CoChat
Sign Up
Cited by 333Cannabis and Cannabinoid ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Cannabinoids reveal importance of spike timing coordination in hippocampal function

Robbe, David, Montgomery, Sean M, Thome, Alexander, Rueda-Orozco, Pavel E, McNaughton, Bruce L, Buzsaki, György·2006·Nature Neuroscience
DOI 10.1038/nn1801
Open this paper in CoChat — free account

Abstract

Cannabinoids impair hippocampus-dependent memory in both humans and animals, but the network mechanisms responsible for this effect are unknown. Here we show that the cannabinoids Delta(9)-tetrahydrocannabinol and CP55940 decreased the power of theta, gamma and ripple oscillations in the hippocampus of head-restrained and freely moving rats. These effects were blocked by a CB1 antagonist. The decrease in theta power correlated with memory impairment in a hippocampus-dependent task. By simultaneously recording from large populations of single units, we found that CP55940 severely disrupted the temporal coordination of cell assemblies in short time windows (<100 ms) yet only marginally affected population firing rates of pyramidal cells and interneurons. The decreased power of local field potential oscillations correlated with reduced temporal synchrony but not with firing rate changes. We hypothesize that reduced spike timing coordination and the associated impairment of physiological oscillations are responsible for cannabinoid-induced memory deficits.

Integrity signals

Registry

Crossref · 10.1038/nn1801

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Pyramidal cells in the model tended to fire more than they typically do during theta oscillations in vivo.

    “Indeed, the pyramidal cells in our model described above (Figures 3 and 4) tended to fire more than they typically do during theta oscillations in vivo (e.g., [Soltesz and Deschênes, 1993; Robbe et al., 2006]).”

    From Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit (2016) · cites this paper as Robbe et al., 2006

  • In simulations with scaled-up inhibition, only 1% of the pyramidal cells were active, and they fired at a low rate of 1.8 Hz.

    “In simulations with the model containing this rationally scaled up inhibition, only 1% of the pyramidal cells were active, and they fired at a low rate of 1.8 Hz (data not shown), closely resembling the in vivo condition (Soltesz and Deschênes, 1993; Robbe et al., 2006).”

    From Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit (2016) · cites this paper as Robbe et al., 2006

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Robbe, D., Montgomery, S. M., Thome, A., Rueda-Orozco, P. E., McNaughton, B. L., & Buzsaki, G.
Affiliations
  • Rutgers, The State University of New Jersey (US)
  • University of Arizona (US)
ORCID
Venue
Nature Neuroscience
Publisher
Springer Science and Business Media LLC
Published
2006-11-19
Volume
9
Issue
12
Pages
1526-1533
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
DOI
10.1038/nn1801
OpenAlex
W2114192904
Cited by
333
References
49
Citations by year
2026: 7 · 2025: 10 · 2024: 9 · 2023: 8 · 2022: 16 · 2021: 15 · 2020: 12 · 2019: 8 · 2018: 14 · 2017: 13 · 2016: 18 · 2015: 25 · 2014: 25 · 2013: 13 · 2012: 21
FWCI
14.61
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (R01MH054671, MH54671)
  • National Institute of Neurological Disorders and Stroke (NS 43157, NS-20331, R01NS043157, R01NS034994, NS-34994)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
cannabinoids, delta-9-tetrahydrocannabinol, CP55,940, hippocampus, hippocampal-dependent memory, memory impairment, theta oscillations, gamma oscillations, ripple oscillations, CB1 receptor, temporal synchronization, cell assemblies, local field potentials, pyramidal neurons, interneurons, neural oscillations
MeSH terms
Action Potentials, Animals, Cannabinoids, Cortical Synchronization, Cyclohexanes, Cyclohexanols, Hippocampus, Periodicity, Phenols, Dronabinol, Theta Rhythm, Receptors, Cannabinoid, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review