Sol–gel derived nitric oxide-releasing oxygen sensors
Abstract
An amperometric sol-gel derived sensor that both releases nitric oxide (NO) and measures physiologically relevant concentrations of oxygen (PO2) is described. The sensor consists of a platinum electrode coated with an aminosilane/ethyltrimethoxysilane hybrid xerogel film. Hydrophilic polyurethane (HPU) is doped into the hybrid film to reduce sensor hydration time and increase oxygen permeability. Diazeniumdiolate NO donors are formed within the polymer matrix by exposing the cured film to high pressures of NO. These coatings release up to 7.2 pmol s(-1) cm(-2) of NO over the first 12 h and maintain detectable levels of NO release through 48 h. Sensors modified with HPU-doped, NO-releasing xerogels exhibit a linear response to O2 within 30 min of polarization at -0.65 V vs. Ag/AgCl, and have a sensitivity of approximately 6 nA/mmHg O2. The xerogel coating is stable in buffer solution with minimal fragmentation over 48 h. In vitro biocompatibility studies indicate that these materials effectively reduce platelet adhesion.
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Marxer et al.'s amperometric sol-gel oxygen sensor coating released NO at a flux up to 4.32 × 10−10 mol cm−2 min−1 for the first 12 h.
“The coating released NO at a flux up to 4.32 × 10−10 mol cm−2 min−1 for the first 12 h and effectively reduced platelet adhesion in the in vitro biocompatibility testing when immersed in platelet rich plasma for 1 h at 37 °C.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [266]
Marxer et al.'s coating effectively reduced platelet adhesion in in vitro testing with platelet rich plasma for 1 h at 37 °C.
“The coating released NO at a flux up to 4.32 × 10−10 mol cm−2 min−1 for the first 12 h and effectively reduced platelet adhesion in the in vitro biocompatibility testing when immersed in platelet rich plasma for 1 h at 37 °C.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [266]
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- Authors
- Marxer, S. M., Robbins, M. E., & Schoenfisch, M. H.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- Corresponding author
- Schoenfisch, Mark H.
- Venue
- The Analyst
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2005
- Volume
- 130
- Issue
- 2
- Pages
- 206-212
- ISSN
- 0003-2654 (ISSN-L)
- 1364-5528
- OpenAlex
- W1997466488
- Cited by
- 23
- References
- 34
- Citations by year
- 2022: 1 · 2021: 1 · 2020: 1 · 2019: 1 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 1.63
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Analyst (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- University of North Carolina at Chapel Hill
- National Institute of Biomedical Imaging and Bioengineering (EB 000708, R01EB000708)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Gas Sensing Nanomaterials and Sensors
- Keywords
- nitric oxide release, oxygen sensors, amperometric sensor, sol-gel xerogels, diazeniumdiolates, platinum electrode, biocompatibility, platelet adhesion
- MeSH terms
- Animals, Electrochemistry, Nitric Oxide, Oxygen, Swine, Phase Transition
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