Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones

Pyrrolidinyl‐Spirooxindole Natural Products as Inspirations for the Development of Potential Therapeutic Agents

Galliford, C. V., & Scheidt, K. A. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200701342 · Cited by 2,429

Organocatalytic cascade reactions as a new tool in total synthesis

Grondal, C., Jeanty, M., & Enders, D. (2010) · Nature Chemistry · doi:10.1038/nchem.539 · Cited by 1,582

Construction of Spiro[pyrrolidine‐3,3′‐oxindoles] − Recent Applications to the Synthesis of Oxindole Alkaloids

Marti, C., & Carreira, E. M. (2003) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200300050 · Cited by 1,455

Enantioselective Michael Reaction of Malonates to Nitroolefins Catalyzed by Bifunctional Organocatalysts

Okino, T., Hoashi, Y., & Takemoto, Y. (2003) · Journal of the American Chemical Society · doi:10.1021/ja036972z · Cited by 1,430

Organocatalysis—after the gold rush

Bertelsen, S., & Jørgensen, K. A. (2009) · Chemical Society Reviews · doi:10.1039/b903816g · Cited by 1,295

Asymmetric Aminocatalysis—Gold Rush in Organic Chemistry

Melchiorre, P., Marigo, M., Carlone, A., & Bartoli, G. (2008) · Angewandte Chemie International Edition · doi:10.1002/anie.200705523 · Cited by 1,256

Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C‐3 Position

Zhou, F., Liu, Y., & Zhou, J. (2010) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201000161 · Cited by 1,252

(Thio)urea organocatalysis—What can be learnt from anion recognition?

Zhang, Z., & Schreiner, P. R. (2009) · Chemical Society Reviews · doi:10.1039/b801793j · Cited by 1,109

Reactions of Electron-Deficient Alkynes and Allenes under Phosphine Catalysis

Lu, X., Zhang, C., & Xu, Z. (2001) · Accounts of Chemical Research · doi:10.1021/ar000253x · Cited by 1,030

Combining transition metal catalysis and organocatalysis: a broad new concept for catalysis

Shao, Z., & Zhang, H. (2009) · Chemical Society Reviews · doi:10.1039/b901258n · Cited by 812

Indole synthesis: a review and proposed classification

Taber, D. F., & Tirunahari, P. K. (2011) · Tetrahedron · doi:10.1016/j.tet.2011.06.040 · Cited by 739

Chiral N,N′-Dioxides: New Ligands and Organocatalysts for Catalytic Asymmetric Reactions

Liu, X., Lin, L., & Feng, X. (2011) · Accounts of Chemical Research · doi:10.1021/ar200015s · Cited by 707

Organocatalytic Synthesis of Spiro[pyrrolidin-3,3′-oxindoles] with High Enantiopurity and Structural Diversity

Chen, X.-H., Wei, Q., Luo, S.-W., Xiao, H., & Gong, L.-Z. (2009) · Journal of the American Chemical Society · doi:10.1021/ja905302f · Cited by 577

Chiral Brønsted acids in enantioselective carbonyl activations – activation modes and applications

Rueping, M., Kuenkel, A., & Atodiresei, I. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15087a · Cited by 546

Quantum Mechanical Investigations of Organocatalysis: Mechanisms, Reactivities, and Selectivities

Cheong, P. H.-Y., Legault, C. Y., Um, J. M., Çelebi-Ölçüm, N., & Houk, K. N. (2011) · Chemical Reviews · doi:10.1021/cr100212h · Cited by 540

Construction of bispirooxindoles containing three quaternary stereocentres in a cascade using a single multifunctional organocatalyst

Tan, B., Candeias, N. R., & Barbas, C. F. (2011) · Nature Chemistry · doi:10.1038/nchem.1039 · Cited by 466

Targeting Structural and Stereochemical Complexity by Organocascade Catalysis: Construction of Spirocyclic Oxindoles Having Multiple Stereocenters

Bencivenni, G., Wu, L., Mazzanti, A., Giannichi, B., Pesciaioli, F., Song, M., Bartoli, G., & Melchiorre, P. (2009) · Angewandte Chemie International Edition · doi:10.1002/anie.200903192 · Cited by 448

Recent progress in enantioselective synthesis of C3-functionalized oxindoles: rare earth metals take action

Shen, K., Liu, X., Lin, L., & Feng, X. (2012) · Chem. Sci. · doi:10.1039/c1sc00544h · Cited by 439

Targeting Structural and Stereochemical Complexity by Organocascade Catalysis: Construction of Spirocyclic Oxindoles Having Multiple Stereocenters

Bencivenni, G., Wu, L., Mazzanti, A., Giannichi, B., Pesciaioli, F., Song, M., Bartoli, G., & Melchiorre, P. (2009) · Angewandte Chemie · doi:10.1002/ange.200903192 · Cited by 427

Cinchona Alkaloids in Asymmetric Organocatalysis

Marcelli, T., & Hiemstra, H. (2010) · Synthesis · doi:10.1055/s-0029-1218699 · Cited by 426

Highly Enantioselective [3+2] Annulation of Morita–Baylis–Hillman Adducts Mediated by L‐Threonine‐Derived Phosphines: Synthesis of 3‐Spirocyclopentene‐2‐oxindoles having Two Contiguous Quaternary Centers

Zhong, F., Han, X., Wang, Y., & Lu, Y. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201102094 · Cited by 419

Asymmetric Catalysis of Diels–Alder Reactions with in Situ Generated Heterocyclic ortho-Quinodimethanes

Liu, Y., Nappi, M., Arceo, E., Vera, S., & Melchiorre, P. (2011) · Journal of the American Chemical Society · doi:10.1021/ja206517s · Cited by 398

Unexpected Inversions in Asymmetric Reactions: Reactions with Chiral Metal Complexes, Chiral Organocatalysts, and Heterogeneous Chiral Catalysts

Bartók, M. (2010) · Chemical Reviews · doi:10.1021/cr9002352 · Cited by 382

Thiourea-Catalyzed Highly Enantio- and Diastereoselective Additions of Oxindoles to Nitroolefins: Application to the Formal Synthesis of (+)-Physostigmine

Bui, T., Syed, S., & Barbas, C. F. (2009) · Journal of the American Chemical Society · doi:10.1021/ja903520c · Cited by 351

Design, synthesis and biological evaluations of novel oxindoles as HIV-1 non-nucleoside reverse transcriptase inhibitors. Part I

Jiang, T., Kuhen, K., Wolff, K. C., Yin, H., Bieza, K., Caldwell, J. S., Bursulaya, B. D., Wu, T. Y., & He, Y. (2006) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2006.01.073 · Cited by 301

Enantioselective Michael/Cyclization Reaction Sequence: Scaffold‐Inspired Synthesis of Spirooxindoles with Multiple Stereocenters

Cao, Y., Jiang, X., Liu, L., Shen, F., Zhang, F., & Wang, R. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201104216 · Cited by 261

Core‐Structure‐Oriented Asymmetric Organocatalytic Substitution of 3‐Hydroxyoxindoles: Application in the Enantioselective Total Synthesis of (+)‐Folicanthine

Guo, C., Song, J., Huang, J., Chen, P., Luo, S., & Gong, L. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201107079 · Cited by 248

Reevaluation of the Mechanism of the Baylis–Hillman Reaction: Implications for Asymmetric Catalysis

Aggarwal, V. K., Fulford, S. Y., & Lloyd‐Jones, G. C. (2005) · Angewandte Chemie International Edition · doi:10.1002/anie.200462462 · Cited by 243

Polymer‐Supported Chiral Organocatalysts: Synthetic Strategies for the Road Towards Affordable Polymeric Immobilization

Kristensen, T. E., & Hansen, T. (2010) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201000319 · Cited by 238

Enantioselective Michael/Cyclization Reaction Sequence: Scaffold‐Inspired Synthesis of Spirooxindoles with Multiple Stereocenters

Cao, Y., Jiang, X., Liu, L., Shen, F., Zhang, F., & Wang, R. (2011) · Angewandte Chemie · doi:10.1002/ange.201104216 · Cited by 237

Organocatalytic Tandem Reaction to Construct Six‐Membered Spirocyclic Oxindoles with Multiple Chiral Centres through a Formal [2+2+2] Annulation

Jiang, K., Jia, Z., Chen, S., Wu, L., & Chen, Y. (2010) · Chemistry – A European Journal · doi:10.1002/chem.200903009 · Cited by 236

Asymmetric Synthesis with Silicon‐Based Bulky Amino Organocatalysts

Xu, L., Li, L., & Shi, Z. (2010) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.200900797 · Cited by 228

An Organocatalytic [3+2] Cyclisation Strategy for the Highly Enantioselective Synthesis of Spirooxindoles

Voituriez, A., Pinto, N., Neel, M., Retailleau, P., & Marinetti, A. (2010) · Chemistry – A European Journal · doi:10.1002/chem.201001791 · Cited by 210

Cinchona‐Alkaloid‐Catalyzed Enantioselective Direct Aldol‐Type Reaction of Oxindoles with Ethyl Trifluoropyruvate

Ogawa, S., Shibata, N., Inagaki, J., Nakamura, S., Toru, T., & Shiro, M. (2007) · Angewandte Chemie International Edition · doi:10.1002/anie.200703317 · Cited by 201

N‐Heterocyclic Carbene‐Catalyzed Cyclization of Unsaturated Acyl Chlorides and Ketones

Shen, L., Shao, P., & Ye, S. (2011) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201100178 · Cited by 198

Organocatalytic Direct Asymmetric Aldol Reactions of 3-Isothiocyanato Oxindoles to Ketones: Stereocontrolled Synthesis of Spirooxindoles Bearing Highly Congested Contiguous Tetrasubstituted Stereocenters

Chen, W.-B., Wu, Z.-J., Hu, J., Cun, L.-F., Zhang, X.-M., & Yuan, W.-C. (2011) · Organic Letters · doi:10.1021/ol200724q · Cited by 195

Synthesis, Absolute Configuration, and Enantiomeric Enrichment of a Cruciferous Oxindole Phytoalexin, (S)-(−)-Spirobrassinin, and Its Oxazoline Analog

Suchý, M., Kutschy, P., Monde, K., Goto, H., Harada, N., Takasugi, M., Dzurilla, M., & Balentová, E. (2001) · The Journal of Organic Chemistry · doi:10.1021/jo0155052 · Cited by 178

Cinchona alkaloid-based phosphoramide catalyzed highly enantioselective Michael addition of unprotected 3-substituted oxindoles to nitroolefins

Ding, M., Zhou, F., Liu, Y.-L., Wang, C.-H., Zhao, X.-L., & Zhou, J. (2011) · Chemical Science · doi:10.1039/c1sc00390a · Cited by 171

Multiple Catalysis with Two Chiral Units: An Additional Dimension for Asymmetric Synthesis

Piovesana, S., Scarpino Schietroma, D. M., & Bella, M. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201005955 · Cited by 167

An Easy Entry to Optically Active Spiroindolinones: Chiral Brønsted Acid‐Catalysed Pictet–Spengler Reactions of Isatins

Duce, S., Pesciaioli, F., Gramigna, L., Bernardi, L., Mazzanti, A., Ricci, A., Bartoli, G., & Bencivenni, G. (2011) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201100050 · Cited by 160

Organocatalytic Michael–Alkylation Cascade: The Enantioselective Nitrocyclopropanation of Oxindoles

Pesciaioli, F., Righi, P., Mazzanti, A., Bartoli, G., & Bencivenni, G. (2011) · Chemistry - A European Journal · doi:10.1002/chem.201003423 · Cited by 157

Organocatalytic asymmetric allylic alkylation of oxindoles with Morita–Baylis–Hillman carbonates

Jiang, K. P., Peng, J., Cui, H., & Chen, Y. (2009) · Chemical Communications · doi:10.1039/b905177e · Cited by 143

Solid-Phase Synthesis of Biologically Active Benzoannelated Nitrogen Heterocycles: An Update

Gil, C., & Bräse, S. (2008) · Journal of Combinatorial Chemistry · doi:10.1021/cc800102t · Cited by 138

Asymmetric alkylation of oxindoles: an approach to the total synthesis of (-)-physostigmine

Lee, T. B. K., & Wong, G. S. K. (1991) · The Journal of Organic Chemistry · doi:10.1021/jo00002a074 · Cited by 135

Highly Enantioselective Organocatalytic α-Amination Reactions of Aryl Oxindoles: Developing Designer Multifunctional Alkaloid Catalysts

Bui, T., Hernández‐Torres, G., Milite, C., & Barbas, C. F. (2010) · Organic Letters · doi:10.1021/ol102493q · Cited by 118

Enantioselective Pictet–Spengler reactions of isatins for the synthesis of spiroindolones

Badillo, J. J., Silva‐Garcia, A., Shupe, B. H., Fettinger, J. C., & Franz, A. K. (2011) · Tetrahedron Letters · doi:10.1016/j.tetlet.2011.08.071 · Cited by 114

Enantioselective Organocatalyticanti-Mannich-Type Reaction ofN-Unprotected 3-Substituted 2-Oxindoles with AromaticN-Ts-aldimines

Cheng, L., Liu, L., Jia, H., et al. (2009) · The Journal of Organic Chemistry · doi:10.1021/jo9006688 · Cited by 112

Core Structure‐Based Design of Organocatalytic [3+2]‐Cycloaddition Reactions: Highly Efficient and Stereocontrolled Syntheses of 3,3′‐Pyrrolidonyl Spirooxindoles

Tan, B., Zeng, X., Leong, W. W. Y., Shi, Z., Barbas, C. F., & Zhong, G. (2011) · Chemistry - A European Journal · doi:10.1002/chem.201103449 · Cited by 107

Organocatalytic Asymmetric α‐Amination of Unprotected 3‐Aryl and 3‐Aliphatic Substituted Oxindoles using Di‐tert‐butyl Azodicarboxylate

Zhou, F., Ding, M., Liu, Y., Wang, C., Ji, C., Zhang, Y., & Zhou, J. E. (2011) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201100379 · Cited by 74

Convolutamides A ∼ F, novel γ-lactam alkaloids from the marine bryozoan Amathia convoluta

Zhang, H., Shigemori, H., Ishibashi, M., et al. (1994) · Tetrahedron · doi:10.1016/s0040-4020(01)81752-x · Cited by 67

Asymmetric hydroxyamination of oxindoles catalyzed by chiral bifunctional tertiary aminethiourea: construction of 3-amino-2-oxindoles with quaternary stereocenters

Jia, L., Huang, J., Peng, L., Wang, L., Bai, J., Tian, F., He, G., Xu, X., & Wang, L. (2011) · Organic & Biomolecular Chemistry · doi:10.1039/c1ob06413d · Cited by 54

Enantioselective addition of oxindoles to aliphatic α,β-unsaturated aldehydes

Bravo, N., Mon, I., Xavier Companyó, Alba, A. R., Moyano, A., & Rios, R. (2009) · Tetrahedron Letters · doi:10.1016/j.tetlet.2009.09.038 · Cited by 46

Cinchona Alkaloid‐Catalyzed Enantioselective Direct Aldol Reaction of N‐Boc‐Oxindoles with Polymeric Ethyl Glyoxylate

Pesciaioli, F., Righi, P., Mazzanti, A., Gianelli, C., Mancinelli, M., Bartoli, G., & Bencivenni, G. (2011) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201100499 · Cited by 14

Recent Advances in Asymmetric Organocatalytic Construction of 3,3′‐Spirocyclic Oxindoles

Hong, L., & Wang, R. (2013) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201200808 · Cited by 718

Recent advances in the synthesis of biologically active spirooxindoles

Santos, M. M. M. (2014) · Tetrahedron · doi:10.1016/j.tet.2014.08.005 · Cited by 398

Catalytic Enantioselective Construction of Spiro Quaternary Carbon Stereocenters

Xu, P.-W., Yu, J.-S., Chen, C., Cao, Z.-Y., Zhou, F., & Zhou, J. (2019) · ACS Catalysis · doi:10.1021/acscatal.8b03694 · Cited by 325

Recent catalytic asymmetric syntheses of 3,3-disubstituted indolin-2-ones and 2,2-disubstituted indolin-3-ones

Dalpozzo, R. (2017) · Advanced Synthesis & Catalysis · doi:10.1002/adsc.201700361 · Cited by 146