Water structure and chaotropicity: their uses, abuses and biological implications

The Concept of Mind

Ryle, G. (2006) · Theories of Mind · doi:10.5040/9798216413257.ch-2 · Cited by 6,809

Some Factors in the Interpretation of Protein Denaturation

Kauzmann, W. (1959) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60608-7 · Cited by 4,870

A Theory of Water and Ionic Solution, with Particular Reference to Hydrogen and Hydroxyl Ions

Bernal, J. D., & Fowler, R. H. (1933) · The Journal of Chemical Physics · doi:10.1063/1.1749327 · Cited by 3,255

Zur Lehre von der Wirkung der Salze: Zweite Mittheilung

Hofmeister, F. (1888) · Archiv für Experimentelle Pathologie und Pharmakologie · doi:10.1007/bf01918191 · Cited by 2,956

Free Volume and Entropy in Condensed Systems III. Entropy in Binary Liquid Mixtures; Partial Molal Entropy in Dilute Solutions; Structure and Thermodynamics in Aqueous Electrolytes

Frank, H. S., & Evans, M. W. (1945) · The Journal of Chemical Physics · doi:10.1063/1.1723985 · Cited by 2,880

Water as an active constituent in cell biology

Ball, P. (2008) · Chemical Reviews · doi:10.1021/cr068037a · Cited by 2,177

Effect of Ions on the Structure of Water: Structure Making and Breaking

Marcus, Y. (2009) · Chemical Reviews · doi:10.1021/cr8003828 · Cited by 1,946

Phase behaviour of metastable water

Poole, P. H., Sciortino, F., Essmann, U., & Stanley, H. E. (1992) · Nature · doi:10.1038/360324a0 · Cited by 1,870

The Hofmeister effect and the behaviour of water at interfaces

Collins, K. D., & Washabaugh, M. W. (1985) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583500005369 · Cited by 1,605

Role of hydration and water structure in biological and colloidal interactions

Israelachvili, J., & Wennerström, H. (1996) · Nature · doi:10.1038/379219a0 · Cited by 1,364

Hydrophobic Effects. Opinions and Facts

Blokzijl, W., & Engberts, J. B. F. N. (1993) · Angewandte Chemie International Edition in English · doi:10.1002/anie.199315451 · Cited by 1,143

Negligible Effect of Ions on the Hydrogen-Bond Structure in Liquid Water

Omta, A. W., Kropman, M. F., Woutersen, S., & Bakker, H. J. (2003) · Science · doi:10.1126/science.1084801 · Cited by 922

The molecular basis for the chemical denaturation of proteins by urea

Bennion, B. J., & Daggett, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0930122100 · Cited by 896

The present state of affairs with Hofmeister effects

Kunz, W., Lo Nostro, P., & Ninham, B. W. (2004) · Current Opinion in Colloid & Interface Science · doi:10.1016/j.cocis.2004.05.004 · Cited by 854

Ionic processes in solution

Selis, S. M. (1953) · Journal of the Franklin Institute · doi:10.1016/0016-0032(53)91168-5 · Cited by 838

Allosteric regulation and catalysis emerge via a common route

Goodey, N. M., & Benkovic, S. J. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.98 · Cited by 667

Human basophil degranulation triggered by very dilute antiserum against IgE

Davenas, E., Beauvais, F., Amara, J., Oberbaum, M., Robinzon, B., Miadonnai, A., Tedeschi, A., Pomeranz, B., Fortner, P., Belon, P., et al. (1988) · Nature · doi:10.1038/333816a0 · Cited by 594

Urea denaturation by stronger dispersion interactions with proteins than water implies a 2-stage unfolding

Hua, L., Zhou, R., Thirumalai, D., & Berne, B. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808427105 · Cited by 532

Review: Protein function at thermal extremes: balancing stability and flexibility

Fields, P. A. (2001) · Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology · doi:10.1016/s1095-6433(00)00359-7 · Cited by 452

The Effect of Electrolytes on the Stability of the Deoxyribonucleate Helix

Hamaguchi, K., & Geiduschek, E. P. (1962) · Journal of the American Chemical Society · doi:10.1021/ja00867a001 · Cited by 398

A New Analysis of Mars “Special Regions”: Findings of the Second MEPAG Special Regions Science Analysis Group (SR-SAG2)

Rummel, J. D., Beaty, D. W., Jones, M. A., Bakermans, C., Barlow, N. G., Boston, P. J., Chevrier, V. F., Clark, B. C., de Vera, J.-P. P., Gough, R. V., et al. (2014) · Astrobiology · doi:10.1089/ast.2014.1227 · Cited by 380

Perturbation of water structure due to monovalent ions in solution

Mancinelli, R., Botti, A., Bruni, F., Ricci, M. A., & Soper, A. K. (2007) · Physical Chemistry Chemical Physics · doi:10.1039/b701855j · Cited by 350

Is there a common water-activity limit for the three domains of life?

Stevenson, A., Cray, J. A., Williams, J. P., Santos, R., Sahay, R., Neuenkirchen, N., McClure, C. D., Grant, I. R., Houghton, J. D. R., Quinn, J. P., et al. (2015) · The ISME Journal · doi:10.1038/ismej.2014.219 · Cited by 329

The putative liquid-liquid transition is a liquid-solid transition in atomistic models of water

Limmer, D. T., & Chandler, D. (2011) · The Journal of Chemical Physics · doi:10.1063/1.3643333 · Cited by 327

Impact of Protein Denaturants and Stabilizers on Water Structure

Batchelor, J. D., Olteanu, A., Tripathy, A., & Pielak, G. J. (2004) · Journal of the American Chemical Society · doi:10.1021/ja039335h · Cited by 324

Hydration of metal surfaces can be dynamically heterogeneous and hydrophobic

Limmer, D. T., Willard, A. P., Madden, P., & Chandler, D. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1301596110 · Cited by 322

New Insights into the Role of Water in Biological Function: Studying Solvated Biomolecules Using Terahertz Absorption Spectroscopy in Conjunction with Molecular Dynamics Simulations

Conti Nibali, V., & Havenith, M. (2014) · Journal of the American Chemical Society · doi:10.1021/ja504441h · Cited by 314

Limits of life in MgCl 2 ‐containing environments: chaotropicity defines the window

Hallsworth, J. E., Yakimov, M. M., Golyshin, P. N., Gillion, J. L. M., D'Auria, G., De Lima Alves, F., La Cono, V., Genovese, M., McKew, B. A., Hayes, S. L., et al. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2006.01212.x · Cited by 284

The Meaning of Water

Strang, V. (2020) · Routledge eBooks · doi:10.4324/9781003087090 · Cited by 282

Stable Liquid Water Droplet on a Water Monolayer Formed at Room Temperature on Ionic Model Substrates

Wang, C., Lu, H., Wang, Z., Xiu, P., Zhou, B., Zuo, G., Wan, R., Hu, J., & Fang, H. (2009) · Physical Review Letters · doi:10.1103/physrevlett.103.137801 · Cited by 281

Aqueous Solutions of Paraffin-Chain Salts.

Lingafelter, E. C. (1949) · Chemical Reviews · doi:10.1021/cr60137a009 · Cited by 271

The biology of habitat dominance; can microbes behave as weeds?

Cray, J. A., Bell, A. N. W., Bhaganna, P., Mswaka, A. Y., Timson, D. J., & Hallsworth, J. E. (2013) · Microbial Biotechnology · doi:10.1111/1751-7915.12027 · Cited by 269

Chaperonins govern growth of Escherichia coli at low temperatures

Ferrer, M., Chernikova, T. N., Yakimov, M. M., Golyshin, P. N., & Timmis, K. N. (2003) · Nature Biotechnology · doi:10.1038/nbt1103-1266 · Cited by 265

Effect of Ions on the Hydrophobic Interaction between Two Plates

Zangi, R., Hagen, M., & Berne, B. J. (2007) · Journal of the American Chemical Society · doi:10.1021/ja068305m · Cited by 264

Optimization to Low Temperature Activity in Psychrophilic Enzymes

Struvay, C., & Feller, G. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms130911643 · Cited by 232

A universal measure of chaotropicity and kosmotropicity

Cray, J. A., Russell, J. T., Timson, D. J., Singhal, R. S., & Hallsworth, J. E. (2013) · Environmental Microbiology · doi:10.1111/1462-2920.12018 · Cited by 208

Counterion Effect on Interfacial Water at Charged Interfaces and Its Relevance to the Hofmeister Series

Nihonyanagi, S., Yamaguchi, S., & Tahara, T. (2014) · Journal of the American Chemical Society · doi:10.1021/ja412952y · Cited by 202

Microbiology of sugar‐rich environments: diversity, ecology and system constraints

Lievens, B., Hallsworth, J. E., Pozo, M. I., Belgacem, Z. B., Stevenson, A., Willems, K. A., & Jacquemyn, H. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.12570 · Cited by 199

Ethanol-induced water stress in yeast

Hallsworth, J. E. (1998) · Journal of Fermentation and Bioengineering · doi:10.1016/s0922-338x(97)86756-6 · Cited by 192

Can Salting-In/Salting-Out Ions be Classified as Chaotropes/Kosmotropes?

Zangi, R. (2010) · The Journal of Physical Chemistry B · doi:10.1021/jp909034c · Cited by 184

Are ionic liquids kosmotropic or chaotropic? An evaluation of available thermodynamic parameters for quantifying the ion kosmotropicity of ionic liquids

Zhao, H. (2006) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.1449 · Cited by 182

Limits of life in hostile environments: no barriers to biosphere function?

Williams, J. P., & Hallsworth, J. E. (2009) · Environmental Microbiology · doi:10.1111/j.1462-2920.2009.02079.x · Cited by 171

The viscosity of strong electrolytes measured by a differential method

Cox, W. M., & Wolfenden, J. H. (1934) · Proceedings of the Royal Society of London. Series A, Containing Papers of a Mathematical and Physical Character · doi:10.1098/rspa.1934.0113 · Cited by 171

Chaotropic solutes cause water stress in Pseudomonas putida

Hallsworth, J. E., Heim, S., & Timmis, K. N. (2003) · Environmental Microbiology · doi:10.1111/j.1462-2920.2003.00478.x · Cited by 168

Solutes determine the temperature windows for microbial survival and growth

Chin, J. P., Megaw, J., Magill, C. L., Nowotarski, K., Williams, J. P., Bhaganna, P., Linton, M., Patterson, M. F., Underwood, G. J. C., Mswaka, A. Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000557107 · Cited by 159

Hydrophobic substances induce water stress in microbial cells

Bhaganna, P., Volkers, R. J. M., Bell, A. N. W., Kluge, K., Timson, D. J., McGrath, J. W., Ruijssenaars, H. J., & Hallsworth, J. E. (2010) · Microbial Biotechnology · doi:10.1111/j.1751-7915.2010.00203.x · Cited by 138

Microbial community of the deep‐sea brine L ake K ryos seawater–brine interface is active below the chaotropicity limit of life as revealed by recovery of mRNA

Yakimov, M. M., Cono, V. L., Spada, G. L., Bortoluzzi, G., Messina, E., Smedile, F., Arcadi, E., Borghini, M., Ferrer, M., Schmitt‐Kopplin, P., et al. (2014) · Environmental Microbiology · doi:10.1111/1462-2920.12587 · Cited by 132

Aggregation and Dispersion of Small Hydrophobic Particles in Aqueous Electrolyte Solutions

Zangi, R., & Berne, B. J. (2006) · The Journal of Physical Chemistry B · doi:10.1021/jp064475+ · Cited by 100

Dynamic hydration shell restores Kauzmann's 1959 explanation of how the hydrophobic factor drives protein folding

Baldwin, R. L. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1414556111 · Cited by 99

Activity and stability of glycolytic enzymes in the presence of ethanol

Millar, D. G., Griffiths-Smith, K., Algar, E. M., & Scopes, R. K. (1982) · Biotechnology Letters · doi:10.1007/bf00127792 · Cited by 95

Water and temperature relations of soil A ctinobacteria

Stevenson, A. W., & Hallsworth, J. E. (2014) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12199 · Cited by 95

Is there a second critical point in liquid water?

Stanley, H. E., Angell, C. A., Essmann, U., et al. (1994) · Physica A Statistical Mechanics and its Applications · doi:10.1016/0378-4371(94)90495-2 · Cited by 94

Pecorino Crotonese cheese: Study of bacterial population and flavour compounds

Randazzo, C. L., Pitino, I., Ribbera, A., & Caggia, C. (2009) · Food Microbiology · doi:10.1016/j.fm.2009.11.010 · Cited by 93

Compatible Solutes Protect against Chaotrope(Ethanol)-Induced, Nonosmotic WaterStress

Hallsworth, J. E., Prior, B. A., Nomura, Y., Iwahara, M., & Timmis, K. N. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.12.7032-7034.2003 · Cited by 86

Volume Exclusion and H-Bonding Dominate the Thermodynamics and Solvation of Trimethylamine-N-oxide in Aqueous Urea

Rösgen, J., & Jackson-Atogi, R. (2012) · Journal of the American Chemical Society · doi:10.1021/ja211530n · Cited by 82

Protein Cold Denaturation as Seen From the Solvent

Davidovic, M., Mattea, C., �Qvist, J., et al. (2008) · Journal of the American Chemical Society · doi:10.1021/ja8056419 · Cited by 78

Microbial weeds in hypersaline habitats: the enigma of the weed-likeHaloferax mediterranei

Oren, A., & Hallsworth, J. E. (2014) · FEMS Microbiology Letters · doi:10.1111/1574-6968.12571 · Cited by 75

Viscosity of Aqueous Solutions and Local Microscopic Structure

Corridoni, T., Mancinelli, R., Ricci, M. A., & Bruni, F. (2011) · The Journal of Physical Chemistry B · doi:10.1021/jp202755u · Cited by 63

A decrease in bulk water and mannitol and accumulation of trehalose and trehalose‐based oligosaccharides define a two‐stage maturation process towards extreme stress resistance in ascospores of N eosartorya fischeri ( A spergillus fischeri )

Wyatt, T. T., Golovina, E. A., van Leeuwen, R., Hallsworth, J. E., Wösten, H. A. B., & Dijksterhuis, J. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.12557 · Cited by 61

Genome and physiology of the ascomycete filamentous fungus X eromyces bisporus , the most xerophilic organism isolated to date

Leong, S. L., Lantz, H., Pettersson, O. V., Frisvad, J. C., Thrane, U., Heipieper, H. J., Dijksterhuis, J., Grabherr, M. G., Pettersson, M. E., Tellgren‐Roth, C., et al. (2014) · Environmental Microbiology · doi:10.1111/1462-2920.12596 · Cited by 54

Fast Anomalous Diffusion of Small Hydrophobic Species in Water

Kirchner, B., Stubbs, J. M., & Marx, D. (2002) · Physical Review Letters · doi:10.1103/physrevlett.89.215901 · Cited by 54

Experimental Binding Energies in Supramolecular Complexes

Biedermann, F., & Schneider, H.-J. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00583 · Cited by 554

General Principles and Strategies for Salting-Out Informed by the Hofmeister Series

Hyde, A. M., Zultanski, S. L., Waldman, J. H., Zhong, Y.-L., Shevlin, M., & Peng, F. (2017) · Organic Process Research & Development · doi:10.1021/acs.oprd.7b00197 · Cited by 526

Water is an active matrix of life for cell and molecular biology

Ball, P. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1703781114 · Cited by 484

Ecology of aspergillosis: insights into the pathogenic potency of Aspergillus fumigatus and some other Aspergillus species

Paulussen, C., Hallsworth, J. E., Álvarez‐Pérez, S., Nierman, W. C., Hamill, P. G., Blain, D., Rediers, H., & Lievens, B. (2017) · Microbial Biotechnology · doi:10.1111/1751-7915.12367 · Cited by 334

Is there a common water-activity limit for the three domains of life?

Stevenson, A., Cray, J. A., Williams, J. P., Santos, R., Sahay, R., Neuenkirchen, N., McClure, C. D., Grant, I. R., Houghton, J. D. R., Quinn, J. P., et al. (2015) · The ISME Journal · doi:10.1038/ismej.2014.219 · Cited by 329