Electromodulated release of nitric oxide through polymer material from reservoir of inorganic nitrite salt
Open accessAbstract
Herein, we report a new approach to electromodulate the release of NO at physiological levels through polymeric materials from a stable nitrite electrolyte reservoir, with potential application in controlling biofilm formation and clotting on intravascular catheters. The NO flux can be turned 'on' and 'off' electrochemically, on demand.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Nitrite can generate NO via electrochemical reduction at an electrode surface using Cu(I) from Cu0 oxidation or Cu(II)-ligand complexes mimicking nitrite reductase.
“Recently, it was demonstrated that nitrite can also be used to generate NO via electrochemical reduction at an electrode surface with either Cu(I) ion generated from oxidation of Cu0145,146 or via the use of Cu(II)-ligand complexes that mimic the active site of nitrite reductase (e.g., Cu(II)-tri(2-pyridylmethyl)amine, Cu(II)TPMA).147”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [145]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.
Ignarro, L. J., Buga, G. M., Wood, K. S., Byrns, R. E., & Chaudhuri, G. (1987) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.84.24.9265 · Cited by 5,074 · see citing works
Role of nitric oxide synthesis in macrophage antimicrobial activity
Nathan, C. F., & Hibbs, J. B. (1991) · Current Opinion in Immunology · doi:10.1016/0952-7915(91)90079-g · Cited by 1,523 · see citing works
An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.
Radomski, M. W., Palmer, R. M., & Moncada, S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.13.5193 · Cited by 1,208 · see citing works
Reducing implant-related infections: active release strategies
Hetrick, E. M., & Schoenfisch, M. H. (2006) · Chemical Society Reviews · doi:10.1039/b515219b · Cited by 1,201 · see citing works
Frost, M. C., Reynolds, M. M., & Meyerhoff, M. E. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2004.06.006 · Cited by 343 · see citing works
Self-citationStrehblow, H., & Titze, B. (1980) · Electrochimica Acta · doi:10.1016/0013-4686(80)90036-5 · Cited by 339 · see citing works
Zhang, H., Annich, G. M., Miskulin, J., Stankiewicz, K., Osterholzer, K., Merz, S. I., Bartlett, R. H., & Meyerhoff, M. E. (2003) · Journal of the American Chemical Society · doi:10.1021/ja0291538 · Cited by 176 · see citing works
Self-citationAnnich, G. M., Meinhardt, J. P., Mowery, K. A., Ashton, B. A., Merz, S. I., Hirschl, R. B., Meyerhoff, M. E., & Bartlett, R. H. (2000) · Critical Care Medicine · doi:10.1097/00003246-200004000-00001 · Cited by 152 · see citing works
Self-citationIn Vivo Chemical Sensors: Tackling Biocompatibility
Frost, M. C., & Meyerhoff, M. E. (2006) · Analytical Chemistry · doi:10.1021/ac069475k · Cited by 145 · see citing works
Self-citationMajor, T. C., Brant, D. O., Reynolds, M. M., Bartlett, R. H., Meyerhoff, M. E., Handa, H., & Annich, G. M. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.12.028 · Cited by 134 · see citing works
Self-citationFleser, P. S., Nuthakki, V. K., Malinzak, L. E., Callahan, R. E., Seymour, M. L., Reynolds, M. M., Merz, S. I., Meyerhoff, M. E., Bendick, P. J., Zelenock, G. B., et al. (2004) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2004.07.007 · Cited by 110 · see citing works
Self-citationInitial stages of anodic oxidation of polycrystalline copper electrodes in alkaline solution
Droog, J. M. M., Alderliesten, C. A., Alderliesten, P. T., & Bootsma, G. A. (1980) · Journal of Electroanalytical Chemistry · doi:10.1016/s0022-0728(80)80075-1 · Cited by 104 · see citing works
Synthesis and Characterization of Polymethacrylate-Based Nitric Oxide Donors
Parzuchowski, P. G., Frost, M. C., & Meyerhoff, M. E. (2002) · Journal of the American Chemical Society · doi:10.1021/ja020268l · Cited by 93 · see citing works
Self-citationNitric Oxide Releasing Polyurethanes with Covalently Linked Diazeniumdiolated Secondary Amines
Reynolds, M. M., Hrabie, J. A., Oh, B. K., Politis, J. K., Citro, M. L., Keefer, L. K., & Meyerhoff, M. E. (2006) · Biomacromolecules · doi:10.1021/bm060028o · Cited by 89 · see citing works
Self-citationOh, B. K., & Meyerhoff, M. E. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00530-1 · Cited by 84 · see citing works
Self-citationThe Anodic Oxidation of Copper Amalgam and Polycrystalline Copper Electrodes in LiOH Solution
Fletcher, S., Barradas, R. G., & Porter, J. D. (1978) · Journal of The Electrochemical Society · doi:10.1149/1.2131336 · Cited by 77 · see citing works
Proteomic analysis of Acinetobacter baumannii in biofilm and planktonic growth mode
Shin, J., Lee, H.-W., Kim, S., & Kim, J. (2009) · The Journal of Microbiology · doi:10.1007/s12275-009-0158-y · Cited by 74 · see citing works
Characterization of oxide layers on copper by linear potential sweep voltammetry
Deutscher, R. L., & Woods, R. (1986) · Journal of Applied Electrochemistry · doi:10.1007/bf01008852 · Cited by 65 · see citing works
The Anodic Polarization Behavior of Copper
Leckie, H. P. (1970) · Journal of The Electrochemical Society · doi:10.1149/1.2407356 · Cited by 43 · see citing works
Shiddiky, M. J. A., O'Mullane, A. P., Zhang, J., Burke, L. D., & Bond, A. M. (2011) · Langmuir · doi:10.1021/la2017819 · Cited by 36 · see citing works
Zhou, Z., & Meyerhoff, M. E. (2005) · Biomacromolecules · doi:10.1021/bm049462l · Cited by 36 · see citing works
Self-citationVoltammetry with disk electrodes and its analytical application
Štulíková, M., & Vydra, F. (1973) · Journal of Electroanalytical Chemistry · doi:10.1016/s0022-0728(73)80519-4 · Cited by 28 · see citing works
The effect of ethylenediaminetetraacetic acid on the ferrous/ferric and cuprous/cupric redox systems
Belcher, R. R., Gibbons, D., & West, T. S. (1955) · Analytica Chimica Acta · doi:10.1016/s0003-2670(00)87815-0 · Cited by 25 · see citing works
The permeability of silicone rubber to metal compounds: Relevance to implanted devices
Donaldson, N., Baviskar, P., Cunningham, J. C., & Wilson, D. (2011) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.33257 · Cited by 22 · see citing works
Polarographic and redox potential studies on copper(I) and copper(II) and their complexes
Srinivasan, K., & Subrahmanya, R. S. (1971) · Journal of Electroanalytical Chemistry · doi:10.1016/s0022-0728(71)80064-5 · Cited by 18 · see citing works
Flagged first, then by citations
Research works printed but not linked: 2
- [4]Schoenfisch MH Hetrick EM Chem. Soc. Rev 2006 35 780 789 16936926
- [5]Meyerhoff ME Frost MC Anal. Chem 2006 78 7370 7377 17128516
Cited by
Sorted by citations
Nitric Oxide: A Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases
Barraud, N., Kelso, M. J., Rice, S., & Kjelleberg, S. J. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140905112822 · Cited by 255 · see citing works
Wo, Y., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2016) · Biomaterials Science · doi:10.1039/c6bm00271d · Cited by 251 · see citing works
Self-citationWo, Y., Li, Z., Brisbois, E. J., Colletta, A., Wu, J., Major, T. C., Xi, C., Bartlett, R. H., Matzger, A. J., & Meyerhoff, M. E. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b07501 · Cited by 128 · see citing works
Self-citationThe quest for blood-compatible materials: Recent advances and future technologies
Hedayati, M., Neufeld, M. J., Reynolds, M. M., & Kipper, M. J. (2019) · Materials Science and Engineering R Reports · doi:10.1016/j.mser.2019.06.002 · Cited by 105 · see citing works
Colletta, A., Wu, J., Wo, Y., Kappler, M., Chen, H., Xi, C., & Meyerhoff, M. E. (2015) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5b00032 · Cited by 89 · see citing works
Self-citationIn Vivo Chemical Sensors: Role of Biocompatibility on Performance and Utility
Soto, R. J., Hall, J. R., Brown, M. D., Taylor, J. B., & Schoenfisch, M. H. (2016) · Analytical Chemistry · doi:10.1021/acs.analchem.6b04251 · Cited by 85 · see citing works
Ren, H., Wu, J., Xi, C., Lehnert, N., Major, T., Bartlett, R. H., & Meyerhoff, M. E. (2014) · ACS Applied Materials & Interfaces · doi:10.1021/am406066a · Cited by 69 · see citing works
Self-citationThromboresistant/anti-biofilm catheters via electrochemically modulated nitric oxide release
Ren, H., Colletta, A., Koley, D., Wu, J., Xi, C., Major, T. C., Bartlett, R. H., & Meyerhoff, M. E. (2015) · Bioelectrochemistry · doi:10.1016/j.bioelechem.2014.12.003 · Cited by 55 · see citing works
Self-citationRen, H., Bull, J. L., & Meyerhoff, M. E. (2016) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.6b00215 · Cited by 31 · see citing works
Self-citationFallon, B. P., & Mychaliska, G. B. (2021) · Translational Pediatrics · doi:10.21037/tp-20-136 · Cited by 28 · see citing works
Mechanistic analysis of the photolytic decomposition of solid-state S-nitroso-N-acetylpenicillamine
Sheet, P. S., Lautner, G., Meyerhoff, M. E., & Schwendeman, S. P. (2023) · Nitric Oxide · doi:10.1016/j.niox.2023.11.001 · Cited by 13 · see citing works
Self-citationZhang, Q., & Meyerhoff, M. E. (2021) · Electroanalysis · doi:10.1002/elan.202100174 · Cited by 11 · see citing works
Self-citationElectrochemical generation of nitric oxide for medical applications
White, C. J., Lehnert, N., & Meyerhoff, M. E. (2021) · Electrochemical Science Advances · doi:10.1002/elsa.202100156 · Cited by 10 · see citing works
Self-citationHe, X. J., Zou, C. W., Zhang, L., Wu, P., Yao, Y., Dong, K., Ren, Y., Hu, W. W., Li, Y., Luo, H., et al. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202403468 · Cited by 8 · see citing works
Zou, H., Gao, Y. S., Ding, Z., & Liu, C. (2026) · Journal of the American Chemical Society · doi:10.1021/jacs.5c21704 · Cited by 6 · see citing works
Novák, O., Redd, B., & Brown, R. B. (2013) · International SoC Design Conference · doi:10.1109/isocc.2013.6863998 · Cited by 3 · see citing works
Improving the hemocompatibility of catheters via NO release/generation
Wo, Y., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-100497-5.00013-6 · Cited by 2 · see citing works
Self-citationElectrochemical NO Generation: Past, Present, and FuturePreprint
Pung, M. J., Jolly, B. J., & Liu, C. (2023) · ChemRxiv · doi:10.26434/chemrxiv-2023-fbtc1 · Cited by 1 · see citing works
A small low-power wireless integrated microsystem
Redd, B. (2016) · J. Willard Marriott Library · doi:10.26053/0h-cby9-9000
Reply to Letter to the Editor: The Artificial Womb: What is the Next Step?
Church, J. T., & Mychaliska, G. B. (2018) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2018.10.069
- Authors
- Höfler, L., Koley, D., Wu, J., Xi, C., & Meyerhoff, M. E.
- Affiliations
- University of Michigan (US)
- Corresponding author
- Meyerhoff, Mark E.
- Venue
- RSC Advances
- Publisher
- Royal Society of Chemistry (RSC)
- Published
- 2012
- Volume
- 2
- Issue
- 17
- Pages
- 6765
- ISSN
- 2046-2069 (ISSN-L)
- PMC
- PMC3414219
- OpenAlex
- W2072729037
- Cited by
- 20
- References
- 25
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2021: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 1
- FWCI
- 1.51
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- RSC Advances (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Institute of Biomedical Imaging and Bioengineering (R01EB004527, R01EB000783)
- Topics
- Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Keywords
- nitric oxide release, polymers, electrochemical modulation, on-demand drug delivery, biofilm formation, catheter clotting, intravascular catheters
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review