Tailoring nanocarriers for intracellular protein delivery

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

Takahashi, K., & Yamanaka, S. (2006) · Cell · doi:10.1016/j.cell.2006.07.024 · Cited by 26,673

Nanocarriers as an emerging platform for cancer therapy

Peer, D., Karp, J. M., Hong, S., Farokhzad, O. C., Margalit, R., & Langer, R. (2007) · Nature Nanotechnology · doi:10.1038/nnano.2007.387 · Cited by 8,710

Magnetic iron oxide nanoparticles: Synthesis, stabilization, vectorization, physicochemical characterizations and biological applications

Laurent, S., Forge, D., Port, M., Roch, A., Robic, C., Vander Elst, L., & Muller, R. N. (2008) · Chemical Reviews · doi:10.1021/cr068445e · Cited by 6,852

Emerging applications of stimuli-responsive polymer materials

Stuart, M. A. C., Huck, W. T. S., Genzer, J., Müller, M., Ober, C. K., Stamm, M., Sukhorukov, G. B., Szleifer, I. G., Tsukruk, V. V., Urban, M. W., et al. (2010) · Nature Materials · doi:10.1038/nmat2614 · Cited by 5,798

Strategies in the design of nanoparticles for therapeutic applications

Petros, R. A., & DeSimone, J. M. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd2591 · Cited by 3,651

Knocking down barriers: advances in siRNA delivery

Whitehead, K. A., Langer, R., & Anderson, D. G. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2742 · Cited by 3,115

Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity

Boisselier, É., & Astruc, D. (2009) · Chemical Society Reviews · doi:10.1039/b806051g · Cited by 2,832

Polymeric systems for controlled drug release

Uhrich, K. E., Cannizzaro, S. M., Langer, R. S., & Shakesheff, K. M. (1999) · Chemical Reviews · doi:10.1021/cr940351u · Cited by 2,633

Design and development of polymers for gene delivery

Pack, D. W., Hoffman, A. S., Pun, S., & Stayton, P. S. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1775 · Cited by 2,568

Protein Therapeutics: A Summary and Pharmacological Classification

Leader, B., Baca, Q. J., & Golan, D. E. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2399 · Cited by 2,161

Polymeric Nanoparticles for Drug Delivery

Beach, M. A., Nayanathara, U., Gao, Y., Zhang, C., Xiong, Y., Wang, Y., & Such, G. K. (2024) · Chemical Reviews · doi:10.1021/acs.chemrev.3c00705 · Cited by 1,279

DNA Nanotechnology-Enabled Drug Delivery Systems

Hu, Q., Li, H., Wang, L., Gu, H., & Fan, C. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00663 · Cited by 1,140

Nanotechnology: A New Opportunity in Plant Sciences

Wang, P., Lombi, E., Zhao, F. J., & Kopittke, P. M. (2016) · Trends in Plant Science · doi:10.1016/j.tplants.2016.04.005 · Cited by 1,104

Cucurbituril chemistry: a tale of supramolecular success

Masson, E., Ling, X., Joseph, R., Kyeremeh‐Mensah, L., & Lu, X. (2011) · RSC Advances · doi:10.1039/c1ra00768h · Cited by 940

Getting Across the Cell Membrane: An Overview for Small Molecules, Peptides, and Proteins

Yang, N. J., & Hinner, M. J. (2015) · Methods in Molecular Biology · doi:10.1007/978-1-4939-2272-7_3 · Cited by 826

Intracellular Delivery by Membrane Disruption: Mechanisms, Strategies, and Concepts

Stewart, M. P., Langer, R., & Jensen, K. F. (2018) · Chemical Reviews · doi:10.1021/acs.chemrev.7b00678 · Cited by 767

Enzyme-responsive nanomaterials for controlled drug delivery

Hu, Q., Katti, P. S., & Gu, Z. (2014) · Nanoscale · doi:10.1039/c4nr04249b · Cited by 683

Polyphenol‐Containing Nanoparticles: Synthesis, Properties, and Therapeutic Delivery

Guo, Y., Sun, Q., Wu, F., Dai, Y., & Chen, X. S. (2021) · Advanced Materials · doi:10.1002/adma.202007356 · Cited by 663

Self‐assembled DNA nanoclews for the efficient delivery of CRISPR–Cas9 for genome editing

Sun, W., Ji, W., Hall, J. M., Hu, Q., Wang, C., Beisel, C. L., & Gu, Z. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201506030 · Cited by 629

Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles

Wang, M., Zuris, J. A., Meng, F., Rees, H., Sun, S., Deng, P., Han, Y., Gao, X., Pouli, D., Wu, Q., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520244113 · Cited by 624

CRISPR/Cas9-based genome editing for disease modeling and therapy: challenges and opportunities for nonviral delivery

Wang, H.-X., Li, M., Lee, C. M., Chakraborty, S., Kim, H.-W., Bao, G., & Leong, K. W. (2017) · Chemical Reviews · doi:10.1021/acs.chemrev.6b00799 · Cited by 560

To PEGylate or not to PEGylate: Immunological properties of nanomedicine’s most popular component, polyethylene glycol and its alternatives

Shi, D., Beasock, D., Fessler, A., Szebeni, J., Ljubimova, J. Y., Afonin, K. A., & Dobrovolskaia, M. A. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2021.114079 · Cited by 535

Supramolecular regulation of bioorthogonal catalysis in cells using nanoparticle-embedded transition metal catalysts

Tonga, G. Y., Jeong, Y., Duncan, B., Mizuhara, T., Mout, R., Das, R., Kim, S. T., Yeh, Y., Yan, B., Hou, S., et al. (2015) · Nature Chemistry · doi:10.1038/nchem.2284 · Cited by 500

Biomineralized Metal–Organic Framework Nanoparticles Enable Intracellular Delivery and Endo-Lysosomal Release of Native Active Proteins

Chen, T., Yi, J., Zhao, Y., & Chu, X. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b04457 · Cited by 465

Stimuli-responsive nanomaterials for therapeutic protein delivery

Lu, Y., Sun, W., & Gu, Z. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.08.015 · Cited by 415

Nanotechnology for protein delivery: Overview and perspectives

Yu, M., Wu, J., Shi, J., & Farokhzad, O. C. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.10.012 · Cited by 410

Nanoscale ATP-Responsive Zeolitic Imidazole Framework-90 as a General Platform for Cytosolic Protein Delivery and Genome Editing

Yang, X., Tang, Q., Jiang, Y. Y., Zhang, M., Wang, M., & Mao, L. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b11996 · Cited by 407

Emerging micro- and nanotechnology based synthetic approaches for insulin delivery

Mo, R., Jiang, T., Di, J., Tai, W., & Gu, Z. (2014) · Chemical Society Reviews · doi:10.1039/c3cs60436e · Cited by 389

Catalase-Integrated Hyaluronic Acid as Nanocarriers for Enhanced Photodynamic Therapy in Solid Tumor

Phua, S. Z. F., Yang, G., Lim, W. Q., Verma, A., Chen, H., Thanabalu, T., & Zhao, Y. (2019) · ACS Nano · doi:10.1021/acsnano.9b01087 · Cited by 375

Self-assembly of extracellular vesicle-like metal–organic framework nanoparticles for protection and intracellular delivery of biofunctional proteins

Cheng, G., Li, W., Ha, L., Han, X., Hao, S., Wan, Y., Wang, Z., Dong, F., Zou, X., Mao, Y., et al. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b03584 · Cited by 371

Polymeric nanostructured materials for biomedical applications

Tang, Z., He, C., Tian, H., Ding, J., Hsiao, B. S., Chu, B., & Chen, X. (2016) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2016.05.005 · Cited by 370

Nanoparticle approaches against bacterial infections

Gao, W., Thamphiwatana, S., Angsantikul, P., & Zhang, L. (2014) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1282 · Cited by 358

Materials and methods for delivery of biological drugs

Zelikin, A. N., Ehrhardt, C., & Healy, A. M. (2016) · Nature Chemistry · doi:10.1038/nchem.2629 · Cited by 321

Nanostraw–Electroporation System for Highly Efficient Intracellular Delivery and Transfection

Xie, X., Xu, A. M., Leal‐Ortiz, S., Cao, Y., Garner, C. C., & Melosh, N. A. (2013) · ACS Nano · doi:10.1021/nn400874a · Cited by 313

DNA-Functionalized Metal–Organic Framework Nanoparticles for Intracellular Delivery of Proteins

Wang, S., Chen, Y., Wang, S., Li, P., Mirkin, C. A., & Farha, O. K. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.8b12705 · Cited by 304

Gel–Liposome‐Mediated Co‐Delivery of Anticancer Membrane‐Associated Proteins and Small‐Molecule Drugs for Enhanced Therapeutic Efficacy

Jiang, T., Mo, R., Bellotti, A., Zhou, J., & Gu, Z. (2014) · Advanced Functional Materials · doi:10.1002/adfm.201303222 · Cited by 297

Cell-permeable nanobodies for targeted immunolabelling and antigen manipulation in living cells

Herce, H. D., Schumacher, D., Schneider, A. F. L., Ludwig, A. K., Mann, F. A., Fillies, M., Kasper, M., Reinke, S. O., Krause, E., Leonhardt, H., et al. (2017) · Nature Chemistry · doi:10.1038/nchem.2811 · Cited by 294

Smart Design of Nanomaterials for Mitochondria‐Targeted Nanotherapeutics

Liew, S. S., Qin, X., Zhou, J., Li, L., Huang, W., & Yao, S. Q. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.201915826 · Cited by 296

Rational Design of Nanocarriers for Intracellular Protein Delivery

Qin, X., Yu, C., Wei, J., Li, L., Zhang, C., Wu, Q., Liu, J., Yao, S. Q., & Huang, W. (2019) · Advanced Materials · doi:10.1002/adma.201902791 · Cited by 286

ARMMs as a versatile platform for intracellular delivery of macromolecules

Wang, Q., Yu, J., Kadungure, T., Beyene, J., Zhang, H., & Lu, Q. (2018) · Nature Communications · doi:10.1038/s41467-018-03390-x · Cited by 275

Polymers for cytosolic protein delivery

Lv, J., Fan, Q., Wang, H., & Cheng, Y. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119358 · Cited by 266

Tissue Engineering Tools For Modulation of the Immune Response

Boehler, R. M., Graham, J. G., & Shea, L. D. (2011) · BioTechniques · doi:10.2144/000113754 · Cited by 269

Combinatorially Designed Lipid‐like Nanoparticles for Intracellular Delivery of Cytotoxic Protein for Cancer Therapy

Wang, M., Alberti, K. A., Sun, S., Arellano, C. L., & Xu, Q. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201311245 · Cited by 250

Mesoporous Silica Nanoparticles for Protein Protection and Delivery

Xu, C., Lei, C., & Yu, C. (2019) · Frontiers in Chemistry · doi:10.3389/fchem.2019.00290 · Cited by 247

Mesoporous silica nanoparticles: Synthesis, pharmaceutical applications, biodistribution, and biosafety assessment

Farjadian, F., Roointan, A., Mohammadi‐Samani, S., & Hosseini, M. H. (2018) · Chemical Engineering Journal · doi:10.1016/j.cej.2018.11.156 · Cited by 248

Microneedles Integrated with Pancreatic Cells and Synthetic Glucose‐Signal Amplifiers for Smart Insulin Delivery

Ye, Y., Yu, J., Wang, C., Nguyen, N., Walker, G. M., Buse, J. B., & Gu, Z. (2016) · Advanced Materials · doi:10.1002/adma.201506025 · Cited by 239

Multifunctional nanoparticles for targeted delivery of immune activating and cancer therapeutic agents

Feng, J., Liu, X., Li, L., Mallapragada, S. K., Narasimhan, B., & Wang, Q. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.10.012 · Cited by 224

Bypassing Endocytosis: Direct Cytosolic Delivery of Proteins

Du, S., Liew, S. S., Li, L., & Yao, S. Q. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b06584 · Cited by 225

Interfacing Materials Science and Biology for Drug Carrier Design

Such, G. K., Yan, Y., Johnston, A. P. R., Gunawan, S. T., & Caruso, F. (2015) · Advanced Materials · doi:10.1002/adma.201405084 · Cited by 220

Genome Editing for Cancer Therapy: Delivery of Cas9 Protein/sgRNA Plasmid via a Gold Nanocluster/Lipid Core–Shell Nanocarrier

Wang, P., Zhang, L., Xie, Y., Wang, N., Tang, R., Zheng, W., & Jiang, X. (2017) · Advanced Science · doi:10.1002/advs.201700175 · Cited by 215

Protein delivery into cells using inorganic nanoparticle–protein supramolecular assemblies

Scaletti, F., Hardie, J., Lee, Y.-W., Luther, D. C., Ray, M., & Rotello, V. M. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00008e · Cited by 208

Encapsulation of Plasmid DNA by Nanoscale Metal–Organic Frameworks for Efficient Gene Transportation and Expression

Li, Y., Zhang, K., Liu, P., Chen, M., Zhong, Y. L., Ye, Q., Wei, M. Q., Zhao, H., & Tang, Z. (2019) · Advanced Materials · doi:10.1002/adma.201901570 · Cited by 208

Nanomotor-Enabled pH-Responsive Intracellular Delivery of Caspase-3: Toward Rapid Cell Apoptosis

de Ávila, B. E., Ramírez‐Herrera, D. E., Campuzano, S., Angsantikul, P., Zhang, L., & Wang, J. (2017) · ACS Nano · doi:10.1021/acsnano.7b01926 · Cited by 201

Poly(α-l-lysine)-based nanomaterials for versatile biomedical applications: Current advances and perspectives

Zheng, M., Pan, M., Zhang, W., Lin, H., Wu, S., Lu, C. T., Tang, S., Liu, D., & Cai, J. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.12.001 · Cited by 199

Enhanced Anticancer Efficacy by ATP‐Mediated Liposomal Drug Delivery

Mo, R., Jiang, T., & Gu, Z. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201400268 · Cited by 196

Nano-therapeutics: A revolution in infection control in post antibiotic era

Zaidi, S., Misba, L., & Khan, A. U. (2017) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2017.06.015 · Cited by 196

Drug Carriers for the Delivery of Therapeutic Peptides

Du, A. W., & Stenzel, M. H. (2014) · Biomacromolecules · doi:10.1021/bm500169p · Cited by 192

Biomedical polymers: synthesis, properties, and applications

Chen, W., Chen, Q., Chen, Q., Cui, C., Duan, S., Kang, Y., Liu, Y., Liu, Y., Muhammad, W., Shao, S., et al. (2022) · Science China Chemistry · doi:10.1007/s11426-022-1243-5 · Cited by 197

Direct delivery of functional proteins and enzymes to the cytosol using nanoparticle-stabilized nanocapsules

Tang, R., Kim, C. S., Solfiell, D. J., Rana, S., Mout, R., Velázquez-Delgado, E. M., Chompoosor, A., Jeong, Y., Yan, B., Zhu, Z.-J., et al. (2013) · ACS Nano · doi:10.1021/nn402753y · Cited by 188

Bioengineered nanogels for cancer immunotherapy

Ma, X., Li, S., Liu, Y., Zhang, T., Xue, P., Kang, Y., Sun, Z., & Xu, Z. (2022) · Chemical Society Reviews · doi:10.1039/d2cs00247g · Cited by 186

Current advances in self-assembled nanogel delivery systems for immunotherapy

Tahara, Y., & Akiyoshi, K. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.10.004 · Cited by 186

Structure-Dependent and Glutathione-Responsive Biodegradable Dendritic Mesoporous Organosilica Nanoparticles for Safe Protein Delivery

Yang, Y., Wan, J., Niu, Y., Gu, Z., Zhang, J., Yu, M., & Yu, C. (2016) · Chemistry of Materials · doi:10.1021/acs.chemmater.6b03896 · Cited by 181

Core‐Cone Structured Monodispersed Mesoporous Silica Nanoparticles with Ultra‐large Cavity for Protein Delivery

Xu, C., Yu, M., Noonan, O., Zhang, J., Song, H., Zhang, H., Lei, C., Niu, Y., Huang, X., Yang, Y., et al. (2015) · Small · doi:10.1002/smll.201501449 · Cited by 180

ATP-responsive DNA-graphene hybrid nanoaggregates for anticancer drug delivery

Mo, R., Jiang, T., Sun, W., & Gu, Z. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.01.053 · Cited by 178

Engineering bacterial outer membrane vesicles as transdermal nanoplatforms for photo-TRAIL–programmed therapy against melanoma

Peng, L., Wang, M., Chu, Y., Zhang, L., Niu, J., Shao, H.-T., Yuan, T., Jiang, Z., Gao, J., & Ning, X. (2020) · Science Advances · doi:10.1126/sciadv.aba2735 · Cited by 180

Templated Self-Assembly of a Covalent Polymer Network for Intracellular Protein Delivery and Traceless Release

Dutta, K., Hu, D. Y., Zhao, B., Ribbe, A. E., Zhuang, J., & Thayumanavan, S. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b01214 · Cited by 176

Nanocarrier‐Mediated Cytosolic Delivery of Biopharmaceuticals

He, W., Xing, X., Wang, X., Wu, D., Wu, W., Guo, J., & Mitragotri, S. (2020) · Advanced Functional Materials · doi:10.1002/adfm.201910566 · Cited by 179

Cellular processing and destinies of artificial DNA nanostructures

Lee, D. S., Qian, H., Tay, C. Y., & Leong, D. T. (2016) · Chemical Society Reviews · doi:10.1039/c5cs00700c · Cited by 179

Leveraging Physiology for Precision Drug Delivery

Sun, W., Hu, Q., Ji, W., Wright, G., & Gu, Z. (2017) · Physiological Reviews · doi:10.1152/physrev.00015.2016 · Cited by 169

Tumor Microenvironment-Mediated Construction and Deconstruction of Extracellular Drug-Delivery Depots

Hu, Q., Sun, W., Lü, Y., Bomba, H. N., Ye, Y., Jiang, T., Isaacson, A., & Gu, Z. (2016) · Nano Letters · doi:10.1021/acs.nanolett.5b04343 · Cited by 164

Recent Advances in Anti-cancer Protein/Peptide Delivery

Liu, X., Wu, F., Ji, Y. I., & Yin, L. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.8b00750 · Cited by 163

Self-Assembled Peptide Drug Delivery Systems

Yang, J., An, H., & Wang, H. (2020) · ACS Applied Bio Materials · doi:10.1021/acsabm.0c00707 · Cited by 164

Bio-Inspired Synthetic Nanovesicles for Glucose-Responsive Release of Insulin

Tai, W., Mo, R., Di, J., Subramanian, V., Gu, X., Buse, J. B., & Gu, Z. (2014) · Biomacromolecules · doi:10.1021/bm500364a · Cited by 159

General Strategy for Direct Cytosolic Protein Delivery via Protein–Nanoparticle Co-engineering

Mout, R., Ray, M., Tay, T., Sasaki, K. E., Tonga, G. Y., & Rotello, V. M. (2017) · ACS Nano · doi:10.1021/acsnano.7b02884 · Cited by 158

The Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics

Qian, L., Lin, X., Gao, X., Khan, R. U., Liao, J.-Y., Du, S., Ge, J., Zeng, S., & Yao, S. Q. (2023) · Chemical Reviews · doi:10.1021/acs.chemrev.2c00915 · Cited by 155

Challenges in carrier‐mediated intracellular delivery: moving beyond endosomal barriers

Stewart, M. P., Lorenz, A. S., Dahlman, J. E., & Sahay, G. (2015) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1377 · Cited by 158

Breakable Hybrid Organosilica Nanocapsules for Protein Delivery

Prasetyanto, E. A., Bertucci, A., Septiadi, D., Corradini, R., Castro‐Hartmann, P., & Cola, L. D. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201508288 · Cited by 157

The design and biomedical applications of self-assembled two-dimensional organic biomaterials

Zhang, X., Gong, C., Akakuru, O. U., Su, Z., Wu, A., & Wei, G. (2019) · Chemical Society Reviews · doi:10.1039/c8cs01003j · Cited by 153

Biocompatible Zwitterionic Sulfobetaine Copolymer‐Coated Mesoporous Silica Nanoparticles for Temperature‐Responsive Drug Release

Sun, J., Yu, Z., Hong, C., & Pan, C. (2012) · Macromolecular Rapid Communications · doi:10.1002/marc.201100876 · Cited by 148

Self‐Sealing Porous Silicon‐Calcium Silicate Core–Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain

Kang, J., Joo, J., Kwon, E. J., Skalak, M., Hussain, S., She, Z., Ruoslahti, E. I., Bhatia, S. N., & Sailor, M. J. (2016) · Advanced Materials · doi:10.1002/adma.201600634 · Cited by 149

A Multistage Cooperative Nanoplatform Enables Intracellular Co‐Delivery of Proteins and Chemotherapeutics for Cancer Therapy

Zhang, P., Zhang, Y., Ding, X., Shen, W. H., Li, M., Wagner, E., Xiao, C., & Chen, X. (2020) · Advanced Materials · doi:10.1002/adma.202000013 · Cited by 148

Delivery of CRISPR/Cas9 for therapeutic genome editing

Xu, X., Wan, T., Xin, H., Li, D., Pan, H., Wu, J., & Ping, Y. (2019) · The Journal of Gene Medicine · doi:10.1002/jgm.3107 · Cited by 134

Mesoporous Silica Nanoparticles with Large Pores for the Encapsulation and Release of Proteins

Tu, J., Boyle, A. L., Friedrich, H., Bomans, P. H. H., Bussmann, J., Sommerdijk, N. A. J. M., Jiskoot, W., & Kros, A. (2016) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b11324 · Cited by 143

Nanoparticles Synergize Ferroptosis and Cuproptosis to Potentiate Cancer Immunotherapy

Li, Y., Liu, J., Chen, Y., Weichselbaum, R. R., & Lin, W. (2024) · Advanced Science · doi:10.1002/advs.202310309 · Cited by 144

Development of Multinuclear Polymeric Nanoparticles as Robust Protein Nanocarriers

Wu, J., Kamaly, N., Shi, J., Zhao, L., Xiao, Z., Hollett, G., John, R. A., Ray, S., Xu, X., Zhang, X., et al. (2014) · Angewandte Chemie International Edition · doi:10.1002/anie.201404766 · Cited by 141

Fluorescent Immunoassay for the Detection of Pathogenic Bacteria at the Single-Cell Level Using Carbon Dots-Encapsulated Breakable Organosilica Nanocapsule as Labels

Lu, Y., Deng, W., Cheng, C., Tan, Y., Xie, Q., & Yao, S. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b18714 · Cited by 140

Reduction and temperature dual-responsive crosslinked polymersomes for targeted intracellular protein delivery

Cheng, R., Meng, F., Ma, S., Xu, H., Liu, H., Jing, X., & Zhong, Z. (2011) · Journal of Materials Chemistry · doi:10.1039/c1jm13536h · Cited by 138

Molecular engineering solutions for therapeutic peptide delivery

Acar, H., Ting, J., Srivastava, S., LaBelle, J. L., & Tirrell, M. (2017) · Chemical Society Reviews · doi:10.1039/c7cs00536a · Cited by 139

Protein nanoparticles for therapeutic protein delivery

Estrada, L. P. H., & Champion, J. A. (2015) · Biomaterials Science · doi:10.1039/c5bm00052a · Cited by 136

DNA-Mediated Cellular Delivery of Functional Enzymes

Brodin, J. D., Sprangers, A. J., McMillan, J. R., & Mirkin, C. A. (2015) · Journal of the American Chemical Society · doi:10.1021/jacs.5b09711 · Cited by 138

In‐Situ Encapsulation of Protein into Nanoscale Hydrogen‐Bonded Organic Frameworks for Intracellular Biocatalysis

Tang, J., Liu, J., Zheng, Q., Li, W., Sheng, J., Mao, L., & Wang, M. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202105634 · Cited by 131

Self‐Assembled DNA Nanoclews for the Efficient Delivery of CRISPR–Cas9 for Genome Editing

Sun, W., Ji, W., Hall, J. M., Hu, Q., Wang, C., Beisel, C. L., & Gu, Z. (2015) · Angewandte Chemie · doi:10.1002/ange.201506030 · Cited by 132

pH and Reduction Dual-Bioresponsive Polymersomes for Efficient Intracellular Protein Delivery

Zhang, J., Wu, L., Meng, F., Wang, Z., Deng, C., Liu, H., & Zhong, Z. (2011) · Langmuir · doi:10.1021/la203843m · Cited by 130

Integrating Combinatorial Lipid Nanoparticle and Chemically Modified Protein for Intracellular Delivery and Genome Editing

Chang, J., Chen, X., Glass, Z., Gao, F., Mao, L., Wang, M., & Xu, Q. (2018) · Accounts of Chemical Research · doi:10.1021/acs.accounts.8b00493 · Cited by 130

Polymer-based nanoparticles for protein delivery: design, strategies and applications

Zhao, H., Lin, Z. Y., Yildirimer, L., Dhinakar, A., Zhao, X., & Wu, J. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb00308g · Cited by 128

EGFR and CD44 Dual-Targeted Multifunctional Hyaluronic Acid Nanogels Boost Protein Delivery to Ovarian and Breast Cancers In Vitro and In Vivo

Chen, J., Ouyang, J., Chen, Q., Deng, C., Meng, F., Zhang, J., Cheng, R., Lan, Q., & Zhong, Z. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.7b06879 · Cited by 124

pH/Sugar Dual Responsive Core-Cross-Linked PIC Micelles for Enhanced Intracellular Protein Delivery

Ren, J., Zhang, Y., Zhang, J., Gao, H., Liu, G., Ma, R., An, Y., Kong, D., & Shi, L. (2013) · Biomacromolecules · doi:10.1021/bm4007387 · Cited by 123

Nanogels: Synthesis, properties, and recent biomedical applications

Duan, Q., Zhu, Y., Jia, H., Wang, S., & Wu, F. (2023) · Progress in Materials Science · doi:10.1016/j.pmatsci.2023.101167 · Cited by 124

Controlled radical polymerization in dispersed systems for biological applications

Gurnani, P., & Perrier, S. (2020) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2020.101209 · Cited by 122

Spherical Nucleic Acid Nanoparticles: Therapeutic Potential

Kapadia, C. H., Melamed, J. R., & Day, E. S. (2018) · BioDrugs · doi:10.1007/s40259-018-0290-5 · Cited by 126

Intracellular Delivery of Functional Native Antibodies under Hypoxic Conditions by Using a Biodegradable Silica Nanoquencher

Yuan, P., Zhang, H., Qian, L., Mao, X., Du, S., Yu, C., Peng, B., & Yao, S. Q. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201705578 · Cited by 119

Biodegradable Inorganic Nanostructured Biomaterials for Drug Delivery

Cai, A., Zhu, Y., & Qi, C. (2020) · Advanced Materials Interfaces · doi:10.1002/admi.202000819 · Cited by 119

Microfluidic Isolation and Enrichment of Nanoparticles

Xie, Y., Rufo, J., Zhong, R., Rich, J. T., Li, P., Leong, K. W., & Huang, T. J. (2020) · ACS Nano · doi:10.1021/acsnano.0c06336 · Cited by 122

Advances in nanomaterials for treatment of hypoxic tumor

Zou, M., Liu, W., Chen, H., Bai, X., Gao, F., Ye, J., Cheng, H. L., & Zhang, X. (2020) · National Science Review · doi:10.1093/nsr/nwaa160 · Cited by 118

Ultrasound-activated particles as CRISPR/Cas9 delivery system for androgenic alopecia therapy

Ryu, J., Won, E.-J., Lee, H. A. R., Kim, J. H., Hui, E., Kim, H.-P., & Yoon, T. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119736 · Cited by 118

A dual strategy to improve the penetration and treatment of breast cancer by combining shrinking nanoparticles with collagen depletion by losartan

Cun, X., Ruan, S., Chen, J., Zhang, L., Li, J., He, Q., & Gao, H. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.12.002 · Cited by 115

Supramolecularly Engineered Circular Bivalent Aptamer for Enhanced Functional Protein Delivery

Jiang, Y. Y., Pan, X., Chang, J., Niu, W., Hou, W., Kuai, H., Zhao, Z., Liu, J., Wang, M., & Tan, W. (2018) · Journal of the American Chemical Society · doi:10.1021/jacs.8b03442 · Cited by 116

Natural Polyphenols Augment Cytosolic Protein Delivery by a Functional Polymer

Liu, C., Shen, W., Li, B., Li, T., Chang, H., & Cheng, Y. (2019) · Chemistry of Materials · doi:10.1021/acs.chemmater.8b04672 · Cited by 115

A Dual Functional Nanoreactor for Synergistic Starvation and Photodynamic Therapy

Zhu, Y., Shi, H., Li, T., Yu, J., Guo, Z., Cheng, J., & Liu, Y. (2020) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.0c01039 · Cited by 112

DNA‐mediated Construction of Hollow Upconversion Nanoparticles for Protein Harvesting and Near‐Infrared Light Triggered Release

Zhou, L., Chen, Z., Dong, K., Yin, M., Ren, J., & Qu, X. (2013) · Advanced Materials · doi:10.1002/adma.201304437 · Cited by 111

Nanocarriers for intracellular delivery of proteins in biomedical applications: strategies and recent advances

Zhu, C., Mu, J., & Liang, L. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02969-5 · Cited by 36

Nanocarrier-Based Approaches for Intracellular Protein Transport in Therapeutic Applications

Darweesh, M. F., Mohammadi, S., Al-Hamadani, M., Moustafa, M., & Al‐Harrasi, A. (2026) · CRC Press eBooks · doi:10.1201/9781003653196-5

Rational Design of Nanocarriers for Intracellular Protein Delivery

Qin, X., Yu, C., Wei, J., Li, L., Zhang, C., Wu, Q., Liu, J., Yao, S. Q., & Huang, W. (2019) · Advanced Materials · doi:10.1002/adma.201902791 · Cited by 286

Synthetic Nanocarriers for Intracellular Protein Delivery

Du, J., Jin, J., Yan, M., & Lu, Y. (2011) · Current Drug Metabolism · doi:10.2174/138920012798356862 · Cited by 57

Intracellular delivery of therapeutic proteins. New advancements and future directions

Porello, I., & Cellesi, F. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1211798 · Cited by 52