Nitric Oxide Donors: A Continuing Opportunity in Drug Design
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Reduced NO levels are associated with high blood pressure, deep vein thrombosis, intimal hypertension, restenosis, endothelial dysfunction, and prolonged wound healing in diabetic patients.
“Reduced NO levels are associated with many health complications and/or diseases, such as high blood pressure, deep vein thrombosis, intimal hypertension, restenosis, endothelial dysfunction, and prolonged wound healing times in diabetic patients, etc.1,131,132”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [131]
Nitroglycerin, sodium nitroprusside, and molsidomine have been used clinically for chest pain, blood pressure control, and pulmonary hypertension, respectively.
“Various NO-related drugs have been used in the clinical settings for many years: nitroglycerin (converted to NO by enzymes) for chest pain, sodium nitroprusside for controlling blood pressure, and molsidomine for pulmonary hypertension.131”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [131]
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- Authors
- Hanson, S. R., Hutsell, T. C., Keefer, L. K., Mooradian, D. L., & Smith, D. J.
- Affiliations
- Emory University (US)
- Frederick National Laboratory for Cancer Research (US)
- University of Minnesota (US)
- University of Akron (US)
- Venue
- Advances in Pharmacology
- Publisher
- Elsevier
- Published
- 1995
- Volume
- 34
- Pages
- 383-398
- ISSN
- 1054-3589 (ISSN-L)
- OpenAlex
- W1545632096
- Cited by
- 47
- References
- 30
- Citations by year
- 2024: 2 · 2020: 1 · 2019: 2 · 2016: 1 · 2014: 1 · 2013: 2
- FWCI
- 5.86
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Advances in pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (HL 31469, HL-48667, R01HL031469, P01HL048667)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
- Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
- Keywords
- nitric oxide donors, restenosis after angioplasty, vascular graft thrombosis, vascular smooth muscle cell proliferation, platelet deposition, infusion devices, drug design
- MeSH terms
- Animals, Cardiovascular Agents, Humans, Nitric Oxide, Drug Design
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