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Cited by 266

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

Brain-derived neurotrophic factor protects against tau-related neurodegeneration of Alzheimer’s disease

Open access
Jiao, S-S, Shen, L-L, Zhu, C, Bu, X-L, Liu, Y-H, Liu, C-H, Yao, X-Q, Zhang, L-L, Zhou, H-D, Walker, D G, Tan, J, Götz, J, Zhou, X-F, Wang, Y-J·2016·Translational Psychiatry
DOI 10.1038/tp.2016.186
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Abstract

Reduced expression of brain-derived neurotrophic factor (BDNF) has a crucial role in the pathogenesis of Alzheimer’s disease (AD), which is characterized with the formation of neuritic plaques consisting of amyloid-beta (Aβ) and neurofibrillary tangles composed of hyperphosphorylated tau protein. A growing body of evidence indicates a potential protective effect of BDNF against Aβ-induced neurotoxicity in AD mouse models. However, the direct therapeutic effect of BDNF supplement on tauopathy in AD remains to be established. Here, we found that the BDNF level was reduced in the serum and brain of AD patients and P301L transgenic mice (a mouse model of tauopathy). Intralateral ventricle injection of adeno-associated virus carrying the gene encoding human BDNF (AAV-BDNF) achieved stable expression of BDNF gene and restored the BDNF level in the brains of P301L mice. Restoration of the BDNF level attenuated behavioral deficits, prevented neuron loss, alleviated synaptic degeneration and reduced neuronal abnormality, but did not affect tau hyperphosphorylation level in the brains of P301L mice. Long-term expression of AAV-BDNF in the brain was well tolerated by the mice. These findings suggest that the gene delivery of BDNF is a promising treatment for tau-related neurodegeneration for AD and other neurodegenerative disorders with tauopathy.

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Metadata

Authors
Jiao, S.-S., Shen, L.-L., Zhu, C., Bu, X.-L., Liu, Y.-H., Liu, C.-H., Yao, X.-Q., Zhang, L.-L., Zhou, H.-D., Walker, D. G., Tan, J., Götz, J., Zhou, X.-F., & Wang, Y.-J.
Venue
Translational Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2016-10-04
Volume
6
Issue
10
Pages
e907-e907
ISSN
2158-3188 (ISSN-L)
DOI
10.1038/tp.2016.186
OpenAlex
W2529170838
Cited by
266
References
48
FWCI
9.81
Type
journal article
Language
en
Open access
gold

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