Object recognition memory and the rodent hippocampus

Broadbent, Nicola J.; Gaskin, Stephane; Squire, Larry R.; Clark, Robert E.

doi:10.1101/lm.1650110

Cited by 568Memory and Neural MechanismsMemory Processes and InfluencesNeurogenesis and neuroplasticity mechanisms

Object recognition memory and the rodent hippocampus

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Broadbent, Nicola J., Gaskin, Stephane, Squire, Larry R., Clark, Robert E.·2010·Learning & Memory

DOI 10.1101/lm.1650110PMC PMC2807177

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Abstract

In rodents, the novel object recognition task (NOR) has become a benchmark task for assessing recognition memory. Yet, despite its widespread use, a consensus has not developed about which brain structures are important for task performance. We assessed both the anterograde and retrograde effects of hippocampal lesions on performance in the NOR task. Rats received 12 5-min exposures to two identical objects and then received either bilateral lesions of the hippocampus or sham surgery 1 d, 4 wk, or 8 wk after the final exposure. On a retention test 2 wk after surgery, the 1-d and 4-wk hippocampal lesion groups exhibited impaired object recognition memory. In contrast, the 8-wk hippocampal lesion group performed similarly to controls, and both groups exhibited a preference for the novel object. These same rats were then given four postoperative tests using unique object pairs and a 3-h delay between the exposure phase and the test phase. Hippocampal lesions produced moderate and reliable memory impairment. The results suggest that the hippocampus is important for object recognition memory.

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Novel object recognition involves hippocampal and parahippocampal structures.
“Using novel object recognition which involves hippocampal and parahippocampal structures,24”
From Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress (2014) · cites this paper as [24]
Some studies showed that rats with hippocampal lesions had impaired NOP (across delays from 10 minutes to 24 hours) memory.
“Some studies showed that rats with hippocampal lesions had impaired NOP (across delays from 10 minutes to 24 hours) memory (Ainge et al., 2006; Broadbent et al., 2010; Broadbent et al., 2004; Clark et al., 2000), whereas the majority of the studies employing hippocampal lesions in rats failed to report an influence in the NOP test (Albasser et al., 2012; Albasser et al., 2010; Barker and Warburton”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Broadbent et al., 2010
Long-term NOP impairment was consistently found when the hippocampus was damaged after the learning session.
“Nevertheless, long-term NOP impairment was consistently found when the hippocampus was damaged after the learning session (Broadbent et al., 2010; Gaskin et al., 2003; Haijima and Ichitani, 2012).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Broadbent et al., 2010
Animals with hippocampus lesion, after being submitted to repeated exposure of the sample trial in the NOP test, exhibited impaired recognition memory when tested within 5, but not 8, weeks after the lesions.
“In studies investigating retrograde memory, animals with hippocampus lesion, after being submitted to repeated exposure of the sample trial in the NOP test, exhibited impaired recognition memory when tested within 5, but not 8, weeks after the lesions (Broadbent et al., 2010; Gaskin et al., 2003; Haijima and Ichitani, 2012).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Broadbent et al., 2010

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Self-citation
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Authors: Broadbent, N. J., Gaskin, S., Squire, L. R., & Clark, R. E.
Affiliations: University of California System (US)
ORCID: Squire, Larry R.
Clark, Robert E.
Venue: Learning & Memory
Publisher: Cold Spring Harbor Laboratory
Published: 2009-12-22
Volume: 17
Issue: 1
Pages: 5-11
ISSN: 1072-0502 (ISSN-L)
1549-5485
DOI: 10.1101/lm.1650110
PMC: PMC2807177
OpenAlex: W2046922635
Cited by: 568
References: 24
Citations by year: 2026: 20 · 2025: 24 · 2024: 31 · 2023: 24 · 2022: 46 · 2021: 44 · 2020: 47 · 2019: 31 · 2018: 47 · 2017: 38 · 2016: 51 · 2015: 34 · 2014: 32 · 2013: 38 · 2012: 21
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Learning & Memory (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation (0542013)
U.S. Department of Veterans Affairs
James S. McDonnell Foundation
Kavli Foundation
National Institute on Aging (P50AG005131, P50-AG05131)
National Institute of Mental Health (P50 AG05131, AG05131, R01MH024600)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: object recognition memory, hippocampus, hippocampal lesions, anterograde amnesia, retrograde amnesia, memory impairment, rats
MeSH terms: Analysis of Variance, Animals, Behavior, Animal, Exploratory Behavior, Hippocampus, Male, Memory, Random Allocation, Time Factors, Rats, Long-Evans, Rats

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Object recognition memory and the rodent hippocampus

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