Cited by 20Conducting polymers and applicationsAntimicrobial agents and applicationsPolymer Surface Interaction Studies

Electromodulated release of nitric oxide through polymer material from reservoir of inorganic nitrite salt

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Höfler, Lajos, Koley, Dipankar, Wu, Jianfeng, Xi, Chuanwu, Meyerhoff, Mark E.·2012·RSC Advances

Abstract

Herein, we report a new approach to electromodulate the release of NO at physiological levels through polymeric materials from a stable nitrite electrolyte reservoir, with potential application in controlling biofilm formation and clotting on intravascular catheters. The NO flux can be turned 'on' and 'off' electrochemically, on demand.

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Crossref · 10.1039/c2ra20853a

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  • Nitrite can generate NO via electrochemical reduction at an electrode surface using Cu(I) from Cu0 oxidation or Cu(II)-ligand complexes mimicking nitrite reductase.

    “Recently, it was demonstrated that nitrite can also be used to generate NO via electrochemical reduction at an electrode surface with either Cu(I) ion generated from oxidation of Cu0145,146 or via the use of Cu(II)-ligand complexes that mimic the active site of nitrite reductase (e.g., Cu(II)-tri(2-pyridylmethyl)amine, Cu(II)TPMA).147”

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Research works printed but not linked: 2

  1. [4]Schoenfisch MH Hetrick EM Chem. Soc. Rev 2006 35 780 789 16936926
  2. [5]Meyerhoff ME Frost MC Anal. Chem 2006 78 7370 7377 17128516

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Authors
Höfler, L., Koley, D., Wu, J., Xi, C., & Meyerhoff, M. E.
Affiliations
University of Michigan (US)
Corresponding author
Meyerhoff, Mark E.
Venue
RSC Advances
Published
2012
Volume
2
Issue
17
Pages
6765
ISSN
2046-2069 (ISSN-L)
OpenAlex
W2072729037
Cited by
20
References
25
Citations by year
2026: 1 · 2025: 1 · 2023: 2 · 2021: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 1
FWCI
1.51
Type
journal article
Language
en
Open access
Locations
  • RSC Advances (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Biomedical Imaging and Bioengineering (R01EB004527, R01EB000783)
Topics
  • Physical Sciences › Materials Science › Polymers and Plastics › Conducting polymers and applications
  • Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
Keywords
nitric oxide release, polymers, electrochemical modulation, on-demand drug delivery, biofilm formation, catheter clotting, intravascular catheters

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