Cerebral blood flow identifies responders to transcranial magnetic stimulation in auditory verbal hallucinations
Open accessAbstract
Auditory hallucinations comprise a critical domain of psychopathology in schizophrenia. Repetitive transcranial magnetic stimulation (TMS) has shown promise as an intervention with both positive and negative reports. The aim of this study was to test resting-brain perfusion before treatment as a possible biological marker of response to repetitive TMS. Twenty-four medicated patients underwent resting-brain perfusion magnetic resonance imaging with arterial spin labeling (ASL) before 10 days of repetitive TMS treatment. Response was defined as a reduction in the hallucination change scale of at least 50%. Responders (n=9) were robustly differentiated from nonresponders (n=15) to repetitive TMS by the higher regional cerebral blood flow (CBF) in the left superior temporal gyrus (STG) (P<0.05, corrected) before treatment. Resting-brain perfusion in the left STG predicted the response to repetitive TMS in this study sample, suggesting this parameter as a possible bio-marker of response in patients with schizophrenia and auditory hallucinations. Being noninvasive and relatively easy to use, resting perfusion measurement before treatment might be a clinically relevant way to identify possible responders and nonresponders to repetitive TMS.
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Higher left STG activation in a pre-TMS resting-state scan was found in those later classified as 'responders' to the TMS treatment paradigm.
“a recent neuroimaging study showing higher left STG activation in a pre-TMS resting-state scan in those that were later classified as ‘responders’ to the TMS treatment paradigm”
From Auditory verbal hallucinations as atypical inner speech monitoring, and the potential of neurostimulation as a treatment option (2013) · cites this paper as Homan et al., 2012
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- Authors
- Homan, P., Kindler, J., Hauf, M., Hubl, D., & Dierks, T.
- Affiliations
- University of Bern (CH)
- Corresponding author
- Dierks, T
- Venue
- Translational Psychiatry
- Published
- 2012-11-20
- Volume
- 2
- Issue
- 11
- Pages
- e189-e189
- ISSN
- 2158-3188 (ISSN-L)
- PMC
- PMC3565757
- OpenAlex
- W2057645958
- Cited by
- 80
- References
- 55
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 5 · 2020: 4 · 2019: 8 · 2018: 2 · 2017: 11 · 2016: 8 · 2015: 9 · 2014: 5 · 2013: 7
- FWCI
- 3.38
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (unspecified)
- Locations
- Translational Psychiatry (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- BORIS (University Library Bern) (submittedVersion)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (112578, 33CM30, 32003B, 124114)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Psychiatry and Mental health › Electroconvulsive Therapy Studies
- Keywords
- auditory verbal hallucinations, schizophrenia, repetitive transcranial magnetic stimulation, cerebral blood flow, arterial spin labeling, treatment response prediction, biomarkers, superior temporal gyrus
- MeSH terms
- Adult, Brain, Cerebrovascular Circulation, Electron Spin Resonance Spectroscopy, Female, Hallucinations, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Prognosis, Schizophrenia, Temporal Lobe, Treatment Outcome, Transcranial Magnetic Stimulation
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