Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules

Signaling Recognition Events with Fluorescent Sensors and Switches

de Silva, A. P., Gunaratne, H. Q. N., Gunnlaugsson, T., Huxley, A. J. M., McCoy, C. P., Rademacher, J. T., & Rice, T. E. (1997) · Chemical Reviews · doi:10.1021/cr960386p · Cited by 6,995

Fluorogenic and Chromogenic Chemosensors and Reagents for Anions

Martínez-Máñez, R., & Sancenón, F. (2003) · Chemical Reviews · doi:10.1021/cr010421e · Cited by 3,076

Design principles of fluorescent molecular sensors for cation recognition

Valeur, B. (2000) · Coordination Chemistry Reviews · doi:10.1016/s0010-8545(00)00246-0 · Cited by 2,377

Tools and Tactics for the Optical Detection of Mercuric Ion

Nolan, E. M., & Lippard, S. J. (2008) · Chemical Reviews · doi:10.1021/cr068000q · Cited by 2,345

Fluorescent and colorimetric sensors for detection of lead, cadmium, and mercury ions

Kim, H. N., Ren, W. X., Kim, J. S., & Yoon, J. (2012) · Chem. Soc. Rev. · doi:10.1039/c1cs15245a · Cited by 2,253

Fluorescent Chemosensors Based on Spiroring-Opening of Xanthenes and Related Derivatives

Chen, X., Pradhan, T., Wang, F., Kim, J. S., & Yoon, J. (2012) · Chemical Reviews · doi:10.1021/cr200201z · Cited by 1,984

Energy transfer: a spectroscopic ruler.

Stryer, L., & Haugland, R. P. (1967) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.58.2.719 · Cited by 1,957

New sensing mechanisms for design of fluorescent chemosensors emerging in recent years

Wu, J., Liu, W., Ge, J., Zhang, H., & Wang, P. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00224k · Cited by 1,858

A new trend in rhodamine-based chemosensors: application of spirolactam ring-opening to sensing ions

Kim, H. N., Lee, M. H., Kim, H. J., Kim, J. S., & Yoon, J. (2008) · Chemical Society Reviews · doi:10.1039/b802497a · Cited by 1,649

Fluorescent and colorimetric probes for detection of thiols

Chen, X., Zhou, Y., Peng, X., & Yoon, J. (2010) · Chemical Society Reviews · doi:10.1039/b925092a · Cited by 1,580

Fluoro- and Chromogenic Chemodosimeters for Heavy Metal Ion Detection in Solution and Biospecimens

Quang, D. T., & Kim, J. S. (2010) · Chemical Reviews · doi:10.1021/cr100154p · Cited by 1,355

Calixarene-Derived Fluorescent Probes

Kim, J. S., & Quang, D. T. (2007) · Chemical Reviews · doi:10.1021/cr068046j · Cited by 1,246

Colorimetric and fluorescent anion sensors: an overview of recent developments in the use of 1,8-naphthalimide-based chemosensors

Duke, R. M., Veale, E. B., Pfeffer, F. M., Kruger, P. E., & Gunnlaugsson, T. (2010) · Chemical Society Reviews · doi:10.1039/b910560n · Cited by 1,220

Excited state intramolecular proton transfer (ESIPT): from principal photophysics to the development of new chromophores and applications in fluorescent molecular probes and luminescent materials

Zhao, J., Ji, S., Chen, Y., Guo, H., & Yang, P. (2012) · Phys. Chem. Chem. Phys. · doi:10.1039/c2cp23144a · Cited by 1,192

Calixarene‐Derived Fluorescent Probes

Kim, J. S., & Quang, D. T. (2007) · ChemInform · doi:10.1002/chin.200749272 · Cited by 1,052

FRET-Based Small-Molecule Fluorescent Probes: Rational Design and Bioimaging Applications

Yuan, L., Lin, W., Zheng, K., & Zhu, S. (2013) · Accounts of Chemical Research · doi:10.1021/ar300273v · Cited by 1,021

A Long-Wavelength Fluorescent Chemodosimeter Selective for Cu(II) Ion in Water

Dujols, V., Ford, F., & Czarnik, A. W. (1997) · Journal of the American Chemical Society · doi:10.1021/ja971221g · Cited by 987

Recent progress on polymer-based fluorescent and colorimetric chemosensors

Kim, H. N., Guo, Z., Zhu, W., Yoon, J., & Tian, H. (2011) · Chem. Soc. Rev. · doi:10.1039/c0cs00058b · Cited by 959

Energy transfer cassettes based on organic fluorophores: construction and applications in ratiometric sensing

Fan, J., Hu, M., Zhan, P., & Peng, X. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35273g · Cited by 821

Excited-state proton coupled charge transfer modulated by molecular structure and media polarization

Demchenko, A. P., Tang, K.-C., & Chou, P.-T. (2013) · Chem. Soc. Rev. · doi:10.1039/c2cs35195a · Cited by 763

Zn2+-Triggered Amide Tautomerization Produces a Highly Zn2+-Selective, Cell-Permeable, and Ratiometric Fluorescent Sensor

Xu, Z., Baek, K.-H., Kim, H. N., Cui, J., Qian, X., Spring, D. R., Shin, I., & Yoon, J. (2010) · Journal of the American Chemical Society · doi:10.1021/ja907334j · Cited by 692

Unique Sandwich Stacking of Pyrene-Adenine-Pyrene for Selective and Ratiometric Fluorescent Sensing of ATP at Physiological pH

Xu, Z., Singh, N. J., Lim, J., Pan, J., Kim, H. N., Park, S., Kim, K. S., & Yoon, J. (2009) · Journal of the American Chemical Society · doi:10.1021/ja906855a · Cited by 590

Heptamethine Cyanine Dyes with a Large Stokes Shift and Strong Fluorescence: A Paradigm for Excited-State Intramolecular Charge Transfer

Peng, X., Song, F., Lu, E., Wang, Y., Zhou, W., Fan, J., & Gao, Y. (2005) · Journal of the American Chemical Society · doi:10.1021/ja043413z · Cited by 572

A Ratiometric Fluorescent Probe for Rapid Detection of Hydrogen Sulfide in Mitochondria

Chen, Y., Zhu, C., Yang, Z., Chen, J., He, Y., Jiao, Y., He, W., Qiu, L., Cen, J., & Guo, Z. (2013) · Angewandte Chemie International Edition · doi:10.1002/anie.201207701 · Cited by 563

A Rapid Aqueous Fluoride Ion Sensor with Dual Output Modes

Hu, R., Feng, J., Hu, D., Wang, S., Li, S., Li, Y., & Yang, G. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.201000790 · Cited by 546

Long-range photoinduced through-bond electron transfer and radiative recombination via rigid nonconjugated bridges: distance and solvent dependence

Oevering, H., Paddon‐Row, M. N., Heppener, M., et al. (1987) · Journal of the American Chemical Society · doi:10.1021/ja00245a014 · Cited by 542

Development of an Iminocoumarin-Based Zinc Sensor Suitable for Ratiometric Fluorescence Imaging of Neuronal Zinc

Komatsu, K., Urano, Y., Kojima, H., & Nagano, T. (2007) · Journal of the American Chemical Society · doi:10.1021/ja072432g · Cited by 542

Fluorescent and colorimetric chemosensors for detection of nucleotides, FAD and NADH: highlighted research during 2004–2010

Zhou, Y., Xu, Z., & Yoon, J. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00169d · Cited by 412

A Ratiometric Two-Photon Fluorescent Probe Reveals Reduction in Mitochondrial H2S Production in Parkinson’s Disease Gene Knockout Astrocytes

Bae, S. K., Heo, C. H., Choi, D. J., Sen, D., Joe, E.-H., Cho, B. R., & Kim, H. M. (2013) · Journal of the American Chemical Society · doi:10.1021/ja404004v · Cited by 411

Hepatocyte-Targeting Single Galactose-Appended Naphthalimide: A Tool for Intracellular Thiol Imaging in Vivo

Lee, M. H., Han, J. H., Kwon, P.-S., Bhuniya, S., Kim, J. Y., Sessler, J. L., Kang, C., & Kim, J. S. (2012) · Journal of the American Chemical Society · doi:10.1021/ja210065g · Cited by 408

Signal Ratio Amplification via Modulation of Resonance Energy Transfer: Proof of Principle in an Emission Ratiometric Hg(II) Sensor

Coskun, A., & Akkaya, E. U. (2006) · Journal of the American Chemical Society · doi:10.1021/ja066144g · Cited by 391

Fluorescence Sensing of Anions via Intramolecular Excimer Formation in a Pyrophosphate-Induced Self-Assembly of a Pyrene-Functionalized Guanidinium Receptor

Nishizawa, S., Kato, Y., & Teramae, N. (1999) · Journal of the American Chemical Society · doi:10.1021/ja991497j · Cited by 351

Fluorescence Sensing of Anions Based on Inhibition of Excited-State Intramolecular Proton Transfer

Wu, Y., Peng, X., Fan, J., Gao, S., Tian, M., Zhao, J., & Sun, S. (2007) · The Journal of Organic Chemistry · doi:10.1021/jo061634c · Cited by 349

Development of a Ratiometric Fluorescent Zinc Ion Probe in Near-Infrared Region, Based on Tricarbocyanine Chromophore

Kiyose, K., Kojima, H., Urano, Y., & Nagano, T. (2006) · Journal of the American Chemical Society · doi:10.1021/ja060399c · Cited by 337

Fluorescent Biomembrane Probe for Ratiometric Detection of Apoptosis

Shynkar, V. V., Klymchenko, A. S., Kunzelmann, C., Duportail, G., Muller, C. D., Demchenko, A. P., Freyssinet, J.-M., & Mely, Y. (2007) · Journal of the American Chemical Society · doi:10.1021/ja068008h · Cited by 335

Benzimidazole-Based Ratiometric Two-Photon Fluorescent Probes for Acidic pH in Live Cells and Tissues

Kim, H. J., Heo, C. H., & Kim, H. M. (2013) · Journal of the American Chemical Society · doi:10.1021/ja409971k · Cited by 333

Direct Fluorescence Monitoring of the Delivery and Cellular Uptake of a Cancer-Targeted RGD Peptide-Appended Naphthalimide Theragnostic Prodrug

Lee, M. H., Kim, J. Y., Han, J. H., Bhuniya, S., Sessler, J. L., Kang, C., & Kim, J. S. (2012) · Journal of the American Chemical Society · doi:10.1021/ja303998y · Cited by 309

A Novel, Cell-Permeable, Fluorescent Probe for Ratiometric Imaging of Zinc Ion

Maruyama, S., Kikuchi, K., Hirano, T., Urano, Y., & Nagano, T. (2002) · Journal of the American Chemical Society · doi:10.1021/ja026442n · Cited by 307

Rational Design of Ratiometric Near-Infrared Fluorescent pH Probes with Various pKa Values, Based on Aminocyanine

Myochin, T., Kiyose, K., Hanaoka, K., Kojima, H., Terai, T., & Nagano, T. (2011) · Journal of the American Chemical Society · doi:10.1021/ja1063058 · Cited by 284

Pyrene-functionalized oligonucleotides and locked nucleic acids (LNAs): Tools for fundamental research, diagnostics, and nanotechnology

Østergaard, M. E., & Hrdlicka, P. J. (2011) · Chemical Society Reviews · doi:10.1039/c1cs15014f · Cited by 256

Molecular Engineering of a TBET-Based Two-Photon Fluorescent Probe for Ratiometric Imaging of Living Cells and Tissues

Zhou, L., Zhang, X., Wang, Q., Lv, Y., Mao, G., Luo, A., Wu, Y., Wu, Y., Zhang, J., & Tan, W. (2014) · Journal of the American Chemical Society · doi:10.1021/ja504015t · Cited by 250

Rational Design of FRET-Based Ratiometric Chemosensors for in Vitro and in Cell Fluorescence Analyses of Nucleoside Polyphosphates

Kurishita, Y., Kohira, T., Ojida, A., & Hamachi, I. (2010) · Journal of the American Chemical Society · doi:10.1021/ja103615z · Cited by 239

Ratiometric optical oxygen sensing: a review in respect of material design

Feng, Y., Cheng, J., Zhou, L., Zhou, X., & Xiang, H. (2012) · The Analyst · doi:10.1039/c2an35907c · Cited by 233

A colorimetric and ratiometric fluorescent probe for thiols and its bioimaging applications

Zhu, B., Zhang, X., Li, Y., Wang, P., Zhang, H., & Zhuang, X. (2010) · Chemical Communications · doi:10.1039/c0cc00477d · Cited by 208

Fluorescence Imaging of Intracellular Cadmium Using a Dual-Excitation Ratiometric Chemosensor

Taki, M., Desaki, M., Ojida, A., Iyoshi, S., Hirayama, T., Hamachi, I., & Yamamoto, Y. (2008) · Journal of the American Chemical Society · doi:10.1021/ja803429z · Cited by 203

Fluorescent, Through-Bond Energy Transfer Cassettes for Labeling Multiple Biological Molecules in One Experiment

Jiao, G.-S., Thoresen, L. H., & Burgess, K. (2003) · Journal of the American Chemical Society · doi:10.1021/ja037193l · Cited by 190

Mitochondrial Thioredoxin-Responding Off–On Fluorescent Probe

Lee, M. H., Han, J. H., Lee, J.-H., Choi, H. G., Kang, C., & Kim, J. S. (2012) · Journal of the American Chemical Society · doi:10.1021/ja308446y · Cited by 161

A highly selective fluorescent ESIPT probe for the dual specificity phosphatase MKP-6

Kim, T., Kang, H. J., Han, G., Chung, S. J., & Kim, Y. (2009) · Chemical Communications · doi:10.1039/b911145j · Cited by 156

Optical methods in cell physiology

Ronot, X., & Adolphe, M. (1987) · Biochimie · doi:10.1016/0300-9084(87)90035-6 · Cited by 154

A Dual Fluorochrome Probe for Imaging Proteases

Kircher, M. F., Weissleder, R., & Josephson, L. (2004) · Bioconjugate Chemistry · doi:10.1021/bc034151d · Cited by 124

Encapsulated Energy-Transfer Cassettes with Extremely Well Resolved Fluorescent Outputs

Ueno, Y., Jose, J., Loudet, A., Pérez‐Bolívar, C., Anzenbacher, P., & Burgess, K. (2010) · Journal of the American Chemical Society · doi:10.1021/ja107193j · Cited by 112

A naphthalimide based chemosensor for Zn 2+ , pyrophosphate and H 2 O 2 : sequential logic operations at the molecular level

Kumar, M., Kumar, N., & Bhalla, V. (2012) · Chemical Communications · doi:10.1039/c2cc37728d · Cited by 85

Toward a Chemical Marker for Inflammatory Disease: A Fluorescent Probe for Membrane-Localized Thioredoxin

Lee, M. H., Jeon, H. M., Han, J. H., Park, N., Kang, C., Sessler, J. L., & Kim, J. S. (2014) · Journal of the American Chemical Society · doi:10.1021/ja503356q · Cited by 85

Selective detection of endogenous H2S in living cells and the mouse hippocampus using a ratiometric fluorescent probe

Zhang, L., Meng, W., Lu, L., Xue, Y., Li, C., Zou, F., Liu, Y., & Zhao, J. (2014) · Scientific Reports · doi:10.1038/srep05870 · Cited by 65

Ratiometric optical nanoprobes enable accurate molecular detection and imaging

Huang, X., Song, J., Yung, B. C., Huang, X., Xiong, Y., & Chen, X. (2018) · Chemical Society Reviews · doi:10.1039/c7cs00612h · Cited by 820

Aggregation-Induced Emission Luminogens for Activity-Based Sensing

Wang, D., & Tang, B. Z. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00305 · Cited by 510

Fluorescent chemosensors manipulated by dual/triple interplaying sensing mechanisms

He, L., Dong, B., Liu, Y., & Lin, W. (2016) · Chemical Society Reviews · doi:10.1039/c6cs00413j · Cited by 455

Activity‐Based NIR Enzyme Fluorescent Probes for the Diagnosis of Tumors and Image‐Guided Surgery

Li, H., Kim, D., Yao, Q., Ge, H., Chung, J., Fan, J., Wang, J., Peng, X., & Yoon, J. (2021) · Angewandte Chemie International Edition · doi:10.1002/anie.202009796 · Cited by 363

In Vivo Imaging of Endogenously Produced HClO in Zebrafish and Mice Using a Bright, Photostable Ratiometric Fluorescent Probe

Duan, C., Won, M., Verwilst, P., Xu, J., Kim, H. S., Zeng, L., & Kim, J. S. (2019) · Analytical Chemistry · doi:10.1021/acs.analchem.9b00224 · Cited by 322