ghorbanhosseini, S. S., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1152672 · Cited by 39 · see citing works
The regulatory mechanisms of oncomiRs in cancer
Otmani, K., Rouas, R., Berehab, M., & Lewalle, P. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116165 · Cited by 40 · see citing works
Sasabe, E., Tomomura, A., Liu, H., Sento, S., Kitamura, N., & Yamamoto, T. (2021) · Cancer Science · doi:10.1111/cas.15225 · Cited by 38 · see citing works
Pontecorvi, G., Bellenghi, M., Puglisi, R., Carè, A., & Mattia, G. (2019) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2019.12.010 · Cited by 37 · see citing works
LncRNA Biomarkers of Inflammation and Cancer
Reggiardo, R. E., Maroli, S. V., & Kim, D. H. (2022) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-92034-0_7 · Cited by 39 · see citing works
Yap, T., Pruthi, N., Seers, C. A., Belobrov, S., McCullough, M. J., & Celentano, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041197 · Cited by 35 · see citing works
Exosomal proteome analysis of human plasma to monitor sepsis progression
Xu, Y., Ku, X., Wu, C., Cai, C., Tang, J., & Yan, W. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.04.006 · Cited by 35 · see citing works
Exosomes and their implications in central nervous system tumor biology
Mrowczynski, O., Zacharia, B. E., & Connor, J. R. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.06.006 · Cited by 35 · see citing works
Exosomal microRNAs (exoMIRs): micromolecules with macro impact in oral cancer
Dhar, R., Mallik, S., & Devi, A. (2022) · 3 Biotech · doi:10.1007/s13205-022-03217-z · Cited by 34 · see citing works
miR-1246 as a therapeutic target in oral submucosa fibrosis pathogenesis
Liu, C., Liao, Y., Hsieh, P., Yu, C., Chueh, P. J., Lin, T., Yang, P.-Y., Yu, C., & Chou, M. (2019) · Journal of the Formosan Medical Association · doi:10.1016/j.jfma.2019.02.014 · Cited by 33 · see citing works
Emerging functions and clinical applications of exosomes in human oral diseases
Peng, Q., Yang, J., & Zhou, G. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00424-0 · Cited by 37 · see citing works
Cancer stem cell–associated miRNAs serve as prognostic biomarkers in colorectal cancer
Toden, S., Shigeyasu, K., Cardenas, J., Gu, J., Hutchins, E. D., Keuren‐Jensen, K. R. V., Uetake, H., Toiyama, Y., & Goel, A. (2019) · JCI Insight · doi:10.1172/jci.insight.125294 · Cited by 32 · see citing works
MicroRNA profile in the squamous cell carcinoma: prognostic and diagnostic roles
Ghafouri‐Fard, S., Gholipour, M., Taheri, M. N., & Shirvani-Farsani, Z. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e05436 · Cited by 32 · see citing works
Jafari, A., Karimabadi, K., Rahimi, A., Rostaminasab, G., Khazaei, M., Rezakhani, L., & Jouybari, T. A. (2023) · Technology in Cancer Research & Treatment · doi:10.1177/15330338231205999 · Cited by 31 · see citing works
Mitra, A., Yoshida-Court, K., Solley, T. N., Mikkelson, M. D., Yeung, C. L. A., Nick, A. M., Lu, K. H., & Klopp, A. H. (2021) · Scientific Reports · doi:10.1038/s41598-021-88163-1 · Cited by 31 · see citing works
Qiao, Y., Liang, X. H., Yan, Y., Lu, Y., Zhang, D., Yao, W., Wu, W., & Yan, Z. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00217 · Cited by 31 · see citing works
Ribeiro, I. P., Melo, J. B., & Carreira, I. M. (2019) · Molecular Cytogenetics · doi:10.1186/s13039-019-0447-z · Cited by 31 · see citing works
Prospective applications of microRNAs in oral cancer: A review (Review)
Fang, C., & Li, Y. (2019) · Oncology Letters · doi:10.3892/ol.2019.10751 · Cited by 30 · see citing works
Song, J., Hu, Y., Li, J., Zheng, H., Wang, J., Guo, L., Ning, R., Li, H., Yang, Z., Fan, H., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177657 · Cited by 28 · see citing works
DENN domain-containing protein FAM45A regulates the homeostasis of late/multivesicular endosomes.
Zhang, J., Zhang, K., Qi, L.-J., Hu, Q., Shen, Z., Liu, B., Deng, J., Zhang, C.-S., & Zhang, Y.-L. (2019) · Biochimica et biophysica acta. Molecular cell research · doi:10.1016/j.bbamcr.2019.02.006 · Cited by 22 · see citing works
MicroRNA-1246 Mediates Drug Resistance and Metastasis in Breast Cancer by Targeting NFE2L3
Dai, Y., Pan, Y., Quan, M., Chen, Q., Pan, Y., Ruan, Y.-Y., & Sun, J. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.677168 · Cited by 27 · see citing works
Bano, A., Vats, R., Yadav, P., & Bhardwaj, R. (2022) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2022.103799 · Cited by 27 · see citing works
Zhang, D., Li, D., Shen, L., Hu, D., Tang, B., Guo, W., Wang, Z., Zhang, Z., Wei, G., & He, D. (2020) · Oncology Reports · doi:10.3892/or.2020.7496 · Cited by 26 · see citing works
He, L., Guo, J., Fan, Z., Yang, S., Zhang, C., Cheng, B., & Xia, J. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110635 · Cited by 26 · see citing works
Transcriptional Targeting and MicroRNA Regulation of Lentiviral Vectors
Merlin, S., & Follenzi, A. (2019) · Molecular Therapy — Methods & Clinical Development · doi:10.1016/j.omtm.2018.12.013 · Cited by 25 · see citing works
Solé, C., & Lawrie, C. H. (2019) · Cancers · doi:10.3390/cancers12010096 · Cited by 27 · see citing works
Huang, Q., Hsueh, C., Guo, Y., Wu, X., Li, J.-Y., & Zhou, L. F. (2020) · IUBMB Life · doi:10.1002/iub.2274 · Cited by 25 · see citing works
Song, L., Cui, Z., & Guo, X. (2020) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmaa085 · Cited by 25 · see citing works
Characterization of miRNAs in Milk Small Extracellular Vesicles from Enzootic Bovine Leukosis Cattle
Tsukada, F., Takashima, S., Wakihara, Y., Kamatari, Y. O., Shimizu, K., Okada, A., & Inoshima, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231810782 · Cited by 25 · see citing works
Antimetastatic effects of Eclipta prostrata extract on oral cancer cells
Liao, M.-Y., Chuang, C., Hsieh, M., Chou, Y., Lin, C., Chen, W., Lai, C.-T., Chen, M., & Yang, S. (2018) · Environmental Toxicology · doi:10.1002/tox.22577 · Cited by 25 · see citing works
Novel Epigenetic Biomarkers in Pregnancy-Related Disorders and Cancers
Karin‐Kujundžić, V., Šola, I. M., Predavec, N., Potkonjak, A., Somen, E., Mioč, P., Šerman, A., Vranić, S., & Šerman, L. (2019) · Cells · doi:10.3390/cells8111459 · Cited by 25 · see citing works
MicroRNAs in Metastasis and the Tumour Microenvironment
Solé, C., & Lawrie, C. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094859 · Cited by 24 · see citing works
Bioprobes-regulated precision biosensing of exosomes: From the nanovesicle surface to the inside
Peng, X., Qin, X., Qin, Y., Xiang, Y., Zhang, G., & Yang, F. (2022) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2022.214538 · Cited by 24 · see citing works
Exosomal cargoes in OSCC: current findings and potential functions
Zhao, C., Zhang, G.-R., Liu, J., Zhang, C.-H., Yao, Y., & Liao, W. (2020) · PeerJ · doi:10.7717/peerj.10062 · Cited by 23 · see citing works
- Authors
- Sakha, S., Muramatsu, T., Ueda, K., & Inazawa, J.
- Affiliations
- Tokyo Medical and Dental University (JP)
- Japanese Foundation For Cancer Research (JP)
- Corresponding author
- Inazawa, Johji
- Venue
- Scientific Reports
- Published
- 2016-12-08
- Volume
- 6
- Issue
- 1
- Pages
- 38750-38750
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC5144099
- OpenAlex
- W2560618296
- Cited by
- 201
- References
- 42
- Citations by year
- 2026: 8 · 2025: 11 · 2024: 18 · 2023: 14 · 2022: 31 · 2021: 29 · 2020: 31 · 2019: 32 · 2018: 17 · 2017: 10
- FWCI
- 10.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- Japan Agency for Medical Research and Development
- Ministry of Education, Culture, Sports, Science and Technology (15H05908, 15K18401, 25250019)
- Japan Society for the Promotion of Science (15H05908, 16KT0116, 26890012, 26710007, 16K14630, 15K18401, 25250019)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- exosomes, exosomal microRNAs, miR-1246, miR-342-3p, oral squamous cell carcinoma, metastasis, cell motility, cell invasion, ERK signaling, Akt signaling, intercellular communication, miRNA-based therapy
- MeSH terms
- Carcinoma, Squamous Cell, Humans, Mouth Neoplasms, Neoplasm Invasiveness, Neoplasm Metastasis, Guanine Nucleotide Exchange Factors, Tumor Suppressor Proteins, MicroRNAs, Exosomes
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