Cited by 544Nanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryDendrimers and Hyperbranched Polymers

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Tailoring nanocarriers for intracellular protein delivery

Gu, Zhen, Biswas, Anuradha, Zhao, Muxun, Tang, Yi·2011·Chemical Society Reviews

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Abstract

Proteins play a crucial role in life, taking part in all vital processes in the body. In the past decade, there was increasing interest in delivering active forms of proteins to specific cells and organs. Intracellular protein delivery holds enormous promise for biological and medical applications, including cancer therapy, vaccination, regenerative medicine, treatment for loss-of-function genetic diseases and imaging. This tutorial review surveys recent developments in intracellular protein delivery using various nanocarriers. Methods such as lipid-mediated colloidal systems, polymeric nanocarriers, inorganic systems and protein-mediated carriers are reviewed. Advantages and limitations of current strategies, as well as future opportunities and challenges are also discussed.

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See all 544

Authors: Gu, Z., Biswas, A., Zhao, M., & Tang, Y.
Affiliations: California NanoSystems Institute (US)
Corresponding author: Gu, Zhen
Tang, Yi
ORCID: Gu, Zhen
Tang, Yi
Venue: Chemical Society Reviews
Publisher: Royal Society of Chemistry (RSC)
Published: 2011
Volume: 40
Issue: 7
Pages: 3638
ISSN: 0306-0012 (ISSN-L)
1460-4744
DOI: 10.1039/c0cs00227e
OpenAlex: W2135198179
Cited by: 543
References: 90
Citations by year: 2026: 7 · 2025: 19 · 2024: 28 · 2023: 38 · 2022: 46 · 2021: 47 · 2020: 59 · 2019: 51 · 2018: 56 · 2017: 42 · 2016: 43 · 2015: 32 · 2014: 34 · 2013: 21 · 2012: 13
FWCI: 1.44
Type: journal article
Language: en
Open access: closed
Locations: Chemical Society Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: David and Lucile Packard Foundation
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
Keywords: intracellular protein delivery, nanocarriers, polymeric nanocarriers, inorganic nanocarriers, targeted protein delivery, cancer therapy, vaccination, regenerative medicine, protein imaging
MeSH terms: Animals, Cell Line, Drug Carriers, Humans, Proteins, Protein Transport, Intracellular Space, Nanostructures

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Tailoring nanocarriers for intracellular protein delivery

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