Improved in Vivo Performance of Amperometric Oxygen ( P O2) Sensing Catheters via Electrochemical Nitric Oxide Generation/Release
Open accessAbstract
A novel electrochemically controlled release method for nitric oxide (NO) (based on electrochemical reduction of nitrite ions) is combined with an amperometric oxygen sensor within a dual lumen catheter configuration for the continuous in vivo sensing of the partial pressure of oxygen (PO2) in blood. The on-demand electrochemical NO generation/release method is shown to be fully compatible with amperometric PO2 sensing. The performance of the sensors is evaluated in rabbit veins and pig arteries for 7 and 21 h, respectively. Overall, the NO releasing sensors measure both venous and arterial PO2 values more accurately with an average deviation of −2 ± 11% and good correlation (R2 = 0.97) with in vitro blood measurements, whereas the corresponding control sensors without NO release show an average deviation of −31 ± 28% and poor correlation (R2 = 0.43) at time points >4 h after implantation in veins and >6 h in arteries. The NO releasing sensors induce less thrombus formation on the catheter surface in both veins and arteries (p < 0.05). This electrochemical NO generation/release method could offer a new and attractive means to improve the biocompatibility and performance of implantable chemical sensors.
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Applying different potentials on electrodes can modulate the NO generation rate, offering a steady, controllable, physiologically relevant NO flux compared with chemically based NO generation.
“Applying different potentials on the electrodes can modulate the rate of NO generation, which offers a steady, controllable, and physiologically relevant flux of NO, compared to the chemically-based NO generation.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [258]
Sensors with electrochemical NO generation provided very accurate oxygen responses in rabbit veins and pig arteries.
“In both cases, the sensors with electrochemical NO generation provided very accurate oxygen responses, while control sensors deviated from the real values by 30–40 % after 5 h of implantation because the local oxygen was consumed by the activated platelets and other cells trapped in the thrombus formed on the surface of the control sensors.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [258]
This electrochemical approach has been used to develop multi-lumen catheters with one lumen dedicated to generating NO electrochemically to reduce thrombus and microbial biofilm formation on catheter surfaces.
“This approach has been utilized to develop a new generation of multi-lumen catheters in which one lumen is dedicated to generating NO electrochemically to reduce thrombus and microbial biofilm formation on the surface of the catheters.147,258”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [258]
The control sensor deviation was because local oxygen was consumed by activated platelets and other cells trapped in thrombus on the control sensor surfaces.
“In both cases, the sensors with electrochemical NO generation provided very accurate oxygen responses, while control sensors deviated from the real values by 30–40 % after 5 h of implantation because the local oxygen was consumed by the activated platelets and other cells trapped in the thrombus formed on the surface of the control sensors.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [258]
Control sensors deviated from real oxygen values by 30-40% after 5 h of implantation.
“In both cases, the sensors with electrochemical NO generation provided very accurate oxygen responses, while control sensors deviated from the real values by 30–40 % after 5 h of implantation because the local oxygen was consumed by the activated platelets and other cells trapped in the thrombus formed on the surface of the control sensors.”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [258]
Ren et al. demonstrated a dual lumen catheter combining an amperometric oxygen sensor with electrochemical NO generation using Cu(II)TPMA as mediator for nitrite reduction to NO.
“In a separate study, Ren et al. recently demonstrated the use of a dual lumen catheter configuration to combine an amperometric oxygen sensor (in one lumen) with the electrochemical NO generation in the other lumen using Cu(II)TPMA as the mediator for reduction of nitrite ions to NO258 (see Figure 8).”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [258]
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- Authors
- Ren, H., Coughlin, M. A., Major, T. C., Aiello, S., Rojas Pena, A., Bartlett, R. H., & Meyerhoff, M. E.
- Affiliations
- University of Michigan (US)
- University of Michigan , , , ,
- Corresponding author
- Meyerhoff, Mark E.
- Venue
- Analytical Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-07-23
- Volume
- 87
- Issue
- 16
- Pages
- 8067-8072
- ISSN
- 0003-2700 (ISSN-L)
- 1520-6882
- PMC
- PMC4556045
- OpenAlex
- W2419451964
- Cited by
- 30
- References
- 29
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 7
- FWCI
- 2.41
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Analytical Chemistry (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-119403-01)
- National Institute of Biomedical Imaging and Bioengineering (EB-000783)
- Topics
- Physical Sciences › Engineering › Electrical and Electronic Engineering › Electrochemical sensors and biosensors
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Physical Sciences › Chemistry › Electrochemistry › Electrochemical Analysis and Applications
- Keywords
- nitric oxide release, amperometric oxygen sensor, oxygen partial pressure, implantable catheters, double-lumen catheter, thrombus formation, biocompatibility
- MeSH terms
- Animals, Electrochemistry, Monitoring, Physiologic, Nitric Oxide, Oxygen, Rabbits, Swine, Biosensing Techniques
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